• Journal of KIBIM
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• v.2 no.1
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• pp.7-17
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• 2012

In recent years, building information modeling (BIM) has been an important issue within the architect, engineering, and construction (AEC) industry. BIM provides a way to share and exchange semantically rich information about the buildings in order to achieve a successful level of collaboration, communication, and interaction between stakeholders throughout the life cycle of the project. However, despite the recognition of its potential, BIM has not yet been utilized in the construction, operation, and maintenance stages because of the need to reorganize the BIM by reflecting the as-built status of the buildings. In order to improve and increase the use of BIM at all phases of a project, several research efforts are exploring the creation of an as-built BIM that is based on advanced sensors. However, there is a lack of literature and investigation on this research area to date within the domestic AEC industry. The aim of this study is to suggest ways in which BIM can be utilized within the construction, operation, and maintenance stages based on advanced sensors so that it is an approach that might be usefully carried forward. This paper begins by presenting a review of the existing BIM research and achievement in order to determine the limitations of the use of BIM in the domestic AEC industry. Conclusively, this paper suggests a direction for the future applications of BIM and describes how it can benefit from additional research.

• YAKHAK HOEJI
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• v.58 no.4
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• pp.255-261
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• 2014

Poly-pharmacy has been on the rise because of aging of population and chronic disease. Most of drug metabolism happens in the liver by CYP isozymes and the metabolism by CYP450 enzymes. The Cytochrome P450 (CYP) is a superfamily of enzymes that catalyzes the oxidations of many endogenous and exogenous compounds. Primary human Hepatocytes (HH) are considered as the gold standard model for In vitro drug interaction studies. However, there are several limitations (cost, limited life span) for using HH cells. HepaRG cells are being used as a possible alternative. HepaRG cells were cultured in William E medium containing the positive control inducers (1A2: 10, 25, 50 ${\mu}M$ omeprazole, 2C9 and 2C19: 10 ${\mu}M$ rifampin, 3A4: 10, 25, 50 ${\mu}M$ rifampin) at $37^{\circ}C$, 5 % $CO_2$ in a humidified atmosphere. This study was to evaluate the induction of CYP isozymes (1A2, 2C9, 2C19 and 3A4) using LC-MS/MS. We evaluated the potential induction ability of Bosentan, as a drug of pulmonary artery hypertension, in HepaRG cells. For reference, dose of the Bosentan is determined to the basis of the $C_{max}$ (835 mg/ml) value. The enzyme activity demonstrated that CYP2C9 and 3A4 were induced up to 20 times by Bosentan. Like as In vivo, the enzyme activity of CYP2C9 and CYP3A4 is significantly induced in a dose-dependent by Bosentan.

• Journal of the Korean GEO-environmental Society
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• v.13 no.11
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• pp.37-42
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• 2012

This study investigated the use of Geobacter lovleyi with TBOS(Tetrabutoxysilane) for TCE(Trichloroethylene) dechlorination. The TCE dechlorination by Geobacter lovleiy was mathematically described as the independent variables such as initial concentration of TCE, protein mass of Geobacter lovleyi and initial concentration of TOBS, and these were modeled by the use of response surface methodology(RSM). These experiments were carried out as a Box-Behnken Design(BBD) consisting of 15 experiments. The application of RSM yielded the following equation, which is empirical relationship for the dechlorination efficiency($Y_1$, %) of TCE and first order kinetic constant of TCE($Y_2,\;d^{-1}$) by independent variables in coded unit : $Y_1=-11.50X_1$(initial concentration of TCE) + $4.25X_2$(protein mass as Geobacter lovleyi injected mass) - $4.75X_3$(initial concentration of TBOS) - ${6.58X_1}^2$ - ${8.58X_2}^2$ + 93.67, $Y_2=-10.92X_1+5.06X_2-4.89X_3-{4.93X_3}^2-2.19X_1X_2+2.54X_1X_3-2.19X_2X_3+16.71$. In this case, the value of the adjusted determination coefficient(adjusted $R^2$= 0.975 and 0.934) were closed to 1, showing a high significance of the model. Statistical results showed the order of TCE dechlorination at experimental factors to be initial TCE concentration > initial TBOS concentration > protein mass, but the interaction effects were non-significant.

• Journal of the Korea Concrete Institute
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• v.25 no.4
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• pp.401-409
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• 2013

In the present study, numerical analysis was performed for hydrodynamic motion and structural performance on four different concrete floating structures, which have same cross-section but different length. The hydrodynamic analysis of floating structures is carried out using ANSYS AQWA with the different 34 wave load on regular wave period from three seconds to ten seconds in 35 m water depth. In order to evaluate structural performance of floating structures under the critical wave load which obtained from hydrodynamic analysis. The integrated analysis is also carried out through the mapping method, which can directly connect the wave-induced hydraulic pressure obtained form ANSYS AQWA to Finite Element Model in ANSYS Mechanical. As a results of this study, the hydrodynamic motion of floating structures is decreased as the length of structure increased. It means that the effect of wave-structure interaction is strongly dependent on the relationship between a wave period and a length of structure. Moreover, it is found that tension stress on bottom slab of floating structure is occurred by the critical wave load, the sectional force is not influenced by length of a structure.

• Journal of the Korean Geosynthetics Society
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• v.12 no.4
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• pp.77-86
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• 2013

Laboratory pullout tests were conducted to evaluate pullout performance of steel strip reinforcements with deformed steel bars as transverse members. The steel strip reinforcement has an installation hole to assemble a deformed steel bar. Jumunjin standard sand is used to form a relative density of ground model to 80%. Frictional resistance of steel strip reinforcement without transverse member increases sharply at the initial displacement and quickly decreases with displacement. Maximum frictional resistance increases linearly as normal pressure increasing, and soil-reinforcement interaction friction angle(${\rho}_{peak}$) of a steel strip reinforcement is estimated to $14.64^{\circ}$. Passive resistance increases with displacement and converge into maximum passive resistance in most cases. Maximum passive resistance increases linearly as normal pressure increasing irrespective of shape of the steel reinforcement. Pullout force of steel strip reinforcements with installation holes or transverse members largely increases about 4 to 7 times compared to frictional resistance force of steel strip reinforcements when embedment length($L_e$) of steel strip reinforcements is 500 mm. In the case of using 2 transverse members, interference effect is observed due to the spacing of 2 transverse members and location of assembly holes and transverse members.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5284-5291
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• 2012

This research is to develop the Web-Based Ventilator Management Education Program that reflects the needs of nursing site nursing which is intended to help nursing duties. ISD model-building process has been developed for the analysis, design, development, operation, and evaluation of methods. The education program was developed from April to July 2011, and SPSS 18.0 was used for data analysis. The analysis stage, document review and requirement analysis, content analysis, learner analysis, technology and environment analysis have been executed. Through the processes, higher education requirements for the practical ventilator, a large number of subjects under the age of 30, and the career of less than 3 years of ICU were searched. At the design stage, the education content that was presented by the content expert group was executed in information design, mutual interaction design, synchronization design through discussion with program experts. At the development stage, author made the story flow and gathered data and integrated it through the review of related document and data. At the operation and evaluation stage, author executed the developed program and revised and supplemented it on the basis of the evaluation results through the experts and subjects evaluation. The Web-Based Ventilator Management Education Program could contribute to the improvement of nursing because the program has been developed to reflect the diverse needs of nursing practice in the process of building program.

• Journal of Life Science
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• v.30 no.9
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• pp.826-833
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• 2020

Phospholipase C gamma (PLCγ) has critical roles in receptor tyrosine kinase- and non-receptor tyrosine kinase-mediated cellular signaling relating to the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂] to produce inositol 1,4,5 trisphosphate (IP₃) and diacylglycerol (DAG), which promote protein kinase C (PKC) and Ca²⁺ signaling to their downstream cellular targets. PLCγ has two isozymes called PLCγ1 and PLCγ2, which control cell growth and differentiation. In addition to catalytically active X- and Y-domains, both isotypes contain two Src homology 2 (SH2) domains and an SH3 domain for protein-protein interaction when the cells are activated by ligand stimulation. PLCγ also contains two pleckstrin homology (PH) domains for membrane-associated phosphoinositide binding and protein-protein interactions. While PLCγ1 is widely expressed and appears to regulate intracellular signaling in many tissues, PLCγ2 expression is restricted to cells of hematopoietic systems and seems to play a role in the regulation of immune response. A distinct mechanism for PLCγ activation is linked to an increase in phosphorylation of specific tyrosine residue, Y783. Recent studies have demonstrated that PLCγ mutations are closely related to cancer, immune disease, and brain disorders. Our review focused on the physiological roles of PLCγ by means of its structure and enzyme activity and the pathological functions of PLCγ via mutational analysis obtained from various human diseases and PLCγ knockout mice.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.44 no.1
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• pp.56-63
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• 2007

In this paper, an eye tracking method is presented using a neural network (NN) and mean-shift algorithm that can accurately detect and track user's eyes under the cluttered background. In the proposed method, to deal with the rigid head motion, the facial region is first obtained using skin-color model and con-nected-component analysis. Thereafter the eye regions are localized using neural network (NN)-based tex-ture classifier that discriminates the facial region into eye class and non-eye class, which enables our method to accurately detect users' eyes even if they put on glasses. Once the eye region is localized, they are continuously and correctly tracking by mean-shift algorithm. To assess the validity of the proposed method, it is applied to the interface system using eye movement and is tested with a group of 25 users through playing a 'aligns games.' The results show that the system process more than 30 frames/sec on PC for the $320{\times}240$ size input image and supply a user-friendly and convenient access to a computer in real-time operation.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.11 no.2
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• pp.198-208
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• 2000

Objectives：This study was conducted to evaluate the effects of the attachment promotion program which was designed to promote attachment between autistic children and their mothers. The program was consisted of play activity centered mother-child interaction, educational activity for mothers by lecture, video-feedback session, and emotional supports. Methods：The subjects were consisted of 11 pairs of mother and child(7 for participant group：PG, 4 for non-participant group：NPG), who were 2-4 years-old autistic children. The data were collected by video-taping, behavioral observations, and analyzed by Wilcoxon Rank(Sign) Sum Test and Content Analysis. Results：The total attachment score increased from pre test to post-test of PG was significantly higher than that of NPG. The scores of attachment behaviors indicating proximity, mutuality and affect increased significantly(p<.05), while some behaviors indicating synchrony and jointattention did not. Especially the affectionate behaviors of PG demonstrated the most notable changes and they became more active, voluntary and reciprocal. After the program, the mother's nurturing behaviors of PG increased more than that of NPG, with no significant difference between two groups. The mother's behaviors to her child of PG became more child-centered, positively responsive, supportively expressive. As the attachment was promoted, there were also positive changes in the children's autistic behaviors with a great deal of individual differences. Conclusion：Our findings suggest that Mother-Child Attachment Promotion Program could be an effective early intervention model for autistic children.

• The Korea Journal of Herbology
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• v.22 no.4
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• pp.253-260
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• 2007

Objectives : Intracerebral hemorrhage (ICH) is characterized by breakdown of blood vessels within the brain parenchyma. Fundamental therapeutic strategies for ICH, particularly those aimed at neuroprotection, have to be established. So in this experiment, the effects of Woowhangchongshim-won, a traditional prescription formula for treating Cerebral Apoplexy in Asian countries, were investigated. Methods : After intraperitoneal injection of chloralhydrate, rats were placed in a stereotaxic frame. ICH was induced by injection of 1 U collagenase type IV and drug was administered orally for 10 days. The molecular profile of cerebral hemorrhage in rat brain tissue was measured using micro array technique to identify up- or down- regulated genes in brain tissue. These genes induced by brain damage were mainly concerned with general metabolic process such as primary metabolic process, cellular metabolic process, macromolecule metabolic process, and biosynthetic process. Results : The number of genes increased in control and not-changed in experiment was 374, and decreased in control and not-changed in experiment was 527. We are concerned with genes that can be recovered by treatment with medicine, it is especially interesting to above types of genes. Conclusions : Upon medicine treatment to the rat having cerebral hemorrhage, expressions of some genes were restored to normal level. Further analysis using protein interaction database identified some key molecules that can be used for elucidation of therapeutical mechanism of medicine in future.