• BMB Reports
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• v.50 no.12
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• pp.640-646
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• 2017

Regulatory B cells, also well-known as IL-10-producing B cells, play a role in the suppression of inflammatory responses. However, the epigenetic modulation of regulatory B cells is largely unknown. Recent studies showed that the bromodomain and extra-terminal domain (BET) protein inhibitor JQ1 controls the expression of various genes involving cell proliferation and cell cycle. However, the role of BET proteins on development of regulatory B cells is not reported. In this study, JQ1 potently suppressed IL-10 expression and secretion in murine splenic and peritoneal B cells. While bromodomain-containing protein 4 (BRD4) was associated with $NF-{\kappa}B$ on IL-10 promoter region by LPS stimulation, JQ1 interfered the interaction of BRD4 with $NF-{\kappa}B$ on IL-10 promoter. In summary, BRD4 is essential for toll like receptor 4 (TLR4)-mediated IL-10 expression, suggesting JQ1 could be a potential candidate in regulating IL-10-producing regulatory B cells in cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1583-1588
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• 2016

Background: Polycystic ovary syndrome (PCOS) is considered to be a multifactorial disorder resulting from the interaction of several predisposing and protective genetic variants. PCOS is associated with low-grade chronic inflammation. Elevated levels of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1) are demonstrated in women with PCOS. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and multifactorial diseases that have an inflammatory component. The aim of the study was to assess the possible association of Gly241Arg polymorphism of ICAM-1 gene located on chromosome 19p13 in determining risk of PCOS in Kashmiri women. Materials and Methods: Gly241Arg SNP in DNA from peripheral blood leukocytes of 220 PCOS cases and 220 age matched non-PCOS healthy controls was analysed using allel specific PCR. Results: The genotype and allele frequency distributions of Gly241Arg SNP showed insignificant difference between the PCOS cases and control women, indicating no role of this SNP in PCOS susceptibility. The odds ratio for Arg/Arg genotype was 0.87 (95% CI=0.32-2.3) [P=0.79], for Gly/Arg genotype was 0.98 (95% CI= 0.66-1.47) [P=1] and for Arg/Arg+Gly/Arg genotype was 0.97 (95% CI=0.65-1.45) [P=0.92]. The genotypic frequencies of ICAM-1codon 241 showed statistically insignificant difference between cases and controls (${\chi}^2=0.07$; p=0.96) Nor the studied polymorphism was found to affect clinical and laboratory parameters significantly. Conclusions: Although Gly241Arg polymorphism have not shown significant association with PCOS. Further, specifically designed studies on large cohorts are required to conclusively establish any role of ICAM-1 gene polymorphisms in PCOS in our study.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4383-4386
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• 2015

Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. However, little is known on C1561T-GCPII as a risk factor for colorectal cancer. Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Materials and Methods: 164 controls and 38 adenomatous polyp cases were analysed to determine blood folate and plasma homocysteine (Hcy) level, dietary intake of natural methylfolate, synthetic pteroylglutamic acid (PteGlu), vitamin C and C1561T-GCPII genotype. Results: In controls and cases, 7.3 and 18.4 percent of subjects respectively, were found to have the CT genotype, increasing the risk for adenomatous polyp occurrence 2.86 times (95% CI:1.37-8.0, p=0.035). Total dietary folate, methylfolate and PteGlu intake and the level of erythrocyte folate and plasma Hcy did not predict the occurrence of an adenomatous polyp. However, dietary natural vitamin C intake was associated with adenomatous polyp risk within C1561T-GCPII CT genotype subjects (p=0.037). Conclusions: The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.

• Korean Journal of Veterinary Research
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• v.36 no.3
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• pp.699-707
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• 1996

This study was designed to examine the involvement of lead in function of target organ, and the protective effect of selenium in lead-treated guinea pigs for 8 weeks. The effects of exposure to 0.5% lead acetate(lead) and/or 4ppm sodium selenite(selenium) in feed on serveral aspects were evaluated by measuring thyroid stimulating hormone(TSH), triiodothyronine($T_3$), thyroxine($T_4$), serum biochemical activities, organ weights, and serum and organ lead concentrations in growing animals. The many indicators of endocrine function(TSH, $T_3$, and $T_4$ in serum), enzyme and biochemical activities(${\alpha}$-glutamyltranspeptidase, alkaline phosphatase, lactate dehydrogenase, triglyceride, creatinine, $Ca^{2+}$ in serum), and organ weights(kidney, spleen and testis) were correlated with lead exposure or showed significantly different mean values between the exposed and controls. These changes on some aspects were reversed by combination-fed of selenium, but did not statistically significant. The organ(kidney, liver, spleen, testis and brain) and serum lead concentrations of lead-fed group were clearly higher than that of controls. Selenium supplementation resulted in a significant protection against lead accumulation in liver and testis. These results suggest that lead can cause a toxic effect on several organ and that selenium seems to has a protective effect on specific reaction by lead-induced organic function toxicity.

• Journal of the Korea Society of Computer and Information
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• v.11 no.5 s.43
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• pp.127-137
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• 2006

We propose two phase filtering scheme to develop an efficient mechanism for XML databases to control query-based access. An access control environment for XML documents and some techniques to deal with fine-grained authorization priorities and conflict resolution issues are proposed. Despite this, relatively little work has been done to enforce access controls particularly for XML databases in the case of query-based access. The basic idea utilized is that a user query interaction with only necessary access control rules is modified to an alternative form through a query optimization technique, which is guaranteed to have no access violations using tree-aware metadata of XML schemas. The scheme can be applied to any XML database management system and has several advantages such as small execution time overhead, fine-grained controls, and safe and correct query modification. The experimental results clearly demonstrate the efficiency of the approach.

• Health Policy and Management
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• v.29 no.2
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• pp.228-236
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• 2019

Background: This study investigates the impact of weekend admission with a patient safety indicator (PSI) on 30-day mortality among long-term insurance beneficiaries. Methods: Data were obtained from the National Health Insurance Service-Senior claim database from 2002 to 2013. To obtain unbiased estimates of odds ratio, we used a nested case-control study design. The cases were individuals who had a 30-day mortality event after their last medical utilization, while controls were selected by incidence density sampling based on age and sex. We examined the interaction between the main independent variables of weekend admission and PSI by categorizing cases into four groups: weekend admission/PSI, weekend admission/non-PSI, weekday admission/PSI, and weekday admission/non-PSI. Results: Of the 83,400 individuals in the database, there were 20,854 cases (25.0%) and 62,546 controls (75.0%). After adjusting for socioeconomic, health status, seasonality, and hospital-level factors, the odds ratios (ORs) of 30-day mortality for weekend admission/PSI (OR, 1.484; 95% confidence interval [CI], 1.371-1.606) and weekday admission/PSI (OR, 1.357; 95% CI, 1.298-1.419) were greater than for patients with weekday admission/non-PSI. Conclusion: This study indicated that there is an increased risk of mortality after weekend admission among patients with PSI as compared with patients admitted during the weekday without a PSI. Therefore, our findings suggest that recognizing these different patterns is important to identify at-risk diagnosis to minimize the excess mortality associated with weekend admission in those with PSI.

• International Journal of Computer Science & Network Security
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• v.24 no.6
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• pp.161-170
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• 2024

With the technological advances, the humans have made so much progress in the ease of living and now incorporating the use of sight, motion, sound, speech etc. for various application and software controls. In this paper, we have explored the project in which gestures plays a very significant role in the project. The topic of gesture control which has been researched a lot and is just getting evolved every day. We see the usage of computer vision in this project. The main objective that we achieved in this project is controlling the computer settings with hand gestures using computer vision. In this project we are creating a module which acts a volume controlling program in which we use hand gestures to control the computer system volume. We have included the use of OpenCV. This module is used in the implementation of hand gestures in computer controls. The module in execution uses the web camera of the computer to record the images or videos and then processes them to find the needed information and then based on the input, performs the action on the volume settings if that computer. The program has the functionality of increasing and decreasing the volume of the computer. The setup needed for the program execution is a web camera to record the input images and videos which will be given by the user. The program will perform gesture recognition with the help of OpenCV and python and its libraries and them it will recognize or identify the specified human gestures and use them to perform or carry out the changes in the device setting. The objective is to adjust the volume of a computer device without the need for physical interaction using a mouse or keyboard. OpenCV, a widely utilized tool for image processing and computer vision applications in this domain, enjoys extensive popularity. The OpenCV community consists of over 47,000 individuals, and as of a survey conducted in 2020, the estimated number of downloads exceeds 18 million.

• Anxiety and mood
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• v.20 no.1
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• pp.8-16
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• 2024

Objective : The purpose of this study is to compare the signal obtained from the frontal 2-electrodes EEG with that obtained from the temporal, central, and parietal 2 electrodes. Methods : EEGs were recorded in a total of 67 patients with major depressive disorder (MDD), 104 patients with schizophrenia (SCZ), and 29 patients with Alzheimer's disease (AD). For each disease group, there were healthy controls (HC) that were paired accordingly (HC1=69, HC2=104, HC3=27). The following measurements were compared across electrodes: band power, alpha peak frequency (APF), APF power, alpha asymmetry (AA), and Kolmogorov complexity (KC). Results : Statistically significant differences were found in band power measured from frontal electrodes compared to electrodes placed in other locations. Specifically, the power of theta waves was measured higher in the temporal electorodes, alpha 1 and alpha 2 waves in the parietal, beta 1 and beta 2 in the central, and gamma waves in the temporal electrodes. Both SCZ and AD patients showed increased theta power in all electrodes. In SCZ patients, APF decreased in the central and temporal electrodes, but the APF power analysis showed no difference between the patients and controls. Additionally, AD patients exhibited increased AA in the central EEG, while SCZ patients showed decreased KC in the parietal and temporal electrodes. Conclusion : Depending on the electrode location, sensitive EEG frequencies differed. Compared with signals from other electrodes, frontal EEG in MDD patients revealed generally constant signal values, though the temporo-parieto-central electrodes appeared to be more reliable in SCZ and AD patients.

• Journal of the Korea Computer Graphics Society
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• v.27 no.3
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• pp.55-63
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• 2021

This study proposes an interface for providing mobile interaction suitable for mobile virtual reality (VR) and analyzes it through comparative experiments. The proposed interface is premised on not using additional equipment except for the mobile head-mounted display(HMD) in consideration of accessibility and usability. And the interface that controls the movement interaction using the user's gaze is designed in two phases. The key is to minimize the occurrence of negative factors such as VR sickness that can be caused by straight line movement in virtual reality. To this end, two phases are designed: an interface composed of forward/backward buttons to move the gaze toward the ground, and an interface composed of left and right buttons on the front in consideration of the gaze change in real walking motion. An application that can compare and analyze movement interactions through the proposed interface is produced, and a survey experiment is conducted to analyze the user's satisfaction with the interface experience and the negative impact on the movement process. It was confirmed that the proposed movement interaction reduced negative effects such as VR sickness along with a satisfactory interface experience for users.

• Sleep Medicine and Psychophysiology
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• v.11 no.2
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• pp.100-105
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• 2004

Objectives: Major depression is associated with an increased risk of cardiovascular mortality. One possible explanation for this association is that major depression influences autonomic neurocardiac regulation. However, previous studies on the relationship between heart rate variability (HRV) and major depression have revealed conflicting results. The purpose of this study is to clarify that major depressive patients compared to healthy controls show a reduction in HRV as an expression of reduced modulation of vagal activity to the heart. Methods: According to DSM-IV, the time and frequency domain HRV indices (5-min resting study) of 30 patients with major depressive disorder were compared with those of 30 healthy controls. Standardized HRV tests enable quantitative estimation of autonomic nervous system function. Results: After controlling for age and gender, subjects with major depression showed a higher heart rate and significantly lower modulation of cardiovagal activity compared to controls. The total power (TP) band, very low frequency (VLF: 0.003-0.04 Hz) band, low frequency (LF: 0.04-0.15 Hz) band, and high frequency (HF: 0.15-0.4 Hz) band were significantly reduced in subjects with major depression compared to control subjects. Conclusion: Patients with major depression may suffer from functional disturbances in the interaction between the sympathetic and parasympathetic autonomic systems.