• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.308-313
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• 2014

Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway plays an important role in the transcriptional regulation of AP-1 expression. Although the histone post-translational modifications (PTMs) are assumed to affect the AP-1 transcriptional regulation by the PI3K/Akt pathway, the detailed mechanisms are completely unknown. In the present study, we show that heterochromatin 1 gamma ($HP1{\gamma}$) plays a negative role in TPA-induced c-Jun and c-Fos expression. We show that TPA-induced Akt1 directly phosphorylates $HP1{\gamma}$, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-$3{\varepsilon}$. Collectively, these our data illustrate that the activation of PI3K/Akt pathway may play a permissive role in the recruitment of histone readers or other coactivators on the chromatin, thereby affecting the degree of AP-1 transcription.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.603-606
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• 2002

Numerical analysis and its inverse design process of 2nd stage of JT8D aircraft engine is described. One of the most important factors that affect the performante of turbomachine is secondary flow in the blade passage, so that the performance of turbomachine can be improved by controlling secondary flow. In this paper, as a method to control secondary flow, commercial inverse design program, TurboDesign is used. Meridional derivative of angular momentum is selected as a parameter to control blade leading in this program, To validate inverse designed model, computational analysis is applied which includes rotor-stator-interaction. In this paper, CFB results of both original and inverse designed model are compared to examine how much the performance improves without reduction of work output.

• Journal of Mechanical Science and Technology
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• v.20 no.7
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• pp.1043-1050
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• 2006

The aerodynamic interaction between a wing and a rail is investigated using a boundary-element method. The source and doublet singularities are distributed on the wing and its guide-way rail surface. The unknown strengths of the singularities are determined by inverting the aerodynamic influence coefficient matrices. Present method is validated by comparing computed results with the other numerical data. Rail width and rail height affect the aerodynamic characteristics of the wing only if the rail is narrower than the wing span. Although the present results are limited to the inviscid, irrotational flows, it is believed that the present method can be applied to the conceptual design of the high speed ground transporters moving over the rail.

• Interaction and multiscale mechanics
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• v.2 no.4
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• pp.431-454
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• 2009

This paper presents a simple model for studying the dynamic response of multi-span bridges resting on piers with different heights and subjected to earthquake forces acting transversely to the bridge, but varying spatially along its length. The analysis is carried out using the modal superposition technique, while the solution of the resulting integral-differential equations is obtained via the Laplace transformation. It has been found that the piers' height and the quality of the foundation soil can affect significantly the dynamic behavior of such bridges. Typical examples showing the effectiveness of the method are presented with useful results listed.

• Smart Structures and Systems
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• v.4 no.4
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• pp.439-448
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• 2008

Optical fiber sensors are by now broadly accepted as an innovative and reliable device for structural health monitoring, to be used either embedded into or bonded on structures. The accuracy of the strain measurement achievable by optical fiber sensors is critically dependent on the characteristics of the bonding of the various interface layers involved in the sensor bonding/embedding (structure material and gluing agent, fiber coating and gluing agent, fiber coating and fiber core). In fact, the signal of the bonded/embedded optical fiber sensor must correspond to the strain experienced by the monitored structure, but the quality of each involved interface can affect the strain transfer. This paper faces the characterization, carried on by both mechanical tests and morphological analysis, of the strain transfer function resulting with epoxidic and vinylester gluing agent on polyimide and acrylate coated optical fibers.

• Computational Structural Engineering : An International Journal
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• v.1 no.1
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• pp.71-80
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• 2001

A reliability approach to evaluate structural performance has gained increased acceptability and usage over the past two decades. Most reliability analyses are based on the reliability of an individual component without examining the entire structural system. These analyses often result in either unnecessary repairs or unsafe structures. This study uses examples of series, parallel, and series-parallel models of structural systems to illustrate how the component reliabilities affect the reliability of the entire system. The component-system reliability interaction can be used to develop optimum lifetime inspection and repair strategies for structural systems. These examples demonstrate that such strategies must be based on the reliability of the entire structural system. They also demonstrate that the location of an individual component in the system has a profound effect on the acceptable reliability of that component. Furthermore, when a structure is deteriorating over time, the reliability importance of various components is a1so changing with time. For this reason, the most critical component in the early life of the structure may not tie the most critical later.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.73-80
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• 2007

In this paper, the characteristics of noise and vibration of high speed train is analyzed depending on its speed. The speed is a very important parameter because it can affect the interaction between the train and the environment as well as the characteristics of the train itself. To measure its characteristics, we analyzed the signals from microphones and accelerometers which were attached to the passenger car of the high speed train. The signals from each sensor were stored in the recorder, and then analyzed by using the signal processing program. The data from each sensor are analyzed with the spectrogram. From the spectrogram, we found some distinct characteristics of the passenger car. Also, the characteristics of the noise propagation were inferred from the spectrogram.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.1875-1881
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• 2007

Deformations of bridge deck ends on abutments or on transition between bridge decks can cause extreme deformations on track. Especially, since slab track is fixed onto the bridge deck slab on concrete slab track-installed bridges, deformations of bridge deck ends directly affect the track behavior, and thus these interactions can bring about the premature failure of rail fastenings or other deteriorations to lower the serviceability. In this study, a foreign standard to evaluate forces on track components caused by the track-bridge interactions and the serviceability of bridge deck ends is investigated, and for the real bridges, the serviceability of bridge deck ends according to several parameters of bridge and track is analyzed. It is found that arrangements and spring coefficients of bridge bearings, as well as distance between bridge bearing and last rail support, support spacings, rail support spring coefficient, are very important parameters.

• Journal of Sensor Science and Technology
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• v.14 no.6
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• pp.438-443
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• 2005

In this paper, we introduce the on-line test of the current collection characteristics for HSR 350x(Korea High Speed Train project) that have been performed in the Kyoung-bu high-speed line since 2002. Through the analysis of measured data during on-line test, the variation trends of contact force between pantograph and catenary according to the track conditions and driving patterns are reviewed. This study shows that the track conditions do not affect on the dynamic performance between pantograph and the driving patterns are important factors in determining the good interaction of them.

• Journal of the Korean housing association
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• v.25 no.3
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• pp.63-72
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• 2014

This study examined the special features and domestic status of the shared-house from the increasing number of single-person households, and also studied demand characteristics of the shared-house targeting young single-person household. Moreover, it found affecting factors of residential inclination on the shared-house with the binary logic model. Some of field research and interviews for the survey were conducted, and the analyzed result from this study as follows: Firstly, the domestic shared-house, introduced between the end of 2012 and early 2013, has been rapidly increased and has some features such as decreasing in housing expenses and increasing in social interaction. Secondly, the demand for shared-house by residential experience of single-person household differs according to the demographic characteristics. Thirdly, the factors that affect residential inclination of shared-house are character types, community life experience, awareness, and need for shared house.