• Proceedings of the Korean Geotechical Society Conference
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• 2001.03a
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• pp.363-370
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• 2001

A computationally efficient algorithm to analyze a group pile behavior is proposed by consideration of both soil-pile and pile-cap interactions. Using toad transfer method the nonlinear characteristics of the soil-pile interaction for a single pile is modeled by piecewise linear soil springs (p-y, t-z, and q-z curves). Beam-column method, one of the most practical approaches, is used for numerical modeling of the soil-pile system. In addition to the group effect resulting from the soil-pile-soil interaction, for a more realistic analysis it is essential to consider the effect of pile-cap interaction including geometric configuration of the piles in a group and conectivity conditions between piles and the cap. This paper mainly focuses on the pile-cap interaction and the development of a rational numerical procedure of its incorporation with the beam-column method.

• Structural Engineering and Mechanics
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• v.29 no.1
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• pp.1-16
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• 2008

Tunnels are generally constructed below the ground water table, which produces a long-term interaction between the tunnel lining and the surrounding geo-materials. Thus, in conjunction with tunnel design, the presence of water may require a number of considerations such as: leakage and water load. It has been reported that deterioration of a drainage system of tunnels is one of the main factors governing the long-term hydraulic and structural lining-ground interaction. Therefore, the design procedure of an underwater tunnel should address any detrimental effects associated with this interaction. In this paper an attempt to identify the coupled structural and hydraulic interaction between the lining and the ground was made using a numerical method. A main concern was given to local hindrance of flow into tunnels. Six cases of local deterioration of a drainage system were considered to investigate the effects of deterioration on tunnels. It is revealed that hindrance of flow increased pore-water pressure on the deteriorated areas, and caused detrimental effects on the lining structures. The analysis results were compared with those from fully permeable and impermeable linings.

• BMB Reports
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• v.45 no.8
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• pp.476-481
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• 2012

Flavodoxin (Fld) has been demonstrated to bind to ferredoxin-NADP$^+$ reductase A (FprA) in Pseudomonas putida. Two residues ($Phe^{256}$, $Lys^{259}$) of FprA are likely to be important for interacting with Fld based on homology modeling. Site-directed mutagenesis and pH-dependent enzyme kinetics were performed to further examine the role of these residues. The catalytic efficiencies of FprA-$Ala^{259}$ and FprA-$Asp^{259}$ proteins were two-fold lower than those of the wild-type FprA. Homology modeling also strongly suggested that these two residues are important for electron transfer. Thermodynamic properties such as entropy, enthalpy, and heat capacity changes of FprA-$Ala^{259}$ and FprA-$Asp^{259}$ were examined by isothermal titration calorimetry. We demonstrated, for the first time, that $Phe^{256}$ and $Lys^{259}$ are critical residues for the interaction between FprA and Fld. Van der Waals interactions and hydrogen bonding were also more important than ionic interactions for forming the FprA-Fld complex.

• Proceedings of the Korean Geotechical Society Conference
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• 2004.03b
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• pp.839-846
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• 2004

The objective of this study is the evaluation of the tunneling effect on the groundwater-surface water interaction. The designed tunnel line is laid beneath the Gapo-cheon, which runs throughout study area. And, the pre-evaluation of the tunnel-influence on the Gapo-cheon is urgently needed. However, it is very difficult to find out the similar domestic and/or foreign cases. In this study, we would exclude the numerical modeling technique with insufficient data. Instead of the evaluation of the tunneling effect on the groundwater-surface water interaction with the numerical modeling, we monitored the flow rate of surface water at various point. We measured the flow rate of surface water at 5 points. With the results of surface flow, we can conclude that 39% of flow rate in Gapo-cheon is contributed by the groundwater discharge, as baseflow.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.9
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• pp.1269-1275
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• 2015

Turbine-generator torsional response is caused by interaction between electrical transient air-gap torque and mechanical characteristics of turbine-generator shafts. There are various factors that affects torsional interaction such as fault, circuit breaker switching and generator mal-synchronizing, etc. Fortunately, we can easily simulate above torsional interaction phenomena by using ElectroMagnetic Transient Program (EMTP). However, conventional EMTP shows the incomplete response of super- synchronous torsional mode since it does not consider turbine blade section. Therefore, in this paper, we introduced mechanical-electrical analogy for detailed modeling of turbine-generator shaft system including low pressure turbine blade section. In addition, we derived the natural frequencies of modeled turbine-generator shaft system including turbine blade section and analyzed the characteristics of mechanical torque response at shaft coupling and turbine blade root area according to power system balanced/unbalanced faults.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2317-2325
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• 2014

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily and mediates transmembrane efflux of many drugs. Since it is involved in multi-drug resistance activity in various cancer cells, the development of P-gp inhibitor is one of the major concerns in anticancer therapy. Human P-gp protein has at least two "functional" drug binding sites that are called "H" site and "R" site, hence it has multi-binding-specificities. Though the amino acid residues that constitute in drug binding pockets have been proposed by previous experimental evidences, the shapes and the binding poses are not revealed clearly yet. In this study, human P-gp structure was built by homology modeling with available crystal structure of mouse P-gp as a template and docking simulations were performed with inhibitors such as verapamil, hoechst33342, and rhodamine123 to construct the interaction between human P-gp and its inhibitors. The docking simulations were performed 500 times for each inhibitor, and then the interaction frequency of the amino acids at the binding poses was analyzed. With the analysis results, we proposed highly contributing residues that constitute binding pockets of the human P-gp for the inhibitors. Using the highly contributing residues, we proposed the locations and the shapes of verapamil binding site and "R" site, and suggested the possible position of "H" site.

• Proceeding of EDISON Challenge
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• 2016.03a
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• pp.90-95
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• 2016

Heat Shock 70kDa Protein 1-Like(HSPA1L)는 Heat-shock protein70(HSP70) family에 속하는 chaperone protein으로 polypeptide folding, assembly, protein degradation 등 다양한 biological processes에 관여하고 있다. HSPA1L은 human methyltransferase-like protein 21A(METTL21A)에 의해 lysine residue에 methylation이 일어나게 되는데, 암세포에서 일반적인 HSPA1L은 주로 세포질에서 발견되는 반면 methylated HSPA1L의 경우 주로 핵에서 발견이 됨으로써 HSPA1L methylation이 암 세포 성장에 중요할 역할을 할 것이라 추측되며 anti-cancer drug target으로 주목 받고 있다. 하지만 현재 HSPA1L의 구조가 부분적으로만 밝혀져 있어 HSPA1L와 METTL21A가 어떤 residue들이 interaction 하여 binding을 하는지에 대해서 아직 밝혀 지지 않았다. 이로 인해 anti-cancer drug target으로서의 연구에 제한이 있다. 이번 연구에서는 homology modeling(Galaxy-TBM, Galaxy-refine)을 통해 HSPA1L 전체 구조를 밝혀 낸 후, HSPA1L 와 METTL21A를 protein-protein docking을 통해 binding pose 예측을 하였다. 이러한 binding pose를 protein interaction analysis하여 HSPA1L과 METTL21A binding에 관여하는 중요 residue들을 밝혀 냈다. 이러한 structural information은 methylated HSPA1L와 암 세포 성장간의 연관성, 더 나아가 anti-cancer drug 개발로 까지도 이어 질 수 있을 것이라 생각한다.

• Coupled systems mechanics
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• v.3 no.4
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• pp.367-384
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• 2014

The study deals with the physical modeling of a typical single storeyed building frame resting on pile foundation and embedded in cohesive soil mass using the finite element based software SAP-IV. Two groups of piles comprising two and three piles, with series and parallel arrangement thereof, are considered. The slab provided at top and bottom of the frame along with the pile cap is idealized as four noded and two dimensional thin shell elements. The beams and columns of the frame, and piles are modeled using two noded one dimensional beam-column element. The soil is modeled using closely spaced discrete linear springs. A parametric study is carried out to investigate the effect of various parameters of the pile foundation, such as spacing in a group and number of piles in a group, on the response of superstructure. The response considered includes the displacement at the top of the frame and bending moment in columns. The soil-structure interaction effect is found to increase the displacement in the range of 38 -133% and to increase the absolute maximum positive and negative moments in the column in the range of 2-12% and 2-11%. The effect of the soil- structure interaction is observed to be significant for the type of foundation and soil considered in this study. The results obtained are compared further with those of Chore et al. (2010), wherein different idealizations were used for modeling the superstructure frame and sub-structure elements (foundation). While fair agreement is observed in the results in either study, the trend of the results obtained in both studies is also same.

• Nuclear Engineering and Technology
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• v.56 no.8
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• pp.3450-3462
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• 2024

This paper presents a computational framework for drop time assessment of a control element assembly (CEA) under fuel assembly (FA) deformations. The proposed framework consists of three key components: 1) finite element modeling of CEA, 2) fluid-structure interaction to compute drag force, and 3) modeling of frictional contact between CEA and FA. Specially, to accommodate the large motion of CEA, beam elements based on absolute nodal coordinate formulation (ANCF) are adopted. The continuity equation is utilized to calculate the drag force, considering flow changes in the cross-sectional area during the CEA drop. Lastly, beam-inside-beam frictional contact model is employed to capture practical contact conditions between CEA and FA. The proposed framework is validated through experiments under two scenarios: free falls of CEA within FA, encompassing undeformed and deformed scenarios. The experimental validation of the framework demonstrated that the drop time of CEA can be accurately predicted under the complex coupling effects of fluid and frictional contact. The drop times of the S-shaped deformation case is longer than those of the C-shaped deformation case, affirming the time delay due to frictional force. The validation confirms the potential applicability to access the safety and reliability of nuclear power plants under extreme conditions.

• Korean Journal of Computational Design and Engineering
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• v.15 no.2
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• pp.136-143
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• 2010

Realistic Modeling is to maximize the reality of the environment in which perception is made by virtual environment or remote control using two or more senses of human. Especially, the field of haptic rendering, which provides reality through interaction of visual and tactual sense in realistic model, has brought attention. Haptic rendering calculates the force caused by model deformation during interaction with a virtual model and returns it to the user. Deformable model in the haptic rendering has more complexity than a rigid body because the deformation is calculated inside as well as the outside the model. For this model, Gibson suggested the 3D ChainMail algorithm using volumetric data. However, in case of the deformable model with non-homogeneous materials, there were some discordances between visual and tactual sense information when calculating the force-feedback in real time. Therefore, we propose an algorithm for the Volume Haptic Rendering of non-homogeneous deformable object that reflects the force-feedback consistently in real time, depending on visual information (the amount of deformation), without any post-processing.