• Title/Summary/Keyword: Interaction Matrix

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Targeting Cell-Cell and Cell-Matrix Interactions and Its Therapeutic Applications

  • Kim, In-San
    • Proceedings of the PSK Conference
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    • 2003.10a
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    • pp.100-101
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    • 2003
  • Cell-cell and cell-matrix interaction is clearly required for metazoans not only to hold their cells together but also to conduct more sophisticated biological processes. Each cell has adhesion molecules on its cell membrane to link extracellular matrix and adjacent cells to the intracellular cytoskeleton, and also to transduce signals. In complex metazoans, information is transmitted from one cell to another by mechanisms such as direct intercellular communication, soluble signal molecules among distant cells, and local cellular environments formed by highly specialized extracellular matrix. (omitted)

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PERFORMANCE EVALUATION OF U-Mo/Al DISPERSION FUEL BY CONSIDERING A FUEL-MATRIX INTERACTION

  • Ryu, Ho-Jin;Kim, Yeon-Soo;Park, Jong-Man;Chae, Hee-Taek;Kim, Chang-Kyu
    • Nuclear Engineering and Technology
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    • v.40 no.5
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    • pp.409-418
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    • 2008
  • Because the interaction layers that form between U-Mo particles and the Al matrix degrade the thermal properties of U-Mo/Al dispersion fuel, an investigation was undertaken of the undesirable feedback effect between an interaction layer growth and a centerline temperature increase for dispersion fuel. The radial temperature distribution due to interaction layer growth during irradiation was calculated iteratively in relation to changes in the volume fractions, the thermal conductivities of the constituents, and the oxide thickness with the burnup. The interaction layer growth, which is estimated on the basis of the temperature calculations, showed a reasonable agreement with the post-irradiation examination results of the U-Mo/Al dispersion fuel rods irradiated at the HANARO reactor. The U-Mo particle size was found to be a dominant factor that determined the fuel temperature during irradiation. Dispersion fuel with larger U-Mo particles revealed lower levels of both the interaction layer formation and the fuel temperature increase. The results confirm that the use of large U-Mo particles appears to be an effective way of mitigating the thermal degradation of U-Mo/Al dispersion fuel.

Seismic response of a rigid foundation embedded in a viscoelastic soil by taking into account the soil-foundation interaction

  • Messioud, Salah;Sbartai, Badreddine;Dias, Daniel
    • Structural Engineering and Mechanics
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    • v.58 no.5
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    • pp.887-903
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    • 2016
  • This study analyses the seismic response of a three-dimensional (3-D) rigid massless square foundation resting or embedded in a viscoelastic soil limited by rigid bedrock. The foundation is subjected to harmonic oblique seismic waves P, SV, SH and R. The key step is the characterization of the soil-foundation interaction by computing the impedance matrix and the input motion matrix. A 3-D frequency boundary element method (BEM) in conjunction with the thin layer method (TLM) is adapted for the seismic analysis of the foundation. The dynamic response of the rigid foundation is solved from the wave equations by taking into account the soil-foundation interaction. The solution is formulated using the frequency BEM with the Green's function obtained from the TLM. This approach has been applied to analyze the effect of soilstructure interaction on the seismic response of the foundation as a function of the kind of incident waves, the angles of incident waves, the wave's frequencies and the embedding of foundation. The parametric results show that the non-vertical incident waves, the embedment of foundation, and the wave's frequencies have important impact on the dynamic response of rigid foundations.

Structural damping for soil-structure interaction studies

  • Lutes, Loren D.;Sarkani, Shahram
    • Structural Engineering and Mechanics
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    • v.3 no.2
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    • pp.107-120
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    • 1995
  • A soil-structure interaction formulation is used here which is based on consideration of the dynamics of the structure with a free, rather than a fixed, base. This approach is shown to give a quite simple procedure for coupling the dynamic characteristics of the structure to those of the foundation and soil in order to obtain a matrix formulation for the complete system. In fixed-base studies it is common to presume that each natural mode of the structure has a given fraction of critical damping, and since the interaction formulation uses a free-base model, it seems natural for this situation to assign the equal modal damping values to free-base modes. It is shown, though, that this gives a structural model which is significantly different than the one having equal modal damping in the fixed-base modes. In particular, it is found that the damping matrix resulting in equal modal damping values for free-based modes will give a very significantly smaller damping value for the fundamental distortional mode of the fixed-base structure. Ignoring this fact could lead one to attribute dynamic effects to interaction which are actually due to the choice of damping.

A MICROSTRUCTURAL MODEL OF THE THERMAL CONDUCTIVITY OF DISPERSION TYPE FUELS WITH A FUEL MATRIX INTERACTION LAYER

  • Williams, A.F.;Leitch, B.W.;Wang, N.
    • Nuclear Engineering and Technology
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    • v.45 no.7
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    • pp.839-846
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    • 2013
  • This paper describes a finite element model of the microstructure of dispersion type nuclear fuels, which can be used to determine the effective thermal conductivity of the fuels during irradiation. The model simulates a representative region of the fuel as a prism shaped unit cell made of brick elements. The elements within the unit cell are assigned material properties of either the fuel or the matrix depending on position, in such a way as to represent randomly distributed fuel particles with a size distribution similar to that of the as manufactured fuel. By applying an appropriate heat flux across the unit cell it is possible to determine the effective thermal conductivity of the unit cell as a function of the volume fraction of the fuel particles. The presence of a fuel/matrix interaction layer is simulated by the addition of a third set of material properties that are assigned to the finite elements that surround each fuel particle. In this way the effective thermal conductivity of the material may also be determined as a function of the volume fraction of the interaction layer. Work is on going to add fission gas bubbles in the fuel as a fourth phase to the model.

Harmonic seismic waves response of 3D rigid surface foundation on layer soil

  • Messioud, Salah;Sbartai, Badredine;Dias, Daniel
    • Earthquakes and Structures
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    • v.16 no.1
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    • pp.109-118
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    • 2019
  • This study, analyses the seismic response for a rigid massless square foundation resting on a viscoelastic soil layer limited by rigid bedrock. The foundation is subjected either to externally applied forces or to obliquely incident seismic body or surface harmonic seismic waves P, SV and SH. A 3-D frequency domain BEM formulation in conjunction with the thin layer method (TLM) is adapted here for the solution of elastodynamic problems and used for obtained the seismic response. The mathematical approach is based on the method of integral equations in the frequency domain using the formalism of Green's functions (Kausel and Peck 1982) for layered soil, the impedance functions are calculated by the compatibility condition. In this study, The key step is the characterization of the soil-foundation interaction with the input motion matrix. For each frequency the impedance matrix connects the applied forces to the resulting displacement, and the input motion matrix connects the displacement vector of the foundation to amplitudes of the free field motion. This approach has been applied to analyze the effect of soil-structure interaction on the seismic response of the foundation resting on a viscoelastic soil layer limited by rigid bedrock.

Stability Enhancement by the Interaction of Diffusion Flames (다수 비예혼합 화염의 안정화 특성)

  • Kim, Jin-Sun;Lee, Byeong-Jun
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.27 no.10
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    • pp.1420-1426
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    • 2003
  • The stability of turbulent nonpremixed interacting flames is investigated in terms of nozzle configuration shapes and kind of fuels. Four nozzle arrangements - cross 5, matrix 8, matrix 9 and circle 8 nozzles - are used in the experiment. There are many parameters affecting flame stability in multi-nozzle flames such as nozzle separation distance, fuel flowrates and nozzle configuration etc. Key factors to enhance blowout limit are the nozzle configuration and the existence of center nozzle. Even nozzle exit velocity equal 204 m/s, flame is not extinguished when there is not a center nozzle and s/d=15.3∼27.6 in matrix-8 and circular-8 configurations. At these conditions, recirculation of burnt gas is related with stability augmentation. Fuel mole fraction measurements using laser induced fluorescence reveal lifted flame base is not located at the stoichiometric contour.

pH-Dependent Drug Release from Polymethacrylic Acid Hydrogel Matrix (Polymethacrylic Acid 하이드로겔 매트릭스로부터의 pH 의존성 약물 방출)

  • Kim, Kyung-Chung;Kim, Kil-Soo;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
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    • v.19 no.4
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    • pp.179-183
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    • 1989
  • Drug release experiments were performed based on pH-sensitive swelling behaviors of polymethacrylic acid. 5-Fluorouracil as a nonionic model drug revealed release patterns depending solely on pH-dependent swelling kinetics of polymethacrylic acid. In contrast, release of propranolol hydrochloride as a cationic model drug was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics. Accordingly, a zero-order release pattern was obtained at pH 7, which was distinguished from the general matrix type drug release pattern.

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Modification of Yttrium-Stabilized Zirconia Ceramics Using Calcium Phosphate

  • Chang, Myung Chul
    • Journal of the Korean Ceramic Society
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    • v.50 no.4
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    • pp.257-262
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    • 2013
  • A biomimetic approach was applied for the chemical deposition of calcium phosphate (CaP) coatings on 3 mole% yttrium-stabilized zirconia [3YSZ] powders. The solid-state reaction of 3YSZ powders with the addition of CaP was investigated for the development of biodegradable zirconia ceramics. The solid-state interaction between the 3YSZ matrix powders and the CaP additives differed from the behavior of commercial zirconia matrix powders. The 3YSZ powders were chemically reacted with precursors for the CaP formation. 3YSZ powders were mixed in an aqueous solution of Ca-P precursors and the CaP was precipitated on the surface of the 3YSZ matrix powders. The CaP-doped YSZ powders were calcined at $1100^{\circ}C$ and shaped powder blocks were then fired at $1600^{\circ}C$ for 2 h. The CaP phase formation was investigated using FE-SEM and XRD analysis.