• Journal of Pharmaceutical Investigation
• /
• v.36 no.5
• /
• pp.331-338
• /
• 2006

A rapid, selective and sensitive reverse-phase HPLC methods for the determination of atenolol and chlorthalidone in human serum and whole blood were validated, and applied to the pharmacokinetic study of atenolol and chlorthalidone combination therapy. Atenolol and an internal standard, pindolol, were extracted from human serum by liquid-liquid extraction, and analyzed on a $\mu$-Bondapak C18 $10-{\mu}$ column in a mobile phase of methanol-0.01 M potassium dihydrogenphosphate(30:70, v/v, adjusted to pH 3.5) and fluorescence detection(emission: 300 nm, excitation: 224 nm). Chlorthalidone and an internal standard, probenecid, were extracted form human whole blood by liquid-liquid extraction, and analyzed on a Luna C18 $5-{\mu}$ column in a mobile phase of acetonitrile containing 77% 0.01 M sodium acetate and UV detection at 214 nm. These analysis were performed at three different laboratories using the same quality control(QC) samples. The chromatograms showed good resolution, sensitivity, and no interference by human serum and whole blood, respectively. The methods showed linear responses over a concentration range of 10-1,000 ng/mL for atenolol and 0.05-20 ${\mu}g/mL$ for chlorthalidone, with correlation coefficients of greater than 0.999 at all the three laboratories. Intra- and inter-day assay precision and accuracy fulfilled international requirements. Stability studies(freeze-thaw, short-, long-term, extracted sample and stock solution) showed that atenolol and chlorthalidone were stable. The lower limit of quantitation of atenolol and chlorthalidone were 10 ng/mL and 0.05 ${\mu}g/mL$, respectively, which was sensitive enough for pharmacokinetic studies. These methods were applied to the pharmacokinetic study of atenolol and chlorthalidone in human volunteers following a single oral administration of Hyundai $Tenoretic^{\circledR}$ tablet(atenolol 50 mg and chlorthalidone 12.5 mg) at three different laboratories.

• Journal of rehabilitation welfare engineering & assistive technology
• /
• v.7 no.2
• /
• pp.47-54
• /
• 2013

In this paper, we present an inertial sensor-based motion capturing system to measure and analyze whole body movements. This system implements a wireless AHRS(attitude heading reference system) we developed using a combination of rate gyroscope, accelerometer and magnetometer sensor signals. Several AHRS modules mounted on segments of the patient's body provide the quaternions representing the patient segments's orientation in space. We performed 3D motion capture using the quaternion data calculated. And a method is also proposed for calculating three-dimensional inter-segment joint angle which is an important bio-mechanical measure for a variety of applications related to rehabilitation. To evaluate the performance of our AHRS module, the Vicon motion capture system, which offers millimeter resolution of 3D spatial displacements and orientations, is used as a reference. The evaluation resulted in a RMSE of 2.56 degree. The results suggest that our system will provide an in-depth insight into the effectiveness, appropriate level of care, and feedback of the rehabilitation process by performing real-time limbs or gait analysis during the post-stroke recovery process.

• Mass Spectrometry Letters
• /
• v.8 no.4
• /
• pp.109-113
• /
• 2017

Single analytical procedure including extraction, liquid chromatography, and mass spectrometric analysis was evaluated for the simultaneous measurement of lysophospholipids (LPLs). LPLs, particularly, lysophosphatidic acids (LPA) and sphingosine 1-phosphate (S1P) are lipid messengers ubiquitously found in various biological matrix. The molecular species mediate important physiological roles in association with many diseases (e.g. cancer, inflammation, and neurodegenerative disease), which emphasize the significance of the simple and reliable analytical method for biomarker discovery and molecular mechanistic understanding. Thus, we developed analytical method mainly focusing on, but not limited by those lipid species S1P and LPA using reverse phase liquid chromatography-tandem mass spectrometry (RPLC-ESI-MS-MS). Extraction method was modified based on Folch method with optimally minimal level of ionization additive (ammonium formate 10 mM and formic acid). Reverse-phase liquid-chromatography was applied for chromatographical separation in combination with negative ionization mode electrospray-coupled Orbitrap mass spectrometry. The method validation was performed on human blood plasma in a non-targeted lipid profiling manner with full-scan MS mode and data-dependent MS/MS. The proposed method presented good inter-assay precision for primary targets, S1P and LPA. Subsequent analysis of other types of LPLs identified a broad range of lysophosphatidylcholines (LPCs) and lysophosphatidyl-ethanolamines (LPEs).

• Korean Journal of Remote Sensing
• /
• v.33 no.6_1
• /
• pp.993-1001
• /
• 2017

Drought is a worldwide natural disaster with extensively adverse impacts on natural ecosystems, agricultural products, social communities and regional economy. Various global satellite observations, including SMAP soil moisture, GRACE terrestrial water storage, Terra and Aqua vegetation productivity, evapotranspiration, and satellite precipitation measures are currently used to characterize seasonal timing and inter-annual variations of regional water supply pattern, vegetation growth, drought events, and its associated influence ecosystems and human society. We suggest the satellite monitoring system development to quantify meteorological, eco-hydrological, and socio-ecological factors related to drought events, and characterize spatial and temporal drought patterns in Korea. The combination of these complementary remote sensing observations(visible to microwave bands) provide an effective means for evaluating regional variations in the timing, frequency, and duration of drought, and availability of water supply influencing vegetation and crop growth. This integrated drought monitoring could help national capacity to deal with natural disasters.

• Journal of the Korean Society of Safety
• /
• v.32 no.6
• /
• pp.81-88
• /
• 2017

This study deals with the optimal design of a hybrid control system composed of a combination of active control system and passive control system for effective seismic performance improvement of two adjacent structures. The proposed hybrid control system adopts a configuration of installing an active control device in one building and connecting two adjacent structures with a passive control device so that the one-side active control force can be bi-directionally applied to both buildings through the passive connecting devices. In order to derive the optimal performance of the proposed system, the design parameters of the passive and active control systems were searched using the genetic algorithm. Numerical simulations of 10-story and 8-story buildings have been performed to verify the effectiveness of the proposed technique. For the purpose of comparison, the conventional independent control system with two identical active control systems being installed separately for each structure was also optimally designed and its seismic response has been evaluated as well. From the comparative results of the two control systems, it is demonstrated that the proposed hybrid control system requires larger control force for its one-side active control device than the conventional independent control system does for each of both-side active devices, but quite less than the total control force required for both-side devices of the independent control system, while maintaining similar seismic performance. Therefore, the proposed system is more economical and reliable than the conventional independent control system with two identical active devices.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.10
• /
• pp.2676-2683
• /
• 2009

The objective of this thesis is to improve the quality of a software product based on the enhancement of a software design quality using a better error detecting method. Also, this thesis is based on a software design method called as MOA(Methodology for Object to Agents) which uses an ontology based ODES(A Method based on Ontology for Detecting Errors in the Software Design) model as a common information model. At this thesis, a new format of error detecting method was defined. The method is implemented during a transformation process from UML model to ODES model using a ODES model, a Inter-View Inconsistency Detection technique and a combination of ontologic property of consistency framework and related rules. Transformation process to ODES model includes lexicon analysis and meaning analysis of a software design using of multiple mapping table at algorithm for the generation of ODES model instance.

• Journal of Korean Society of Steel Construction
• /
• v.24 no.3
• /
• pp.279-287
• /
• 2012

A double split tee connection is used as a connection that is suitable for ordinary moment frames or special moment frames according to the combination of variables of the thickness of the T-stub flange and the gauge distance of the high-strength bolts. In order to demonstrate safe structural behavior, a double split tee connection must meet the requirements for inter-story drift angles and the moment of connection, as defined in the Korea Building Code-Structural. In order to determine whether the these requirements are met, it is necessary to predict rotational stiffness and the ultimate plastic moment of the connection. Therefore, this study primarily aimed to propose an analytical model for predicting the rotational stiffness of a double split tee connection under a static load. Toward this end, a three-dimensional, non-linear finite element analysis was carried out. Then, the applicability of the proposed model was verified after comparing the test results of this study with other studies.

• Journal of the Economic Geographical Society of Korea
• /
• v.3 no.1
• /
• pp.53-81
• /
• 2000

Between 1980 and 1997 the Korean textile and clothing industry (KTCI) experienced the transformation of export-led accumulation regime rooted in domestically-derived price competitiveness into the combination between foreign mass production involving the geographical extension of productive forces and quality strategy based on upgrading technology and automation involved in the domestic market for high quality and price products. This restructuring of the KTCI is rooted at the crisis in the export-led growth regime implemented unity 1980 due to the rapid increase in wage levels by the ‘great labour movement’occurred in 1987. In particular, increased wage and collective bargaining realized through labour empowerment led to the crisis in the conjoin between mass production and mass export based on long working hours and low wage structure. The aim of this paper is to explore the transformation of development modes between 1980 and 1997 that can help us in understanding the fundamental reasons for the restructuring of the KTCI. To this end, the paper identifiles the changing accumulation regimes between 1980 and 1997 mediated by wage-labour relations, inter-firm relations and state-film relations, which are insitutional forms of the modes of regulation.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.47 no.5
• /
• pp.18-24
• /
• 2010

In this paper, a new matrix decoding system using vector based Virtual Source Location Information (VSLI) is proposed as an alternative to the conventional Dolby Pro logic II/IIx system for reconstructing multi-channel output signals from matrix encoded two channel signals, Lt/Rt. This new matrix decoding system is composed of passive decoding part and active part. The passive part makes crude multi-channel signals using linear combination of the two encoded signals(Lt/Rt) and the active part enhances each channel regarding to the virtual source which is emergent in each inter channel. Since the virtual sources are related to the perceptual sound images in virtual sound field, the reconstructed multi-channel sound results in good dynamic perception and stable image localization. Moreover, the good channel separation is maintained with nonlinear trigonometric enhancing function.

• Journal of Broadcast Engineering
• /
• v.20 no.6
• /
• pp.837-847
• /
• 2015

In this paper, the reception performance of spatial modulation multiple-output multiple-input (MIMO) is analyzed for high speed terrestrial broadcasting. The MIMO scheme is required to reduce the inter symbol interference (ISI) and spatial correlation. The spatial modulation scheme solves the problem of ISI, but the spatial correlation degrades the reception performance of SM scheme. The space-time block coded spatial modulation (STBC-SM) is combined the SM system with space-time block code (STBC) for reducing the effects of the spatial correlation. However, the STBC-SM scheme degrades the spectral efficiency by transmitting same data in the two symbol period. The double space-time transmit diversity with spatial modulation (DSTTD-SM) scheme transmits the data with full antenna combination. To adapt these SM MIMO systems into the terrestrial broadcasting system, the reception performance is analyzed using computer simulation in SUI channel environments.