• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.6 no.1
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• pp.48-65
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• 1995

This paper deals with the analysis of the unintentional radiation from the TDX-1B subscriber Board. According to the demand of digital systems and developement of high speed switching devices, electro- magnetic noise intensity and it's bandwidth occupancy in spectrum are increasing and so there is a serious possibility causing the various EMI phenomena. More accurate radiation model was established by using the Finite Difference Time Domain (FDTD) analysis, and the EMI probabilistic analysis of the digital switching system was performed. For validating the proposed model and its calculated results, on-promises test was performed and compared with the calculated results. These results may be applicable to be used for EMI model in large digital system, and prediction of EMI effect from a large digital system, and the EMI control design when designing digital system to meet inter- national EMI regulation.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.5
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• pp.667-678
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• 2021

The industrial life cycle theory was extended to the product life cycle theory and the corporate life cycle theory, but a conceptual life cycle was presented, and quantitative empirical evidence for this was insufficient. It is intended to improve appropriate resource planning and resource allocation by quantitatively predicting the industrial cycle and its position (age) in the cycle. Human resources, tangible assets, and industrial output analysis were conducted based on 28 years of actual data of 39 industries in Korea by applying the Gompertz model, which is a population ecology prediction model. By predicting with the Gompertz model, the coefficient of determination R2 value was 97% or more, confirming the high suitability with the actual cumulative sales value of the industry. A numerical model for calculating the life cycle of each industry, calculating the saturation of input resources for each industry, and diagnosing the financial stability of the industry was presented. These results will contribute to the decision-making of industrial policy officers for budget planning appropriately for each stage of industry development. Future research will apply the numerical model of this study to foreign national industries, complete an inter-industry convergence diagnostic model (e.g. ease of convergence, suitability of convergence, etc.) for renewal of fading industries.

• Mycobiology
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• v.50 no.1
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• pp.55-65
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• 2022

Lichen is a symbiotic mutualism of mycobiont and photobiont that harbors diverse organisms including endolichenic fungi (ELF). Despite the taxonomic and ecological significance of ELF, no comparative investigation of an ELF community involving isolation of a pure culture and high-throughput sequencing has been conducted. Thus, we analyzed the ELF community in Parmotrema tinctorum by culture and metabarcoding. Alpha diversity of the ELF community was notably greater in metabarcoding than in culture-based analysis. Taxonomic proportions of the ELF community estimated by metabarcoding and by culture analyses showed remarkable differences: Sordariomycetes was the most dominant fungal class in culture-based analysis, while Dothideomycetes was the most abundant in metabarcoding analysis. Thirty-seven operational taxonomic units (OTUs) were commonly observed by culture-and metabarcoding-based analyses but relative abundances differed: most of common OTUs were underrepresented in metabarcoding. The ELF community differed in lichen segments and thalli in metabarcoding analysis. Dissimilarity of ELF community intra lichen thallus increased with thallus segment distance; inter-thallus ELF community dissimilarity was significantly greater than intra-thallus ELF community dissimilarity. Finally, we tested how many fungal sequence reads would be needed to ELF diversity with relationship assays between numbers of lichen segments and saturation patterns of OTU richness and sample coverage. At least 6000 sequence reads per lichen thallus were sufficient for prediction of overall ELF community diversity and 50,000 reads per thallus were enough to observe rare taxa of ELF.

• Korean Journal of Radiology
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• v.25 no.6
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• pp.550-558
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• 2024

Hepatocellular carcinoma (HCC) is a biologically heterogeneous tumor characterized by varying degrees of aggressiveness. The current treatment strategy for HCC is predominantly determined by the overall tumor burden, and does not address the diverse prognoses of patients with HCC owing to its heterogeneity. Therefore, the prognostication of HCC using imaging data is crucial for optimizing patient management. Although some radiologic features have been demonstrated to be indicative of the biologic behavior of HCC, traditional radiologic methods for HCC prognostication are based on visually-assessed prognostic findings, and are limited by subjectivity and inter-observer variability. Consequently, artificial intelligence has emerged as a promising method for image-based prognostication of HCC. Unlike traditional radiologic image analysis, artificial intelligence based on radiomics or deep learning utilizes numerous image-derived quantitative features, potentially offering an objective, detailed, and comprehensive analysis of the tumor phenotypes. Artificial intelligence, particularly radiomics has displayed potential in a variety of applications, including the prediction of microvascular invasion, recurrence risk after locoregional treatment, and response to systemic therapy. This review highlights the potential value of artificial intelligence in the prognostication of HCC as well as its limitations and future prospects.

• Journal of Broadcast Engineering
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• v.13 no.3
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• pp.310-318
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• 2008

The H.264/AVC standard achieves higher coding efficiency than previous video coding standards with the rate-distortion optimization (RDO) technique which selects the best coding mode and reference frame for each macroblock. As a result, the complexity of the encoder have been significantly increased. In this paper, a fast intra-mode decision algorithm is proposed to reduce the computational load of intra-mode search, which is based on the inverse tree-structure edge prediction algorithm. First, we obtained the dominant edge for each $4{\times}4$ block from local edge information, then the RDO process is only performed by the mode which corresponds to dominant edge direction. Then, for the $8{\times}8$ (or $16{\times}16$) block stage, the dominant edge is calculated from its four $4{\times}4$ (or $16{\times}16$) blocks' dominant edges without additional calculation and the RDO process is also performed by the mode which is related to dominant edge direction. Experimental results show that proposed scheme can significantly improve the speed of the intra prediction with a negligible loss in the peak signal to noise ratio (PSNR) and a little increase of bits.

• Journal of Broadcast Engineering
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• v.13 no.5
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• pp.732-743
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• 2008

In H.264/AVC, 4$\times$4 block transform is used for intra and inter prediction instead of 8$\times$8 block transform. Using small block size coding, H.264/AVC obtains high temporal prediction efficiency, however, it has limitation in utilizing spatial redundancy. Motivated on these points, we propose a multi-dimensional transform which achieves both the accuracy of temporal prediction as well as effective use of spatial redundancy. From preliminary experiments, the proposed multi-dimensional transform achieves higher energy compaction than 2-D DCT used in H.264. We designed an integer-based transform and quantization coder for multi-dimensional coder. Moreover, several additional methods for multi-dimensional coder are proposed, which are cube forming, scan order, mode decision and updating parameters. The Context-based Adaptive Variable-Length Coding (CAVLC) used in H.264 was employed for the entropy coder. Simulation results show that the performance of the multi-dimensional codec appears similar to that of H.264 in lower bit rates although the rate-distortion curves of the multi-dimensional DCT measured by entropy and the number of non-zero coefficients show remarkably higher performance than those of H.264/AVC. This implies that more efficient entropy coder optimized to the statistics of multi-dimensional DCT coefficients and rate-distortion operation are needed to take full advantage of the multi-dimensional DCT. There remains many issues and future works about multi-dimensional coder to improve coding efficiency over H.264/AVC.

• Investigative Magnetic Resonance Imaging
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• v.25 no.3
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• pp.164-171
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• 2021

Purpose: Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Brain atrophy in this disease spectrum begins in the medial temporal lobe structure, which can be recognized by magnetic resonance imaging. To overcome the unsatisfactory inter-observer reliability of visual evaluation, quantitative brain volumetry has been developed and widely investigated for the diagnosis of MCI and AD. The aim of this study was to assess the prediction accuracy of quantitative brain volumetry using a fully automated segmentation software package, NeuroQuant^®, for the diagnosis of MCI. Materials and Methods: A total of 418 subjects from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease cohort were included in our study. Each participant was allocated to either a cognitively normal old group (n = 285) or an MCI group (n = 133). Brain volumetric data were obtained from T1-weighted images using the NeuroQuant software package. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to investigate relevant brain regions and their prediction accuracies. Results: Multivariate logistic regression analysis revealed that normative percentiles of the hippocampus (P < 0.001), amygdala (P = 0.003), frontal lobe (P = 0.049), medial parietal lobe (P = 0.023), and third ventricle (P = 0.012) were independent predictive factors for MCI. In ROC analysis, normative percentiles of the hippocampus and amygdala showed fair accuracies in the diagnosis of MCI (area under the curve: 0.739 and 0.727, respectively). Conclusion: Normative percentiles of the hippocampus and amygdala provided by the fully automated segmentation software could be used for screening MCI with a reasonable post-processing time. This information might help us interpret structural MRI in patients with cognitive impairment.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.3
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• pp.170-179
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• 2020

Tidal asymmetry would occur owing to shallow water tides at the Western Coast of macro tidal area. Especially, as ebb dominance of Mokpo coastal zone is known as the most prominent in Korea, it had been studied by domestic researchers. The cause of ebb dominance in Mokpo area is considered due to extensive inter-tidal zone in Muan Bay, and this has been studied based on amplification ratio, relative phase and skewness of tide/tidal flow curves in order to analyze qualitative tidal asymmetry. Furthermore, it was possible to figure out tidal characteristics with the difference of tidal amplitude and phase with Mokpo Harbor by observing the tide for 15 days in Muan Bay, which showed 40 minutes shorter ebbing time than at Mokpo Harbor. In addition, tidal flow prediction data in Mokpo North Harbor and Mokpo-Gu were analyzed. Meanwhile, the basis regarding qualitative interpretation of bed sediment and suspended sediment was provided by examining the qualitative changes in tidal asymmetry for spring-neap tidal cycle through the PCA/SWA indices. In addition, by examining long-term changes of ebb dominance in Mokpo Port, tidal characteristics of the past, present and future in this area, which is related to tidal asymmetry, is also provided.

• Korean Chemical Engineering Research
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• v.55 no.1
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• pp.27-33
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• 2017

The determination of disulfide bonds is important for comprehensive understanding of the chemical structure of protein. So far, many strategies for the disulfide bond analysis have been suggested in terms of speed and sensitivity. However, most of these strategies have not considered free thiol residues in the target protein in the process of determining the disulfide bond. We suggested the strategy which was composed of four steps for the identification of disulfide bonds; the first step was the prediction of possible disulfide bonds, the second step was the determination of free cysteine residues, the third step was the analysis of disulfide bond using a high-resolution mass spectrometry, and the final step was the determination of disulfide bonds based on the comprehensive verification. In this study, we performed the characterization of disulfide bonds for the recombinant protein (HRPE1), where 1 and 5 inter- and intra-chain disulfide bonds were identified, respectively.

• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.