• 대한한방내과학회지
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• 제41권6호
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• pp.1231-1244
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• 2020

Objective: This study was conducted to report the glucose-lowering effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 21 patients with type 2 diabetes mellitus who were administered Daeshiho-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san at Kyung-Hee University Korean Medical Hospital from 2014 to 2019. The hypoglycemic effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS) and 2-hour postprandial glucose (PP2) levels. For safety assessment, the effects of herbal extracts on liver and kidney function were analyzed by liver function tests, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and kidney function tests, including blood urea nitrogen (BUN) and creatinine (Cr). Patients were stratified according to their glycated hemoglobin (<6.5 or >6.5) levels and the kind of herbal extract used for treatment. Results: After administration of herbal extracts, FBS and PP2 significantly decreased to 20.24 mg/dL and 35.0 mg/dL respectively. Subgroup analysis revealed that, regardless of the glycated hemoglobin level, FBS and PP2 were significantly reduced in both groups. The safety profile showed no significant difference before and after taking herbal extracts. Conclusions: Daeshigo-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san may show the further glucose-lowering effects on patients with type 2 diabetes mellitus who have already treated with anti-hyperglycemic agents.

• 대한한의학방제학회지
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• 제31권4호
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• pp.361-371
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• 2023

Objectives : Gastric cancer is a malignant tumor of the digestive tract that not only has a high mortality rate, but also affects quality of life. In Traditional Korean Medicine, acupuncture and herbal medicines can increase the survival rate for Gastric cancer and improve the quality of life. Traditional Korean Medicine treatment played an important role when used alone or in combination with chemotherapy. However, there is still insufficient evidence to support the efficacy and safety of Traditional Korean Medicine in patients undergoing chemotherapy after surgery. Therefore, the purpose of this study is to systematically evaluate the effect of oriental medicine treatment on patients as a complementary therapy for Gastric cancer. Methods : 2 researchers will search using EMBASE, Pubmed, CNKI, Cochrane Library, CiNii, KMBASE, KISS, OASIS, RISS, ScienceON. The search period of the database is from inception until June 2022. This study will include a randomized controlled trial of GC for acupuncture and herbal treatment. Primary outcomes include anti-cancer effects. Secondary outcomes evaluate survival rates and improvements in quality of life. The data uses Review Manager Software 5.4. Results : This study will provide a systematic evaluation by synthesizing the anti-cancer effect, survival rate and quality of life of Gastric cancer when Traditional Korean Medicine is combined with chemotherapy. Conclusion : The conclusion of this study will provide a basis for determining whether Traditional Korean Medicine treatment for Gastric cancer treatment is an effective and safe treatment method in clinical practice.

• 한국자연치유학회지
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• 제13권2호
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• pp.71-84
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• 2024

배경: 이 연구는 성인 후기를 대상으로 건반악기를 활용한 음악 중재가 인지 기능에 미치는 영향을 조사하기 위해 국내외에서 수행된 25개의 실험 연구를 분석한 문헌 고찰이다. 건반악기 음악 중재는 손 기능과 미세 조정 능력 등 감각·운동 영역의 개선뿐만 아니라, 작업 능력, 주의력, 집중력, 기억력 등 인지 영역의 기능에도 긍정적인 영향을 미친다는 것을 보여주었다. 목적: 이 연구의 목적은 성인 후기의 대상군을 대상으로 건반악기를 활용한 음악 중재가 인지 기능에 미치는 영향을 고찰하고, 이러한 중재의 유용성을 평가하는 것이다. 방법: 연구 방법으로는 통합적 문헌 고찰(Integrative Literature Review) 방식을 사용하였으며, 2000년부터 2023년까지 발표된 관련 논문들을 PRISMA 지침에 따라 체계적으로 선별하였다. 데이터베이스 검색을 통해 선정된 논문들은 연구 대상자, 연구 방법, 검사 도구, 중재 방법과 내용, 연구 결과를 중심으로 분석하였다. 결과: 분석 결과, 건반악기를 활용한 음악 중재가 인지 기능 향상에 중요한 역할을 한다는 것이 입증되었다. 특히, 피아노 연주는 청각 능력, 주의력, 작업 기억, 손 기능 개선, 뇌 가소성 촉진에 효과적임을 보였다. 연구 대상자들은 중재 전후에 걸친 사전·사후 검사를 통해 이러한 변화를 정량적으로 평가하였다. 결론: 본 연구는 성인후기를 대상으로 한 건반악기 중재가 인지 기능 향상에 긍정적인 영향을 미친다는 것을 확인하였으며, 이는 인지 저하 예방 및 뇌 건강 증진을 위한 효과적인 중재 전략으로서의 가능성을 제시한다. 향후 연구에서는 이러한 중재의 장기적 효과를 평가하고, 최적의 중재 전략을 개발할 수 있다는 것에 의의가 있다.

• 대한한방내과학회지
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• 제45권3호
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• pp.335-341
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• 2024

목적: 암 환자 치료에 대한 반응률은 종양 세포가 면역 회피 반응을 일으키면서 떨어지게 된다. 방사선 치료나 항암 치료 같은 표준 치료들은 병을 고치거나 환자들의 생명을 연장하는 목적으로 쓰이나 그 독성이나 부작용으로 인해 효과가 제한되고 있다. 한약은 아시아 지역에서 활용되고 있는 대표적인 보완 의학이며 면역 작용을 증강시키기 위해 널리 사용되고 있다. 이 프로토콜은 향후 암 환자들의 면역 기능을 개선시키는 데 있어서 한약의 객관적인 유효성을 체계적 문헌 고찰로 평가하고자 한다. 방법: 검색할 데이터베이스는 다음과 같다: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure(CNKI), Korean databases including Regional Information Sharing Systems(RISS), National Digital Science Library(NDSL), Oriental Medicine Advanced Searching Integrated System(OASIS). 한약을 이용해 암 환자들의 면역 기능 개선을 다룬 전향적 무작위 대조 연구들을 포함시키고, 면역 기능과 관련된 모든 지표들(CD3, CD4, CD8, CD4/CD8 비율, CD19(B세포), CD11(수지상세포), CD56(NK세포), 대식세포 등)을 분석한다. 결과: 암 환자의 면역 기능과 관련된 지표들을 포함시켜 체계적 문헌 고찰과 메타 분석을 수행할 예정이다. 결론: 한약의 암 환자 면역 기능 개선 유효성을 객관적으로 알리고, 본 연구를 통해 환자와 의료진에게 암 치료에 있어서 새로운 선택지를 넓힐 수 있도록 방향을 제시하고자 한다.

• 한방재활의학과학회지
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• 제31권4호
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• pp.105-116
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• 2021

Objectives Lumbar herniated intervertebral disc (L-HIVD) is common disease in which Western-Korean collaborative treatment is performed in Korea. This study aimed to analyze Western-Korean collaborative treatment utilization of Korean patients with L-HIVD using Health Insurance Review & Assessment Service's Patients Sample Data. Methods This study used the Health Insurance Review & Assessment Service-National Patient Sample (HIRA-NPS) in 2018. Claim data of L-HIVD patients were extracted. The claim data were rebuilt with the operational concept of 'episode of care' and divided into Korean medicine episode group (KM), Western medicine episode group (WM) and collaborative treatment episode group (CT). General characteristics, medical expenses and healthcare utilization were analyzed. In addition, the difference of average visit day and average medical expenses between non-collaborative group (KM plus WM) and CT were analyzed by the propensity score matching method. Results A Total of 64,333 patients and 365,745 claims were extracted. The number of episodes of WM, KM and CT was 69,383 (92.97%), 3,903 (5.23%), and 1,341 (1.80%) respectively. The frequency of collaborative treatment episode was higher in women and the age of 50s. The most frequently described treatment in CT was acupuncture therapy. As a result of the propensity score matching, the number of visit days and medical expenses in the collaborative treatment group was higher than in the non-collaborative group. Conclusions The analysis of healthcare utilization of Korean-Western collaborative treatment may be used as basic data for establishing medical policies and systematic collaborative treatment model in the future.