The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Herbal Medicines for the Improvement of Immune Function in Patients with Cancer: A Protocol for Systematic Review and Meta-Analysis

한약의 암 환자에 대한 면역기능 개선 효과 : 체계적 문헌고찰과 메타분석 프로토콜

  • Young-Min Cho (East West Cancer Center, Daejeon Korean Medicine Hospital of Daejeon University) ;
  • Soobin Jang (Dept. of Preventive Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Mi Mi Ko (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Han-eum Joo (East West Cancer Center, Daejeon Korean Medicine Hospital of Daejeon University) ;
  • Hwa-Seung Yoo (East West Cancer Center, Daejeon Korean Medicine Hospital of Daejeon University) ;
  • Mi-Kyung Jeong (KM Convergence Research Division, Korea Institute of Oriental Medicine)
  • 조영민 (대전대학교 대전한방병원 동서암센터) ;
  • 장수빈 (대구한의대학교 예방의학교실) ;
  • 고미미 (한국한의학연구원 한의과학연구부) ;
  • 주한음 (대전대학교 대전한방병원 동서암센터) ;
  • 유화승 (대전대학교 대전한방병원 동서암센터) ;
  • 정미경 (한국한의학연구원 한의약융합연구부)
  • Received : 2024.04.19
  • Accepted : 2024.06.25
  • Published : 2024.06.30
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Abstract

Objectives: Patients with cancer eventually fail to respond to therapy when malignant cells develop effective ways to evade immunosurveillance. Conventional cancer treatments, such as radiation therapy and chemotherapy, aim to cure the disease or prolong the patient's life. However, the toxicity and side effects of conventional treatments limit their efficacy. Herbal medicine is a typical complementary and integrative form of medicine for cancer treatment in Asia. This protocol evaluates the effectiveness of herbal medicines in improving the immune function of patients with cancer. Methods: The following electronic databases will be searched: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), and Korean databases including Regional Information Sharing Systems (RISS), National Digital Science Library (NDSL), and Oriental Medicine Advanced Searching Integrated System (OASIS). Additionally, prospective randomized controlled trials that evaluate the effectiveness of herbal medicines on immune function in patients with cancer will be included in this review. All outcomes related to the immune function of patients with cancer (e.g., CD3, CD4, CD8, CD4/CD8 ratio, CD19 (B cells), dendritic cells (CD11), CD56 (NK cells), and macrophages) will be included in this review. Results: This review is expected to provide data on the effectiveness of herbal medicines on improving immune functions in patients with cancers. Conclusion: This systematic review will help patients and clinicians establish new management options for cancer treatment.

목적: 암 환자 치료에 대한 반응률은 종양 세포가 면역 회피 반응을 일으키면서 떨어지게 된다. 방사선 치료나 항암 치료 같은 표준 치료들은 병을 고치거나 환자들의 생명을 연장하는 목적으로 쓰이나 그 독성이나 부작용으로 인해 효과가 제한되고 있다. 한약은 아시아 지역에서 활용되고 있는 대표적인 보완 의학이며 면역 작용을 증강시키기 위해 널리 사용되고 있다. 이 프로토콜은 향후 암 환자들의 면역 기능을 개선시키는 데 있어서 한약의 객관적인 유효성을 체계적 문헌 고찰로 평가하고자 한다. 방법: 검색할 데이터베이스는 다음과 같다: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure(CNKI), Korean databases including Regional Information Sharing Systems(RISS), National Digital Science Library(NDSL), Oriental Medicine Advanced Searching Integrated System(OASIS). 한약을 이용해 암 환자들의 면역 기능 개선을 다룬 전향적 무작위 대조 연구들을 포함시키고, 면역 기능과 관련된 모든 지표들(CD3, CD4, CD8, CD4/CD8 비율, CD19(B세포), CD11(수지상세포), CD56(NK세포), 대식세포 등)을 분석한다. 결과: 암 환자의 면역 기능과 관련된 지표들을 포함시켜 체계적 문헌 고찰과 메타 분석을 수행할 예정이다. 결론: 한약의 암 환자 면역 기능 개선 유효성을 객관적으로 알리고, 본 연구를 통해 환자와 의료진에게 암 치료에 있어서 새로운 선택지를 넓힐 수 있도록 방향을 제시하고자 한다.

Keywords

Acknowledgement

This study was supported by the Korea Institute of Oriental Medicine, Republic of Korea (KSN2022240), and the Korea Health Industry Development Institute (KHIDI), Republic of Korea (HF20C0038). The funding source will have no input for interpretation or publication of the study results.

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