• BMB Reports
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• v.55 no.11
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• pp.553-558
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• 2022

Hepatocellular carcinoma (HCC) is dangerous cancer that often evades early detection because it is asymptomatic and an effective detection method is lacking. For people with chronic liver inflammation who are at high risk of developing HCC, a sensitive detection method for HCC is needed. In a meta-analysis of The Cancer Genome Atlas pan-cancer methylation database, we identified a CpG island in the USP44 promoter that is methylated specifically in HCC. We developed methylation-sensitive high-resolution melting (MS-HRM) analysis to measure the methylation levels of the USP promoter in cell-free DNA isolated from patients. Our MS-HRM assay correctly identified 40% of patients with early-stage HCC, whereas the α-fetoprotein test, which is currently used to detect HCC, correctly identified only 25% of early-stage HCC patients. These results demonstrate that USP44 MS-HRM analysis is suitable for HCC surveillance.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1997.10a
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• pp.105-108
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• 1997

Previous studies in stock market predictions using artificial intelligence techniques such as artificial neural networks and case-based reasoning, have focused mainly on spot market prediction. Korea launched trading in index futures market (KOSPI 200) on May 3, 1996, then more people became attracted to this market. Thus, this research intends to predict the daily up/down fluctuant direction of the price for KOSPI 200 index futures to meet this recent surge of interest. The forecasting methodologies employed in this research are the integration of genetic algorithm and artificial neural network (GAANN) and the integration of genetic algorithm and case-based reasoning (GACBR). Genetic algorithm was mainly used to select relevant input variables. This study adopts the categorical data preprocessing based on expert's knowledge as well as traditional data preprocessing. The experimental results of each forecasting method with each data preprocessing method are compared and statistically tested. Artificial neural network and case-based reasoning methods with best performance are integrated. Out-of-the Model Integration and In-Model Integration are presented as the integration methodology. The research outcomes are as follows; First, genetic algorithms are useful and effective method to select input variables for Al techniques. Second, the results of the experiment with categorical data preprocessing significantly outperform that with traditional data preprocessing in forecasting up/down fluctuant direction of index futures price. Third, the integration of genetic algorithm and case-based reasoning (GACBR) outperforms the integration of genetic algorithm and artificial neural network (GAANN). Forth, the integration of genetic algorithm, case-based reasoning and artificial neural network (GAANN-GACBR, GACBRNN and GANNCBR) provide worse results than GACBR.

• Journal of Bio-Environment Control
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• v.30 no.4
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• pp.367-376
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• 2021

Strawberry cultivation in Korea is grown in greenhouse, but most farms manage their water supply using a timer control method based on the experience of growers. The timer control has problems in that it is difficult to consider the weather condition, the growth stage of crops, and the moisture content of the substrate, so that the crops cannot be managed at an optimal level, and the accuracy of cultivation management are lacking. The watering methods using integrated solar irradiance and substrate moisture contents are control systems that provide eco-friendly and precise water supply considering the growth conditions of crops. The purpose of this study was to compare the combined water supply control with integrated solar irradiance and substrate moisture contents and timer control method in hydroponic cultivation of strawberries using coir, and to set the optimal integrated solar irradiance level for complex water supply control. The irrigation system was automatically watered when it reached 100, 150, 250 J·cm^-2 based on the external solar irradiance, and forced irrigation was performed at a substrate moisture content of less than 60% in all treatments. The amount of irrigation at once was 50 mL. The timer treatment was applied as a control. The smaller the level of integrated radiation to start watering, the greater the daily amount of irrigation. Both the fresh weight and dry weight per plant were higher in the complex irrigation control method than the timer control, and the 100 and 150 J·cm^-2 treatment had the highest fresh weight, and the 100 J·cm^-2 treatment showed a significantly higher dry weight. The yield was also significantly higher in the complex control method than in the timer, and the early yield increased as the level of integrated solar irradiance was smaller. The fresh weight of fruit was the lowest in the timer-controlled irrigation. As a result of this study, the possibility of combined control irrigation method using integrated solar irradiance and substrate moisture content was confirmed for precise water supply management of strawberries in hydroponics.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.13 no.11
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• pp.875-881
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• 2003

The received signal of a mobile phone is normally sensed through two independent means which are the sound generation of a speaker and vibration generation of a vibration motor. As an improvement scheme to meet the consumer's demand on weight reduction and miniaturization of a mobile phone, the design and development of an integrated vibration and sound generating device are performed in this research. To this purpose, the optimal shapes of the voice coil. the permanent magnet and the vibration plate are designed, and the excitation force applied to the vibration system of the new device is estimated and verified through theoretical analyses, computer simulation, and experiments using an expanded model. In addition, vibration performance comparison of the device with the existing vibration motor is performed, and from the overall process, therefore, the method and procedure for the vibration performance analysis of the integrated vibration and sound generating device are established.

• Journal of The Korea Institute of Healthcare Architecture
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• v.12 no.1
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• pp.27-39
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• 2006

This study was intended to present the proper operational scheme and present the criterion for establishment of proper convenient facilities and its planning method and the proper method of laying all sorts of teaching aids out. For this purpose, it attempted to investigate the type of crippled disorder and the behavioral characteristics of schoolchildren with crippled disorder with a focus on the descriptive study on disabled schoolchildren receiving complete integrated education. And it sought to analyze the present situation of complete integrated education and the case of integrated education and dissect the realities of its operation and the realities of the establishment of convenient facilities for disabled schoolchildren with a focus on the survey research.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.570-575
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• 2013

Enhancing utilization of buildings is gaining in importance in response to a challenging economy; thus, there is a need for a method that analyzes space, user, and user activity in an integrated way to provide project stakeholders with utilization information to support their decision-making about buildings. Conventional methods, such as architectural programming and post-occupancy evaluation, lack a formal relationship between user activity and other information, and therefore, are coarse-grained. This relationship has been formalized by two relatively new methods that provide fine-grained utilization information: workplace planning and space-use analysis. We characterize these two methods with focuses on their usage in different phases (i.e., planning, design, occupancy), required information that needs to be gathered, and the achievement and limitations in terms of three criteria, i.e., consistency, efficiency, and transparency. This characterization would not only help project stakeholders select and use a method that best meets their purposes for enhancing utilization of their buildings, but also provide researchers with promising research topics regarding enhancing utilization of buildings.

• Nuclear Engineering and Technology
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• v.44 no.4
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• pp.415-420
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• 2012

It is important to understand the amount of time required to execute an emergency procedural task in a high-stress situation for managing human performance under emergencies in a nuclear power plant. However, the time to execute an emergency procedural task is highly dependent upon expert judgment due to the lack of actual data. This paper proposes an analytical method to estimate the operator's performance time (OPT) of a procedural task, which is based on a measure of the task complexity (TACOM). The proposed method for estimating an OPT is an equation that uses the TACOM as a variable, and the OPT of a procedural task can be calculated if its relevant TACOM score is available. The validity of the proposed equation is demonstrated by comparing the estimated OPTs with the observed OPTs for emergency procedural tasks in a steam generator tube rupture scenario.

• Proceedings of the KIEE Conference
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• 1995.07b
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• pp.546-549
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• 1995

Recently, electric utility is facing substantially new stream of business environment, such as pressure of business restructuring, competition with private IPPs, diversification of supply-side and demand-side resource options, environmental externalities and uncertainties. Integrated resource planning(IRP) is very useful and powerful approach for solving complex and diversified electricity supply and demand problems. This paper presents a standardized IRP procedure using multi-attribute decision analysis approach. The selection of the most desirable plan is based on multi-attribute trade-off/risk analysis method and score ranking method. As a case study, 50 plans with 12 scenarios are analyzed.

• Natural Product Sciences
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• v.24 no.4
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• pp.288-292
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• 2018

High-performance countercurrent chromatography (HPCCC) coupled with reversed-phase highperformance liquid chromatography (RP-HPLC) method was developed to isolate dihydrophaseic acid 3'-O-${\beta}$-D-glucopyranoside (DHPAG) from the extract of Nelumbo nucifera seeds. Enriched DHPAG sample (2.3 g) was separated by HPCCC using ethyl acetate/n-butanol/water system (6:4:10, v/v/v, normal-phase mode, flow rate: 4.0 mL/min) to give 23.1 mg of DHPAG with purity of 88.7%. Further preparative RP-HPLC experiment gave pure DHPAG (16.3 mg, purity > 98%). The current study demonstrates that utilization of CCC method maximizes the isolation efficiency compared with that of solid-based conventional column chromatography.

• Journal of The Korean Association For Science Education
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• v.29 no.7
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• pp.759-766
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• 2009

This study was conducted to examine 10 Belizean teachers' conceptions about the causes of seasonal change. This research was conducted with an integrated method using a open ended written test and an interview which included a drawing. There are four categories, explained by the teachers, as the causes of seasonal changes. They are; climate, rotation of the earth on its axis, revolution of the earth around the sun, and the tilting of earth's axis as it revolves. Most teachers misunderstood that the first of three categories was responsible for seasonal change. Second, it is more effective to use the integrated method shown in this research than to use only a written test when seriously investigating the causes and understanding of seasonal change. Third, 8 out of 10 teachers could not correctly explain the causes of seasonal change. The reasons for seasonal change seemed to be hard for the informants to understand even though it was taught in elementary, middle, high school, and college elective classes.