• Korean Journal of Head & Neck Oncology
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• v.25 no.1
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• pp.28-32
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• 2009

Background : The most frequently reported risk factors for head and neck suamous cell carcinoma are smoking and alcohol. But in a recent overview, human papilloma virus(HPV) infection was revealed the important carcinogenic factor in oropharyngeal cancer. We aimed to clarify whether HPV directly effects on the oncogenesis and biologic behavior of hean and neck squamous cell carcinoma by comparison with infection prevalence, and physical status of virus. Material and Method : We used HPV genotyping DNA chip(Biocore, Korea, Seoul) arrayed by multiple oligonucleotide probes of L1 sequence of 26 types of HPV and HPV genotypes are identified by fluorescence scanner. The copy numbers of HPV E2 and E6 open reading frames(ORF) were assessed using a TaqMan-based 5'-exonuclease quantitative real-time PCR assay. The ratio of E2 to E6 copy numbers was calculated to determine the physical status of HPV-16 viral gene. Results : We observed a significant difference in HPV prevalence between tonsillar cancer group and control group(73.1% vs. 11.6%), and most of the HPVs were type 16(87.2%) and integrated(94.1%) state. In terms of oral tongue cancer, we demonstrate that 30.5% has integrated HPV-16 in cancer tissue. But Glottic cancer only 1% is related to HPV-16 integration. Conclusion : This study revealed significant relationship of HPV prevalence with oropharyngeal and oral tongue squamous cell carcinoma. Most of HPV were 16 type and integrated or mixed, HPV-16 integration could be directly related to the carcinogenesis.

• Journal of The Korea Institute of Healthcare Architecture
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• v.27 no.2
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• pp.15-24
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• 2021

Purpose: This study is to present basic data on the Architectural planning of the college of medicine by arranging the functional zoning planning, functional unit planning, and circulation planning, based on the diversification of medical education and the changes of Learning spaces. Methods: This study was conducted by literature review on existing medical education method and learning space planning. And then on-site surveys and questionnaire were conducted on existing facilities. Results: The diversification of medical education has already been progressing for a long time, and the development of information technology is integrated into the learning space, and the evolution of the learning method and the flexibility of the learning space give effect to the change of the learning space. ① This study reconstructed the existing classification method of university facilities into the fuctional zoning method that combines the architectural concept of function and movement. ② The functions and functional units of the college of medicine according to the proposed functional zone were arranged, and the space required for the medical college was suggested. ③ The function and type of movement of medical college can be classified into professor/student fusion type, teaching and research separation type, and learning and learning shared space integrated arrangement type. In the future, it is necessary to consider fusion type or integrated arrangement type rather than separation type. Implications: the evolution of the learning method and the flexibility of the learning space give effect to the change of the learning space.

• Journal of Preventive Medicine and Public Health
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• v.38 no.3
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• pp.252-258
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• 2005

Major approaches of Social epidemiology; 1)holistic, ecological approach, 2)population based approach, 3)development and life-course approach, 4)contextual multi-level approach, have stressed the importance of not only social context of health and illness, but also the population based strategy in the health interventions. Ultimately, it provides the conceptual guidelines and methodological tools to lead toward the healthy public policies; integrated efforts to improve condition which people live: secure, safe, adequate, and sustainable livelihoods, lifestyles, and environments, including housing, education, nutrition, information exchange, child care, transportation, and necessary community and personal social and health services.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.147-147
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• 1996

• Genomics & Informatics
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• v.4 no.1
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• pp.40-44
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• 2006

Toxicogenomics combines transcriptome, proteome and metabolome profiling with conventional toxicology to investigate the interaction between biological molecules and toxicant or environmental stress in disease caution. Toxicogenomics faces the problems of comparison and integration across different sources of data. Cause of unusual characteristics of toxicogenomic data, researcher should be assisted by data analysis and annotation for getting meaningful information. There are already existing repositories which claim to stand for toxicogenomics database. However, those just contain limited abilities for toxicogenomic research. For supporting toxicologist who comes up against toxicogenomic data flood, now we propose novel toxicogenomics knowledgebase system, XPERANTO-TOX. XPERANTO-TOX is an integrated system for toxicogenomic data management and analysis. It is composed of three distinct but closely connected parts. Firstly, Data Storage System is for reposit many kinds of '-omics' data and conventional toxicology data. Secondly, Data Analysis System consists of analytical modules for integrated toxicogenomics data. At last, Data Annotation System is for giving extensive insight of data to researcher.

• BMB Reports
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• v.50 no.11
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• pp.539-545
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• 2017

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated $eIF2{\alpha}$ kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understand how stressed cells coordinate gene expression at translational and transcriptional levels. The translational attenuation associated with this pathway has been largely attributed to the phosphorylation of the translational initiation factor $eIF2{\alpha}$. However, independent studies are now pointing to a second translational regulation step involving a downstream ISR target, 4E-BP, in the inhibition of eIF4E and specifically cap-dependent translation. The activation of 4E-BP is consistent with previous reports implicating the roles of 4E-BP resistant, Internal Ribosome Entry Site (IRES) dependent translation in ISR active cells. In this review, we provide an overview of the translation inhibition mechanisms engaged by the ISR and how they impact the translation of stress response genes.

• Journal of the Korean Society of Physical Medicine
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• v.1 no.1
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• pp.117-123
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• 2006

Objectives : The purpose of this study was conducted to find correct facilitation and clinical facilitation with proprioceptive neuromuscular facilitation (PNF). Methods : This is a literature study with books, articles, seminar note and books for PNF international course. Results : Treatment approach was changed from managements of reflex to facilitation. The facilitation will make passive or active motion. But it can not match with normal functional activities, lack of the active movement, and facilitation of musculoskeletal can interaction with environment. Conclusions : Facilitation of the Functional activities in the main therapy goal. Any necessary information, such as visual and acoustical information must be integrated. Spatial summation and temporal summation integrated also. Integrated information for the facilitation will be increased activity of alpha-motorneurons, activity of interneurons, and muscle fiber structural changes from slow twitch fibers to fast twitch fibers. Suggested facilitate goal-oriented of movements at a functional level and reduce stiffness at structural level.

• Tuberculosis and Respiratory Diseases
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• v.72 no.5
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• pp.401-408
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• 2012

Cardiopulmonary resuscitation (CPR) is a series of life-saving actions that improve the chances of survival, following cardiac arrest. Successful resuscitation, following cardiac arrest, requires an integrated set of coordinated actions represented by the links in the Chain of Survival. The links include the following: immediate recognition of cardiac arrest and activation of the emergency response system, early CPR with an emphasis on chest compressions, rapid defibrillation, effective advanced life support, and integrated post-cardiac arrest care. The newest development in the CPR guideline is a change in the basic life support sequence of steps from "A-B-C" (Airway, Breathing, Chest compressions) to "C-A-B" (Chest compressions, Airway, Breathing) for adults. Also, "Hands-Only (compression only) CPR" is emphasized for the untrained lay rescuer. On the basis of the strength of the available evidence, there was unanimous support for continuous emphasis on high-quality CPR with compressions of adequate rate and depth, which allows for complete chest recoil, minimizing interruptions in chest compressions and avoiding excessive ventilation. High-quality CPR is the cornerstone of a system of care that can optimize outcomes beyond return of spontaneous circulation (ROSC). There is an increased emphasis on physiologic monitoring to optimize CPR quality, and to detect ROSC. A comprehensive, structured, integrated, multidisciplinary system of care should be implemented in a consistent manner for the treatment of post-cardiac arrest care patients. The return to a prior quality and functional state of health is the ultimate goal of a resuscitation system of care.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.1
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• pp.80-96
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• 2022

Nowadays, artificial intelligence promotes the rapid development of skin cancer detection technology, and the federated skin cancer detection model (FSDM) and dual generative adversarial network model (DGANM) solves the fragmentation and privacy of data to a certain extent. To overcome the problem that the many-objective evolutionary algorithm (MaOEA) cannot guarantee the convergence and diversity of the population when solving the above models, a many-objective evolutionary algorithm based on integrated strategy (MaOEA-IS) is proposed. First, the idea of federated learning is introduced into population mutation, the new parents are generated through sub-populations employs different mating selection operators. Then, the distance between each solution to the ideal point (SID) and the Achievement Scalarizing Function (ASF) value of each solution are considered comprehensively for environment selection, meanwhile, the elimination mechanism is used to carry out the select offspring operation. Eventually, the FSDM and DGANM are solved through MaOEA-IS. The experimental results show that the MaOEA-IS has better convergence and diversity, and it has superior performance in solving the FSDM and DGANM. The proposed MaOEA-IS provides more reasonable solutions scheme for many scholars of skin cancer detection and promotes the progress of intelligent medicine.

• Herbal Formula Science
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• v.25 no.1
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• pp.39-49
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• 2017

Objectives : The contents of the literature associated with the medical records were entered into the database. We want to find the structure and search methods for efficient utilization of the database. Methods : The contents were entered into the database using the 'Access 2014 of the MS'. The Query Sentences were created and utilized for a search. Results : We could find information about the prescriptions, medical records and patients by the herbs and symptom combinations using the single table named 'Integrated Knowledge' and queries. Integrated Knowledge is a table that gathered patient information, prescription information and symptom information together. Conclusions : If you store patient, prescription and symptom information on a single table, you could search and use the results by various combinations of the various elements included in the table. These results could help curing patients on the basis of evidence-based treatment at the clinics.