• 한방안이비인후피부과학회지
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• 제23권1호
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• pp.260-269
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• 2010

Background : Bojungikgitang(BJT) and Banhabaekchulchonmatang(BBT) are known to treat the tinnitus patients, which were registered Korean National Health Insurance coverage lists. Objective : Few studies have evaluated economic benefits of both herbal medicines. This research is to investigate the cost-effectiveness of Bojungikgitang(BJT) and Banhabaekchulchonmatang(BBT) in chronic tinnitus patients over nineteen years old. Method : We built the decision tree model of chronic tinnitus and executed the deterministic analysis and threshold sensitivity analysis based on randomized clinical trial. Effectiveness was measured in quality-adjusted life-years(QALYs), and costs were in 2009 KRW(South Korean Currency). The perspective is societal, time horizon is 10 weeks, and Korean willingness to pay threshold is assumed to 20,000,000KRW. Results : In the base case analysis, BJT treatment resulted is better outcomes as low cost, so BJT is dominant medicine and BBT is dominated. But both cost per QALYs (BJT is 3,120,339KWN per QALY, BBT is 3,505,780KWN per QALY) are lower than the threshold, that could be covered by Korean National Health Insurance(KNHI). Conclusion : This study results showed that BJT was more cost-effective than BBT treating tinnitus patients for 10 weeks, and the cost per QALYs of both alternatives were lower than Korean national threshold.

• Korean Journal of Acupuncture
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• 제39권2호
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• pp.34-42
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• 2022

Objectives : Parkinson's disease (PD) is a neurodegenerative disease caused by dopaminergic neuronal death in the substantia nigra pars compacta. PD is known to be linked with mitochondrial dysfunction and increased oxidative stress. In this study, anti-cytotoxic and anti-oxidative effect of 12 herbal formulae were compared. Methods : According to experts' advice, 12 types of herbal formulae (Gamisoyosan, Galgeuntang, Galgeunhaegitang, Banhabaekchoolcheonmatang, Bojungikgitang, Boheotang, Sihogyejitang, Sihosogantang, Sihocheonggantang, Ojeoksan, Cheongsanggyeontongtang and Palmultang) were selected from 56 types of herbal formulae covered by the National Health Insurance Service in Korea. To detect anti-oxidative effect, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was performed, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to detect anti-cytotoxic effect of 12 herbal formulae using SH-SY5Y human neuroblastoma cells. Results : In DPPH assay, anti-oxidant activity was increased in a dose-dependent manner and half maximal inhibitory concentration was highest in the order of Galgeuntang, Gamisoyosan, Galgeunhaegitang, Ojeoksan, Palmultang, Sihogyejitang, Sihosogantang, Cheongsanggyeontongtang, Sihocheonggantang, Bojungikgitang, Boheotang and Banhabaekchoolcheonmatang. In MTT assay, concentration of 80% cell survival was highest in the order of Sihosogantang, Cheongsanggyeontongtang, Sihocheonggantang, Sihogyejitang, Bojungikgitang, Galgeuntang, Ojeoksan, Boheotang, Palmultang, Galgeunhaegitang, Banhabaekchoolcheonmatang and Gamisoyosan. Formulae with more than 50% DPPH radical scavenging activity at concentrations for 80% cell survival were Sihosogantang, Cheongsanggyeontongtang, Sihogyejitang, Galgeuntang and Sihocheonggantang. Conclusions : Sihosogantang, Cheongsanggyeontongtang, Sihogyejitang, Galgeuntang and Sihocheonggantang extracts can be candidate medicines for PD, but the effect should be validated in PD models.

• 대한예방한의학회지
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• 제24권2호
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• pp.1-15
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• 2020

Objectives : The objectives of this study were to investigate why and how China used traditional Chinese medicine as a response to COVID-19 and how its performance was achieved, and to explore ways to utilize traditional Korean medicine in Korea. Methods : We examined the information through government data and media articles. China's COVID-19 progress and policy response were reviewed and compared with Korea. Based on this, the characteristics of traditional Chinese medicine response in China were identified. Results : Based on legal basis, China makes the overall use of traditional Chinese medicines to respond to COVID-19. Traditional Chinese medicine has been applied to health insurance, the licensing regulations have been eased, and traditional Chinese medical specialists were dispatched. The medical care guidelines were developed and R&D were carried out. In addition, policies related to traditional Chinese medicine included policies for preventive treatment, the combination of Chinese and Western medicine, and telemedicine. Conclusions : Traditional Chinese medicine response to COVID-19 was included within the overall national quarantine policy, providing medical services for the mild stage. In addition, R&D was conducted to establish a basis for the utilization of traditional Chinese medicines. Traditional Korean medicine also needs to be prepared so that it can be used as a complement to the response of communicable diseases.

• 치위생과학회지
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• 제5권2호
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• pp.51-56
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• 2005

이 연구는 치과진료에서 처방되는 약제를 분석함으로써 해당 치과병 의원의 정보 자료의 제공 등으로 자율적 개선 노력 유도 및 지속적인 처방행태 변화추이 공개로 적정처방 및 벤 치마킹유도와 국민에게 항생제, 주사제 등의 약제 사용실태 홍보로 적정 약제 사용을 위한 인식 변화 유도에 기여하고자 이 연구를 시행하였다. 2003년 7월 1일부터 9월 31일까지 요양기관 34,226개소의 건강보험 외래약제 처방내역을 이용하여 항생제, 주사제의 투약일수율 및 처방률, 투약일당 약품비, 처방건당 약품목수와 고가약품목수의 비중에 대해 분석한 결과 다음과 같은 결론을 얻었다. 1. 항생제에 대한 투약일수율은 치과의원이 90.11%로 전년 동기 및 전분기보다 낮게 나타났으나, 처방률은 15.50%로 전년 동기 및 전분기보다 높게 나타났다. 치과병원의 투약일수율과 처방율은 각각 71.57%와 21.05%로 전분기보다 다소 높게 나타났다. 타종별 요양기관보다는 치과 병 의원의 투약일수율은 매우 높으나 처방률은 낮게 나타났다. 2. 주사제에 대한 투약일수율과 처방률은 치과의원이 각각 0.13%과 0.05%로 전년 동기보다는 감소추세로 나타났으며, 치과병원의 투약일수율과 처방률도 각각 1.03%과 0.88%로 전분기보다 다소 낮게 나타났다. 타 요양기관 종별보다는 치과병 의원의 주사제 투약일수율과 처방률은 매우 낮은 것으로 나타났다. 3. 약품목수는 치과의원이 2.79개로 전년 동기보다는 낮아졌으나 전분기보다는 높게 나타났으며, 치과병원은 2.67개로 전년 동기 및 전분기에 비해 증가된 것으로 나타났다. 타종별 요양기관보다는 치과병 의원 모두 약품목수가 적은 것으로 나타났다. 4. 투약일당 약품비는 치과의원이 863원으로 전년 동기 및 전분기에 비해 증가추세로 나타났으며, 치과병원은 1,385원로 전분기보다 낮게 나타났다. 타종별 요양기관보다는 치과병 의원 모두 낮은 것으로 나타났다. 5. 고가약품목수 비중은 치과의원이 46.43%로 전분기보다 높게 나타났으며, 치과병원은 54.05%로 전분기보다 매우 높게 나타났다. 병 의원에 비해 치과병 의원이 고가약품 목수 비중이 높은 것으로 나타났다. 6. 지역별 외래처방 현황 분석시 항생제 처방률은 광주지역이 가장 높고 대전지역이 가장 낮은 것으로 나타났으며, 주사제 처방률은 2/4분기 결과와 마찬가지로 영남지역이 모두 높은 반면, 수도권 지역은 모두 낮은 처방률로 나타났으며, 지역별 변이도 매우 커 최대지역의 처방률이 최소지역의 처방률의 2배 이상 높은 것으로 나타났다. 투약일당 약품비는 울산지역이 가장 높고 전북지역이 가장 낮게 나타나며, 처방건당 약품목수는 경기지역이 가장 높고 제주지역이 가장 낮게 나타났다.

• 대한한의학회지
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• 제41권2호
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• pp.107-121
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• 2020

Objectives: The purpose of this study was to identify the characteristics of patients who visited the emergency room (ER) of a Korean medicine (KM) hospital and to provide basic data for further research. Methods: We conducted a retrospective analysis using electronic medical records of 263 patients who visited the ER of OO University Oriental Hospital from January 1 to December 31, 2019. Results: Of the 263 patients' medical records, 245 were included in this analysis. The male-to-female ratio was 1.09:1. The average age was 52 years, with patients in their 40s having the largest distribution. The district where the hospital was located had the largest number of patients. The distribution by visit time was the lowest in the early morning. Most patients visited on Sunday, in September, and on the day of onset. The admission rate was 39.18%, and largest number of patients was admitted to the Department of Acupuncture and Moxibustion. The percentage of patients who revisited the KM hospital as an outpatient were 26.17%. The diagnosis for most patients was musculoskeletal disease. Acupuncture was the most common treatment, accounting for 62.45% of the cases, followed by herbal medicines, accounting for 54.69% of the cases. National health insurance was the most common type of insurance registered. Most patients visited the ER of the KM hospital via the ER of the hospital. Conclusions: This clinical analysis helped us identify the characteristics of patients visiting the ER of a KM hospital. Continuous data accumulation is required in relation to this for further studies.

• 대한임상독성학회지
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• 제4권1호
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• pp.25-31
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• 2006

Purpose: In the year of 2005, it enforced the basic study for establishing program of Poison Control Center by National Institute of Toxicologic Research. The object of our survey is to analyze the characteristics of intoxication from the City of Goyang by same protocol. Methods: We retrospectively reviewed the data of medical records of the intoxication patient in the two hospitals of the Goyang from 2004 June 1st to 2005 May 31th. The investigation protocol applied the TESS report form which was used from the Basic study for establishing program of Poison Control Center. Results: The intoxication patients were total 269 persons, the patients of A hospital were 184 persons, B hospital were 185 persons. The most common intoxication materials were medicines, in afterwords it was an agricultural chemical. The most common place of intoxication was the home. The intentional suicidal attempts in the reason of intoxication were 51.2%. The rate of the patients who discharges from the emergency department was 50.4% and death rate was 4.3%. Conclusion: We concluded that the continuous and systemic report and analysis should be accomplished from the Goyang area.

• 한국임상약학회지
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• 제20권1호
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• pp.39-49
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• 2010

The present study was aimed to examine the occurrence and influencing factors therapeutic duplication (TD) of medications for anxiety disorders by analyzing the relevant prescription data. In this study, the prescription data issued on March 19, 2008 in domestic medical institutes were utilized. TD was defined as more than two medications under the same therapeutic classification per prescription based on the Anatomical Therapeutic Classification (ATC) code. The assessment of TD was performed based on the number of cases and on the ratio determined. To identify the influencing factor of TD, the variables related to the differences in the TD ratio were analyzed based on the results of the Chi-Square test conducted with the variables; patients, medical institutes, diseases, and treatments. The number and ratio of TD were determined to be 1,333 out of the total of 19,219 anxiety disorder cases, and 6.94%, most cases involving benzodiazepine derivatives, respectively. The TD ratio was found to be higher in relation to males than to females. Patients with national health insurance benefits have a higher TD ratio compared to the medical-aid beneficiaries. The TD ratios were highest in clinics, psychiatry divisions, and Gyeongsang district. The TD ratio of the cases with more than two anxiety disorders was found to be higher than that of the cases with only one anxiety disorder. As the number of medications per prescription increased, the TD ratio was shown to have become gradually higher. In conclusion, in order to prevent TD, the concurrent DUR system should be implemented. The prescribers and pharmacists must be educated regarding duplicated medications to promote the safe and effective use of medicines, without unnecessary TD.

• 의료법학
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• 제23권2호
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• pp.3-36
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• 2022

의약품 리베이트 문제를 해결하기 위해서는 위법행위를 한 자를 제재하는 것과 함께 리베이트를 하지 않아도 의약품 판매촉진 경쟁에서 이길 수 있는 방법을 제공하는 구조적인 법 제도 개선이 필요하다. 이전에 국회와 정부는 제재를 강화하는 방안에만 노력을 기울였다. 그 결과 2014년 처분 대상 의약품을 시장에서 퇴출시킴으로써 제약회사에게 막대한 손실을 입힐 수 있는 제재 방법인 급여정지 제도를 도입하였다. 하지만 제도 도입 3년 만에 급여정지 처분이 환자의 의약품 접근권을 침해한다는 문제를 인식하고 2018년에 급히 급여정지 제도를 폐지하였다. 국회는 2021년 상징적으로 남아 있던 3차 위반 시 급여정지 처분도 모두 과징금 갈음이 되도록 입법을 하였다. 이렇게 급여정지 처분에 대한 입법자의 반성적 입장이 분명하지만 보건복지부는 구법 기간 동안의 리베이트에 대해서는 구법 상 급여정지 처분을 하여야 한다는 법 해석을 하고 있다. 구법 상 보건복지부 재량으로 되어 있는 과징금 갈음에 대해서도 법 개정 전 구법 하에서 취했던 좁은 기준을 그대로 유지하고 적극적으로 재량을 행사하지 않겠다는 입장이다. 본고에서는 급여정지 제도 도입의 이유가 된 의약품 리베이트 문제를 개관하고 급여정지 제도의 도입, 폐지 경위를 살핀 후 급여정지 처분의 위헌적 요소와 급여정지 처분의 위법성을 검토한다.

• International journal of advanced smart convergence
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• 제2권2호
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• pp.40-42
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• 2013

Recent medical industry is an aging society and the application of national health insurance, with state-of-the-art research and development, including the pharmaceutical market is greatly increased. The nation's health care industry through new support expansion and improve the quality of life for the research and development will be needed. In addition, systemic administration of basic medical supplies, or drugs are needed, the drug at the same time managing how systematic analysis of pharmaceutical ingredients, based on data through the purchase of new medicines and pharmaceutical ingredients automatically classified by analyzing the statistics of drug purchases and the future a system that can predict a patient is needed. In this study, the drugs to the patient according to the component analysis and predictions for future research techniques, k-means clustering and k-NN (Nearest Neighbor) Comparative studies through experiments using the techniques employ a more efficient method to study how to proceed. In this study, the effects of the drugs according to the respective components in time according to the number of pieces in accordance with the patient by analyzing the statistics by predicting future patient better medical industry can be built.

• 대한예방한의학회지
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• 제17권1호
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• pp.65-76
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• 2013

Objectives : Aim of this study is to contribute to establishment of the Traditional Korean Medicine (TKM) policies in the future. Final assessment for 12 of the forecasting projects was carried out on the TKM policies that deduced by professionals in 1996 whether or not to realize in 2013. Methods : We investigated governmental and private research projects, reports and papers, and laws and systems on the forecasting projects. We reviewed them through the Traditional Korean Medicine Information Portal OASIS (http://oasis.kiom.re.kr), Korean studies Information Service System (KISS) (http://kiss.kstudy.com/) and DBpia (http://www.dbpia.co.kr/), Akomnews(http://www.akomnews.com/), THE MINJOK MEDICINE NEWS(http://www.mjmedi.com/), Ministry of Government Legislation(http://www.law.go.kr/). Results : Of the 12 forecasting projects, five were judged as 'realization', four were as 'partial realization' and three were as 'un-realization', The realization rate was 75.0%. Three un-realized projects included the TKM insurance coverage for various herbal medicines, leadership secure on medical technicians and commercialization of the TKM managing system on senior medicare policy. Realization of the future forecasting TKM policy projects was decided depending on conditions such as the importance, domestic capability levels, principal agents, methods and restrains. Conclusions : Continuous studies and new developed forecasting projects for the TKM policies will be required to realize the projects in the future.