• Journal of Information Technology Applications and Management
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• 제20권3호
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• pp.79-92
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• 2013

Word-of-mouths (WOMs) are now an important information source for purchase decision. Due to the advance in internet technology, people now can share online their consumption experience, both positive and negative, to others. The WOMs may diffuse to not only their friends but also enormous online users. When consumers dissatisfy the product or service, they may share the dissatisfactory experience to others as WOM, which may bring out discussions for the product or service. The discussions on the negative WOM may help to communicate the negative information to enormous others, which may damage the sale of the product or service. The diffusion and life cycle of negative WOM is an important issue for managers. However, few studies focus on it. Thus, the current study focuses on the discussion pattern and life cycle of negative WOMs by observing the 782 discussion articles in a large online community.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• 제9권5호
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• pp.157-171
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• 2014

This study has empirically analyzed the effect of government technology development supports on the performance of SME's (Small-and-Medium-Sized Enterprises). To analyze the effects of government technology development supports on the performance of SME's, this paper collected data from 271 Korean SMEs and tested hypothesis on the key questions. The result shows that government technology development supports had a meaningful positive effect on the performance of SMEs in terms of innovation. It was also understood that the closer the ties were with large enterprises, the higher the R&D personnel ratio was. Furthermore, when the SME was a certified venture, the government technology development supports had less influence on the SME's technological innovation. On the other hand, SME's technological innovation performance in relation to the government supports showed an improvement when the business environment of SME's was hostile. This study offers theoretical and practical implications, as it more accurately analyses the effect of government technology development supports on the performance of SME's, for which data were collected and analyzed for the same companies two separate times. Last of all, the limitation of this study is discussed in terms of the sample selection, data collection method, variables measurement method, etc.

• Journal of Life Science
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• 제28권1호
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• pp.50-57
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• 2018

Millettia erythrocalyx, a species of plant in the Fabaceae family, is widely distributed in the tropical and subtropical regions of the world, such as the Indies, China, and Thailand. The antiviral activity of flavonoids from M. erythrocalyx has been reported; however, the antioxidative and anticancer activities of M. erythrocalyx remain unclear. In this study, we evaluated the antioxidative and anticancer effects of ethanol extract of M. erythrocalyx (EEME) and the molecular mechanism of its anticancer activity in human hepatocellular carcinoma HepG2 cells. EEME exhibited significant antioxidative effects, with a concentration at 50% inhibition ($IC_{50}$) value of $2.74{\mu}g/ml$, as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay; moreover, it inhibited cell proliferation in a dose-dependent manner in HepG2 cells. Cell cycle analyses showed that EEME induced HepG2 cell accumulation in the subG1 phase in a dose-dependent manner. EEME also induced apoptosis of HepG2 cells, with increases in apoptotic cells and apoptotic bodies, as detected by Annexin V and 4,6-diamidino-2-phenylindole (DAPI) staining, respectively. Treatment with EEME resulted in increased expression of First apoptosis signal (Fas), a death receptor, and Bcl-2-associated X protein (Bax), a proapoptotic protein, and the activation of caspase-3, 8, and 9, resulting in the cleavage of poly (Adenosine diphosphate-ribose) polymerase (PARP). Collectively, these results suggest that EEME may exert an anticancer effect in HepG2 cells by inducing apoptosis via both the intrinsic and extrinsic pathways.

• The Journal of the Korea Contents Association
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• 제17권5호
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• pp.221-233
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• 2017

To survive in the ever-changing environment, organizations need to improve or innovate their business processes. As a result, to attain this objective, BPM (Business Process Management) concept is widely adopted in modern enterprises. BPM life cycle consists of diagnosis, design, implementation and enactment. Conventionally, diagnosis of business process within the BPM life cycle is usually conducted by manual methods such as interviews, questionnaires and direct observations of process. And (re)designing business processes is also usually done manually under supervision of business experts from scratch. It is time-consuming and error-prone tasks. The objective of this research is to integrate the diagnosis and (re)design phase of BPM life cycle by sharing automatically generated process model and basic statistics in the diagnosis phase based on the process mining method. Eventually, this approach will lead to automate the tasks of diagnosis and design of business process. To implement and to show the usefulness of the proposed framework, two case studies were conducted in this research.

• Journal of Korea Society of Industrial Information Systems
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• 제23권5호
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• pp.119-134
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• 2018

Today, many firms face the environment of high uncertainty and severe competition due to the rapid technology development and the diverse needs of customers. In the business environment, one of the most important ways to gain sustainable competitive advantage and future growth engine is related to NPD (New Product Development), which is a very important issue for practice and academia. Thus, this study intends to provide new values to practitioners and researchers related to NPD by analyzing current research trends and future trends in NPD field. For this, we bibliometrically analyzed keyword networks which consist of keywords that were already published in the eminent journals from Scopus database to generate insights that have not been captured in the previous reviews on the topic. As a result, we could understand the extant research streams in NPD field, and suggest the changes of specific research topics based on the connected relationships among keywords over the time. In addition, we also foresaw the general future research trends in NPD field based on the keywords according to preferential attachment processes. Through this study, it was confirmed that NPD keyword network is a small world network that follows the distribution of power law and the growth of network is formed by link formation by keyword preferential attachment. In addition, through component analysis and centrality analysis, keywords such as Innovation, New product innovation, Risk management, Concurrent engineering, Research and development, and Product life cycle management are highly centralized in NPD keyword network. On the other hand, as a result of examining the change of preferential attachment of keywords over the time, we suggested the required new research direction including i) NPD collaboration with suppliers, ii) NPD considering market uncertainty, iii) NPD considering convergence with the other academic areas like technology management and knowledge management, iv) NPD from SME(Small and medium enterprises) perspective. The results of this study can be used to determine the research trends of NPD and the new research themes for interdisciplinary studies with other disciplines.

• Microbiology and Biotechnology Letters
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• 제42권1호
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• pp.73-81
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• 2014

Salsola collina, also known as Russian thistle, is widely distributed in and around waste facilities, roadsides, and drought and semi-drought areas, and is used as a traditional folk remedy in Chinese medicine for the treatment of hypertension. In this study, we have evaluated the anti-oxidative and anti-cancer activities of the ethanol extract of S. collina Pall. (EESC), and the molecular mechanisms of its anti-cancer effects on human colon carcinoma HT29 cells. EESC exhibited anti-oxidative activity through DPPH radical scavenging capacity and showed cytotoxic activity in a dose-dependent manner in HT29 cells. After EESC treatment, HT29 cells altered their morphology, becoming smaller and irregular in shape. EESC also induced cell accumulation in the G2/M phase in a dose-dependent manner, accompanied by a decrease of cell population in the G1 phase. The G2/M arrest by EESC was associated with the increased expression of cyclin-dependent kinase (CDK) inhibitor p21 and Wee1 kinase, which phosphorylates, or inactivates, Cdc2. EESC treatment induced the phosphorylation of Cdc2 and Cdc25C, and inhibited cyclin A and Cdc25C protein expression. In addition, S arrest was induced by the highest concentration of EESC treatment, associated with a decrease of cyclin A and Cdk2 expression. These findings suggest that EESC may possess remarkable anti-oxidative activity and exert an anti-cancer effect in HT29 cells by cell cycle regulation.

• Journal of Information Technology Services
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• 제14권1호
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• pp.41-51
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• 2015

The purpose of this research is to investigate the relationship between job creation and ICT usage in service industries. This research is particularly important because job creation is one of the most critical issues for the country. With technology innovation and system integration, manufacturing industries do not create enough employment, therefore, the society relies on service industries for creating job opportunities. Until now, due to limitations, analysis of job creation in service industries through ICT usage has not been investigated in depth. Thus, development of an effective ICT support policy was impossible. In this research, we used seven methods to investigate overall relationship between ICT usage level and job creation. A rule of large numbers has been applied to reach conclusion. Through this research, the government can focus its investment on service industries where job creation rate is the highest. We can expect both reinforcement in competitiveness of our service industry and continuous creation in employment, eventually leading to a virtuous cycle.

• Journal of Information Technology Services
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• 제10권4호
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• pp.295-307
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• 2011

The purpose of this research is to find a better knowledge service R&D management process. There are four basic characteristics in service : intangibility, inseparability, inconsistency, and no inventory. These intrinsic characteristics require us to change the traditional manufacturing sector based R&D management process. It is necessary to develop an effective knowledge service R&D management model to improve the competitiveness of the service industry and Korean economy. A model case knowledge service R&D has been performed to find a better R&D management model. The whole cycle of R&D process, such as planning, selection, performing, and evaluation has been reviewed by real experience. Several important aspects of R&D process are compared between manufacturing R&D and service R&D. A knowledge service R&D management framework has been suggested. The results of this research can be used for building a better service R&D management process.

• Transactions on Electrical and Electronic Materials
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• 제15권4호
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• pp.193-197
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• 2014

Si-carbon composites as anode materials for lithium rechargeable batteries were prepared simply by mixing Si nanoparticles with carbon black and/or graphite through a solution process. Si nanoparticles were well dispersed and deposited on the surface of the carbon in a tetrahydrofuran solution. Si-carbon composites showed more than 700 mAh/g of initial capacity under less than 20% loading of Si nanoparticle in the composites. While the electrode with only Si nanoparticles showed fast capacity fading during continuous cycling, Si-carbon composite electrodes showed higher capacities. The cycle performances of Si nanoparticles in composites containing graphite were improved due to the role of the graphite as a matrix.

• Journal of Korean Institute of Industrial Engineers
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• 제32권4호
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• pp.298-313
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• 2006

Six sigma is focused on quality improvement through variation reduction, while lean is on process flow improvement and lead time reduction by waste elimination. However, lean cannot bring a process under statistical control and six sigma alone cannot dramatically improve process speed. Lean six sigma was developed to achieve faster rate of improvement in customer satisfaction, cost, quality, process speed, and invested capital. In this paper we present the importance of using value stream mapping and suggest a guideline on how to integrate lean and six sigma by is proposed.