• 아태비즈니스연구
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• 제10권4호
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• pp.49-63
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• 2019

The export regulation of semiconductor core materials, which began with the recent revision of the export management regulations of Japan, raises the need for a new cooperation network. A hierarchical management network that was effective in the fast-follower system requires organic cooperation between the public sector and industry through a multilateral network that emphasizes horizontal co-operation among innovation actors. This study focused on the relational capital that exists among members of a business association such as an association that has been relatively marginalized from previous studies. In addition, this study aimed to analyze the effect of network activity characteristics such as industry-university linkage and informal exchange on technological innovation. Through this, I would like to draw implications for enhancing the effectiveness of the government's R & D support and innovation performance of R & D companies. Based on the results of the SMEs R & D survey, this study found that relational capital, informal exchange had a positive effect on technological innovation performance. However, if the relational capital exceeds a certain level, it is analyzed that there is a negative effect due to group think and lock-in effect. This means that informal exchange channels should be expanded for innovation and enhancement, and relational capital should be managed in consideration of the negative effects that may occur when certain levels are exceeded.

• Bulletin of the Korean Chemical Society
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• 제28권12호
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• pp.2495-2497
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• 2007

• 생명과학회지
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• 제28권2호
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• pp.216-222
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• 2018

Desmodium heterocarpon은 콩과에 속하는 덩굴식물로 주로 한국, 일본 등의 아시아 국가에 분포되어 있다. 본 연구에서는 식물에 존재하는 신규 기능성 소재 개발의 일환으로 Desmodium heterocarpon 에탄올 추출물(DHEE)의 항산화 및 항염증 생리활성을 DPPH 라디칼 소거능, ROS 소거능, NO 생성 억제능 및 관련 단백질 발현을 통해 분석하였다. 먼저 DHEE의 항산화능을 DPPH 라디칼 소거능을 통해 분석한 결과 높은 소거활성을 보여 DHEE가 매우 강한 항산화능을 보유함을 확인하였다. 또한 RAW 264.7 세포주에서 H2O2에 의해 유도된 ROS에 대한 DHEE의 소거능을 분석한 결과 농도의존적인 강한 ROS 소거능을 보였다. 뿐만 아니라 대표적인 항산화 효소 중 하나로 항산화능 보유 천연물에 의해 발현이 유도되는 HO-1 및 그 전사 인자인 Nrf2의 단백질 발현이 DHEE의 처리에 의해 유의적으로 증가됨을 보였다. 한편 DHEE가 LPS에 의해 유도된 NO 생성에 미치는 영향을 분석한 결과 농도 의존적인 NO 생성 저해능을 보였으며 이는 NO 생성 단백질인 iNOS의 발현 저해에서 기인함을 확인하였다. 이러한 결과를 통해 DHEE의 높은 항산화능과 항염증 활성을 확인하였으며 향후 잠재적인 기능성 소재로서 유용하게 활용될 수 있을 것으로 판단된다. 추후 계속적인 연구를 통해 활성 물질의 규명이 필요할 것으로 보인다.

• 한국미생물·생명공학회지
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• 제41권3호
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• pp.341-349
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• 2013

본 연구에서는 통초(Tetrapanax papyriferus)와 희렴(Siegesbeckia pubescens)의 항산화 및 항비만 활성을 DPPH radical 소거능과 세포실험계를 이용하여 분석하였다. 통초와 희렴의 DPPH radical 소거능의 50% 저해능($IC_{50}$)은 각각 65.23과 47.79 ${\mu}g/ml$로 나타났다. 또한 두 시료 모두 농도 의존적으로 lipase 효소 활성을 유의적으로 억제시켰으며, 3T3-L1 preadipocyte를 이용하여 지방세포 분화 및 지방생성에 미치는 영향을 분석한 결과 통초와 희렴 모두 지방 세포 분화, 지방 축적, TG 함량 등을 독성 없이 농도의존적으로 억제함을 보였다. 이러한 통초와 희렴의 지방세포분화억제능은 핵심 작용 인자인 $C/EBP{\alpha}$, $C/EBP{\beta}$, 그리고 $PPAR{\gamma}$의 유전자 및 단백질 발현조절에서 기인함을 확인하였다. 또한 통초와 희렴 간의 항비만 시너지 효과를 분석한 결과 각 시료의 단독 처리시보다 병용 처리시 더 높은 지방세포분화억제능을 보여 두 시료간에 시너지 효과를 보유함을 확인하였다. 이러한 결과는 통초 및 희렴의 항비만 활성 및 그 작용 기전을 밝힌 것이며 추후 계속적인 연구를 통해 활성 물질의 규명이 필요할 것으로 판단된다.

• 한국미생물·생명공학회지
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• 제42권3호
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• pp.249-257
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• 2014

본 연구에서는 백두구(A. cardamomum L.) 메탄올 추출물(ACME)의 항산화 및 항비만 활성을 DPPH radical 소거능과 췌장 lipase 효소 활성 억제능, 그리고 세포실험계를 이용하여 분석하였다. 그 결과 ACME는 DPPH radical을 농도 의존적으로 소거하였으며 DPPH radical 소거능의 50% 저해농도($IC_{50}$)는 $25.15{\mu}g/ml$로 나타났다. 또한 ACME는 농도 의존적으로 lipase 효소 활성을 유의적으로 억제시켰으며, 3T3-L1 preadipocyte를 이용하여 지방세포 분화 및 지방생성, 생성된 지방의 분해에 미치는 영향을 분석한 결과 ACME는 지방세포 분화, 세포 내 지방 축적, TG 함량 등을 독성 없이 농도의존적으로 억제하였으며 지방세포 내 중성지방을 유의적으로 분해시키는 것으로 나타났다. 이러한 백두구의 지방세포 분화 억제능은 핵심 작용 인자인 $C/EBP{\alpha}$, $C/EBP{\beta}$, 그리고 $PPAR{\gamma}$의 유전자 및 단백질 발현조절에서 기인함을 확인하였다. 이러한 결과는 백두구가 보유한 항산화능과 췌장 lipase 활성 저해능, 지방세포 분화 억제능, 지방세포 내 지방 분해능을 통한 항비만 활성을 처음으로 밝혀낸 것이며 추후 계속적인 연구를 통해 활성 물질의 규명이 필요할 것으로 판단된다.

• Journal of Information Technology Applications and Management
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• 제22권3호
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• pp.115-128
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• 2015

Although the telecommunications service industry has become a basic infrastructure component of the information and communication technology (ICT) industry, it is now losing its reputation as a cash cow due to achieving a saturation of service subscribers, especially in South Korea. With the exception of improving network speeds, network operators are experiencing difficulties in creating new innovations. Therefore, new innovations for the telecommunications service industry should be identified in conjunction with government policies for industry promotion. To examine the innovative capabilities of a specific industry, innovation system theories were used as a framework for research. However, existing innovation systems are limited with regard to explaining the openness of relationships and user participation which are general properties of the ICT industry. Moreover, as sources of innovative activity, additional values such as financial support and collaboration are more appropriate. This study presents a new innovation system based on innovation values. We analyze the telecommunications service industry and prioritize the importance of telecommunication policies within South Korea. An in-depth interview with experts based on the innovation system framework is conducted first. Next, innovation factors derived from the interview are applied within an analytic hierarchy process (AHP), leading to a prioritization of innovation factors for the telecommunications service industry.

• 지식경영연구
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• 제17권3호
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• pp.117-136
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• 2016

External knowledge search is critical to expand the firm's knowledge base, increasing the innovation performance. However, prior literature has paid less scholarly attention on the boundary condition of the search activity. In particular, the few literatures on the contingency factors are either conceptual or focus on the firm characteristics such as resources and capability. In this regard, this study argues the negative moderating effect of knowledge protection and environmental uncertainty of a firm on the positive relationship between external knowledge search and innovation performance, because these contingency factors hamper the reciprocity and the mutual trust between the firm and its external partner that provides knowledge needed in the innovation process. The empirical analysis is based on the sample drawn from Korean Innovation Survey, provided by STEPI in Korea. The sample consists of 1,637 respondent firms that experienced product innovation during the survey period. We could find statistically supporting results for the negative moderating effect on the positive relationship between external knowledge search and innovation performance. This study extends the academic debate on the boundary conditions of external knowledge search and provides managerial implications for successful product innovation.

• STI Policy Review
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• 제5권1호
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• pp.112-130
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• 2014

Many actors are involved in the development of regional innovation systems (RIS) such as universities, private firms, research institutions, governments, and public agencies. In a country like Korea, where the central government takes more than 95% of the total government R&D budget, the role of regional authorities in science, technology, and innovation are fairly limited, although in recent years some regional governments have tried to promote innovation activity in their localities. This paper looks into the Gyeonggi Institute of Science and Technology Promotion (GSTEP) in Gyeonggi Province and examines its emerging role and achievements in innovation policymaking. It was found out that GSTEP engages in knowledge brokering with the purpose of helping firms participate in regional technological innovation processes. The knowledge brokering roles of this regional authority are described along with their implications for regional innovation policy. This study aims for a deeper understanding of the nature of the regional authority's role in a RIS through the case study of regional actors transitioning from being subordinators to becoming active participants with greater participation on policymaking and implementation.

• 한국시스템다이내믹스연구
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• 제6권1호
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• pp.71-98
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• 2005

If Korea Research & Development reinforces integrated control function, indeed would Korea Research & Development's output be increased? Truly, could Korea's competition be ultimately improved with technology innovation and accumulation of knowledge. Can reinforcement of Integrated control that reinforced efficiency of Research & Development's investment effects make Korea Research & Development's investment,itself, be decreased? I try to answer clearly that in a way to reorganize Korea technology Administration's system, introduced Korea Research & Development integrated control system's establishment is what to effect Korea innovation system's direction after answering clearly previous mentioned problems. In this study, to answer these problems view theoretical discussion about Korea innovation system, integrated control system and system dynamics. Set up analytic tools of system dynamics which includes Korea innovation system and integrated control system. Then, draw a general casual loop diagram, which includes established Korea Research & Development's integrated control system, of Korea innovation system's activity. In based these, develop situation model to analyze trend of Korea innovation system and derive a political meaning by analyzing value of Korea innovation system's major inflow, outflow and stock variations according to extent of Korea Research & Development's integrated control in the same model.

• 품질경영학회지
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• 제42권3호
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• pp.459-476
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• 2014

Purpose: This study was designed to identify whether organizational characteristics of Korean companies can make differences in innovative capability and Malcolm Baldridge management quality standard. In addition, based on the results and by verifying the influence of the innovative capability to management quality activity, it was to investigate the relations between the two factors. Methods: The subjects of this study were workers at major companies and small-and-medium sized companies. T-test was used to identify differences in innovative capabilities of industrial and age, position classifications, and regression analysis was employed to verify the influences of the innovative capability to the management quality activity. Results: The size of company caused some differences in market innovative sector regarding innovative capability. Management quality activity showed differences because of the sizes of companies and their supply types, while innovative capability influenced on all sectors of management quality activity. Conclusion: In this study Malcolm Baldridge management quality standard was applied to Korean companies. The results verified the meaningful influence of innovative capability to management quality activity. This means that the management quality activity can make a better performance when the innovative capability is good enough. Thus, the enhancement of management quality activity requires the boost of innovative capabilities of organization members.