• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권6호
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• pp.518-526
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• 2019

Purpose: Limited means exist to assess gastrointestinal activity in pediatric patients postoperatively. Recently, myoelectric gastrointestinal activity recorded by cutaneous patches has been shown in adult patients to be predictive of clinical return of gastrointestinal function postoperatively. The aim of this case series is to demonstrate the feasibility of this system in pediatric patients and to correlate myoelectric signals with return of bowel function clinically. Methods: Pediatric patients undergoing abdominal surgery were recruited to have wireless patches placed on the abdomen within two hours postoperatively. Myoelectric data were transmitted wirelessly to a mobile device with a user-interface and forwarded to a cloud server where processing algorithms identified episodes of motor activity, quantified their parameters and nominally assigned them to specific gastrointestinal organs based on their frequencies. Results: Three patients (ages 5 months, 4 year, 16 year) were recruited for this study. Multiple patches were placed on the older subjects, while the youngest had a single patch due to space limitations. Rhythmic signals of the stomach, small intestine, and colon could be identified in all three subjects. Patients showed gradual increase in myoelectric intestinal and colonic activity leading up to the first recorded bowel movement. Conclusion: Measuring myoelectric intestinal activity continuously using a wireless patch system is feasible in a wide age range of pediatric patients. The increase in activity over time correlated well with the patients' return of bowel function. More studies are planned to determine if this technology can predict return of bowel function or differentiate between physiologic ileus and pathologic conditions.

• 기술혁신학회지
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• 제20권4호
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• pp.1212-1242
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• 2017

본 연구에서는 중소기업의 기술혁신 장려 정책의 중요한 수단 중 하나인 혁신형 기업 인증 제도의 효과를 기술적 혁신 활동과 성과라는 측면에서 고찰하였다. 이를 위해 중소기업청과 중소기업중앙회에서 실시한 2013~2015년 '중소기업 기술통계조사' 결과를 이용하여, 벤처기업 확인, 이노비즈 인증, 메인비즈 인증 등 혁신형 기업 인증을 받은 혁신형 중소기업과 그렇지 않은 일반 중소기업을 비교하였다. 그 결과 혁신형 중소기업이 기술적 혁신 활동과 성과에 관련된 많은 세부 지표에서 비교 우위에 있는 것으로 나타났다. 그러나 외부사용 연구개발비 비중, 기술개발 시도건수와 성공건수 등은 조사년도에 따라 차이가 없는 것으로 나타나 본 제도의 사후 관리를 강화할 필요가 있는 것으로 판단된다. 한편 자체조달연구개발비 비중은 3개년 조사 모두에서 오히려 일반 중소기업이 혁신형 중소기업에 비해 유의미하게 높은 것으로 나타나, 혁신형 중소기업에 대한 정부의 자금 지원이 기업의 자체 연구개발 투자의 대체재가 아닌 보완재로 사용될 수 있도록 유인하는 제도적 장치가 필요할 것으로 보인다. 또한 기업의 기술적 혁신 활동과 성과는 인증 여부보다는 기업의 규모와 참여 업종에 더 큰 영향을 받으므로, 기술혁신 장려 정책 수립 시 이에 대한 고려가 필요할 것으로 판단된다.

• 지식경영연구
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• 제13권2호
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• pp.73-93
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• 2012

Although a wide range of theoretical researches have emphasized on the importance of knowledge management in cooperative R&D network, the empirical researches to synthetically examine the role of organizational learning and open innovation which influence on the performance of technological innovation are not enough to meet academic and practical demands. This study is to investigate the effect of open innovation and organizational learning in venture business on technological competitive advantage and establish the mediating role of organizational learning. For the purpose, the questionnaires, made based on the reviewing previous researches, were collected from 274 Korean venture businesses whose managerial focus is on developing technological innovation. As a result of analysis, the relational dimensions of open innovation - network, intensity and trust shared by a firm with external R&D partners - as well as the internal organizational learning system and competence have positive influence on building technological competitive advantage whose sub-variables are technological excellence, market growth potential and business feasibility. In addition, it is identified that organizational learning has the mediating and moderating effect in the relationship between open innovation and technological competitive advantage. These results imply that open innovation complements and expend the range of limited resources and the scope of innovation in technology-intensive small and medium-sized enterprises. Besides, organizational learning activity reinforces the use of knowledge and resources, obtained from external R&D partners. On the basis of these results, detailed issues and discussion were made in the conclusion.

• Journal of the Korean Wood Science and Technology
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• 제47권4호
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• pp.459-471
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• 2019

Several species of Aquilaria and Gyrinops are native to Indonesia and well known as agarwood-producing trees with a high economic value. Their bioactive compounds have a wide spectrum of uses, such as in medicine and cosmetics. These genera have undergone extensive search for novel bioactive compounds. The purpose of this study was to isolate, identify, and characterize the endophytic fungi community associated with Aquilaria malaccensis, A. microcarpa, Gyrinops versteegii, and A. crassna trees and investigate their bioactive properties as antioxidant agents and antagonists. A total of 50 fungi were successfully isolated from different tissues of the four species of agarwood-producing trees. Two isolates exhibited strong antioxidant activity, namely, Apodus oryzae (R2MC3A, $IC_{50}$ 60.92 mg/mL) and Diaporthe sp. (P1DS1[C], $IC_{50}$ 76.65 mg/mL). Two isolates, Pestalotiopsis theae (P3BS3[B]) and Curvularia sp. (P2CD3A), showed >75% antifungal activity against pathogenic Fusarium solani. The results revealed that endophytic fungi associated with the studied agarwood-producing trees had potential antioxidant and antifungal activities for further applications in biotechnology.

• 품질경영학회지
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• 제32권4호
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• pp.196-207
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• 2004

TDR(Tear Down & Redesign)means that renounce the past resolutely, from a white paper condition, let's change directions. That is, let's redesign from the basic of the establishment of the construction process. Through the switchover the conception, innovate totally the whole existing processes. TDR is the best core innovation activity. The ultimate aim of the TDR activity induces the employees to do more productive business and obtain excellent results in the future by solving the problems, which are the nonproductive business in the business process on the objective view, the business that customers don't recognize the value, the same old practice of business, and the unsettled business from the restriction of resources. By organizing the related to workers of those business, they can solve the problems for 3-4months by full time working This paper inquires what are the obstruction factors on the process of executing TDR activity. Through the search of the reformation plan for the improvement of immersion degree, it presents some methods to be successful business.

• 한국미생물·생명공학회지
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• 제44권2호
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• pp.117-123
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• 2016

본 연구에서는 C. pubescens Burkill 에탄올 추출물(CPEE)의 항산화능과 항염증 생리활성을 DPPH 라디칼 소거능, ROS 생성 억제능, NO 소거 활성 등을 통해 분석하였다. 먼저 CPEE의 항산화능을 DPPH 라디칼 소거능으로 분석한 결과 강한 소거능을 보였으며, 좀 더 자세한 항산화능 작용기작을 알아보기 위해 ROS 생성 억제능으로 분석한 결과 농도 의존적으로 강한 ROS 소거능을 보였다. 뿐만 아니라 대표적인 항산화 효소인 HO-1 및 그 전사 인자인 Nrf2의 단백질 발현에 미치는 영향을 분석한 결과 CPEE에 의해 HO-1 및 Nrf2의 발현이 증가됨을 보였다. 한편 CPEE가 LPS에 의해 유도된 NO 생성에 미치는 영향을 분석한 결과 농도의 존적인 NO 생성 저해능을 보였으며 이는 NO 생성 단백질인 iNOS의 발현 저해에서 기인함을 확인하였다. 이러한 결과를 통해 CPEE의 높은 항산화능과 항염증 활성을 확인하였으며 향후 잠재적인 기능성 소재로서 유용하게 활용될 수 있을 것으로 판단된다.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2005년도 추계학술대회
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• pp.19-29
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• 2005

Since 1980's, many enterprises have constructed Strategy Information System and tried BPR, ISP. Also, they implemented ERP and practiced the Process Innovation and Six Sigma for Management Innovation in todays, Although most companies had provious good plans, but those are not satisfied. Because of failed to change management and continued next activity. Many Project for Process innovation are ended as disposal project in many case, if they want next project, they need a new plan which needs additional fund and re source. This paper studied Process Innovation and Six Sigma in many things and proposed new model for continued project on the master plan. Also it proposed next study subject about ERP Optimization and Harmonization after implemented ERP which is considered as next step of PI.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 2006년도 제28회 동계학술발표회 논문집
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• pp.170-186
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• 2006

The guarantee funds for government policy fund, venture capital investment fund, technology guarantee debt are the core parts of the external financing system in the constant technology innovation company. However, the enterpriser's requirement to keep the technology innovation with minimized management intervention and policy maker's hope to advance technology development with clear operation of funds is enough to request for research of the project investment plan to the R&D project. This paper will analyze whether technology innovation company that creates cash flow prefers to the project investment as a financing program or not, and if prefers, what characters of company affect on this preference. The more the company that pursuit the additional R&D activity separated to on-going items becomes over the fixed size, the more prefers the project investment as future external fund-raising. Together with that, this paper suggests that we can apply the plan like special purpose vehicle, SWORD(Stock Warrant Off-Balance sheet R&D) and R&D Limited Partnership as R&D project investment policy, and improve the system itself.

• 대한안전경영과학회지
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• 제8권5호
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• pp.119-130
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• 2006

Since 1980's, many enterprises have constructed Strategy Information System and tried BPR, ISP. Also, they implemented ERP and practiced the Process Innovation and Six Sigma for Management Innovation in todays. Although most companies had previous good plans, but those are not satisfied. Because of failed to change management and continued next activity. Many Project for Process innovation are ended as disposal project in my case, if they want next project, they need a new plan which needs additional fund and resource. This paper studied Process Innovation and Six Sigma in many things and proposed new model for continued project on the master plan. Also it proposed next study subject about ERP Optimization and Harmonization after implemented ERP which is considered as next step of PI.

• Journal of Ginseng Research
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• 제41권3호
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• pp.373-378
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• 2017

Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.