• The Transactions of the Korea Information Processing Society
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• v.6 no.5
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• pp.1166-1176
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• 1999

The spationtemporal databases support a historical informations as well as spatial managements for various kinds of objects in the real world, and can be efficiently used in many applications such as geographic information system, urban plan system, car navigation system. However it is difficult to represent efficiently historical operations with conventional database query language for spatial objects. In terms of cost for query processing, it also degenerates performance of query processing because of syntactic limitations which is innate in conventional query representation. So in this paper, we introduce a new query language, entitled as STQL, which has been extended on the basis of the most popular relational database query language SQL. And we implement as well as evaluate a spationtemporal query processing system that get a query written by STQL and then process it in a main memory.

• Korean Journal of Transplantation
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• v.28 no.3
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• pp.113-120
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• 2014

Two-signal models are useful in explaining various types of immune responses. In particular, secondary, so-called costimulatory, signals are critically required for the process of T-cell activation, survival, differentiation, and memory formation. Early studies in rodent models showed that targeting T-cell costimulatory pathways elicits immunological tolerance, providing a basis for development of costimulatory therapeutics in allograft rejection. However, as the classic definition of T-cell costimulation continues to evolve, simple blockade of costimulatory pathways has limitations in prevention of allograft rejection. Furthermore, functions of costimulatory molecules are much more diverse than initially anticipated and beyond T cells. In this mini-review, we will discuss CD137-CD137L bidirectional signals as examples showing that two-signals can be applicable to multiple phases of immune responses.

• Journal of Life Science
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• v.29 no.7
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• pp.817-823
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• 2019

Immune system provides defense integrity of body against external invaders. In order to accomplish the important defending role immune system is composed of many different components which are regenerated continuously during lifespan. The key components are professional killing cells such as macrophage, neutrophil, natural killer cell, and cytotoxic T cell and professional blocking molecule, antibody, which is produced by plasma cell, the terminal differentiated B cell. Immune response is orchestrated harmoniously by all these components mediated through antigen presenting cells such as dendritic cells. Immune responses can be divided into two ways: innate immune response and adaptive immune response depending on induction mechanism. Aging is a broad spectrum of physiological changes. Likewise other physiological changes, the immune components and responses are wane as aging is progressing. Immune responses become decline and dysregulating, which is called immunosenescense. Immune components of both innate and adaptive immune response are affected as aging progresses leading to increased vulnerability to infectious diseases. Numbers of immune cells and amounts of soluble immune factors were decreased in aged animal models and human and also functional and structural alterations in immune system were reduced and declined. Cellular intrinsic changes were discovered as well. Recent researches focusing on aging have been enormously growing. Many advanced tools were developed to bisect aging process in multi-directions including immune system area. This review will provide a broad overview of aging-associated changes of key components of immunity.

• Science of Emotion and Sensibility
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• v.18 no.2
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• pp.3-18
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• 2015

Numerosity perception is considered as an innate ability of human being where its sensivitiy may widely vary across each individual person. The present study explored the relationship between visual working memory (VWM), visual search efficiency, and numerosity sensitivity. To accomplish this, we calculated each participant's K-value from change detection performance representing one's storage capacity in VWM, slopes of search RTs representing the search efficiency, and discrimination sensitivity for a quantity difference across two sets of dot arrays representing the numerosity sensitivity. The correlational analysis across the measurements revealed that participants with a high VWM capacity better discriminated the numerosity difference in the arrays when the spatial information in the two dot arrays was preserved. In contrast, the participants with high search efficiency discriminated better the difference in the arrays when the spatial information in the arrays was not preserved. The results indicate high VWM-capacity individuals were presumably able to use a strategy of storing the dot arrays by grouping them into a smaller pattern of dot arrays while high search-efficiency individuals were able to use a strategy of rapidly switching their focused attention across the dots in the arrays to count each individual dot. These in sum suggest that individual differences in numerosity sensitivity rely on one's working memory capacity as well as their efficient use of switching focused attention.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.1A
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• pp.53-64
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• 2004

As to medium data which is involved in the form of streaming for a multimedia application, it characterizes that spatial locality occurs strongly but temporal locality appears even weaker. In this paper, with regard to dynamic prefetching, we suggest a method to make the most of memory reference regularities which typically innate by nature in the multimedia data with strong spatial locality but with weak temporal locality. Especially, the suggested method has a remarkable capability such that it can reduce prefetching errors substantially compared to existing prefetching methods for an application Program which divides an way into small sub-blocks and, plus executes in the unit of sub-block. We carried out experiments to test the suggested method using various MediaBench benchmarks. From the results, we have confirmed that the occurrences of prefetching error decrease effectively than those of existing linear prefetching methods.

• The KIPS Transactions:PartD
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• v.16D no.1
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• pp.139-144
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• 2009

Neural network is a very exciting and generic framework to develop almost all ranges of machine learning technologies and its potential is far beyond its current capabilities. Among other characteristics, neural network acts as associative memory obtained from the values structurally stored in synaptic inherent structure. Due to innate complexity of neural networks system, in its practical implementation and maintenance, multifaceted problems are known to be unavoidable. In this paper, we present design and implementation details of GUI software which can be valuable tool to maintain and develop neural networks. It has capability of displaying every state of synaptic weights with network nodal relation in each learning step.

• IMMUNE NETWORK
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• v.9 no.4
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• pp.127-132
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• 2009

Background: Toll-like receptors (TLRs) play a fundamental role in innate immunity through their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are expressed in T cells are reported to function as co-stimulatory receptors. However, the functional capacity of TLRs on CD4 T and CD8 T cells has not been directly compared. Here we compared CD4 and CD8 T cell responses to TLR2 ligand plus TCR-mediated stimulation. Methods: TLR2 expression was analyzed on T cell subsets under naive and alloantigen-primed conditions. We analyzed the effects of TLR2 co-stimulation on proliferation and survival of T cell subsets in vitro when stimulated with soluble anti-CD3 in the presence or absence of synthetic ligand $Pam_3CSK_4$. Results: TLR2 expression on CD8 T cells was induced following activation; this expression was much higher than on CD4 T cells. Thus, the molecule was constitutively expressed on Listeriaspecific memory CD8 T cells. Based on these expression levels, proliferation and survival were markedly elevated in CD8 T cells in response to the TLR2 co-stimulation by $Pam_3CSK_4$ compared with those in CD4 T cells. Conclusion: Our data show that TLR2 co-stimulation is more responsible for proliferation and survival of CD8 T cells than for that of CD4 T cells.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.1
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• pp.56-63
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• 2016

We consider a satellite mission scheduling problem, which is a promising problem in recent satellite industry. This problem has various considerations such as customer importance, due date, limited capacity of energy and memory, distance of the location of each mission, etc. Also we consider the objective of each satellite such as general purpose satellite, strategic mission and commercial satellite. And this problem can be modelled as a general knapsack problem, which is famous NP-hard problem, if the objective is defined as to maximize the total mission score performed. To solve this kind of problem, heuristic algorithm such as taboo and genetic algorithm are applied and their performance are acceptable in some extent. To propose more efficient algorithm than previous research, we applied a particle swarm optimization algorithm, which is the most promising method in optimization problem recently in this research. Owing to limitation of current study in obtaining real information and several assumptions, we generated 200 satellite missions with required information for each mission. Based on generated information, we compared the results by our approach algorithm with those of CPLEX. This comparison shows that our proposed approach give us almost accurate results as just less than 3% error rate, and computation time is just a little to be applied to real problem. Also this algorithm has enough scalability by innate characteristic of PSO. We also applied it to mission scheduling problem of various class of satellite. The results are quite reasonable enough to conclude that our proposed algorithm may work in satellite mission scheduling problem.

• Safety and Health at Work
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• v.8 no.2
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• pp.198-205
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• 2017

Background: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. Methods: Seventy-four women ragpickers (median age, 30 years) and 65 age-matched control housemaids were enrolled. Flow cytometry was used to measure leukocyte subsets, and leukocyte expressions of $Fc{\gamma}$ receptor I (CD64), $Fc{\gamma}RIII$ (CD16), complement receptor 1 (CD35) and CR3 (CD11b/CD18), and CD14. Serum total immunoglobulin-E was estimated with enzyme-linked immunosorbent assay. Results: Compared with the controls, ragpickers had significantly (p < 0.0001) higher levels of CD8-T-cytotoxic, CD16+CD56+natural killer, and CD4+CD45RO+memory T-cells, but depleted levels of CD19+B-cells. The percentage of CD4+T-helper-cells was lower than the control group (p < 0.0001), but their absolute number was relatively unchanged (p = 0.42) due to 11% higher lymphocyte counts in ragpickers. In ragpickers, the percentages of CD14+CD16+intermediate and CD14dim CD16+nonclassical monocyte subsets were elevated with a decline in CD14+CD16-classical monocytes. The expressions of CD64, CD16, CD35, and CD11b/CD18 on both monocytes and neutrophils, and CD14 on monocytes were significantly higher in ragpickers. In addition, ragpickers had 2.7-times more serum immunoglobulin-E than the controls (p < 0.0001). After controlling potential confounders, the profession of ragpicking was positively associated with the changes. Conclusion: Ragpicking is associated with alterations in both innate (neutrophils, monocytes, and natural killer cell numbers and expression of complement and $Fc{\gamma}$ receptors) and adaptive immunity (numbers of circulating B cells, helper, cytotoxic, and memory T cells).

• Education of Primary School Mathematics
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• v.14 no.3
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• pp.237-259
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• 2011

Mathematics learning disabilities is a specific learning disorder affecting the normal acquisition of arithmetic and spatial skills. Reported prevalence rates range from 5 to 10 percent and show high rates of comorbid disabilities, such as dyslexia and ADHD. In this study, the characteristics and the causes of this disorder has been examined. The core cause of mathematics learning disabilities is not clear yet: it can come from general cognitive problems, or disorder of innate intuitive number module could be the cause. Recently, researchers try to subdivide mathematics learning disabilities as (1) semantic/memory type, (2) procedural/skill type, (3) visuospatial type, and (4) reasoning type. Each subtype is related to specific brain areas subserving mathematical cognition. Based on these findings, the author has performed a basic research to develop grade specific diagnostic tests: number processing test and math word problems for lower grades and comprehensive math knowledge tests for the upper grades. The results should help teachers to find out prior knowledge, specific weaknesses of students, and plan personalized intervention program. The author suggest diagnostic tests are organized into 6 components. They are number sense, conceptual knowledge, arithmetic facts retrieval, procedural skills, mathematical reasoning/word problem solving, and visuospatial perception tests. This grouping will also help the examiner to figure out the processing time for each component.