• Archives of Pharmacal Research
• /
• 제8권3호
• /
• pp.159-168
• /
• 1985

In attempt to develop a drug delivery system using serum albumin microspheres, bovine serum albumin microspheres containing antitumor agent, cytarabine, were prepared. The shape, surface characteristics, size distribution, behavior of in vitro distribution, drug release behaior, and degradation of albumin microspheres in animal liver tissue homogenate and proteolytic enzyme were investigated. The shape of albumin microspheres was spherical and the surface was smooth and compact. The size distribution of the albumin microspheres was affected by dispersion forces during emulsification and albumin concentration. Distribution of albumin mirospheres after intravenous administration in rabbit was achieved immediately. In vitro, albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin concentration ratio and size distribution. After drug release test, the morphology of albumin micropheres was not changed. Albumin microsphere matrix was degraded by the rabbit liver tissue homogenate and proteolytic enzyme. The degree of degradation was affected by heating temperature.

• 한국안전학회지
• /
• 제30권5호
• /
• pp.131-137
• /
• 2015

For the evaluation of safety margin of a nuclear power plant using a conservative methodology, the influence of applied assumptions such as initial conditions and boundary conditions needs to be assessed deliberately. Usually, a combination of the most conservative initial conditions is determined, and the safety margin for the transient is evaluated through the analysis for this conservative conditions. In existing conservative methodologies, a most-conservative condition is searched through the analyses for the maximum, minimum, and nominal values of the major parameters. In the present study, we investigates a new approach which can be applied to choose a most-conservative initial condition effectively when a best-estimate computer code and a conservative evaluation methodology are utilized for the evaluation of safety margin of transients. By constituting the band of various initial conditions using the random sampling of input parameters, the sensitivity study for various parameters are performed systematically. A method of sampling the value of control or operation parameters for a certain range is adopted by use of MOSAIQUE program, which enables to minimize the efforts for achieving the steady-state for various different conditions. A representative control parameter is identified, which governs the reactor coolant flow rate, pressurizer pressure, pressurizer level, and steam generator level, respectively. It is shown that an appropriate distribution of input parameter is obtained by adjusting the range and distribution of the control parameter.

• Structural Engineering and Mechanics
• /
• 제90권4호
• /
• pp.357-370
• /
• 2024

Due to the fact that the mechanism of the effects of temperature and initial geometric imperfection on low-velocity impact problem of axially moving plates is not yet clear, the present paper is to fill the gap. In the present paper, the nonlinear dynamic behavior of axially moving imperfect graphene platelet reinforced metal foams (GPLRMF) plates subjected to lowvelocity impact in thermal environment is analyzed. The equivalent physical parameters of GPLRMF plates are estimated based on the Halpin-Tsai equation and the mixing rule. Combining Kirchhoff plate theory and the modified nonlinear Hertz contact theory, the nonlinear governing equations of GPLRMF plates are derived. Under the condition of simply supported boundary, the nonlinear control equation is discretized with the help of Gallekin method. The correctness of the proposed model is verified by comparison with the existing results. Finally, the time history curves of contact force and transverse center displacement are obtained by using the fourth order Runge-Kutta method. Through detailed parameter research, the effects of graphene platelet (GPL) distribution mode, foam distribution mode, GPL weight fraction, foam coefficient, axial moving speed, prestressing force, temperature changes, damping coefficient, initial geometric defect, radius and initial velocity of the impactor on the nonlinear impact problem are explored. The results indicate that temperature changes and initial geometric imperfections have significant impacts.

• 터널과지하공간
• /
• 제21권3호
• /
• pp.192-204
• /
• 2011

본 연구에서는 시공단계를 정확하게 고려하여 3차원 해석을 수행하고, 이와 동일한 결과를 나타내는 2차원 해석 결과를 얻고자 천단변위를 기준으로 하여 하중분배율을 결정하였다. 2차원 해석 결과와 3차원 해석 결과에서 천단변위의 총량에는 차이가 있어, 이를 극복하고자 각 단계에서의 천단변위 값을 총 변위량으로 나눈 '천단변위비'를 비교 대상으로 정하였다. 또한 숏벤치 공법이나 미니벤치 공법의 경우에서처럼 상하 반단면 분할굴착에서 벤치의 길이가 짧은 경우에는 하부 반단면의 굴착이 완료된 후에도 굴진면의 지지효과가 사라지지 않는 상황이 발생한다. 이러한 상황을 해석에 반영하고자 4번째 하중분배계수를 도입하여 굴진면 전진 효과를 구현하도록 하였다. 그 결과 전단면 굴착, 상하 반단면 분할굴착, 벤치 길이의 변화 및 초기 응력 상태 등을 고려한 다양한 경우에 대하여 합리적으로 하중분배율을 결정하는 방법을 제시하였다.

• 한국안전학회지
• /
• 제32권6호
• /
• pp.1-8
• /
• 2017

P-PIE is a program developed to estimate failure probability of pipes and pressure vessels considering fatigue and stress corrosion crack growth. Using the program, crack growth simulation was performed with an initially existing crack in order to examine the effects of initial crack depth distribution on the leak probability of pipes. In the simulation stress corrosion crack growth was considered and several crack depth distribution models were used. From the results it was found that the initial crack depth distribution gives great effect on the leak probability of pipes. The log-normal distribution proposed by Khaleel and Simonen gives lower leak probability compared other exponential distribution models. The effects of the number and the quality of pre-service and in-service inspections on the leak probability were also examined and it was recognized that the number and the quality of pre-service and in-service inspections are also give great effect on the leak probability. In order to reduce the leak probability of pipes in plants it is very important to improve the quality of inspections. When in-service inspection is performed every 10 years and the quality of inspection is above the very good level, the leak probability shows nearly constant value after the first inspection for an initially existing crack.

• 한국수자원학회논문집
• /
• 제30권4호
• /
• pp.379-387
• /
• 1997

논에서의 수문 특성을 현장 조사 및 측정하고, 강우-유출 자료로부터 논의 최대 잠재저류장의 확률적 특성을 분석하여, 선행강우조건에 따른 CN을 추정하였다. 추정된 CN은 AMC II의 경우 78이었으며, AMC-I, III의 경우에는 각각 63, 88이었다. 논의 강우-유출자료에 의한 CN은 년 홍수량 자료의 적용여부가 불확실하므로 이를 보완하고, 물고높이나 초기담수심의 영향을 구체적으로 규명하기 위하여 논의 물수지 모형을 구성하였다. 논의 유출량은 선행 강우뿐 아니라 초기담수심에 따라 변화하므로 최대 잠재저류량을 이용하여 CN을 결정하기에는 어려움이 따른다. 따라서, 최대 잠재저류량의 경우와 같이 담수심의 확룰분포함수를 이용하여 CN을 추정하였다. 물수지모형을 이용하여 확률담수심, 물고높이 및 기상자료로부터 논의 유출량을 추정하였다. 추정된 유출량으로부터 CN을 계산하고, 확률 담수심에 해당하는 CN-I, CN-II, CN-III을 결정하였으며, 그 값은 각각 70, 79, 89이었다.

• 산업기술연구
• /
• 제21권B호
• /
• pp.155-161
• /
• 2001

In this study, we analyzed the $NO_X$ removal efficiency and particle size distribution by the pulsed corona discharge process and investigated the effect of several process variables. The NO removal efficiencies and the particle characteristics were measured and analyzed as the function of initial concentrations of NO, $H_2O$, and $NH_3$, applied voltage, pulse frequency and residence time. As the frequency of applied voltage increases, or as the applied voltage increases or as the residence time increases, the NO removal efficiency increases. The change of initial $NH_3$ and $H_2O$ concentrations do not affect the NO removal efficiency significantly. The particle concentration and size increases with the increases of initial NO concentration, residence time and applied voltage.

• 인터넷정보학회논문지
• /
• 제7권3호
• /
• pp.83-91
• /
• 2006

본 논문에서는 인증서를 사용하는 모든 암호시스템 분야에 응용될 수 있는 인증 및 키 복원 프로토콜로 PKINIT를 응용한 안전한 초기인증 공개키 암호시스템 모델을 연구하였다. 멤버들에 대한 인증은 서버와 사용자간에 인증서를 기반으로 공개 키 암호에 의한 초기인증과 세션 키 분배, 응용자원 서버들과의 비밀통신에서 키의 유실을 고려한 키 복구지원 프로토콜을 제안하였다.

• 한국생산제조학회지
• /
• 제4권4호
• /
• pp.25-32
• /
• 1995

This study is to inspect the influence of the initial residual stress on fatigue crack growth behavior after the distribution of the initial residual stress is measured when the crack is growing from the compressive residual stress field. Also, the tensile residual stress field. Also, the influence of the variation of residual stress distribution on fatigue crack growth behavior at the crack tip is studied when the initial crack occurs on weld metal, bead interface and HAZ (Heat Affected Zone), respectively. For this purpose, CT-type specimen that crack parallel to the welding bead were manufactured by butt welding on the Al. Alloy 1100-O plate.

• 한국방재학회 논문집
• /
• 제9권2호
• /
• pp.11-15
• /
• 2009

본 논문에서는 균일 모멘트 하중을 받는 박판 아치의 탄성 좌굴에 관한 연구를 수행하였다. 초기 곡률을 고려한 비선형 변형률-변위 관계식을 전체 포텐셜 에너지 방정식의 이차 변분에 대입하여 초기 곡률 효과를 포함하는 에너지 방정식을 유도하였다. 휨 모멘트에 의한 단면 내 법선 변형률이 선형으로 분포한다는 초기 곡률 효과에 대한 가정사항을 유도과정에 일관되게 적용하였다. 균일 모멘트 하중을 받는 아치의 휨-비틀림 좌굴하중에 관한 제차해를 제시하고 타 연구자의 결과와 비교하였다.