• Journal of Genetic Medicine
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• v.10 no.2
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• pp.81-87
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• 2013

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension. PHA is a heterogeneous disorder both clinically and genetically and can be divided into three subgroups; PHA type 1 (PHA1), type 2 (PHA2) and type 3 (PHA3). PHA1 and PHA2 are genetic disorders, and PHA3 is a secondary disease of transient mineralocorticoid resistance mostly associated with urinary tract infections and obstructive uropathies. PHA1 includes two different forms with different severity of the disease and phenotype: a systemic type of disease with autosomal recessive inheritance (caused by mutations of the amiloride-sensitive epithelial sodium channel, ENaC) and a renal form with autosomal dominant inheritance (caused by mutations of the mineralocorticoid receptor, MR). In the kidneys, the distal nephron takes charge of the fine regulation of water absorption and ion handling under the control of aldosterone. Two major intracellular actors necessary for the action of aldosterone are the MR and the ENaC. Impairment of the intracellular aldosterone signal transduction pathway results in resistance to the action of mineralocorticoids, which leads to PHA. Herein, ion handling the distal nephron and the clinico-genetic findings of PHA are reviewed with special emphasis on PHA type 1.

• Korean Journal of Breeding Science
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• v.40 no.3
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• pp.211-214
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• 2008

Haploid system by anther culture allows the development of homozygous lines when doubled. The response of anther culture to Basta (glufosinate) resistance was investigated on transgenic plants (cv. Anjungbyeo) in order to identify inheritance of bar gene associated with Basta. Most of the regenerated transgenic plants were sterile, and only a few plants produced viable seeds ($A_1$) in the greenhouse. The bar gene was analysis by PCR in basta resistant transgenic plant ($TA_0$). The transgenic seeds ($A_1$) were significantly germinated in Basta solution compared with non-transformed seeds. As a result of anther culture, in regenerated haploid plants, segregation ratio was 1:1 in five of eight cross combinations. In diploid plants, segregation ratio was 1:1 in seven of eight cross combinations. Although there was some differences in the cross combinations, most of the combinations had 1:1 segregation ratio which supports the theory. The difference may be a result of the small sample size or the difference of anther culture response caused by genotypic difference. Hence, when many cross combinations were anther-cultured the results would support the theory.

• Korean Journal of Agricultural Science
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• v.3 no.1
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• pp.17-21
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• 1976

This study was conducted to determine the inheritance of resistance in some rice varieties such as WASE AIKOKU 3, ZENITH, TETEP and TKM 6 to isolate 71-23 of Xanthomonas Oryzae in Korea. From the test in $F_1$ and $F_2$ populations of crosses between resistant and susceptible parents, it was observed that resistance of them were controlled by one dominant gene.

• Current Research on Agriculture and Life Sciences
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• v.9
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• pp.127-133
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• 1991

PI201232, a pepper line resistant to Phytophthora capsici Leonian, was crossed with PI2713222 and P1163192, resistant to Xanthomonas campestTis pv. vesicatoria (Doidge) Dye and inheritance of the resistance to each disease and genetic relationship between the two disease resistances was studied. Non-hypersensitive resistance to race 3 of X. c. pv. vesicatoria of PI271322 was inherited in a quantitative mode. Resitance to P. capsici of PI201232 was inherited in a mode close to two dominant alleles. Hypersensitive resistance to race 1 of X. c. pv. vesicatoria of PI271322 was inherited in a mode of single dominant allele. PI 163192 was consistently resistant to both race 1 and race 3 of X c. pv. vesicatoria and the resistance was inherited in a quantitative mode with high dominance effect. Resistance to X. c. pv. vesicatoria was inherited independently from resistance to P. capsici.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.42 no.6
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• pp.712-721
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• 1997

The objectives of this study were; (1) to identify and localize QTLs for resistance to soybean cyst nematode(SCN) race 5 on RAPD map, (2) to idntify the magnitude and mode of inheritance for each QTL, and (3) to identify the best combinations of QTLs for resistance to SCN race 5. Based on the univariate regression analysis, we detected 26 markers(22 RAPD and 4 RFLP) which showed significant association(P<0.05) with resistance to SCN race 5. From MAPMAKER /QTL analysis, we identified two regions (LGC-20 and Group 2) for resistance to SCN race 5. The QTL that was localized at 8.0 cM from pK418C on LGC-20 showed a recessive mode of inheritance and the QTL that was localized between W03 and E02$^3$ on Group 2 showed a dominant mode of inheritance. Two pairs of flanking markers (E02$^3$ and W03, pK418C and pK418E$_1$) and one unlinked RAPD marker, G10$^1$ were used for multiple regression analysis. Marker combination which was composed of 4 markers, E02$^3$, G10$^1$, W03, and pK418E$_1$, explained the highest amount of phenotypic variation by SCN (35.2％). Further research for the identification of QTLs for resistance to SCN race 5 to explain larger portion of phenotypic variation is needed.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.58 no.2
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• pp.91-106
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• 2013

Exserohilum turcicum is considered serious destructive disease of maize (Zea mays L.) in North Korea. This study aimed to understand genetic inheritance and combining ability of newly bred lines of maize tolerant to E. turcicum by diallel crosses. Three diallel sets for two different ecological regions and one agronomic trait; eastern (E), northern (N) and stay green (SG) involving 29 inbred lines were tested in eight locations of 2000 and 2001. E. turcicum infections were under natural conditions, respectively. Lines used were selected for high yield potential in test crosses with good agronomic traits and tolerance to biotic and abiotic stresses. Selection for race specific high resistance to biotic stresses was avoided to select quantitatively inherited genes. Host plant responses to E. turcicum were rated on a scale of 1 (highly tolerant) to 9 (highly susceptible). Highly significant variations were recorded in all trials. General combining ability (GCA) mean square was roughly twice that of specific combining ability (SCA). The genotype (G) by environment (E) interaction was highly significant. The overall results of genetic studies in three diallel sets show that genetic control for inbred tolerance to E. turcicum is polygenic and quantitatively inherited. New inbreds; E-3, N-1 and SG-4 confer better tolerance to E. turcicum than the widely used inbreds; Mo17, and B73. Proper use of genetic information from this study shall increase of corn production under high E. turcicum infection in the Far Eastern Regions of Korea and China.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.29 no.1
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• pp.11-14
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• 1984

The inheritance of scent in rice leaf and its genetic association with base color, hull color and resistance to bacterial leaf blight were studied in F$_2$ population of two rice crosses, P-33-C-19 (scented)/Zhu-Lian-Ai and P-33-C-19/Kataktara DA2. The scent was identified by leaf analysis at tillering stage. The scented and non-scented plants segregated in the ratio of 1scented: 3non-scented showing that a recessive gene responsible for the expression of scentedness. The scentedness was independently segregated with base color. hull color and resistance to bacterial leaf blight.

• Korean journal of applied entomology
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• v.19 no.3 s.44
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• pp.156-162
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• 1980

The inheritance and varietal differences of resistance to bacterial leaf blight caused by Xanthomonas oryzae in rice were studied. Among eighteen cultivars used, 'IR2061-465-1-5-5', 'IR2061-552-6-9', 'IR 1561-228-9-3', ana 'Milyang42, were found to have a high level of resistance to the three isolates of X. oryzae at maximum tillering and flowering stage. Varietal differences in lesion development of the cultivars belonging to the same varietal group were clearly recognized. For the genetic study on bacterial leaf blight resistance, two rice breeding lines 'IR2061-465-1-5-5', 'IR1561-228-3-3' were crossed with susceptible cultivar 'Milyang 23'. The $F_1,F_2,\;and\;F_3$ progenies were evaluated at flowering stage using the bacterial isolate 'JN 7853'(II). Average lesion length of the $F_1$ plants of the crosses showed longer than that of resistant parents, and the frequency distribution of lesion length in the $F_2\;and\;F_3$ populations showed continuous variation.

• Korean journal of applied entomology
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• v.24 no.4 s.65
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• pp.219-222
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• 1986

The inheritance and allelism tests of the genes resistant to bacterial blight in some rice breeding lines and varieties were studied. Resistance to isolate JB 8206 was found to be controlled by a single dominant gene in the rice varieties such as, Cheongcheongbyo, Yeongpungbyo, Nampungbyo, Samgangbyo, Hangangchalbyo, and Milyang 42. The resistance in varieties like Pungsanbyo and Baegyangbyo, to isolates JB 8206 and KN 8298 appeared to be governed by a single dominant gene. Evidence from the allelism test indicates that Pungsanbyo, Cheongcheongbyo, Milyang 30, and Baegunchalbyo may have the same dominant gene for resistance to isolate JB 8206, and that Suweon 312, Baegyangbyo as well as Baegunchalbyo may have the other same dominant gene.

• Journal of Sericultural and Entomological Science
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• v.24 no.1
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• pp.28-31
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• 1982

Flacherie virus (FV) is an important pathogen in the silkworm, which often gives serious damage to farmers for cocoon production. The inbred parents and F$_1$'s from an eight-parent diallel were examined to determine the inheritance of resistance to flacherie virus in the silkworm. Three resistant (R), two intermediate (M) and three susceptible (S) inbreds were used in the diallel with no reciprocals. Mean resistance was measured by survival rates of larvae which were fed on mulberry leaves sprayed with diluted mid-gut homogenate of FV infected larvae. Broad-sense heritability was obtained according to inbreds and F$_1$ family performance. Estimation of general (GCA) and specific combining ability (SCA) was made according to Griffing's Model 1, Method 2. Mean FV resistance of F$_1$ family displayed additive effect of the major gene, while heterotic effect was not significant. Considerable variation in FV resistance within F$_1$ groups of R$\times$S and S$\times$S indicated that action of minor genes for FV resistance may have been involved. FV resistance of inbreds perse and predominant effect of the major gene over minor gene(s) satisfactorily predicted the FV resistance of the hybrids. Broadsense heritability value of FV resistance on the basis of F$_1$ family performance averaged 93%, which suggested that environmental effects might have not been important in this experiment. GCA was highly significant for FV resistant among inbreds. GCA effect of 13.1 in Jam 108 was highest and -17.7 in Gyeongchu lowest. Effective selection for high FV resistance would be possible, using inbreds with high GCA effect and low GCA variance. SCA was significant among hybrids. High SCA effect in the hybrid of Geumho$\times$Mudeung (13.7) and Hansaeng #4$\times$Jam 115 (11.6) indicated that the interaction effect of minor genes for resistance to FV in the silkworm could be exploited by standard silkworm breeding procedures.