• Korean Journal of Veterinary Research
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• v.45 no.4
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• pp.545-552
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• 2005

The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovariectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. Chemicals were DEHP, DBP, BPA and NP, were injected sc once daily with combinations of chemicals treatments for 3 days. In the results, the reported estrogenic chemicals DEHP and DBP were both negative in the single dose treatments. But, in the combinations of chemicals treatments, DEHP and DBP increased in bud number of mammary gland. Treatment of ovariectomized mice with combinations of other chemicals resulted in uterine and vaginal hyperplasia. The additive estrogenic effects were seen with the combinations of $17{\beta}$-Bestradiol and DBP treatment. the competitive estrogenic effects were seen with the combinations of $17{\beta}$-Bestradiol and nonylphenol, $17{\beta}$-Bestradiol and bisphenol-A treatments. These results offers a sysmatic and mechanistically informative approach to assessing estrogenicity. it provides a useful profile of activity using a reasonable amount of resources and is compatible with the study of individual chemicals as well as the investigation of interactions among combinations of chemicals. The results described illustrate the intrinsic complexity of evaluating chemicals for estrogenic activities and conform the need for rigorous attention to experimental design and criteria for assessing estrogenic activity.

• Restorative Dentistry and Endodontics
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• v.39 no.3
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• pp.164-171
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• 2014

Objectives: Designing in situ models for caries research is a demanding procedure, as both clinical and laboratory parameters need to be incorporated in a single study. This study aimed to construct an informative guideline for planning in situ models relevant to preexisting caries studies. Materials and Methods: An electronic literature search of the PubMed database was performed. A total 191 of full articles written in English were included and data were extracted from materials and methods. Multiple variables were analyzed in relation to the publication types, participant characteristics, specimen and appliance factors, and other conditions. Frequencies and percentages were displayed to summarize the data and the Pearson's chi-square test was used to assess a statistical significance (p < 0.05). Results: There were many parameters commonly included in the majority of in situ models such as inclusion criteria, sample sizes, sample allocation methods, tooth types, intraoral appliance types, sterilization methods, study periods, outcome measures, experimental interventions, etc. Interrelationships existed between the main research topics and some parameters (outcome measures and sample allocation methods) among the evaluated articles. Conclusions: It will be possible to establish standardized in situ protocols according to the research topics. Furthermore, data collaboration from comparable studies would be enhanced by homogeneous study designs.

• Journal of Korea Game Society
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• v.15 no.4
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• pp.19-28
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• 2015

According to the Infant Educational Law, learning of the children are encouraged through playing, but there are not many tools to learn. Educational Serious Game is a game developed for the purpose of learning. And so, in this paper, we produced serious games for education learning for young children. Contents of the game is the digestive system. And we utilized touch and drag which are kinds of intuitive interface of the mobile platform being able to play easy. At the end of each stage, and it contained a scene that can learn the characteristics of the digestive system. After producing this game, we supplemented something that is inadequate through testing. In addition, the learning effect of the game was confirmed by interviews with the teachers. We hope this will be a fun and informative game for the digestive tract to the children.

• Korean Medical Education Review
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• v.16 no.3
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• pp.126-131
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• 2014

The purpose of this study is to analyze the medical education system of Korea and to propose a method of curriculum redesign. Although there have been many attempts by medical educators to improve the quality of medical education, the results have not been fruitful. First, there exists a limitation to the dualistic curriculum design based on Flexnerianism, and thus, this model does not provide an integrated experience to medical students. Therefore, we propose a unidimensional model for curriculum redesign. Second, it is impossible to promote excellence in medical education without solving the structural problems of teaching and learning, such as the teaching competency of the faculty, large-scale lectures, and team teaching systems. A curricular strategy that emphasizes mutual interaction and teaching accountability is necessary to promote meaningful learning. Third, the current clinical training system, the circulation model, provides incomplete training as well as a lack of sequence and articulation experiences. This system needs to be redesigned in a way that allows only those students who have mastered both the knowledge and the application of medical education to advance to the next step. Fourth, norm-referenced assessments of a medical college distort the learning process and create unconstructive system energy. A criterion-referenced assessment that values cooperation, independent study, and intrinsic motivation is more important for the reliability and validity of the assessment. Medical students should not focus on formative and informative learning. Medical colleges should investigate the multifaceted potential of the students and provide transformative learning to grow students into change agents. For this to take place, curriculum redesign-not new methods of medical education-is required.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.510-519
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• 2020

Within an intelligent automated cyber-physical system, the realization of the autonomous mechanism for data collection, data integration, and data analysis plays a critical role in the design, development, operation, and maintenance of such a system. This construct is particularly vital for fault-tolerant route-finding systems that rely on the imprecise GPS location of the vehicles to properly operate, timely plan, and continuously produce informative feedback to the user. More essentially, the integration of digital twins with cyber-physical route-finding systems has been overlooked in intelligent transportation services with the capacity to construct the network routes solely from the locations of the operating vehicles. To address this limitation, the present study proposes a conceptual architecture that employs digital twin to autonomously maintain, update, and manage intelligent transportation systems. This virtual management simulation can improve the accuracy of time-of-arrival prediction based on auto-generated routes on which the vehicle's real-time location is mapped. To that end, first, an intelligent transportation system was developed based on two primary mechanisms: 1) an automated route finding process in which predictive data-driven models (i.e., regularized least-squares regression) can elicit the geometry and direction of the routes of the transportation network from the cloud of geotagged data points of the operating vehicles and 2) an intelligent mapping process capable of accurately locating the vehicles on the map whereby their arrival times to any point on the route can be estimated. Afterward, the digital representations of the physical entities (i.e., vehicles and routes) were simulated based on the auto-generated routes and the vehicles' locations in near-real-time. Finally, the feasibility and usability of the presented conceptual framework were evaluated through the comparison between the primary characteristics of the physical entities with their digital representations. The proposed architecture can be used by the vehicle-tracking applications dependent on geotagged data for digital mapping and location tracking of vehicles under a systematic comparison and simulation cyber-physical system.

• Archives of design research
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• v.18 no.1 s.59
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• pp.17-26
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• 2005

Nowadays, display-contents are developing to an informative environment. that is under the logic of the media operating system. To perceive the media-environments and produce the cultural contents, the cultural designers seek to understand a skin structure from making up for shape. To appreciate operating system in data and database is not only systematization of form and contents of visual contents but also variety contents into multiple-platform and integrative environments. These days, the spectacle exhibition try to express for their surface design between algorithm of data and database. the information is expressing aesthetic which means presents the integrated contents through the play instinct environment to end-user. That was given web or game to participation is developing with the cellular device and ubiquitous computing system. in the linear perspective, the end-user should be immerse more and more hyper-simulation system because of the operating algorithm of database. To do this, human have need to get the information-ability from multi-platform society. In the virtual environment, database offer the experience of an unheard-of event to end-user that prepare the participants the circumstances priority of signifiers. To do that already based on a fixed sensibility endow with narrative of the freshness- experience.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.11 no.2
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• pp.161-168
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• 2001

The types of exposure data needed in an industry-based study depend on the diseases of interest and the study design to be used. The best situation occurs when we have quantified personal exposure estimates for the agents of interest, the least informative case occurs when we have only knowledge of the fact of employment in a plant, industry, or trade where exposure probability is high. Exposure information for most industry-based studies falls somewhere between these tow extremes. Job exposure matrices(JEM) are designed to link information on occupation with information on exposure to specific workplace hazards. Some forms of systematic error of bias may be less likely to occur in studies that utilize job-exposure matrices to indirectly infer exposures from job titles than in studies that assess exposures by asking subjects about their past exposure. JEM can be used effectively in industry-based studies for historic cohort studies, case-control study to assist with the retrospective assessment of occupational exposures among workers whose individual exposure histories are unavailable. JEM generally consist of a computerized database that links information about job categories and likely exposures. These two major axes may be stratified by calendar time. This article reviews the design of JEM in support of industry-based studies. Specific matrices may find broader applicability along with the increasing availability of detailed hygienic data.

• Archives of design research
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• v.14 no.3
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• pp.145-154
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• 2001

These days, the products like Walkman, mobile phone, notebook PC, PDA are moving together with our body, and in the imaginary world like internet, our other self, Avatar is moving in place of our body on the cyber world. These products are related with our human body, and when considering the ones, attached to the human body, and having the meaning of mental combination like these, as the combination of the human and the products, it is necessary to examine these products in approaching them with respect to the combination relation between the human and the products. As a result of examining we can understand that the products, said to combine with the human body, are coming oui steadily. and recently, the inclination on the combination and the movement appears strongly. As this background, there are a breakdown of dichotomy thought, mixed sexual imitation, cyber culture, techno culture. concept of informative nomands, phenomenon which the division of human and machine becomes vague. and the miniaturization of products. imitation of human, phenomenon that the Inclination on the combination with human is more accelerated by networking. These products combine with human body at each wearing type in the various forms. Its functions become multi-layered, and closer to the human body physically. or its communication becomes high·graded and, they have the recombined form through the existing products which the human has And, they communicate each other. have the strong fashionable property, and the characteristics like the imaginary product to imitate the human body and substitute for the human behave.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.5
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• pp.453-460
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• 2005

Since late 1970s, water quality monitoring had been performed in Korea by various agencies according to their own needs and objectives. Lacking of consistency in principles, such diverse operation has been producing difficulties in management of information on water quality parameters. These difficulties resulted from the fact that the expansion of monitoring networks had been based not on systematic methodology with considerations on scientifically established planning objectives but on personal experiences and subjective judgments in locating monitoring stations. This study aimed, therefore, to develop a selection methodology for locating monitoring stations to provide various informations on water quality to satisfy various monitoring objectives such as understanding short and long term trends of water quality, monitoring violations to water quality standards, identifying external causes and sources affecting water quality changes, supporting utilization of water resources, examining short-term variations in water quality through a concentrated investigation, estimating pollution loads from each unit watershed, supporting water quality modeling, and establishing informative systems for water resources management. Also, we applied the proposed methodology and presented an improved expansion plan for water quality monitoring networks in the Han River.

• Journal of Digital Convergence
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• v.15 no.7
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• pp.445-456
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• 2017

Mobile healthcare apps should be paid more attention not just as software, but also as significant health information providers. We examine the impact of psychological factors (e,g., instrumental efficacy, informational efficacy, health information orientation, playfulness, and responsiveness) on intention to continuous use of mobile healthcare apps. Based on an expanded technology acceptance model (TAM II), this study examined the effects of psychological factors influencing the usage of mobile healthcare apps. The results showed that informational efficacy and instrumental efficacy influenced intention to use through perceived ease of use and perceived usefulness. Playfulness influenced intention to continuous use directly as well as indirectly through perceived ease of use and perceived usefulness. Health information orientation and responsiveness influenced intention to continuous use through perceived usefulness. This study suggests the need for adopting instrumental, informative perspectives and playfulness in contemporary health research and production of mobile healthcare apps.