• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.5977-5982
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• 2014

Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)-mediated signaling landscape. Increasingly it is being realized that pancreatic cancer is a multifaceted and genomically complex disease. Suppression of tumor suppressors, overexpression of oncogenes, epigenetic silencing, and loss of apoptosis are some of the extensively studied underlying mechanisms. Rapidly accumulating in vitro and in vivo evidence has started to shed light on the resistance mechanisms in pancreatic cancer cells. More interestingly a recent research has opened new horizons of miRNA regulation by DR5 in pancreatic cancer cells. It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7. Xenografting DR5 silenced pancreatic cancer cells in SCID-mice indicated that there was notable suppression of tumor growth. There is a paradigm shift in our current understanding of TRAIL mediated signaling in pancreatic cancer cells that is now adding new layers of concepts into the existing scientific evidence. In this review we have attempted to provide an overview of recent advances in TRAIL mediated signaling in pancreatic cancer as evidenced by findings of in vitro and in vivo analyses. Furthermore, we discuss nanotechnological advances with emphasis on PEG-TRAIL and four-arm PEG cross-linked hyaluronic acid (HA) hydrogels to improve availability of TRAIL at target sites.

• Journal of Korean Society of Rural Planning
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• v.15 no.4
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• pp.199-211
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• 2009

The aim of this paper is to investigate the applicability of high spatial resolution remote sensing images for conducting the rural amenity resources survey. There are a large number of rural amenity resources and field reconnaissance without a sufficient preliminary survey involves a big amount of cost and time even if the data quality cannot always be satisfied with the advanced study. Therefore, a new approach should be considered like the state-of-the-art remote sensing technology to support field survey of rural amenity resources as well as to identify the spatial attributes including the geographical location, pathway, area, and shape. Generally high-resolution satellite or aerial photo images are too expensive to cover a large area and not free of meteorological conditions, but recently rapidly-advanced internet-based image services, such as Google Earth, Microsoft Bing maps, Bluebirds, Daum maps, and so on, are expected to overcome the handicaps. The review of the different services shows that Google Earth would be the most feasible alternative for the survey of rural amenity resources in that it provides powerful tools to build spatial features and the attributes and the data format is completely compatible with other GIS(Geographic information system) software. Hence, this study tried to apply the Google Earth service to interpret the amenity resources and proposed the reformed work process conjugating the internet-based high-resolution images like satellite and aerial photo data.

• Journal of Environmental Impact Assessment
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• v.20 no.5
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• pp.685-695
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• 2011

Through the analyses of the distribution characteristics and management practices of the wildlife protection areas, this study intends to present basic data for improving the management of protected areas. 1) Based on the aggregate results of the protected areas, the average ratio of the metro-city and provincial areas to the designated protected areas was 1.49%; except for Chungcheongbuk-do (8.83%) and Gyeongsangnam-do (3.43%), most regions showed specified percentages of about 1%, whereby the analysis suggested that the designated protected areas were too small. 2) Considering the fact that most (86.16%) of the wildlife protection areas are in the regions that are of ecological nature level of grade 1, green nature level of grade 8 or better, and of legal conservation regions and districts, it was shown that these reserves are distributed in regions with excellent natural environmental conditions. 3) Designation of protected areas for the protection of wildlife and fish is deemed to be necessary. Although there are 588 wildlife & plant reserves, there are absolutely no designated areas for protecting plant and fish species. 4) Based on the results of an analysis of the current distribution by types, 92.47% of protected areas were concentrated in the mountains, 0.24% in the agricultural lands, and 7.29% distributed in the lakes/rivers/costal areas. 5) As major improvement projects, proposed were: advancement of management systems for protected areas, expanded designation of protected areas, overhaul of managed areas, designation of protected areas for the protection of wild plants and fish, need for management measures for private property and the surrounding areas, need to secure appropriate management personnel and collaboration, locally-adapted management, eco-information-based management, total management of protected areas, etc.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.12 no.4
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• pp.81-93
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• 2009

This study has focused 302 environmental ordinances enacted from 1974 to 2008 by 16 upper-local governments (7 deignated cities and 9 provinces) and the relationships between them and the development of the Korean local autonomy system. The ordinances have been categorized into three types, the voluntary ones without any obligatory stipulations in laws, the optional ones based on laws, and the law based obligatory ones, which have been examined the enactment years and the contents of them. The local ordinances have been enacted in four periods with a few characteristics, which are "the pre-local-autonomy period (1974-1991)", "the introductory-local-autonomy period (1991-1995)", "the local-autonomy-developing period (1995-1999)", and "the mature-local-autonomy period (after 2000)", along the local autonomy development. 57 ordinances were enacted in the first period, 20 enacted in the second period, 46 enacted in the third period and 179 ordinances in the fourth period. The obligatory ordinances were the most in the first period and in the second period, while the voluntary ordinances were enacted most in the third period. 7 designated cities have pretty more ordinances, 160 in all, than 9 provinces, 142. The tendency to enact earlier in the metropolitan area, SeoulCity, IncheonCity and Gyeonggi province, than the others can be seen. It can be said that the establishment of the local autonomy in Korea had accelerated the development of the local environmental management.

• Journal of The Korean Society of Agricultural Engineers
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• v.56 no.6
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• pp.93-102
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• 2014

Generally data loading is a laborous job to develop models. Meteorological data is basic input data for hydrological models, it is provided through websites of Korea Meteorological Administration (KMA). The website of KMA provides daily meteorological observation data with tabular format classified by years, items, stations. It is cumbersome to manipulate tabular format for model inputs such as time series and multi-item or multi-station data. The provider oriented services which broadcast restricted formed information have caused inconvenient processes. Tim O'Reilly introduces "Web 2.0" which focuses on providing a service based on data. The top ranked IT companies such as google, yahoo, daum, and naver provide customer oriented services with Open API (Application Programming Interface). A RESTful web service, typical implementation for Open API, consists URI request and HTTP response which are simple and light weight protocol than SOAP (Simple Object Access Protocol). The aim of this study is to develop a web-based service that helps loading data for human use instead of machine use. In this study, the developed RESTful web service provides Open API for manipulating meteorological data. The proposed Open API can easily access from spreadsheet programs, web browsers, and various programming environments.

• Journal of Environmental Impact Assessment
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• v.19 no.4
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• pp.409-420
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• 2010

Heritage resources have become important social assets as the global interests in heritage tourism increased. Utilization of heritage as unique tourist destination has positive effects on regional economy, which in turn plays an important role in heritage conservation. However, it was found that the essential quality of heritage resources has been degraded and even destroyed when excessive use was permitted. This undesirable side-effects of heritage tourism have led to the growing concern for sustainable tourism that can contribute to both utilization and conservation of heritage. In order for sustainable tourism to be effectively implemented, it is crucial for visitors to be aware of the need for heritage conservation because they are the most important consumers of the heritage. The purpose of this study was to suggest some basic information for sustainable tourism by investigating visitors' evaluation of conservation and use values of heritage resources. The study sites were the two Korean traditional temples(Sokrisan Bubjusa and Naejangsan Naejangsa) and contingent valuation method was used. 390 visitors in Bubjusa and 308 visitors in Naejangsa participated in the questionnaire survey. From the results, sustainable tourism is possible in such heritage areas as traditional temples because the participants had relatively balanced values for heritage conservation and use. The WTP for natural conservation value was found to be highest in both temples; visitors may be more agreeable with the heritage conservation plan if the sustainability of natural resource is emphasized. Also, the use value of heritage could be influenced by the tourism utilization of the area where the heritage was located. If there are no other famous tourist destinations except the heritage in the area, additional plans to develop alternative destinations should be prepared in order to formulate the agreement on the need to protect the heritage among visitors, local communities, and government.

• Journal of Environmental Impact Assessment
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• v.22 no.3
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• pp.277-290
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• 2013

This study was carried out to propose the new procedure to apply Habitat Evaluation Procedure(HEP) of target species using delphi technique, which is suitable to develop endangered species with few researches and ecological knowledges. To identify habitat quality of specific species in development project site, we can develop habitat model and create habitat suitability maps. In this study, we select the Common Kestrel(Falco tinnunculus) as target species in four areas(Paju, Siheung, Ansan, Hwaseong) which is located near the Seoul metropolitan area. The Delphi technique was selected to get the reliable information on the species and habitats requirements. Through the delphi approach, seven habitat components were determined as suitable variables for the Common Kestrel: density($n/km^2$) of small mammals, area($km^2$) of bare-grounds, pasturelands and riparian, and open area(%), spatial distribution and area of croplands, landscape diversity, breeding sites(tall trees, cliffs, high-rise buildings), and the length of shelf. Habitat variables used in this model were classified into two categories: % of suitable land-cover type(open areas, croplands, pasturelands, wetlands, and baregrounds) and the quality of feeding sites(within 250m from edges of woodlands). Habitat quality of the Common Kestrel was assessed against occurred sites derived from the nationwide survey. Predicted habitat suitability map were closely related to the observed sites of the endangered avian species in the study areas. With the habitat suitability map of the Common Kestrel, we assess the environmental impacts with habitat loss after development project in environmental impact assessment.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.21 no.3
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• pp.99-110
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• 2018

Compared to yellow dust coming from China or particulate matter created naturally in spring due to Total Suspended Particulate(TSP), particulate matter in winter season have much more serious effect on human body as they penetrate cell membranes. Although such particulate matter are becoming a social issue, there are no concrete plans on how to reduce them. Air-purifying plants are limited in maintaining the indoor air quality of large area because it is usually difficult to quantify their performance. In order to improve this, a bio-filter that can be connected to air conditioner is suggested as an option. This study seeks to improve air conditioning model-based monitoring method for bio-filters from prior studies and objectify correlations between applied vegetation and growing environment into quantitative indicators. By doing so, this study seeks to provide criteria on plants applied to artificial soil-based vegetation bio-filters and basic information to set air-conditioning features. The study results confirmed significant tendency on the growing stability of each purifying plant in mechanical air-conditioning environment. Among three models selected for bio-filter vegetation models, epipremnum aureum showed high performance in quantitative indicators, including soil moisture, EC, and leaf temperature, etc., indicating that it would assure the highest growing stability in this test air-conditioning environment.

• Korean Journal of Environment and Ecology
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• v.21 no.2
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• pp.126-133
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• 2007

This study was designed to provide basic visiter information for establishing effective park management strategies. A questionnaire survey was at major entry points in Hallasan National Park(Eorimok and Youngsil). 237 random samples among the visitors on the way back home from their visit were chosen to represent general visitor population. As for the results, visitors' recreational satisfaction level with the area was relatively high. The majority of the visitors were satisfied with 20 uses and management related attributes provided by Hallasan National Park system. However, considering lack of sense of hygienic sanitary facilities, consequential deterioration of natural and cultural resources, and entrance fees as well as other costs, there needs to be a managerial priority on visiter service.

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.444-454
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• 2015

The purpose of this study is to investigate factors related to use-diffusion of Nscreen service as well as consumers' lifestyle and media usage of Nscreen service, which is fundamentally changing both the competitive landscape for business and the daily lives of consumers. The data of 1,524 consumers used in this study were drawn from the first Korea Media Panel Study in 2012 of Korea Information Society Development Institute. This study categorized adopters depending on the usage rate of contents and the variety of media platforms they used. Consumers using various media platforms enjoyed more categories of contents provided by Nscreen services. The variety of media platforms was useful in grouping users to explain the difference between the groups in terms of lifestyle activities. Based on the factor analysis and cluster analysis based on the consumers' lifestyle to find out different characteristics of each clusters, the result elicited some implications.