• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2005.09a
• /
• pp.344-347
• /
• 2005

Helper T(Th) cells regulate immune response by producing various kinds of cytokines in response to antigen stimulation. The regulatory functions of Th cells are promoted by their differentiation into two distinct subsets, Th1 and Th2 cells. Th1 cells are involved in inducing cellular immune response by activating cytotoxic T cells. Th2 cells trigger B cells to produce antibodies, protective proteins used by the immune system to identify and neutralize foreign substances. Because cellular and humoral immune responses have quite different roles in protecting the host from foreign substances, Th cell differentiation is a crucial event in the immune response. The destiny of a naive Th cell is mainly controlled by cytokines such as IL-4, IL-12, and IFN-${\gamma}$. To understand the mechanism of Th cell differentiation, many mathematical models have been proposed. One of the most difficult problems in mathematical modeling is to find appropriate kinetic parameters needed to complete a model. However, it is relatively easy to get qualitative or linguistic knowledge of a model dynamics. To incorporate such knowledge into a model, we propose a novel approach, fuzzy continuous Petri nets extending traditional continuous Petri net by adding new types of places and transitions called fuzzy places and fuzzy transitions. This extension makes it possible to perform fuzzy inference with fuzzy places and fuzzy transitions acting as kinetic parameters and fuzzy inference systems between input and output places, respectively.

• The Korean Journal of Applied Statistics
• /
• v.24 no.6
• /
• pp.1149-1160
• /
• 2011

Model selection and hypothesis testing problems in Bayesian inference are still debated between scholars. Bayesian factors traditionally used as a criterion in Bayesian hypothesis testing and model selection, are easy to understand but sometimes hard to compute. In addition, there are other model selection criterions such as DIC(Deviance Information Criterion) by Spiegelhalter et al. (2002) and Bayesian P-values for testing. In this paper, we briefly introduce the Bayesian hypothesis testing and model selection procedure. In addition we have applied a Bayesian inference to Swiss banknote data by a fitting logistic regression model and computing several test statistics to see if they provide consistent results.

• Journal of Intelligence and Information Systems
• /
• v.15 no.3
• /
• pp.151-165
• /
• 2009

Fuzzy neural network is an integrated model of artificial neural network and fuzzy system and it has been successfully applied in control and forecasting area. Recently ANFIS(Adaptive Network-based Fuzzy Inference System) has been noticed widely among various fuzzy neural network models because of its outstanding accuracy of control and forecasting area. We design a new classification model based on ANFIS and evaluate it in terms of classification accuracy. We identified ANFIS-based classification model has higher classification accuracy compared to existing classification model, C5.0 decision tree model by comparing their experimental results.

• Journal of the Korean Data and Information Science Society
• /
• v.24 no.3
• /
• pp.651-658
• /
• 2013

For the marginal model and generalized estimating equations (GEE) method there is important full covariates conditional mean (FCCM) assumption which is pointed out by Pepe and Anderson (1994). With longitudinal data with time-varying stochastic covariates, this assumption may not necessarily hold. If this assumption is violated, the biased estimates of regression coefficients may result. But if a diagonal working correlation matrix is used, irrespective of whether the assumption is violated, the resulting estimates are (nearly) unbiased (Pan et al., 2000).The quadratic inference functions (QIF) method proposed by Qu et al. (2000) is the method based on generalized method of moment (GMM) using GEE. The QIF yields a substantial improvement in efficiency for the estimator of ${\beta}$ when the working correlation is misspecified, and equal efficiency to the GEE when the working correlation is correct (Qu et al., 2000).In this paper, we interest in whether the QIF can improve the results of the GEE method in the case of FCCM is violated. We show that the QIF with exchangeable and AR(1) working correlation matrix cannot be consistent and asymptotically normal in this case. Also it may not be efficient than GEE with independence working correlation. Our simulation studies verify the result.

• The Transactions of the Korean Institute of Electrical Engineers D
• /
• v.49 no.8
• /
• pp.423-431
• /
• 2000

This paper presents a systematic approach to the input-output data-based fuzzy modeling for the complex and uncertain nonlinear systems, in which the conventional mathematical models may fail to give the satisfying results. To do this, we propose a new method that can yield a successful fuzzy model using a mGA hybrid schemes with a fine-tuning method. We also propose a new coding method fo chromosome for applying the mGA to the structure and parameter identifications of fuzzy model simultaneously. During mGA search, multi-purpose fitness function with a penalty process is proposed and adapted to guarantee the accurate and valid fuzzy modes. This coding scheme can effectively represent the zero-order Takagi-Sugeno fuzzy model. The proposed mGA hybrid schemes can coarsely optimize the structure and the parameters of the fuzzy inference system, and then fine tune the identified fuzzy model by using the gradient descent method. In order to demonstrate the superiority and efficiency of the proposed scheme, we finally show its applications to two nonlinear systems.

• 제어로봇시스템학회:학술대회논문집
• /
• 2000.10a
• /
• pp.372-372
• /
• 2000

In this paper, we propose Neuro Fuzzy Polynomial Networks(NFPN) based on Polynomial Neural Network(PNN) and Neuro-Fuzzy(NF) for model identification of complex and nonlinear systems. The proposed NFPN is generated from the mutually combined structure of both NF and PNN. The one and the other are considered as the premise part and consequence part of NFPN structure respectively. As the premise part of NFPN, NF uses both the simplified fuzzy inference as fuzzy inference method and error back-propagation algorithm as learning rule. The parameters such as parameters of membership functions, learning rates and momentum coefficients are adjusted using genetic algorithms. As the consequence part of NFPN, PNN is based on Group Method of Data Handling(GMDH) method and its structure is similar to Neural Networks. But the structure of PNN is not fixed like in conventional Neural Networks and self-organizing networks that can be generated. NFPN is available effectively for multi-input variables and high-order polynomial according to the combination of NF with PNN. Accordingly it is possible to consider the nonlinearity characteristics of process and to get better output performance with superb predictive ability. In order to evaluate the performance of proposed models, we use the nonlinear function. The results show that the proposed FPNN can produce the model with higher accuracy and more robustness than any other method presented previously.

• Journal of Ocean Engineering and Technology
• /
• v.11 no.3
• /
• pp.170-179
• /
• 1997

This paper presents a hybrid navigation system for AUV to locate its position precisely in rough sea. The tracking system is composed of various sensors such as an inclinometer, a tri-axis magnetometer, a flow meter, and a super short baseline(SSBL) acoustic position tracking system. Due to the inaccuracy of the attitude sensors, the heading sensor and the flowmeter, the predicted position slowly drifts and the estimation error of position becomes larger. On the other hand, the measured position is liable to change abruptly due to the corrupted data of the SSBL system in the case of low signal to noise ratio or large ship motions. By introducing a sensor fusion technique with the position data of the SSBL system and those of the attitude heading flowmeter reference system (AHFRS), the hybrid navigation system updates the three-dimensional position robustly. A Kalman filter algorithm is derived on the basis of the error models for the flowmeter dynamics with the use of the external measurement from the SSBL. A failure detection algorithm decides the confidence degree of external measurement signals by using a fuzzy inference. Simulation is included to demonstrate the validity of the hybrid navigation system.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.13 no.1
• /
• pp.60-68
• /
• 1999

This paper deals with the tracking control problem of industrial robotic manipulators with unknown or changing dynamics. The proposed method makes use of multiple moodels and switching mechanism by fuzzy inference of the manipulator in an indirect adaptive controller architecture. The models used for the indmtification of the manipliator are identical, except for the initial estimates of the unknown inertial pararmeters of the manipulator and its load. The torque input that is applied to the joint actuators is determined at every instant by the identification model that best approximates the robot dynamics. Simulation results are also included to dermnstrate the improvement in the tracking perfermance when the proposed method is used.s used.

• Computers and Concrete
• /
• v.21 no.6
• /
• pp.697-703
• /
• 2018

Compressive strength is one of the most important engineering properties of concrete, and testing of the compressive strength of concrete specimens is often costly and time consuming. In order to provide the time for concrete form removal, re-shoring to slab, project scheduling and quality control, it is necessary to predict the concrete strength based upon the early strength data. However, concrete compressive strength is affected by many factors, such as quality of raw materials, water cement ratio, ratio of fine aggregate to coarse aggregate, age of concrete, compaction of concrete, temperature, relative humidity and curing of concrete. The concrete compressive strength is a quite nonlinear function that changes depend on the materials used in the concrete and the time. This paper presents an adaptive neuro-fuzzy inference system (ANFIS) for the prediction of concrete compressive strength. The training of fuzzy system was performed by a hybrid method of gradient descent method and least squares algorithm, and the subtractive clustering algorithm (SCA) was utilized for optimizing the number of fuzzy rules. Experimental data on concrete compressive strength in the literature were used to validate and evaluate the performance of the proposed ANFIS model. Further, predictions from three models (the back propagation neural network model, the statistics model, and the ANFIS model) were compared with the experimental data. The results show that the proposed ANFIS model is a feasible, efficient, and accurate tool for predicting the concrete compressive strength.

• Journal of the Society of Naval Architects of Korea
• /
• v.56 no.2
• /
• pp.161-167
• /
• 2019

In general, fatigue analysis is performed by using deterministic model to estimate the optimal parameters. However, the deterministic model is difficult to clearly describe the physical phenomena of fatigue failure that contains many uncertainty factors. With regard to this, efforts have been made in this research to compare with the deterministic model and the stochastic models. Firstly, One deterministic S-N curve was derived from ordinary least squares technique and two P-S-N curves were estimated through Bayesian-linear regression model and Markov-Chain Monte Carlo simulation. Secondly, the distribution of Long-term fatigue damage and fatigue life were predicted by using the parameters obtained from the three methodologies and the long-term stress distribution.