• Journal of Dairy Science and Biotechnology
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• 제23권1호
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• pp.65-71
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• 2005

Powered infant formula and baby food contaminated with Enterobacter sakazakii were reported to cause infection among infants and to be associated with sporadic cases and outbreaks of sepsis, menigitis, cerebritis, and necrotizing enterocolitis. Salmonella contamination of infant formula has also been responsible for multiple outbreaks. Other species of Enterobacteriaceae in powdered infant formula may be causative agents, about which there has been no report. Other pathogenic bacteria have been isolated from powdered infant formula but they were not associated with outbreaks among infant. While Enterobacter sakazakii caused disease in all age groups, premature infants under 28 days old and with birth weight are most sensitive to its infection. Even if low contamination level of the bacteria in powdered infant formula and baby food may not cause infection, the possibility to multiplicate during preparation and storage of reconstituted formula may increase. The etiological factors and pathogenecity of S. sakazakii have not been elucidated. There were wide variability in phenotype and genotype between its strains. S. sakazakii has been isolated from factory facility and surroundings more frequently than Salmonella and thus factory environment should be the source for post-processing contamination of the formula with S. sakazakii. Considering current technology to manufacture power infant formula and baby food it is impossible to sterilize powdered formula but the frequency of outbreak hazard by S. sakazakii can be reduced by pasteurizing the formula base before drying and shortening storage time of the reconstituted formula.

• Child Health Nursing Research
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• 제15권1호
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• pp.71-80
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• 2009

Purpose: This study was done to investigate the effects of an infant massage on physical growth and stress response in preterm babies. Method: A nonequivalent control group with pre-posttest design was used with 56 preterm babies in the NICU of E medical center at Daejeon. Data were collected from July 2004 to May 2005. The intervention was given for 15 minutes, once a day for 7 days. Physical growth was measured by weight, length, head circumference, and stress response was measured by serum cortisol level. Mean, %, paired-test, t-test with the SPSS/W in 16.0 program were used to analyze the data. Results: After the intervention, physical growth variables (weight, length, head circumference) in experimental group were higher than that of the control group. Also, the serum cortisol level in the experimental group was lower than that of the control group. But none of these results were not statistically significant. Conclusion: The results of this study suggest that a 7-day intervention period may not be long enough to confirm the effects of infant massage on physical growth and stress reaction. Therefore it is suggested that a longer period of infant massage should be tested to determine if it is effective in improving the physical growth and stress reduction in preterm babies.

• Clinical and Experimental Pediatrics
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• 제57권10호
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• pp.425-433
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• 2014

Adrenal and thyroid hormones are essential for the regulation of intrauterine homeostasis, and for the timely differentiation and maturation of fetal organs. These hormones play complex roles during fetal life, and are believed to underlie the cellular communication that coordinates maternal-fetal interactions. They serve to modulate the functional adaptation for extrauterine life during the perinatal period. The pathophysiology of systemic vasopressor-resistant hypotension is associated with low levels of circulating cortisol, a result of immaturity of hypothalamic-pituitary-adrenal axis in preterm infants under stress. Over the past few decades, studies in preterm infants have shown abnormal clinical findings that suggest adrenal or thyroid dysfunction, yet the criteria used to diagnose adrenal insufficiency in preterm infants continue to be arbitrary. In addition, although hypothyroidism is frequently observed in extremely low gestational age infants, the benefits of thyroid hormone replacement therapy remain controversial. Screening methods for congenital hypothyroidism or congenital adrenal hyperplasia in the preterm neonate are inconclusive. Thus, further understanding of fetal and perinatal adrenal and thyroid function will provide an insight into the management of adrenal and thyroid function in the preterm infant.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.7-14
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• 2008

Special formulas are those in which one of the basic nutrients (usually the protein and/or carrbohydrate) has been changed to an alternative nutrient that an individual baby may better tolerate. The following are specialized formulas : Soy formulas, hypoallergenic formulas, Lactose free formulas, Premature baby formulas, Low phosphate formulas, Formulas for inborn errors of metabolism. Less is known about the long-term effects of feeding babies these special formulas and each formula has its unique properties and indications. The pediatrician must acquaint themselves with all commercially available infant formulas so as to provide the parent with reliable and unbiased information about them.

• Neonatal Medicine
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• 제25권4호
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• pp.191-195
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• 2018

Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a constituent of leukocyte integrins. Clinical features usually begin with a delay in the separation of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections. We experienced a case of leukocyte adhesion deficiency diagnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive care unit presented with a septic hip. Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18. This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.

• Clinical and Experimental Pediatrics
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• 제51권3호
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• pp.233-236
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• 2008

In recent years, Korea has experienced a steadily declining birth rate, which is a serious social problem in the country. Although living conditions have improved, the birth rates for low birth weight infants and preterm babies has increased because more and more women choose to give birth later in life and the social environment has changed. The rise in low birth weight infants may increase infant mortality rates and morbidity rates. However, the recent improvements in neonatal care has elevated the survival rate of low birth weight infants up to 90 percent and lowered the weight of the very low birth weight infants that can now be saved. In this study, we used dynamic population statistics from the Korea National Statistical Office, which represents the current trend of social stratification and the population of this period. We analyzed birth records for a seven-year period and studied the changes in the delivery rate of preterm and low birth weight infants and the problems related to those changes. The results show that the rate of low birth weight infants has increased from 3.79% to 4.35% for the past seven years. The rate of preterm babies rose from 3.79% to 4.89%. The number of babies born from mothers aged 35 or more went up from 6.69% to 11.83% of the total number of the babies born. As maternal age has risen, the risks of delivering a preterm or low birth weight infant have also increased.

• Neonatal Medicine
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• 제17권1호
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• pp.116-122
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• 2010

Kasabach-Merritt 증후군은 거대한 혈관종에 의해 혈소판이 소모되어 감소되는 드문 질환이다. 저자들은 재태주령 32주 미숙아에서 설명되지 않은 복수와 혈소판 감소증의 원인을 찾기 위해 시험적 개복술을 시행하여 장 혈관종을 발견하였으나 광범위하여 수술적 제거를 하지 못하고, SPECT로 확인 후 스테로이드 치료로 혈소판 감소증이 호전된 1례를 경험하였다. 따라서 다른 원인에 의해 설명되지 않는 혈소판 감소증과 파종성 혈관내 응고병증이 있으면 내부 장기의 혈관종을 의심해 볼 필요가 있다고 사료되었다.

• Imaging Science in Dentistry
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• 제34권3호
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• pp.165-169
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• 2004

Craniofacial dysostosis is considered to be one of rarely observed syndromes characterized by premature closing of all cranial sutures. The first patient was a 4-year-old male infant who had been complaining of empyema. Clinical findings showed exophthalmos, hypertelorism and facial asymmetry. Conventional radiographs demonstrated abscence of cranial sutures and underdeveloped maxilla. CT scan demonstrated the digital impressions of the inner surface of the cranial vault, enlarged and depressed sella turcica. The second patient was a 2-year-old female infant who had been complaining of facial deformity. Clinical findings showed hypertelorism and underdeveloped maxilla. Radiographs showed premature synostosis of all cranial sutures, depressed and enlarged sella turcica, and hypoplastic maxilla. 3 years after operation, her look improved. However, resurgery may be considered to decreasing intracranial pressure and for correction of facial deformity. Two interesting cases showing ‘cloverleaf’ skulls were presented.

• Child Health Nursing Research
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• 제21권1호
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• pp.37-45
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• 2015

목적 본 연구는 미숙아로 태어난 유아와 정상아로 태어난 유아의 건강 관련 삶의 질을 비교하고, 미숙아로 태어난 유아의 건강 관련 삶의 질에 영향을 미치는 요인을 파악하여, 이들의 유아기 건강 관련 삶의 질 향상에 기여하기 위하여 시도되었다. 방법 연구 방법은 자가보고식 설문지를 이용하였으며, 연구 대상자는 인터넷 카페에서 미숙아로 출생한 유아의 부모 80명과 정상아 부모 83명이었다. 연구 도구는 TNO-AZL에서 개발한 TAPQOL를 사용하였고, 수집된 자료는 SPSS 20.0을 사용하여 빈도, 백분율, 평균, 표준편차, t-test, ANOVA, 다중회귀분석을 이용하였다. 결과 미숙아로 태어난 유아의 삶의 질 점수는 100점 만점에 80.6점(${\pm}9.9$)이었으며, 정상아로 태어난 유아의 삶의 질 점수는 85.0점(${\pm}8.3$)으로, 미숙아 집단이 정상아 집단에 비해 삶의 질 점수가 4.4점(${\pm}1.4$) 낮았다. 미숙아 집단이 정상아 집단에 비해 삶의 질 점수가 낮은 영역으로는 운동기능, 불안, 긍정적 기분, 활기참 및 의사소통 등이었다. 두 집단간 삶의 질 점수 차이가 가장 큰 영역은 운동기능과 의사소통이었다. 미숙아로 태어난 유아의 건강 관련 삶의 질에 영향을 미치는 변수는 '신생아실 입원기간(7일 이상)'과 '출생체중(1,000 g 미만)'으로 나타났으며, 두 변수의 설명력은 17%였다. 즉, 신생아실 입원기간이 7일 미만이고, 출생 시 체중이 1,000 g 이상인 아동이 그렇지 않은 아동보다 건강 관련 삶의 질 점수가 높았다. 결론 미숙아로 태어난 아동의 건강 관련 삶의 질은 이들의 출생 시 체중 및 신생아실 입원기간 등이 영향을 미치므로 미숙아 추후 프로그램을 개발할 때 출생체중, 재태기간 및 신생아집중치료실 입원기간 등으로 고려해야 할 것이다.

• Journal of Chest Surgery
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• 제30권6호
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• pp.585-590
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• 1997

미숙아에 있어서 동반되는 동맥관개존증은 향후 환아의 경과에 지대한 영향을 미친다. 본 연구는 미숙아 에 있어서 동맥관 개존증으로 진단되어 치료를 받은 례를 관찰 분석하여 그 성적을 살피고 향후 동맥관개 존증의 치료 방향을 설정하고자 하였다. 1994년 12월 부터 1996년 10월까지 신생아 중환자실에 입원하여 동맥관개존증으로 진단을 받은 환자 57 명중을 대상으로 하여 임상기록지를 관찰하였다. 인도메타진 등의 내과적 치료를 받은 환자(I 군)는 48명 (남자 29명, 여자 19명) 이었으며, 수술적 교정을 받은 환아(II 군)는 9명(남자 5명, 여자 4명)이었다. 각군에서의 환아의 평균 재태기간은 각각 29.6$\pm$3.1주, 28.1$\pm$1.6주0>0.05), 평균 출생시 체중은 각각 1,413$\pm$ 580gm, 1,098$\pm$235gm(p.0.05)이였다. 모든 환아에서 일차적으로 인도메타진 치료를 하였으며, 그중 인도메타 진 치료에도 불구하고 동맥관이 막히지 않고 패출혈, BUN의 상승, 소변량 감소 등으로 수술 대상이 되었 (9/57, 16%). 수술은 환자를 이동시키지 않고 신생아중환자실에서 결찰을 시행하였다. 2명의 환아들이 술 후 15일, 47일째 술전 부터 발생한 지속적인 패혈증및 기관지패 鎌紈봐塚막\ulcorner사망하였다. 수술과 직접적으 로 관련된 합병증 및 사망 례는 없었다. 인도메타진으로 내과적 치료만 한 환자 47명중 9명이 합병증(패혈 증, 기관패이형성증, 패내출혈, 신부전 등)으로 인하여 사망하여(19%) 내과적 치료의 실패는 520lo(18fsf였 다. 출생체중을 기준으로 보았을때 체중이 1500gm미만인 경우가 1500gm이상인 경우보다 그 실패율이 높았다(41% 15/38, 16% 3/19, p<0,05). 상기 결과로 부터 크기가 큰 동맥관 개존증, 체중이 적은 미숙아, 선천성 심기형을 동반한 경우 등 일부 미숙아에 있어서는 수술적 결찰술이 일차적 치료법으로 고려 되어야 할 것으로 사료된다. 또한 환아를 수 술장으로 이동하지 않고도 중환자실에서 안전하게 수술할 수 있었다.