• Journal of Institute of Control, Robotics and Systems
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• v.16 no.4
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• pp.396-402
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• 2010

In this paper the principles and structure of a WTS (Wind Turbine Simulator) are described. The proposed WTS is a versatile system specially designed for the purpose of developing and testing new control strategies for wind energy conversion systems. The simulator includes two sub-systems; a torque controller which controls a 3-phase induction motor in order to simulate the wind turbine and wind speed generator which can simulate an actual wind speed. In order to make the proposed system working in real-time, two sub-systems are incorporated into one simulink block by using Real-time workshop. The performance of the proposed system is verified by considering various wind speeds.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1250-1255
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• 2008

Onchungeum(OCE), a herbal formula, has been used for treatment of anemia, discharging blood and skin diseases. In the previous study, we investigated the anti-cancer effect of OCE by G1 arrest of the cell cycle in human hepatocarcinoma cells, Hep3B cells. In this study, it was examined that the difference of anti-proliferative mechanisms by change in the ratio of OCE composition (OCE I) in Hep3B cells. Treatment of OCE I exhibited a relatively strong anti-proliferative activity and caused various morphological changes such as membrane shrinkage and cell floating. In addition, OCE-I arrests the cell cycle at G1 phase, which was associated with the down-regulation of cyclin D1 and Cdk6 expressions. The G1 arrest was also associated with the induction of Cdk inhibitors p27 and p21. Moreover, both p21 and p27 were detected by immunoprecipitation with anti-Cdk4 and anti-Cdk2 antibodies in OCE I-treated cells but in case of OCE, p21 did not make any complexes with Cdk4 and Cdk2. These results suggest that the change in the ratio of OCE composition might induce different mechanisms in anti-cancer efficacy of OCE, which may confer characteristic principles in oriental medical formula.

• Archives of Pharmacal Research
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• v.29 no.4
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• pp.293-297
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• 2006

The fruits of Evodia rutaecarpa Benth (Rutaceae) has long been used for inflammatory disorders and some anti-inflammatory actions of its constituents such as dehydroevodiamine, evodiamine and rutaecarpine were previously reported. Since the pharmacological data is not sufficient to clearly establish the scientific rationale of anti-inflammatory medicinal use of this plant material and the search for its active principles is limited so far, three major constituents (evodiamine, rutaecarpine, goshuyuamide II) were evaluated for their anti-inflammatory cellular action mechanisms in the present study. From the results, evodiamine and rutaecarpine were found to strongly inhibit prostaglandin $E_2$ synthesis from lipopolysaccharide-treated RAW 264.7 cells at $1-10{\mu}M$. Evodiamine inhibited cyclooxygenase-2 induction and NF-kB activation, while rutaecarpine did not. On the other hand, goshuyuamide II inhibited 5-lipoxygenase from RBL-1 cells $(IC_{50}=6.6{\mu}M)$, resulting in the reduced synthesis of leukotrienes. However, these three compounds were not inhibitory against inducible nitric oxide synthase-mediated nitric oxide production from RAW cells up to $50{\mu}M$. These pharmacological properties may provide the additional scientific rationale for anti-inflammatory use of the fruits of E. rutaecarpa.

• Journal of Sasang Constitutional Medicine
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• v.18 no.1
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• pp.30-40
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• 2006

1. Objectives The present study purposed to examine the contents and the principles of music therapy according to Oriental medicine theories in order to prove that music therapy is not a new research area but its principle is found in the long tradition of Oriental medicine. 2. Methods We investigate the possibility of music therapy based on Oriental medicine theories and examine the meanings of music therapy from the viewpoint of Oriental medicine. 3. Conclusions and discussions (1) The principles of music therapy are the principle of homogeneity, catharsis and balance. (2) When one’s mind changes, there are naturally occurred sounds, which are called Oseong (五聲: the oriental five voices exhalation, laughing, singing, wailing and groaning), and the notes defined by arranging the Oseong according to the principle of Ohaeng (五行: the oriental five phases wood, fire, earth, metal, water) are Oheum (五音: the oriental five musical notes Gakeum, Chieum, Gungeum, Sangeum and Wooeum.). If Eum (musical notes) is classified into Ohaeng, it can be divided into Gakeum, Chieum, Gungeum, Sangeum and Wooeum. (3) Change of Sinji (神志: consciousness) induces change of Gigi (氣機: function of Gi), which can change the character of voices. Oseong controls the functions of Ojang (五臟: the oriental five viscera) by ruling one’s Jeongji (情志: emotion). It can reduce the damage of the viscera caused by excessive vent of emotion resulted from unconscious expression of Oseong - Hoseong (呼聲: exhalation), Soseong (笑聲: laughing), Gaseong (歌聲: singing), Gokseong (哭聲: wailing) and Sinseong (呻聲: groaning). (4) Yijeongseungjeong (以情勝情: Control emotion with emotion) therapies, which suppresses an emotion by stimulating another, include Noseungsabeop (怒勝思法: Control anxiety with anger), Heeseungbibeop (喜勝悲法: Control sorrow with joyfulness), (思勝恐法: Control fear with anxiety), Biseungnobeop (悲勝愁法: Control anger with sorrow) and Gongseungheebeop (恐勝喜法: Control joyfulness with fear). (5) Seongeum (聲音: voices and musical notes) can be applied to a stimulation method that not only harmonizes the rhythm of living organs but also controls the occurrence of diseases caused by mutual Pyeonseongpyeonsoi (偏盛偏衰: relative preponderance and weakness) through direct induction of the strength and weakness of Gi function of the oriental five viscera in a human body according to the individual character. Sounds preferred by the patient, the material of an instrument selected by the patient, the character of rhythm and music expressed by the patient and the sound or voice uttered frequently by the patient can be considered in diagnosis and treatments for the patient’s body and mind.

• School Mathematics
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• v.17 no.2
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• pp.157-178
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• 2015

The purpose of this study was to investigate the role of calculators as a cognitive tool rather than calculating tool in learning elementary school mathematics. The calculator activities on multiplying two numbers ending with 0s or two decimal fractions and mixed four operations were developed, and exploratory lessons with the activities were implemented to three 3rd graders and two 5th graders. The results were shown that calculators provided an alternative effective learning environment: students were able to use heuristic thinking, reason inductively and successfully investigate principles of mathematics through the pattern recognition. And finally, we discussed the heuristic method through utilizing calculators.

• Natural Product Sciences
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• v.12 no.2
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• pp.109-112
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• 2006

The chloroform-soluble fraction of the vinegar treated small black soybean [Glycine max (Leguminosae)] showed antiproliferative activity against human myeloid leukemia HL-60 cells, in terms of inhibition of proliferation and induction of apoptosis. Bioassay-guided chromatography of the chloroform-soluble fraction resulted in the isolation of two isoflavonoid compounds, genistein and daidzein, as active principles. Genistein showed more potent antiproliferative effects against HL-60 cells. Treatment of HL-60 cells with genistein induced apoptosis in a dose dependent manner. Apoptosis was judged by the detection of DNA fragmentation by a flow cytometry and the degree of apoptosis was assayed by RT-PCR.

• Natural Product Sciences
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• v.23 no.1
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• pp.21-28
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• 2017

In our program to search for new AMP-activated protein kinase (AMPK) activators from plants that exert potential anticancer property, we found that an EtOAc extract of Myristica fragrans (nutmeg) activated AMPK enzyme in human breast cancer MCF-7 cells. Two major diarylbutane-type lignans, macelignan and meso-dihydroguaiaretic acid (MDGA), were isolated as active principles from this extract. Treatment of breast cancer cells with two compounds induced cellular apoptosis, evidenced by cleavage of poly-(ADP-ribose) polymerase (PARP) and Ser 15 phosphorylation of p53. Moreover, macelignan and MDGA significantly inhibited the colony formation of MCF-7 breast cancer cells on soft agar. Intraperitoneal injection of macelignan and MDGA (20 mg/kg) suppressed the tumor growth of 4T1 mammary cancer cells. These results indicate that the chemopreventive effects of two major diarylbutane-type lignans from Myristica fragrans (nutmeg) may be associated with induction of apoptosis presumably through AMPK activation.

• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.238-246
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• 2006

Recent trends of interior design have a focus on creation of more various meanings rather than past ideology which sought after the compatibility to the function of modem design. These trends requires integral understanding of social and cultural ideologies with a sens of values for a certain periods. In addition, they also require creativity which able to read, find and solve consumer's diverse demand and desire. Considering the effort of trend forecasting in Korea is still heavily rely on the foreign trend shows, it is natural to attempt to study the analytical forecasting methodology based upon more systematic principles which lead to more objective outcome, when the understanding, forcasting and analysis of interior decoration trend are required. In this thesis, the analysis and forecasting of interior decoration trend are studied by means of verbal image code process which involves the induction of design concept through data extraction, classification and analysis, in order to understanding and satisfying the diversified consumer's demand and trend. The coding process of verbal image is understanding as general concept. by extracting common elements from abstract and individual image, and/or specific concept. Therefore, it is proposed that the database building and data mining process of verbal Image, and subsequent development of programming skill can be applied as more efficient tool for various verbal image process.

• Microbiology and Biotechnology Letters
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• v.2 no.1
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• pp.29-35
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• 1974

We have studied the applicability of the principles and inherent advantages of the two-stage dontinuous uclture technique to an enzyme process for the purpose of improving and optimizing the productivity of 3-ketosteroid-delta-1-dehydrogenase. By using a two-stage continuous culture system, the growth st ageand enzyme produdtion stage are separated. In each stage an optimal set of toperaing conditions was determined, and this was tested for feasibility for the period of 10 days. During this period, at least 70％ of the maximum enzyme productivity could be maintained. The important design parameters studied are: (1) optimal specific growth rate in the first stage which corresponds to the maximal cell productivity, (2) the optimal dilution rate in the second stage which in turn determines the size of second stage fermentor and the mean residence time of cells in the second stage, (3) cell concentration in both stages, add (4) the specific enzyme productivity and enzyme productivity of the second stage. In addition, by using two-stage continuous culture system we have been able to reduce or eliminate the effect of catabolite repression due to high medium concentration and the adverse effect of the solvent used to dissolve the inducer. We have found the balance between the opposing effects of induction and repression in the second stage judging from the observation that the enzyme productivity goes through a maximum.

• Journal of the Korean School Mathematics Society
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• v.13 no.3
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• pp.357-379
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• 2010

There are many studies about the method of trying leveled class because we say the Excellence of Education after high school's Equalization Policy. After the leveled c1ass, Ministry of Education, Science and Tech. announced the induction of leveled classes' evaluation in 2008, it is called that students take classes adapted to their levels. This study illustrates criteria of forming evaluation, it composes leveled assessment tests referenced by Gibb's evaluation effects & Cotton's evaluation principles. Before anything else, this study induced contents of studies which is emphasized the structure rather than the arithmetic that is based on Foucault' s analysis of mathematics' class and examination & MacGregor's point of algebra. Since then we made leveled assessment tests which made by students' Question. And then, In this study, we modified evaluation tests appropriately by criteria of evaluation and analysing the result.