• 한국해양공학회지
• /
• 제33권1호
• /
• pp.33-41
• /
• 2019

Estimating fatigue damage is a very important issue in the design of ships. The springing and whipping response, which is the hydro-elastic response of the ship, can increase the fatigue damage of the ship. So, these phenomena should be considered in the design stage. However, the current studies on the the application of springing and whipping responses at the design stage are not sufficient. So, in this study, a prediction method was developed using fluid-structural interaction analysis to assess of the fatigue damage induced by springing and whipping. The stress transfer function (Stress RAO) was obtained by using the 3D FE model in the frequency domain, and the fatigue damage, including linear springing, was estimated by using the wide band damage model. We also used the 1D beam model to develop a method to estimate the fatigue damage, including nonlinear springing and whipping by the vertical bending moment in the short-term sea state. This method can be applied to structural members where fatigue strength is weak to vertical bending moments, such as longitudinal stiffeners. The methodology we developed was applied to 325K VLOC, and we analyzed the effect of the springing and whipping phenomena on the existing design.

• 한국재료학회지
• /
• 제28권11호
• /
• pp.653-658
• /
• 2018

$ZrO_2$ is a candidate material for hip and knee joint replacements because of its excellent combination of biocompatibility, corrosion resistance and low density. However, the drawback of pure $ZrO_2$ is a low fracture toughness at room temperature. One of the most obvious tactics to cope with this problem is to fabricate a nanostructured composite material. Nanomaterials can be produced with improved mechanical properties(hardness and fracture toughness). The high-frequency induction heated sintering method takes advantage of simultaneously applying induced current and mechanical pressure during sintering. As a result, nanostructured materials can be achieved within very short time. In this study, W and $ZrO_2$ nanopowders are mechanochemically synthesized from $WO_3$ and Zr powders according to the reaction($WO_3+3/2Zr{\rightarrow}W+3/2ZrO_2$). The milled powders are then sintered using high-frequency induction heating within two minutes under the uniaxial pressure of 80MPa. The average fracture toughness and hardness of the nanostructured W-3/2 $ZrO_2$ composite sintered at $1300^{\circ}C$ are $540kg/mm^2$ and $5MPa{\cdot}m^{1/2}$, respectively. The fracture toughness of the composite is higher than that of monolithic $ZrO_2$. The phase and microstructure of the composite is also investigated by XRD and FE-SEM.

• Korean Chemical Engineering Research
• /
• 제57권4호
• /
• pp.519-524
• /
• 2019

스테인리스 스틸을 사용한 태양전지는 효율성이 낮지만, 패시배이션을 방지하는 목적의 추가적인 막을 설치하지 않아도 되는 장점을 가지고 있다. 본 연구에서는 스테인리스 스틸을 기반으로 하는 a-Si:H 박막 태양전지 제조에 고분자 재료인 실리콘 수지를 도입하였다. 실리콘 수지의 사용 목적은 스틸표면의 평탄화와 전기 절연성을 도입하는 것이다. 초기 공정에서, 스테일리스 스틸의 표면에 실리콘 수지를 스핀코팅을 통해 $2{\sim}3{\mu}m$ 두께로 코팅하였다. 이후 증착법을 이용하여 알루미늄 박막 코팅을 시도하였다. 알루미늄 증착시, 마이크로미터 크기의 실리콘 수지 표면위에 버클링이 형성되었다. 형성된 실리콘 수지 위로 반도체층 도입 등 추가적인 박막 공정을 실시하였으며, 박막층에 유지된 버클링은 광산란 효과를 증가시켜 태양전지의 효율 향상으로 연계되었음을 알 수 있었다.

• Journal of Ginseng Research
• /
• 제43권3호
• /
• pp.368-376
• /
• 2019

Background: In the current phytochemical research on ginseng, the differentiation and structural identification of ginsenosides isomers remain challenging. In this paper, a two-dimensional mass spectrometry (2D-MS) method was developed and combined with statistical analysis for the direct differentiation, identification, and relative quantification of protopanaxadiol (PPD)-type ginsenoside isomers. Methods: Collision-induced dissociation was performed at successive collision energy values to produce distinct profiles of the intensity fraction (IF) and ratio of intensity (RI) of the fragment ions. To amplify the differences in tandem mass spectra between isomers, IF and RI were plotted against collision energy. The resulting data distributions were then used to obtain the parameters of the fitted curves, which were used to evaluate the statistical significance of the differences between these distributions via the unpaired t test. Results: A triplet and two pairs of PPD-type ginsenoside isomers were differentiated and identified by their distinct IF and RI distributions. In addition, the fragmentation preference of PPD-type ginsenosides was determined on the basis of the activation energy. The developed 2D-MS method was also extended to quantitatively determine the molar composition of ginsenoside isomers in mixtures of biotransformation products. Conclusion: In comparison with conventional mass spectrometry methods, 2D-MS provides more direct insights into the subtle structural differences between isomers and can be used as an alternative approach for the differentiation of isomeric ginsenosides and natural products.

• The Korean Journal of Physiology and Pharmacology
• /
• 제23권5호
• /
• pp.317-328
• /
• 2019

It is known that top-down associative inputs terminate on distal apical dendrites in layer 1 while bottom-up sensory inputs terminate on perisomatic dendrites of layer 2/3 pyramidal neurons (L2/3 PyNs) in primary sensory cortex. Since studies on synaptic transmission in layer 1 are sparse, we investigated the basic properties and cholinergic modulation of synaptic transmission in layer 1 and compared them to those in perisomatic dendrites of L2/3 PyNs of rat primary visual cortex. Using extracellular stimulations of layer 1 and layer 4, we evoked excitatory postsynaptic current/potential in synapses in distal apical dendrites (L1-EPSC/L1-EPSP) and those in perisomatic dendrites (L4-EPSC/L4-EPSP), respectively. Kinetics of L1-EPSC was slower than that of L4-EPSC. L1-EPSC showed presynaptic depression while L4-EPSC was facilitating. In contrast, inhibitory postsynaptic currents showed similar paired-pulse ratio between layer 1 and layer 4 stimulations with depression only at 100 Hz. Cholinergic stimulation induced presynaptic depression by activating muscarinic receptors in excitatory and inhibitory synapses to similar extents in both inputs. However, nicotinic stimulation enhanced excitatory synaptic transmission by ~20% in L4-EPSC. Rectification index of AMPA receptors and AMPA/NMDA ratio were similar between synapses in distal apical and perisomatic dendrites. These results provide basic properties and cholinergic modulation of synaptic transmission between distal apical and perisomatic dendrites in L2/3 PyNs of the visual cortex, which might be important for controlling information processing balance depending on attentional state.

• The Korean Journal of Physiology and Pharmacology
• /
• 제23권5호
• /
• pp.381-392
• /
• 2019

Sperm function and male fertility are closely related to pH dependent $K^+$ current (KSper) in human sperm, which is most likely composed of Slo3 and its auxiliary subunit leucine-rich repeat-containing protein 52 (LRRC52). Onion peel extract (OPE) and its major active ingredient quercetin are widely used as fertility enhancers; however, the effect of OPE and quercetin on Slo3 has not been elucidated. The purpose of this study is to investigate the effect of quercetin on human Slo3 channels. Human Slo3 and LRRC52 were co-transfected into HEK293 cells and pharmacological properties were studied with the whole cell patch clamp technique. We successfully expressed and measured pH sensitive and calcium insensitive Slo3 currents in HEK293 cells. We found that OPE and its key ingredient quercetin inhibit Slo3 currents. Inhibition by quercetin is dose dependent and this degree of inhibition decreases with elevating internal alkalization and internal free calcium concentrations. Functional moieties in the quercetin polyphenolic ring govern the degree of inhibition of Slo3 by quercetin, and the composition of such functional moieties are sensitive to the pH of the medium. These results suggest that quercetin inhibits Slo3 in a pH and calcium dependent manner. Therefore, we surmise that quercetin induced depolarization in spermatozoa may enhance the voltage gated proton channel (Hv1), and activate non-selective cation channels of sperm (CatSper) dependent calcium influx to trigger sperm capacitation and acrosome reaction.

• 기록학연구
• /
• 제44호
• /
• pp.217-241
• /
• 2015

세월호 사건은 해난사고가 극심한 사회적 갈등을 유발하며 정치사회적 사건으로 비화된 경우이며, 사건의 전개과정을 다섯 단계로 나누어 단계별로 생산되는 기록을 살펴보았다. 기록화는 안산의 시민들이 구성한 세월호참사시민기록위원회와 기록관리단체와 전문가들이 결성한 세월호시민아카이브네트워크가 시작하였으며, 두 단체는 가족대책위원회 산하로 통합되어 416기억저장소를 구성하였다. 세월호 사건 기록은 증거성과 역사성을 갖는 사회적 역사적 기록이며, 수집과 동시에 활용하고 기록전문가들이 기록을 생산하며 생산 종료 시점을 예측할 수 없는 특성을 갖고 있다. 사건 기록화는 공공기록과는 다른 내용의 기록을 수집하여 사건을 다른 관점에서 볼 수 있게 하며, 동시대의 기록화, 사회참여운동기록화, 지역사회 기록화의 성격을 갖는다. 세월호 기록은 진상 파악 뿐 아니라 공동체 재건과 치유를 위하여 활용될 수 있다. 사건기록화에서는 기록화 여부의 판단과 예비조사가 필요하며, 기록화를 위해서 필요한 조직을 느슨한 형태로 구성하고 교육에도 사건기록화를 포함시킬 필요가 있다. 사건 기록화는 기록관리의 중립성과 객관성을 확보할 수 있는 방법이며, 그런 의미에서 성숙한 민주주의를 기록학 측면에서 구현하는 것이다.

• Korean Chemical Engineering Research
• /
• 제57권3호
• /
• pp.438-443
• /
• 2019

본 연구에서는 HT-PEMFC 공기극용 Pt계열 연료극 촉매의 인산이온 피독 특성에 대한 새로운 평가 방법을 제시하였다. 이를 위하여, 기존의 전기화학적 인산이온 피독 측정법인 CV와 ORR RDE 측정법이 갖고 있는 문제점을 저감하기 위하여, 과산화수소를 Pt 촉매와의 반응물로 이용하여 고농도 인산 이온 분위기에서의 내피독성 측정값 오차를 감소시켰다. 그 결과 인산이온 농도 0.1 M 이하의 저농도와 0.5 M 이상의 고농도에서 인산농도 대비 전류밀도의 변화가 직선적으로 나타나, 실제 HT-PEMFC의 구동 환경과 유사한 고농도의 인산이온 분위기에서의 Pt계 인산이온 피독 정량화에 대하여 기존의 측정방법에 비해 우수함을 확인하였다.

• 한국인터넷방송통신학회논문지
• /
• 제19권2호
• /
• pp.47-52
• /
• 2019

본 논문에서는 2중 유전체층 사이의 완전도체띠 격자구조에 의한 TE(transverse electric) 산란 문제는 전자파 수치해석 방법으로 알려진 FGMM(Fourier-Galerkin moment method)를 이용하여 해석하였다. 경계조건들은 미지의 계수를 구하기 위하여 이용하였고, 도체띠의 해석을 위해 완전도체 경계조건을 적용하였다. 도체띠의 폭과 주기, 2중 유전층 사이의 비유전율과 두께 및 입사각에 대해 정규화된 반사전력과 투과전력을 계산하였다. 전반적으로 유전율의 값이 증가하면 반사전력은 증가하며, 상대적으로 투과전력은 감소하였다. 유전율이 증가할수록 도체띠에 유도되는 전류밀도는 양쪽 끝으로 진행하면서 증가하였다. 본 논문의 제안된 구조에 대한 수치결과들은 기존 논문의 수치해석 결과들과 비교하여 매우 잘 일치하였다.

• BMB Reports
• /
• 제52권4호
• /
• pp.277-282
• /
• 2019

Currently speaking, it is noted that radiofrequency ablation (RFA) has been the most widely used treatment for hepatocellular carcinoma (HCC) occurring in patients. However, accumulating evidence has demonstrated that the incidence of insufficient RFA (IRFA) may result in the identified rapid progression of residual HCC in the patient, which can greatly hinder the effectiveness and patient reported benefits of utilizing this technique. Although many efforts have been proposed, the underlying mechanisms triggering the rapid progression of residual HCC after IRFA have not yet been fully clarified through current research literature reviews. It was shown in this study that cell proliferation, migration and invasion of residual HepG2 and SMMC7721 cells were significantly increased after the IRFA was simulated in vitro. In other words, it is noted that IRFA could do this by enhancing the image of autophagy of the residual HCC cell via the $HIF-1{\alpha}/BNIP3$ pathway. Consequently, the down-regulation of BNIP3 may result in the inhibition of the residual HCC cell progression and autophagy after IRFA. Our present study results suggest that IRFA could promote residual HCC cell progression in vitro by enhancing autophagy via the $HIF-1{\alpha}/BNIP3$ pathway. For this reason, it is noted that the targeting of the BNIP3 may be useful in preventing the rapid growth and metastasis of residual HCC after IRFA.