• 교육녹색환경연구
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• 제18권3호
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• pp.16-27
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• 2019

본 연구는 장애물 없는 생활환경(BF)인증제도 시행에 따른 학교시설의 BF인증 적용사항에 대한 기본연구로 건축물 BF인증 평가지표를 바탕으로 초등학교 BF 예비인증 자체평가서 분석을 통해 학교시설에 적합한 장애물 없는 생활환경(BF)인증 평가지표의 개선방향을 모색하고자 하였다. 경상권 내 30개교 초등학교를 선정하여 매개시설, 내부시설, 위생시설, 안내시설, 기타시설의 현황과 평가지표를 분석한 결과 학교시설에 반영되는 항목은 배점 기준의 변별력이 다소 미흡하여 배점 기준 등의 개선이 필요한 것을 알 수 있었다. 누구나 이용하기 편리한 학교시설을 위해 중 하위 배점을 획득한 항목에 대해 기준 개선 및 배점 조정으로 질적 향상을 이끌어내야 한다.

• 한국철도학회논문집
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• 제11권5호
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• pp.489-498
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• 2008

일반적으로 허용처짐 기준은 정적 사용성과 구조적안전성에 그 기반을 두고 있으며 진동사용성에 대한 고려는 부족하다. 따라서 진동사용성을 고려할 수 있는 교량의 허용처짐 기준이 필요하다고 판단된다. 본 논문에서는, 한국철도교설계기준의 허용처짐기준을 주파수영역의 진동사용성 기준과 비교하였으며, 프랑스 및 일본의 철도교설계기준의 진동사용성 허용기준 또한 분석하였다. 그 결과, 한국철도교설계기준의 경우 열차의 속도에 따른 기준으로 진동지속시간이 부분적으로 고려되었지만 진동사용성은 만족하지 못하고 있는 것으로 판단되었으며, 국외 철도교설계기준비 분석결과, 진동사용성을 고려한 허용처짐기준을 제시할 수 있을 것으로 판단하였다. 공용중인 철도교량의 진동사용성을 평가하기위하여 다양한 형식의 철도교량의 진동신호를 측정하였다. 그리고, 현장에서 적용하기 편리한 진동사용성 처짐 및 강성한계를 제시하기 위하여 공용중인 교량을 대상으로 차량 교량 상호작용해석을 수행하였다.

• Current Optics and Photonics
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• 제2권2호
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• pp.125-133
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• 2018

We report an in-depth analysis of the design and fabrication of multilayer dielectric (MLD) diffraction gratings for spectral beam combining at a wavelength of 1055 nm. The design involves a near-Littrow grating and a modal analysis for high diffraction efficiency. A range of wavelengths, grating periods, and angles of incidence were examined for the near-Littrow grating, for the $0^{th}$ and $-1^{st}$ diffraction orders only. A modal method was then used to investigate the effect of the duty cycle on the effective indices of the grating modes, and the depth of the grating was determined for only the $-1^{st}$-order diffraction. The design parameters of the grating and the matching layer thickness between grating and MLD reflector were refined for high diffraction efficiency, using the finite-difference time-domain (FDTD) method. A high reflector was deposited by electron-beam evaporation, and a grating structure was fabricated by photolithography and reactive-ion etching. The diffraction efficiency and laser-induced damage threshold of the fabricated MLD diffraction gratings were measured, and the diffraction efficiency was compared with the design's value.

• Journal of Ginseng Research
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• 제45권5호
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• pp.610-616
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• 2021

Background: Thymic stromal lymphopoietin (TSLP) acts as a master switch for inflammatory responses. Ginsenoside Rg3 (Rg3) which is an active ingredient of Panax ginseng Meyer (Araliaceae) is known to possess various therapeutic effects. However, a modulatory effect of Rg3 on TSLP expression in the inflammatory responses remains poorly understood. Methods: We investigated antiinflammatory effects of Rg3 on an in vitro model using HMC-1 cells stimulated by PMA plus calcium ionophore (PMACI), as well as an in vivo model using PMA-induced mouse ear edema. TSLP and vascular endothelial growth factor (VEGF) levels were detected using enzyme-linked immunosorbent assay or real-time PCR analysis. Murine double minute 2 (MDM2) and hypoxia-inducible factor 1α (HIF1α) expression levels were detected using Western blot analysis. Results: Rg3 treatment restrained the production and mRNA expression levels of TSLP and VEGF in activated HMC-1 cells. Rg3 down-regulated the MDM2 expression level increased by PMACI stimulation. The HIF1α expression level was also reduced by Rg3 in activated HMC-1 cells. In addition, Rg3-administered mice showed the decreased redness and ear thickness in PMA-irritated ear edema. Rg3 inhibited the TSLP and VEGF levels in the serum and ear tissue homogenate. Moreover, the MDM2 and HIF1α expression levels in the ear tissue homogenate were suppressed by Rg3. Conclusion: Taken together, the current study identifies new mechanistic evidence about MDM2/HIF1α pathway in the antiinflammatory effect of Rg3, providing a new effective therapeutic strategy for the treatment of skin inflammatory diseases.

• 국제초고층학회논문집
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• 제10권4호
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• pp.323-334
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• 2021

Concrete structures may rarely collapse in fire incidents but fire induced damage to structural members is inevitable as a result of material degradation and thermal expansion. This requires certain repairing measures to be applied to restore the performance of post-fire members. A brief review on investigation of post-fire damage of concrete material and concrete structural members is presented in this paper, followed by a review of post-fire repair research regarding various types of repairing techniques (FRP, steel plate, and concrete section enlargement) and different type of structural members including columns, beams, and slabs. Particularly, the fire scenarios adopted in these studies leading to damage are categorized as three levels according to the duration of gas-phase temperature above 600℃ (t₆₀₀). The repair effectiveness in terms of recovered performance of concrete structural members compared to the initial undamaged performance has been summarized and compared regarding the repairing techniques and fire intensity levels. The complied results have shown that recovering the ultimate strength is achievable but the stiffness recovery is difficult. Moreover, the current fire loading scenarios adopted in the post-fire repair research are mostly idealized as constant heating rates or standard fire curves, which may have produced unrealistic fire damage patterns and the associated repairing techniques may be not practical. For future studies, the realistic fire impact and the system-level structural damage investigation are necessary.

• 천문학회지
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• 제54권4호
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• pp.129-137
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• 2021

It has been established that the acoustic mode parameters of the Sun and Sun-like stars vary over activity cycles. Since the observed variations are not consistent with an activity-related origin, even Sun-like stars showing out-of-phase changes of mode frequencies and amplitudes need to be carefully studied using other observational quantities. In order to test whether the presumed relations between the global seismic parameters are a signature of the stellar activity cycle, we analyze the photometric light curve of HD 49933 for which the first direct detection of an asteroseismic signature for activity-induced variations in a Sun-like star was made, using observations by the CoRoT space telescope. We find that the amplitude of the envelope significantly anti-correlates with both the maximum frequency of the envelope and the width of the envelope unless superflare-like events completely contaminate the light curve. However, even though the photometric proxy for stellar magnetic activity appears to show relations with the global asteroseismic parameters, they are statistically insignificant. Therefore, we conclude that the global asteroseismic parameters can be utilized in cross-checking asteroseismic detections of activity-related variations in Sun-like stars, and that it is probably less secure and effective to construct a photometric magnetic activity proxy to indirectly correlate the global asteroseismic parameters. Finally, we seismically estimate the mass of HD 49933 based on our determination of the large separation of HD 49933 with evolutionary tracks computed by the MESA code and find a value of about 1.2M_☉ and a sub-solar metallicity of Z = 0.008, which agrees with the current consensus and with asteroseismic and non-asteroseismic data.

• 한국항만경제학회지
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• 제37권2호
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• pp.19-31
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• 2021

이 연구는 COVID-19 판데믹 전후 즉, 2019년부터 2021년 현재까지의 해운경기와 동향분석을 통해 이번 컨테이너 해운호황을 면밀히 분석하고 그 원인을 알아보았다. 또한 이 연구는 우리 해운기업이 포스트 코로나 시대에 지속가능한 성장을 위해 정책방향을 제언하였다. 연구 결과, COVID-19 확산이 유발한 수요감소에 대한 대응으로 선사들이 선박가동중단(idle)을 늘렸다는 언론 보도와는 다르게 스크러버 설치를 위해 가동중단선박이 급속히 늘어난 것을 확인하였다. 이 연구에서 제언한 정책방향으로는 선박공급과잉의 원인 분석과 해운산업 증요성에 대한 전국민적 공감대 확보가 필요하다는 것이었다. 구체적으로 첫 번째, 해운정책으로 인해 오히려 선박공급과잉이 심화되었는지 알아볼 필요가 있다는 것, 두 번째, 해운정책의 기조 특히, 호황기 정책 기조를 재검토할 필요가 있다는 것, 세 번째, 불황기 공급확장 정책 이외에 호황기 공급조절 정책과 같은 해운정책의 포트폴리오를 구성해야 한다는 것 등이다. 마지막으로, 정책 당국과 해운 관련 국책연구기관의 해운경기 예측력을 제고시켜야 하며, 지속적으로 선사CEO 대상 선박투자 세미나를 개최하고, S&P 전문가 및 해운시장 분석가를 양성해야 할 것을 주장하였다.

• Journal of Microbiology and Biotechnology
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• 제31권4호
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• pp.501-509
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• 2021

More than half the world's population is thought to be infected with Helicobacter pylori. Although the majority of infected people are asymptomatic, H. pylori infection may cause gastric ulcers and deadly gastric cancer. Owing to the difficulty and invasiveness of current routine culture and diagnostic methods, a highly sensitive and specific noninvasive assay for H. pylori is of interest. This study highlighted the design and performance of a colorimetric magneto loop-mediated isothermal amplification (CM-LAMP) assay to detect H. pylori in spiked saliva samples. LF primers were coated on magnetic nanoparticles by carbodiimide-induced immobilization and functionally used for solid-phase amplification. During the LAMP reaction at 66℃, biotin-tagged FIPs were incorporated into LAMP amplicons. The colorimetric signal developed after the addition of NeutrAvidin horseradish peroxidase conjugate (NA-HRP) and ABTS. None of the tested microorganisms, including closely related bacteria, was shown positive by the CM-LAMP assay except H. pylori isolates. This novel platform was highly specific and 100-fold more sensitive (40 CFU/ml or 0.2 CFU per reaction) than the PCR and conventional LAMP assays for the detection of H. pylori in spiked saliva. Our results demonstrated the feasibility of using this noninvasive molecular diagnostic test to detect H. pylori in saliva samples.

• Journal of Microbiology and Biotechnology
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• 제29권6호
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• pp.923-932
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• 2019

Current strategies of strain improvement processes are mainly focused on enhancing the synthetic pathways of the products. However, excessive metabolic flux often creates metabolic imbalances, which lead to growth retardation and ultimately limit the yield of the product. To solve this problem, we applied a dynamic regulation strategy to produce $\text\tiny{L}$-phenylalanine ($\text\tiny{L}$-Phe) in Escherichia coli. First, we constructed a series of Phe-induced promoters that exhibited different strengths through modification of the promoter region of tyrP. Then, two engineered promoters were separately introduced into a Phe-producing strain xllp1 to dynamically control the expression level of one pathway enzyme AroK. Batch fermentation results of the strain xllp3 showed that the titer of Phe reached 61.3 g/l at 48 h, representing a titer of 1.36-fold of the strain xllp1 (45.0 g/l). Moreover, the $\text\tiny{L}$-Phe yields on glucose of xllp3 (0.22 g/g) were also greatly improved, with an increase of 1.22-fold in comparison with the xllp1 (0.18 g/g). In summary, we successfully improved the titer of Phe by using dynamic regulation of one key enzyme and this strategy can be applied for improving the performance of strains producing other aromatic amino acids and derived compounds.

• 한국수자원학회논문집
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• 제51권spc1호
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• pp.1057-1066
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• 2018

기후변화는 홍수의 가장 큰 원인이 되는 극치강우의 빈도와 크기에 매우 큰 영향을 미치고 있다. 특히, 우리나라에서 발생하는 대규모 재해는 강우에 의한 홍수피해가 대부분을 차지하고 있다. 이러한 홍수피해는 기후변화에 의한 극한강우의 발생 빈도가 높아짐에 따라 새로운 재해양상으로 전개되고 있다. 하지만, 미래 기후변화 시나리오 자료는 해상도의 한계로 인하여 중소규모 하천 및 도시유역에 요구되는 수준의 자료 수집이 불가능한 상태이다. 이러한 문제점을 개선하기 위하여 본 연구에서는 전지구모형에서 생산된 기후변화 시나리오에 대해서 여러 단계의 통계적 상세화 기법을 통하여 우리나라 전역에 대하여 미래 시나리오에 대한 빈도해석이 가능하도록 각 지점의 특성에 따라 시간적으로 상세화하기 위해 개발된 방법 및 과정을 소개하였다. 이를 통해, 시간상세화 자료를 토대로 미래 강우에 대한 빈도해석과 기후변화에 따른 방재성능 목표강우량을 산정하는데 활용할 수 있도록 하였다.