• 한국해양공학회지
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• 제27권4호
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• pp.83-89
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• 2013

A numerical scheme based on a mode superposition method is presented for the dynamic response analysis of a top-tensioned riser (TTR) under sheared current loads. The natural frequencies and mode shapes of the TTR have been calculated analytically for a beam with a slowly varying tension and pinned-pinned boundary conditions at the top and bottom ends. The lift coefficients and corresponding amplitudes used to estimate the vortex-induced modal force and damping for each mode were predicted via iterative calculations based on the input and output power balancing concept. Here, the power-in regions were controlled by the normal distribution function, for which the center was coincident with the lock -in location by local vortex-shedding, and the range was defined by the constant standard deviation for the reduced velocity by the local current speed. Finally, dynamic responses such as root-mean-squared displacement and stress were calculated using the mode superposition technique. In order to verify the presented scheme, a numerical calculation was performed for a TTR under an arbitrary linearly sheared current and linearly varying tension. A comparison with the results of the existing software showed that the presented scheme could give reliable and feasible solutions. Case studies were performed to investigate the effects of various current loads and tensions.

• Current Optics and Photonics
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• 제4권4호
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• pp.273-276
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• 2020

We report on the relationship between output current for quadrant photodetector (QPD) and bias voltage in silicon-based p-i-n (positive-intrinsic-negative) QPD examined using millisecond pulse laser (ms pulse laser) irradiation. The mechanism governing the relationship was further studied experimentally. The output current curves were obtained by carrying out QPD under different bias voltages (0-40 V) irradiated by ms pulse laser. Compared to other photodetectors, the relaxation was created in the output current for QPD which is never present in other photodetectors, such as PIN and avalanche photodetector (APD), and the maximum value of relaxation was from 6.8 to 38.0 ㎂, the amplitude of relaxation increases with bias value. The mechanism behind this relaxation phenomenon can be ascribed to the bias voltage induced Joule heating effect. With bias voltage increasing, the temperature in a QPD device will increase accordingly, which makes carriers in a QPD move more dramatically, and thus leads to the formation of such relaxation.

• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.241-249
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• 2017

Plasma membrane hyperpolarization associated with activation of $Ca^{2+}$-activated $K^+$ channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary ${\gamma}^2$-subunit, LRRC52 (leucine-rich-repeat-containing 52), is known to mediate the pH-sensitive, sperm-specific $K^+$ current KSper in mice, the molecular identity of this channel in human sperm remains controversial. In this study, we tested the classical $BK_{Ca}$ activators, NS1619 and LDD175, on human Slo3, heterologously expressed in HEK293 cells together with its functional interacting ${\gamma}^2$ subunit, hLRRC52. As previously reported, Slo3 $K^+$ current was unaffected by iberiotoxin or 4-aminopyridine, but was inhibited by ~50% by 20 mM TEA. Extracellular alkalinization potentiated hSlo3 $K^+$ current, and internal alkalinization and $Ca^{2+}$ elevation induced a leftward shift its activation voltage. NS1619, which acts intracellularly to modulate hSlo1 gating, attenuated hSlo3 $K^+$ currents, whereas LDD175 increased this current and induced membrane potential hyperpolarization. LDD175-induced potentiation was not associated with a change in the half-activation voltage at different intracellular pHs (pH 7.3 and pH 8.0) in the absence of intracellular $Ca^{2+}$. In contrast, elevation of intracellular $Ca^{2+}$ dramatically enhanced the LDD175-induced leftward shift in the half-activation potential of hSlo3. Therefore, the mechanism of action does not involve pH-dependent modulation of hSlo3 gating; instead, LDD175 may modulate $Ca^{2+}$-dependent activation of hSlo3. Thus, LDD175 potentially activates native KSper and may induce membrane hyperpolarization-associated hyperactivation in human sperm.

• The Korean Journal of Physiology and Pharmacology
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• 제8권2호
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• pp.101-110
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• 2004

Voltage-sensitive release mechanism was pharmacologically dissected from the $Ca^{2+}-induced\;Ca^{2+}\;release$ in the SR $Ca^{2+}$ release in the rat ventricular myocytes patch-clamped in a whole-cell mode. SR $Ca^{2+}$ release process was monitored by using forward-mode $Na^+-Ca^{2+}$ exchange after restriction of the interactions between $Ca^{2+}$ from SR and $Na^+-Ca^{2+}$ exchange within micro-domains with heavy cytosolic $Ca^{2+}$ buffering with 10 mM BAPTA. During stimulation every 10 s with a pulse roughly mimicking action potential, the initial outward current gradually turned into a huge inward current of $-12.9{\pm}0.5\;pA/pF$. From the inward current, two different inward $I_{NCX}s$ were identified. One was $10\;{\mu}M$ ryanodine-sensitive, constituting $14.2{\pm}2.3%$. It was completely blocked by $CdCl_2$ (0.1 mM and 0.5 mM) and by $Na^+-depletion$. The other was identified by 5 mM $NiCl_2$ after suppression of $I_{CaL}$ and ryanodine receptor, constituting $14.8{\pm}1.6%$. This latter was blocked by either 10 mM caffeine-induced SR $Ca^{2+}-depletion$ or 1 mM tetracaine. IV-relationships illustrated that the latter was activated until the peak in $30{\sim}35\;mV$ lower voltages than the former. Overall, it was concluded that the SR $Ca^{2+}$ release process in the rat ventricular myocytes is mediated by the voltage-sensitive release mechanism in addition to the $Ca^{2+}-induced-Ca^{2+}\;release$.

• 한국해안·해양공학회논문집
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• 제27권6호
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• pp.406-418
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• 2015

기존 FUNWAVE-TVD 버전 2.1 모형을 수정한 본 모형의 검증을 위해 고립파 실험, Vincent and Briggs(1989)의 비쇄파 및 쇄파 실험, Luth et al. (1994)의 수리실험을 수행하였다. 쇄파 실험의 경우 기존 결과와 비교하기 위하여 eddy viscosity를 이용한 쇄파 방법도 포함하였다. Eddy viscosity 쇄파 방법을 이용하여 Vincent and Briggs(1989)의 쇄파 실험에 적용한 결과 수정된 모형에서는 수중천퇴 중심의 y축을 기준으로 파랑류(wave-induced current)의 대칭성이 유지되었으나 FUNWAVE-TVD 버전 2.1 모형에서는 대칭성이 유지되지 않았다. 또한 eddy viscosity 쇄파 방법을 이용한 경우가 천수방정식으로 전환하여 쇄파를 모의하는 방법보다 관측치에 더 가깝다. 그리고 FUNWAVE-TVD 버전 2.1 모형에 사용한 기법들과 비교하기 위하여 Erduran et al.(2005)이 제시한 4차 정확도의 MUSCL-TVD 기법과 minmod limiter를 이용한 3차 정확도의 기법을 적용하여 고립파의 전파 양상을 비교 검토하였다.

• 한국해안해양공학회지
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• 제19권6호
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• pp.557-564
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• 2007

타원형 수중천퇴가 있는 지형을 통과하며 변형하는 파랑을 실험한 Vincent and Briggs(1989)의 실험조건을 수치모의하여 규칙파 변형에 대한 파랑과 흐름의 상호작용 효과를 연구하였다. 수치모의를 위해 흐름모형 SHORECIRC와 파랑모형 REF/DIF 1 그리고 SHORECIRC와 파랑모형 SWAN을 결합한 모형과 파랑과 흐름을 동시에 계산하는 FUNWAVE를 이용하였다. 이 수치모의로 부터 수중천퇴상에서 발생된 쇄파류는 수중천퇴후면의 파집중현상을 방해하고, 파랑을 천퇴중심축의 바깥쪽으로 굴절시켜, 파고를 상대적으로 감소시키는 역할을 하는 것을 확인할 수 있었다. 두 결합모형의 수치모의 결과는 쇄파류의 영향을 고려하지 않는 파랑모형만의 결과보다 실험치와 일치하였으나, 중복파가 발생되는 경우 SWAN모형과 REF/DIF모형으로부터 계산되어지는 잉여응력(radiation stress)에 문제가 있다는 것을 알 수 있었다. 또한, FUNWAVE를 이용한 수치모의는 실험결과와 완벽히 일치하였다. 이는 파랑쇄파류의 파랑변형에 미치는 역할의 중요성을 확인시켜주는 것이다.

• 한국초전도ㆍ저온공학회논문지
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• 제15권3호
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• pp.24-28
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• 2013

Fault current limiting (FCL) cable is a kind of superconducting cable which has a function of limiting the fault current at the fault of power grid. The superconducting cable detours the fault current through its stabilizer to keep the temperature as low as possible. On the other hands, the FCL cable permits the temperature rise within some acceptable limit and the fault current is limited by the consequent increase of the resistance of superconducting cable. This kind of FCL cable is called 'resistive FCL cable' because it uses resistive impedance to limit the fault current. In this paper, we suggest a novel concept of FCL cable, which is named as 'inductive FCL cable'. The inductive FCL cable is similar as the magnetic shielding fault current limiter in its operating mechanism. The magnetic field of superconducting cable is almost perfectly shielded by the induced current at the shielding layer during its normal operation. However, at the fault condition, quench occurs at the shielding layer by the induced current higher than its critical current and the magnetic field is spread out of the shielding layer. It will induce additional inductive impedance to the superconducting cable and the inductive impedance can be increased more by installing some material with high magnetic susceptibility around the superconducting cable. We examined the feasibility of inductive FCL cable with simple elemental experiments. The current limiting performance of inductive FCL cable was estimated considering an arbitrary power grid and its fault condition.

• Journal of Ginseng Research
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• 제39권3호
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• pp.257-264
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• 2015

Background: Korean Red Ginseng-a steamed root of Panax ginseng Meyer-has long been used as a traditional medicine in Asian countries. Its antipruritic effect was recently found, but no molecular mechanisms were revealed. Thus, the current study focused on determining the underlying molecular mechanism of Korean Red Ginseng extract (RGE) against histamine-induced itch at the peripheral sensory neuronal level. Methods: To examine the antipruritic effect of RGE, we performed in vivo scratching behavior test in mice, as well as in vitro calcium imaging and whole-cell patch clamp experiments to elucidate underlying molecular mechanisms. Results: The results of our in vivo study confirmed that RGE indeed has an antipruritic effect on histamine-induced scratching in mice. In addition, RGE showed a significant inhibitory effect on histamine-induced responses in primary cultures of mouse dorsal root ganglia, suggesting that RGE has a direct inhibitory effect on sensory neuronal level. Results of further experiments showed that RGE inhibits histamine-induced responses on cells expressing both histamine receptor subtype 1 and TRPV1 ion channel, indicating that RGE blocks the histamine receptor type 1/TRPV1 pathway in sensory neurons, which is responsible for histamine-dependent itch sensation. Conclusion: The current study found for the first time that RGE effectively blocks histamine-induced itch in peripheral sensory neurons. We believe that the current results will provide an insight on itch transmission and will be helpful in understanding how RGE exerts its antipruritic effects.

• 수산해양기술연구
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• 제56권2호
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• pp.114-125
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• 2020

In order to understand the currents around Hampyung Bay and Haeje Peninsula, 2D numerical simulations for tidal currents and tide-induced residual currents were carried out. Dominant semidiurnal tidal currents have reversing form and flow NNE-SSW from northern Haeje Peninsula to Songi Island, E-S at northern Haeje Peninsula and NNW-SSE in Hampyung Bay. In flood, a part of currents from Imja Island~Nakwhol Island flow along the main stream flowing northeast at offshore region and the rest flow into Hampyung Bay flowing east along the northern coast of Haeje Peninsula. In ebb, currents from Hampyung Bay flow west along the northern coast of Haeje Peninsula and run together with the main stream flowing southeast at offshore region. The currents create an anticyclonic circulation in flood and a cyclonic circulation in ebb around Haeje Peninsula including Hampyung Bay. Tidal currents are accumulated on Doripo which located at the entrance of Hampyung Bay and show high current velocities. Tidal currents and tide induced residual currents are weak at the inside of Hampyung Bay which has narrow entrance, shallow water depth and wide intertidal zone. An anticyclonic eddy is formed around Gaksi Island as a result of tide induced residual currents. In northern coast of Haeje Peninsula, slow constant currents flow east. It is expected that a gradual change of sediment and an increase of flushing time for suspended materials are carried by tidal currents occurring in Hampyung Bay.

• 대한전자공학회논문지SD
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• 제38권6호
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• pp.390-397
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• 2001

GIDL(Gate-Induced Drain-Leakage)을 줄일 수 있는 새로운 구조의 ESD(Elevated Source Drain) MOSFET을 제안하고 분석하였다. 제안된 구조는 SDE(Source Drain Extension) 영역이 들려진 형태를 갖고 있어서 SDE 임플란트시 매우 낮은 에너지 이온주입으로 인한 저활성화(low-activation) 효과를 방지 할 수 있다. 제안된 구조는 건식 식각 및 LAT(Large-Angle-Tilted) 이온주입 방법을 사용하여 소오스/드레인 구조를 결정한다. 기존의 LDD MOSFET과의 비교 시뮬레이션 결과, 제안된 ESD MOSFET은 전류 구동능력은 가장 크면서 GIDL 및 DIBL(Drain Induced Barrier Lowering) 값은 효과적으로 감소시킬 수 있음을 확인하였다. GIDL 전류가 감소되는 원인으로는 최대 전계의 위치가 드레인 쪽으로 이동함에 따라 최대 밴드간 터널링이 일어나는 곳에서의 최대 전계값이 감소되기 때문이다.