• Biomedical Science Letters
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• v.12 no.1
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• pp.53-56
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• 2006

The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the circadian pacemaker entrained to the 24-hr day by environmental time cues. Major circadian genes such as mPeriod ($mPer1{\sim}3$) and mCryptochrome ($mCry1{\sim}2$) are actively transcribed by the action of CLOCK/BMAL heterodimers, and in turn, these are being suppressed by the mPER/mCRY complex. In the study, the locomotor activity rhythms of mPer1 Knockout (KO) mice are measured, and the expression profiles of Heat Shock Protein 105kDa (HSP 105) genes in the SCN were measured by in situ hybridization. In agreement with previous reports, the locomotor activity rhythm of mPer1 KO mice was much shorter than that of wildtype. In addition, the total bout of activity of mPer1 KO was less in comparison to control mice. The expression of HSP 105 in the SCN of mPer1 KO mice was ranged from CT6 to CT22, with a peak level at CT14, implying that the gene are under the control of circadian clock. However, the expression of HSP 105 in the SCN of wildtype could not be detected in our study. Further analysis will reveal the direct or indirect regulation by mPer1 on the expression in the SCN and the role of the gene in the circadian clock.

• Research in Community and Public Health Nursing
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• v.9 no.1
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• pp.117-127
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• 1998

The Theory of Planned Behavior has been shown to yield great explanatory power in health behavior as well as social behavior. This study was conducted to test the Theory of Planned Behavior in the prediction and intention of smoking cessation behavior in university student smokers. We conveniently sampled 204 university student smokers and investigated using questionaries, analyzing the data with the Pearson product-moment correlation, and multiple regression. The results are as follows : 1. There are significant correlations in direct and indirect measures of attitude toward smoking cessation behavior, subjective norm, and perceived behavioral control. 2. Behavior belief is significant in predicting attitudes toward smoking cessation behavior. Normative belief is significant in predicting the subjective norm. Control belief is significant in predicting perceived behavioral control. 3. Attitude toward smoking cessation behavior, subjective norm are significant in predicting intention of smoking cessation behavior. In conclusion, this study demonstrated strong support for the Theory of the Planned Behavior and its use to predict smoking cessation behavior in university students smokers. But, as perceived behavioral control is not significant in predicting smoking cessation behavior, indepth research is needed to evaluate the usefullness of the Theory of Planned Behavior and Reasoned Action Theory.

• Biomolecules & Therapeutics
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• v.8 no.1
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• pp.93-98
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• 2000

This study has been carried out to investigate general pharmacological action of bamboo salt (jukyom) in terms of effects on central nervous system and cardiovascular system in experimental animals. After bamboo salt, crude salt or reagent-grade NaCl were orally administered into male ICR mice with dose of 2.0 g/kg, general behavioural syndromes such as body weight and locomotor activity, spontaneous motor activity, pento-barbital-induced sleeping time, muscle incoordination, electroshock-induced convulsion, body temperature and writhing response caused by 0.6% acetic acid solution were observed. Bamboo salt had no influences in these indices for examinition of effect on central nervous system. Additionally, conscious male Sprague Dawley rats fastened overnight won ere treated with bamboo salt, crude salt or reagent-grade NaCl (2.0 g/kg, p.o.) to examine the effect of these salts cardiovascular system. Systolic, median and diastolic food pressure and heart rate were dertemined using tail cuff indirect method. Treatment with Hydralazine (50 mg/kg, p.o) as a positive control produced the decreases in systolic, median and diastolic blood treasure and an increase in heart rate. whereas no changes were observed in bamboo salt, crude salt and reagent-grade NaCl treated groups. These results strongly suggest that bamboo salt may have no effects on general pharmacology of central nervous systems and cardio-vascular systems.

• Journal of the Korean Chemical Society
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• v.15 no.5
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• pp.256-265
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• 1971

An ESR study has been made on free radicals produced in frozen aqueous solutions (ices) of glycine, DL-${\alpha}$-alanine, DL-serine, L-cysteine, DL-leucine and DL-isoleucine by gamma-irradiation at dry ice temperature. All free radicals induced were decayed concomitant to the successive annealing but the radical species which is believed to be dominant seems to be stable even near the melting point of the ice. These dominant species were found to be identical to those resulted from direct action of radiation in the solid at room temperature. Small but significant changes in the spectra of glycine and DL-${\alpha}$-alanine were observed by varying the microwave power. These results seem to support the view that the spectra obtained were composite consisting of more than two different resonances having different power saturation characteristics. The relative contribution of unidentified resonances to the composite spectra was greater for solutions of low concentration. These resonances are assumed to be induced by indirect effects, mainly hydrogen abstraction by radiation produced hydroxyl radicals and also C-N bond cleavage by hydrated electrons.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.2
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• pp.249-260
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• 2020

This study aims to explore the role of Khan's engagement dimension previous study in mediating the relationship between work-life balance and in-role and extra-role performance of salesforce. To measure the data, a quantitative approach conducted through a survey of the sales force in the financial services industry sector in Makassar City, Indonesia. We determine the sample by using purposive sampling technique, and a total of 188 salesforce respondents. SEM-PLS with the second-order model was applied to test the measurement model and the mediator role of the engagement. The results show that the engagement dimension fully mediates the effect of work-life balance on both in-role and extra-role performance direct or indirect effect. the findings in this study also address the great concern of both individuals and organizations that the antecedents of the work-life balance variable are fundamental reasons for improving performance. The results of this study indicate that the work-life balance program positively influences engagement. Overall, we can conclude that commitment not only serves as a means for employees to fulfill formal job requirements. This can also encourage them to take action that goes beyond the precise requirements of their work by presenting them physically, emotionally, and cognitively in the work environment.

• Journal of Distribution Science
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• v.18 no.8
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• pp.65-74
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• 2020

Purpose: The purpose of study is to examine the effects of design thinking-based programs on creative potential, creativity and innovation behavior, as well as the mediating effect of creative potential and creativity. Research design, data and methodology: The study was conducted through a four-step process. First, the previous studies were investigated. Second, a total of three experts were reviewed to improve and supplement the program. Third, a workshop-based design thinking program was conducted four times. Fourth, the effectiveness of the program was reviewed through data analysis. Results: The design thinking-based program was found to have a statistically positive effect on creative potential, creativity, and innovation behavior. As another hypothesis of this study, by applying the design thinking-based program, it was statistically confirmed that creative potential has a direct, indirect effect, and a mediating effect on innovation behavior. Conclusions: These results provide usability for design thinking in terms of direction for creativity-based creative problem solving and innovation. Finally, design thinking can be used to develop and utilize new services and discover new ideas, especially improve the competitiveness of the company. In addition, it means that the level of innovation action can vary depending on the level of the individual's creative potential.

• Journal of Korean Academy of Nursing
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• v.28 no.1
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• pp.210-220
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• 1998

The various and serious types of disaster occur everyday and everywhere on the earth. There is no doubt that it is very timely to discuss about the effectiveness and preparedness of disaster. The purpose of this study is to develop a curriculum on the disaster management through reviewing disaster concepts and the disaster management system. For the empirical relevance of the study, researchers participated in a couple or more disaster training program, reviewed references, and consulted to the experts working on action parts in the area. As a result, the 'Integrated Disaster Management System Model (IDMSM)' was designed, in which four dimensions were explained. Then the 'Disaster Curriculum Model (DCM)' was explored with its theoretical framework based on the system model. The developed curriculum is composed of four levels ; the introductory course, the fundamental course, the advanced course, and the expert course. From this DCM, basically the course-outlines of two subjects in the introductory course, 18 subjects in the fundamental course (5 of direct services. 13 of indirect services) were developed. Also each course-outline was explored by its course objective, learning objectives, contents, and its length. Finally to make the most of the results, suggestions are proposed. The governmental considerations on the policy should support the systematic and integrated educational program to practice, appointing 「Disaster School」 or 「Disaster Training Center」 of relevance and accountabilities. The further study should explore the higher levels of the DCM through interdisciplinary efforts, and develop the text aterials. ilities. The further study should explore the higher levels of the DCM through interdisciplinary efforts, and develop the text materials.

• Proceedings of the KIEE Conference
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• 1999.07g
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• pp.2849-2852
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• 1999

This paper describes the fuzzy PD controller using simplified indirect inference method. First, the fuzzy PD controller is derived from the conventional continuous time linear PD controller. Then the fuzzification, control-rule base, and defuzzification using SIIM in the design of the fuzzy controller are discussed in detail. The resulting controller is a discrete time fuzzy version of the conventional PD controller. which has the same linear structure. but are nonlinear functions of the input signals. The proposed controller enhances the self-tuning control capability. particularly when the process to be controlled is nonlinear. As the SIIM is applied, the fuzzy Inference results can be calculated with splitting fuzzy variables into each action component and are determined as the functional form of corresponding variables. So the Proposed method has the capability of the high speed inference and extending the fuzzy input variables easily. Computer simulation results have demonstrated the superior to the control Performance of the one Proposed by D. Misir et at. Final)y. we simulated the contour control of the X-Y tables with direct control strategies using the proposed fuzzy PD controller.

• Nuclear Engineering and Technology
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• v.53 no.9
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• pp.2866-2877
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• 2021

The complex coupling relationship between liquid sodium and concrete materials affects both the sodium fire characteristics and concrete properties through heat and chemical erosion. In this study, experiments on direct and indirect (separated by a steel plate) contact of the columnar sodium fire with the concrete surface were performed. It was found that the combustion efficiency of liquid sodium in direct contact with concrete was significantly enhanced and accompanied by intermittent explosions and splashing of small concrete fragments. The sodium fire on the surface of the concrete considerably increased the internal temperature, pore size, and distribution density of the concrete. In addition, the depth of influence on the loosening of the concrete structure was also greatly extended. The contact of liquid sodium with the concrete substantially affected its permeability resistance. The water absorption of the concrete surface was increased by more than 70% when liquid sodium directly impacted the bare concrete surface. However, the change in water absorption in the centre of the concrete was primarily affected by the duration of the external heat.

• Journal of Distribution Science
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• v.18 no.12
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• pp.31-43
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• 2020

Purpose: This study examined how many determinant factors (service dimensions, food quality, and price perception) affect revisit intention. This practical concept is service quality (SERVQUAL), customer satisfaction, and repeated/revisit behavioral intention based on the theory of reasoned action (TRA). Research design, data and methodology: This research applied a hybrid mixed-method comprising exploratory and explanatory sequential design by Creswell (2014). The 400 responses were collected in four townships in Myanmar. This study drilled down to exploratory factor analysis (EFA) followed by confirmatory factor analysis (CFA) prior to test the hypothesized factor structure of all the variables resulted in the form of the goodness of fit. For further data analysis, structural equation modeling (SEM) was applied to test the relationships among the variables of the proposed model. Results: The results showed that perceived service quality, food quality, and price perception have direct effects on customer satisfaction and indirect effect on revisit intention. The perceived service quality has the most significant influence while the food quality has the least influence on customer satisfaction. Conclusions: The results are useful for the restaurant managers to better understand the significant strategic choice factors to improve higher quality service amongst restaurants both domestic and international under the stiff competition.