• Title/Summary/Keyword: Indirect Evaluation

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Evaluation of Rhophilin Associated Tail Protein (ROPN1L) in the Human Liver Fluke Opisthorchis viverrini for Diagnostic Approach

  • Geadkaew-Krenc, Amornrat;Grams, Rudi;Phadungsil, Wansika;Chaibangyang, Wanlapa;Kosa, Nanthawat;Adisakwattana, Poom;Dekumyoy, Paron
    • Parasites, Hosts and Diseases
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    • v.58 no.4
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    • pp.475-479
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    • 2020
  • Tegumental and excretory-secretory proteins are reported as diagnostic antigens for human opisthorchiasis. Rhophilin associated tail protein1-like (OvROPN1L) protein of Opisthorchis viverrini sperm tail showed potential as a diagnostic antigen. The OvROPN1L recombinant fragments were assayed for diagnostic antigenicity for human opisthorchiasis using indirect ELISA. The strongest antigenic region was a N-terminus peptide of M1 - P56. One synthetic peptide (P1, L3-Q13) of this region showed the highest antigenicity to opisthorchiasis. Sera from other parasitic infections including Strongyloides stercoralis, hookworm, Taenia spp, minute intestinal flukes, Paragonimus spp showed lower reactivity to P1. Peptide P1 is located in the disordered N-terminus of ROPN1L supporting its suitability as linear epitope. In the Platyhelminthes the N-terminal sequence of ROPN1L is diverging with taxonomic distance further suggesting that peptide P1 has potential as diagnostic tool in the genus Opisthorchis/Clonorchis. It should be further evaluated in combination with peptides derived from other O. viverrini antigens to increase its diagnostic power.

CYTOTOXICITY OF RESIN-BASED ROOT CANAL SEALER, ADSEAL (레진 계열 근관봉함재 Adseal의 세포독성에 관한 연구)

  • Kim, Hee-Jung;Baek, Seung-Ho;Lee, Woo-Cheol;Park, Han-Soo;Bae, Kwang-Shik
    • Restorative Dentistry and Endodontics
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    • v.29 no.6
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    • pp.498-503
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    • 2004
  • The properties of ideal root canal sealers include the ability of sealing the total root canal system and no toxic effects to periradicular tissues. Cytotoxicity test using cell culture is a common screening method for evaluation of the biocompatibility of root canal sealers. The purpose of this study was to investigate the cytotoxic effect of newly developed resin-based sealer (Adseal 1, 2, and 3) comparing with those commercial resin-based sealers (AH26 and AH Plus), ZOE-based sealers (Tubliseal EWT, Pulp Canal Sealer EWT) and calcium hydroxide based sealer (Sealapex), An indirect contact test of cytotoxicity by agar diffusion was performed according to the international standard ISO 10993-5. L929 fibroblast cells were incubated at $37^{\circ}C$ in humidified 5% $CO_2-containing$ air atmosphere. The freshly mixed test materials were inserted into glass rings of internal diameter 5 mm and height 5 mm placed on the agar. After the 24 hrs incubation period, the decolorization zones around the test materials were assessed using an inverted microscope with a calibrated screen. A Decolorization Index was determined for each specimen. Adseal 1. 2, and 3 did not exert any cytotoxic effects, whereas AH26, AH Plus, Tubliseal EWT, Pulp Canal Sealer EWT, and Sealapex produced mild cytotoxicity.

A Sustainable BSC-IT based Framework for Assessing the Strategic Impacts of Green IT Initiatives (그린IT 이니셔티브들 전략적 영향들을 평가하기위한 지속가능한 BSC-IT 기반 프레임워크)

  • Ruiz, Luis;Park, Jeong-Sun
    • Journal of the Korea Safety Management & Science
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    • v.14 no.4
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    • pp.205-210
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    • 2012
  • We don't have time to waste, time is running, and the global warming is an issue that concerns to all of us. Information technology, which on a global level is responsible for 2% of emission of greenhouse gases. However, the remaining 98% is seen as an opportunity for IT to help our planet, our companies and our society. The purpose of this paper is to analyze green information technology (IT) initiatives and their strategic impact. And to have done this, we develope and create a very useful balanced-scorecard framework to explain, understand, and identify the direct and indirect contribution of green IT initiatives. The green IT evaluation framework, called here a sustainable green IT balanced scorecard, integrates the four BSC-IT perspectives with the Zuboff's automate/informate goals of information systems and the contribution of the sustainability (economic, social and environment). This study also seeks to answer the following questions: 1) what are the driving forces for implementing green IT initiatives? 2) How can an analytical framework be built to systematically analyze the benefits and strategic contribution of green IT initiatives? And 3) how green IT initiatives impact the strategic goals of a firm and how they can contribute to the triple bottom line? The framework demonstrates to be useful as a management tool to hopefully integrate environmental and social management with the general management of a company. Besides, the strategy map and measures for each cell of the framework are provided.

The Association between Social Support and Health Behaviors for Metabolic Syndrome Prevention among University Students: The Mediating Effect of Perceived Stress (대학생 집단에서 사회적 지지와 대사증후군 예방 건강 행동 간의 상관관계: 지각된 스트레스의 매개효과)

  • Park, Sooyeon;Cho, Suah;Lee, Eugene;Choi, Sungchul;Choo, Jina
    • Research in Community and Public Health Nursing
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    • v.32 no.3
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    • pp.404-414
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    • 2021
  • Purpose: Health behaviors for metabolic syndrome (MetS) prevention should be emphasized from early adulthood. There is little information on psychosocial factors associated with health behaviors for MetS prevention. The aim of this study was to determine whether there would be a mediating effect of perceived stress on the association between social support and health behaviors for MetS prevention among university students. Methods: This cross-sectional and correlation study was conducted with 502 university students in South Korea. Social support, perceived stress, and lifestyle evaluation for metabolic syndrome scales were used. Online questionnaire survey was conducted between November and December 2019. The mediating effect of social support on health behaviors for MetS prevention was analyzed using PROCESS macro program with bootstrapping method to test our hypotheses. Results: Social support directly influenced perceived stress (β=-.35, p<.001) and health behaviors for MetS prevention (β=.14, p=.002). Health behaviors for MetS prevention was indirectly influenced by perceived stress (β=-.25, p<.001). The size of indirect effect of social support on health behaviors for MetS prevention was 0.06. Conclusions: The association of social support and health behaviors for MetS prevention was partially mediated by perceived stress among university students. Therefore, a university-based nursing intervention should comprise social support strategies with stress management to promote health behaviors for MetS prevention.

Relationship between Crack Width and Gas Diffusion Coefficient of Cracked Acrylic Specimens (균열 아크릴 시편의 기체 확산계수와 균열폭의 관계)

  • Lee, Do-Keun;Lim, Min-Hyuk;Shin, Kyung-Jun
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.6 no.4
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    • pp.245-251
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    • 2018
  • Recently, as the importance of structural maintenance has been increased, studies on self - healing concrete technology are being actively carried out. On the other hand, test for evaluating the self-healing performance is not standardized yet. Although visual test is used as a basic method for measuring crack widths, it is difficult to observe the crack width inside the specimen, and there is a disadvantage that only the local measurement of the surface can be measured due to the inhomogeneous cracking characteristics. Although permeability test has been widely used as an indirect method for measuring crack width, there is a problem due to the viscosity of water, and also a possibility that the internal material of the specimen may be eluted during the test. In this study, we propose a crack width evaluation method using gas diffusion characteristics. Idealized straight cracks were fabricated by acrylic and the diffusion coefficients of specimens were analyzed with respect to crack width and thickness. The experimental results show that the crack width and the diffusion coefficient are in a linear relationship and that the thickness and diffusion coefficient are inversely related.

Evaluation of Impact Energy Absorption Characteristics of Flexible Sand Asphalt Pavement for Pedestrian Way (보도용 연성 샌드 아스팔트 포장의 충격흡수 특성 평가)

  • Choi, Chang-jeong;Dong, Baesun;Kim, Kwang W.;Kim, Sungun
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.3
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    • pp.31-41
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    • 2019
  • More than 90% of roadway in the world are paved as asphalt concrete pavement due to its excellent properties compared with other paving materials; excellent riding quality, flexibility, anti-icing property and easy maintenance-ability. In this study, to make best use of the softer property of the asphalt mixture, the flexible sand asphalt mixture (FSAM) was developed for pedestrian ways. The mix design was conducted to prepare FSAM using PG64-22 asphalt, screenings (sand) less than 5mm, crumb rubber, hydrated lime and limestone powder without coarse aggregate. The deformation strength ($S_D$), indirect tensile strength (ITS) and tensile strength ratio (TSR) tests were conducted to make sure durability of FSAM performance. The impact energy absorption and flexibility were measured by drop-boll test and the resilient modulus ($M_R$) test. The impact energy absorption of FSAM was compared with normal asphalt pavement, concrete pavement, stone and concrete block for pedestrian way. As a result of drop-boll test, FSAM showed higher impact energy absorption compared with other paving materials with the range of 18% to 43%. Impact energy absorption of FSAM increased with increasing test temperature from 5 to $40^{\circ}C$. The results of $M_R$ test at $5^{\circ}C$ showed that the flexibility of FSPA was increased further, because the $M_R$ value of the sand asphalt was measured to be 38% lower than normal dense-graded asphalt mixture (WC-1). Therefore, it was concluded that the FSAM could provide a high impact absorbing characteristics, which would improve walking quality of the pedestrian ways.

Bone Microarchitecture at the Femoral Attachment of the Posterior Cruciate Ligament (PCL) by Texture Analysis of Magnetic Resonance Imaging (MRI) in Patients with PCL Injury: an Indirect Reflection of Ligament Integrity

  • Kim, Hwan;Shin, YiRang;Kim, Sung-Hwan;Lee, Young Han
    • Investigative Magnetic Resonance Imaging
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    • v.25 no.2
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    • pp.93-100
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    • 2021
  • Purpose: (1) To evaluate the trabecular pattern at the femoral attachment of the posterior cruciate ligament (PCL) in patients with a PCL injury; (2) to analyze bone microarchitecture by applying gray level co-occurrence matrix (GLCM)-based texture analysis; and (3) to determine if there is a significant relationship between bone microarchitecture and posterior instability. Materials and Methods: The study included 96 patients with PCL tears. Trabecular patterns were evaluated on T2-weighted MRI qualitatively, and were evaluated by GLCM texture analysis quantitatively. The grades of posterior drawer test (PDT) and the degrees of posterior displacement on stress radiographs were recorded. The 96 patients were classified into two groups: acute and chronic injury. And 27 patients with no PCL injury were enrolled for control. Pearson's correlation coefficient and one-way ANOVA with Bonferroni test were conducted for statistical analyses. This protocol was approved by the Institutional Review Board. Results: A thick and anisotropic trabecular bone pattern was apparent in normal or acute injury (n = 57/61;93.4%), but was not prominent in chronic injury and posterior instability (n = 31/35;88.6%). Grades of PDT and degrees of posterior displacement on stress radiograph were not correlated with texture parameters. However, the texture analysis parameters of chronic injury were significantly different from those of acute injury and control groups (P < 0.05). Conclusion: The trabecular pattern and texture analysis parameters are useful in predicting posterior instability in patients with PCL injury. Evaluation of the bone microarchitecture resulting from altered biomechanics could advance the understanding of PCL function and improve the detection of PCL injury.

Effects of Service Characteristics of a Subscription-based OTT on User Satisfaction and Continuance Intention: Evaluation by Netflix Users (구독형 OTT 서비스 특성이 이용자 만족과 지속 사용 의도에 미치는 영향: 넷플릭스 이용자를 대상으로)

  • Chung, Yongkuk;Zhang, Wei
    • The Journal of the Korea Contents Association
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    • v.20 no.12
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    • pp.123-135
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    • 2020
  • This study examined how the quality of Netflix service affects user satisfaction and continuance intention. This study classified the quality of Netflix service as content diversity, rate system appropriateness, recommendation system, N-screen service, binge viewing, and service quality, and examined the effect of each dimension on user satisfaction and continuous intention. We conduced an online survey on 202 Netflix users and analyzed the data with the SEM. Results are as follows. First, content diversity, recommendation system, binge-viewing and service quality are positively associated with user satisfaction. Second, the N-Screen service has neither direct nor indirect effects on continuance intention. However, rate system has a direct effect on continuance intention. On the other hand, content diversity, recommendation systems, binge-viewing, and quality of service affect continuance intention positively through user satisfaction. Finally, it is shown that user satisfaction and continuance intention have a significant static correlation as predicted.

Case Study on the Analysis of Disaster Vulnerabilities (Focused on the Fire & Explosion in the N-Industrial Complex) (재난 취약성 분석에 관한 사례연구(N공단의 화재·폭발을 중심으로))

  • Ha, Kag Cheon
    • Journal of the Korean Society of Safety
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    • v.36 no.2
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    • pp.94-100
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    • 2021
  • In general, the industrial complex is a place where factories of various industries are concentrated. It is only as efficient as it is designed. However, the risks vary as there are various industries. These features are also associated with various types of disasters. The dangers of natural disasters such as a typhoon, flood, and earthquake, as well as fire and explosions, are also latent. Many of these risks can make stable production and business activities difficult, resulting in massive direct and indirect damage. In particular, decades after its establishment, the vulnerabilities increase even more as aging and small businesses are considered. In this sense, it is significant to assess the vulnerability of the industrial complex. Thus analysing fire and explosion hazards as stage 1 of the vulnerability evaluation for the major potential disasters for the industrial complex. First, fire vulnerabilities were analyzed quantitatively. It is displayed in blocks for each company. The assessment block status and the fire vulnerability rating status were conducted by applying the five-step criteria. Level A is the highest potential risk step and E is the lowest step. Level A was 11.8% in 20 blocks, level B was 22.5% in 38 blocks, level C was 25.4% in 43 blocks, level D was 26.0% in 44 blocks, and level E was 14.2% in 24 blocks. Levels A and B with high fire vulnerabilities were analyzed at 34.3%. Secondly, the vulnerability for an explosion was quantitatively analyzed. Explosive vulnerabilities were analyzed at 4.7% for level A with 8 blocks, 3.0% for level B with 5, 1.8% for level C with 3, 4.7% for level D with 8, and 85.8% for level E with 145. Levels A and B, which are highly vulnerable to explosions, were 7.7 %. Thirdly, the overall vulnerability can be assessed by adding disaster vulnerabilities to make future assessments. Moreover, it can also assist in efficient safety and disaster management by visually mapping quantified data. This will also be used for the integrated control center of the N-Industrial Complex, which is currently being installed.

The Effects of Government R&D Support on Private R&D Investment: Evidence from Innovative Growth Engine Policies (정부 R&D 지원이 민간 R&D 투자에 미치는 영향: 혁신성장동력 정책을 중심으로)

  • Koo, Bon-Jin;Lee, Jong-Seon
    • Asia-Pacific Journal of Business
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    • v.12 no.3
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    • pp.281-294
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    • 2021
  • Purpose - The purpose of this study was verifying the policy effects by field of innovative growth engines, focusing on the discussion of the relationship between government support and corporate R&D activities (substitute/complementary goods), and based on the results, policy recommendations for promoting private R&D were carried out. Design/methodology/approach - Through literature research, academic/theoretical discussions about relationship between government support and corporate R&D activities were synthesized. Next, survey data were collected for companies engaged in the field of innovative growth engines and empirical analysis was conducted on the relationship between government support and R&D activities in 13 major sectors. Findings - First, as a result of analyzing all companies regardless of sector, government R&D subsidies had a positive (+) relationship with R&D activities of companies engaged in innovative growth engines, that is, a complementary relationship. Next, as a result of performing empirical analysis by dividing the 13 fields, it was found that 9 fields were complementary goods in which government support had a positive (+) effect on the R&D activities of companies. On the other hand, in the remaining four fields, the effect of government support on corporate R&D activities was not statistically significant. Research implications or Originality - In order to promote R&D activities of companies in the 9 fields where government support acts as a complementary product, it is necessary to establish policies centered on direct government support. On the other hand, it would be more desirable to seek indirect support rather than direct support in the 4 fields where government support did not have a statistically significant effect on corporate R&D activities.