• Journal of Microbiology and Biotechnology
• /
• 제33권4호
• /
• pp.519-526
• /
• 2023

Panax ginseng is one of the most important herbal medicinal plants consumed as health functional food and can be fermented to achieve better efficacy. Lacticaseibacillus, one of the representative genera among lactic acid bacteria (LAB), has also been used as a probiotic material for health functional foods due to its beneficial effects on the human body. To achieve a synergistic effect by using these excellent dietary supplement ingredients together, a novel LAB strain was isolated from the root of 6-year-old ginseng. Through similarity analysis of 16S rRNAs and whole-genome sequences, the strain was confirmed as belonging to the genus Lacticaseibacillus and was named L. casei KGC1201. KGC1201 not only met all safety standards as food, but also showed excellent probiotic properties such as acid resistance, bile salt resistance, and intestinal adhesion. In particular, KGC1201 exhibited superior acid resistance through morphological observation identifying that the cell surface damage of KGC1201 was less than that of the L. casei type strain KCTC3109. Gene expression studies were conducted to elucidate the molecular mechanisms of KGC1201's acid resistance, and the expression of the glycosyltransferase gene was found to be significantly elevated under acidic conditions. Exopolysaccharides (EPSs) biosynthesized by glycosyltransferase were also increased in KGC1201 compared to KCTC3109, which may contribute to better protection of KGC1201 cells from strong acidity. Therefore, KGC1201, with its increased acid resistance through molecular mechanisms and excellent probiotic properties, can be used in health functional foods to provide greater benefit to overall human health and well-being.

• 약학회지
• /
• 제34권3호
• /
• pp.180-191
• /
• 1990

A comparison was made of the effects of selective ${\alpha_1}-adrenoceptor$ agonist phenylephrine and selective ${\alpha_2}-adrenoceptor$ agonist clonidine on endothelium-containing and endothelium-denuded rings of the rat aorta. In the case of phenylephrine, removal of endothelium increased sensitivity 2.5 fold at $EC_{50}$ level and maximum contractive response 1.4 fold. In the case of clonidine, which gave only 15% of maximum contractive response given to phenylephrine on endothelium-containing rings, removal of the endothelium increased sensitivity 5.6 fold at $EC_{50}$ level and maximum contractive response 5 fold, which was about 55% of that given by phenylephrine. In endothelium-denuded ring, phenylephrine-induced contraction tended to be more increased in tonic contraction than in phasic contraction as compared to that in endothelium-containing ring, while clonidine-induced contraction was monophasic and was increased only in tonic contraction. In the calcium-free solution or in the presence, of verapamil, contraction stimulated by clonidine was almost abolished while that stimulated by phenylephrine produced only phasic contraction. The depression of sensitivity to these agonists in rings with endothelium appeared to be due to the vasodepressor action of endothelium derived relaxing factor (EDRF), because hemoglobin, a specific blocking agent of EDRF, abolished this depression. It is unlikely that the endothelium-dependent relaxation was due to stimulation of release of EDRF, because clonidine did not produce endothelium-dependent relaxation in 5-hydroxytryptamine-precontracted ring even when its contractile action was blocked by the ${\alpha_1}-adrenoceptor$ antagonist, prazosin. When the efficacy of phenylephrine was reduced to about the initial efficacy of clonidine by pretreatment with dibenamine, the contraction-response curves for phenylephrine became very similar to the corresponding curves obtained for clonidine before receptor inactivation. In the dibenamine-treated rings, contraction of phenylephrine was abolished in calcium-free solution or in the presence of verapamil like that obtained for clonidine before receptor inactivation. These results suggest that EDRF spontaneously released from endothelium depress contraction more profoundly in a case of an agonist with low efficacy and the phenylephrine-induced contraction was totally dependent on extracellular calcium as was that obtained for clonidine when the efficacy of phenylephrine was reduced to that of clonidine by irreversible inactivation of ${\alpha_1}-adrenoceptor$ with dibenamine.

• 대한간호학회지
• /
• 제26권3호
• /
• pp.556-575
• /
• 1996

In an attempt to investigate the effect of a muscle strengthening exercise program on muscle strength, pain, depression, self-efficacy and quality of life of patients with knee osteoarthritis, a pre-experiment, one group pre-test & post-test design, was planned. Muscle strengthening exercise was carried out from May 22 through August 14, 1995 at isokinetic exercise room in rehabilitation department of University Hospital in Taejon. The subjects were seven female clients conveniently sampled from University Hospital located in Taejon, between 39 and 61 years of age, who had a osteoarthritis in knee. Muscle strengthening exercise program was composed of three sessions per week, one isokinetic exercise at angular velocity of 60° and 180° with Cybex isokinetic dynamometer and two resistance home exercise sessions with elastic band. Data were analyzed with frequency, percentage of change, Friedman test, Duncan test using SAS program. Results were obtained as follows : 1) Flexion and extension muscle strength at angular velocity of 60° and 180° were increased after 12weeks' exercise than those of before experiment. But exept flexion muscle strength at angular velocity of 180°(F=3.34, P=0.0261), there was no statistically significant difference among muscle strengths, which is measured every 3 weeks. 2) Pain was decreased after 6weeks' exercise than that of before experiment, and after 12weeks' exercise than that of 6weeks' exercise. There was statistically significant difference (F=4.28, P=0.0396). 3) Depression was increased after 6weeks' exercise than that of before experiment, and after 12weeks' execise than that of 6weeks' exercise. There was no statistically significant difference between before experiment and after 6weeks' exercise. But, there was statistically significant difference between after 6weeks' exercise and 12weeks' exercise(F=9.38, P=0.0035). 4) Self-efficacy was decreased after 6weeks' exercise than that of before exercise. But, it was increased after 12weeks' exercise than that of be-fore exercise and after 6weeks' exercise. But there was no statistically significant difference (F=1.46, P=0.2706). 5) Quality of life was increased after 6weeks' exercise than that of before exercise, and after 6weeks' exercise than that of 12weeks' exercise. But there was no statistically significant differ once (F=1.06, P=0.3816). Thus, the significant of muscle strengthening exercise for the improvement of muscle strength, pain, depression, is verified. But, this study was a pre-experiment with small size subjects. So, con-trolled experimental study is necessary to determine the effect of this muscle strengthening exercise program on muscle strength, pain, depression, self-efficacy, and quality of life of patients with knee osteoarthritis.

• 국제교류와 융합교육
• /
• 제4권2호
• /
• pp.1-19
• /
• 2024

본 연구는 창작음악극이 학교부적응 청소년의 학교적응 및 자기효능감 향상에 미치는 효과에 대하여 살펴보았다. 연구대상은 교육청 정서행동평가 및 wee(Wee)클래스 상담교사를 통해 학교부적응 위험군으로 분류된 청소년 229명으로 하였다. 연구기간은 2023년 5월 1일부터 10월 31일까지 주 1회씩, 회기 당 100분으로 구성하여 총 15회기를(로) 진행되었다. 효과성 검증을 위해 창작음악극(창작음악극의 효과성 검증을 위해) 사전, 사후에 김아영(2002)의 학교적응척도, Sherer 등(1982)의 자기효능감 척도(SES)를 실시하고, 대응 t 검증을 통해 결과를 분석하였다. 연구의(연구) 결과, 연구대상의 학교적응(p< .05)과 하위요인인 교우관계(p< .05), 학교수업(p< .05), 학교규칙(p< .05) 모두 창작음악극을 실시하기 전에 비해 사후에 (점수가) 증가하였으며 통계적으로도 유의하였다. 연구대상의 자기효능감(p< .01)과 하위요인인 일반적 자기효능감(p< .01), 사회적 자기효능감(p< .05) 또한 창작음악극 실시하기 전에 비해 사후에 (점수가) 증가하였으며 통계적으로도 유의하였다. 따라서 본 연구는 창작음악극이 학교부적응 청소년의 학교적응 및 자기효능감 향상에 효과적이라는 것을 밝혔다.

• 대한통합의학회지
• /
• 제7권1호
• /
• pp.9-17
• /
• 2019

Purpose : This study assessed the effects of transcranial direct current stimulation (tDCS) on balance, fall efficacy, and fall-related fitness in stroke patients, using a cohort of 30 stroke patients divided into two groups. Methods : The experimental group (was given transcranial direct current stimulation in a virtual reality program) and the control group was given false tDCS in virtual reality. there were 15 patients in each group, receiving appropriate treatment over 30 sessions (30 minutes per session per week over a six-week period). In order to assess the change in balance before and after the intervention, the Berg Balance scale was utilized. Fall efficacy was evaluated using the Korean Falls Efficacy Scale for the Elderly (FES-K), The following exercises were performed by patients to assess fall-related fitness : sitting down in a chair and standing up : walking a 244 cm round= trip, and standing on one foot. Results : After the intervention, the experimental group exhibited significantly increased fall efficacy and fall-related fitness, while the control group exhibited no change. These findings suggest that tDCS has positive effects on balance, fall efficacy, and fall-related fitness in stroke patients. Conclusion : Using tDCS as an intervention would bring positive effects on balance, fall efficacy, and fall-related fitness in stroke patients undergoing rehabilitation.

• 대한간호학회지
• /
• 제43권5호
• /
• pp.690-696
• /
• 2013

Purpose: This study was done to examine the effects of a multicultural education program on nursing students' cultural competence, empathy, and self-efficacy. Methods: In this quasi-experimental study, the participants were assigned to an experimental group (n=40) or a control group (n=40). The data were analyzed using independent t-test, Chi-square or Fisher's exact test, and paired t-test with the SPSS windows 18.0 program. Results: After receiving the multicultural education program, the levels of cultural competence and self-efficacy in the experimental group were higher than in the control group. The level of empathy increased slightly in the experimental group while it decreased in the control group. Conclusion: The results of this study indicate that multicultural education is effective in raising the level of cultural competence and self-efficacy in nursing students. Thus, there is a need for continuous effort to integrate multicultural education programs in the nursing curriculum. Repeated study to test effects of these multicultural education programs should be also necessary.

• 지역사회간호학회지
• /
• 제16권3호
• /
• pp.282-288
• /
• 2005

Purpose: This study was to verify the effects of a smoking cessation program for adolescents. Method: This study was designed to use one group with one pre-test and two post-tests. One post-test was done immediately after the completion of the program and the other after eight weeks. The subjects were 21 male high school students who were smokers when this study was carried out. The smoking cessation program consisted of 5 sessions with smoking cessation education and e-mail service after the program. Variables in this research were nicotine dependency (using Fagerstrom Tolerance Questionnaire) and self-efficacy. Data were analyzed by descriptive statistics and Wilcoxon signed rank test. Results: Immediately after the program and eight weeks later, nicotine dependency for continuous smokers decreased significantly (after the program: Z=-2.319, p=.020, eight weeks later: Z=-1.999. p=.046) and self-efficacy increased significantly (after program: Z=-3.024. p=.002. eight weeks later: Z=-2.381. p=.017). Conclusions: The smoking cessation program was effective in decreasing nicotine dependency in the continuous adolescent smokers and in increasing their self-efficacy, Further study needs to be made with a lager number of smoking adolescents using control group design.

• 한국간호교육학회지
• /
• 제14권1호
• /
• pp.12-19
• /
• 2008

Purpose: This study was performed to explore the effects of an admission-education program on knowledge, self-efficacy, self-care and glucose control in type 2 diabetes patients. Method: A single group pre-post test design was used. Twenty-one patients participated in this program during 6 days which consisted of education and practice about exercise, diet, self-care and prevention of complications. Variables at baseline, 3 months, and 6 months were measured. Results: Knowledge level, self-care level and self-efficacy were significantly increased over time after the admission-education program. The $HbA_1C$ level and glucose level in urine were significantly decreased over time after the admission-education program. Conclusion: The admission-education program can increase levels of knowledge, self-care, self-efficacy and decrease glucose levels. Therefore, this admissioneducation program was shown to have a positive effect on the management of diabetes.

• 대한간호학회지
• /
• 제37권7호
• /
• pp.1073-1079
• /
• 2007

Purpose: The purpose of this study was to identify the effects of a smoking cessation program on the amount of smoking and nicotine dependence and the self-efficacy of smoking cessation for smoking workers. Methods: The total number of subjects was 38 smokers and was divided into two: 16 smokers were placed in the experimental group and 22 in the control group. A nonequivalent control group pretest-posttest design was used. The smoking cessation program consisted of two sessions and was implemented for two hours daily for five days. Data was analyzed by using the SPSS/WIN 11.0 program with $X^2-test$, t-test or Mann-Whitney U and ANCOVA. Results: After the treatment, those belonging to the experimental group showed a significantly decreased amount of smoking, a decreased nicotine dependency and increased self-efficacy compared to the control group. Conclusion: The smoking cessation program was effective for diminishing the amount of smoking, decreasing nicotine dependence and improving self-efficacy. Therefore, this program is recommended as a smoking cessation strategy for adult smokers.

• 가정∙방문간호학회지
• /
• 제24권2호
• /
• pp.200-209
• /
• 2017

Purpose: This study aimed to evaluate the effects of sociodrama on mothers of adolescents receiving special education at school. Methods: The participants were 30 mothers of adolescents with autism and intellectual, physical, emotional, and behavioral disability (experimental group=8, control group=16, 4 excluded). Sociodrama was conducted over 6 weeks (6 sessions). Data were collected using a mixed method. A constructed questionnaire on parenting stress, depression, and parenting self-efficacy was distributed before and after the intervention. A focus group interview was conducted subsequently. Data were collected from May to June 2016 and analyzed using Wilcoxon-Mann-Whitney test and a content analysis. Results: The intervention group showed significant changes in parenting stress (Z=-2.34, p=.019), depression (Z=-.3.46 p=.001), and parenting self-efficacy (Z=-2.82, p=.029) compared with the control group. Results of the qualitative analysis exhibited two themes, namely "changes" and "healing and challenges," which were divided into 4 categories and 9 sub-categories. Conclusion: Sociodrama was effective in reducing the level of parenting stress and depression, and increased the level of parenting self-efficacy in participants. Sociodrama can be recommended as an intervention program for parents raising adolescents receiving special education.