• Fire Science and Engineering
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• v.21 no.3
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• pp.15-23
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• 2007

In the events of a fire in the residential building, highly flammable polyurethane foam sofa produce toxic smokes. In this type of fire, the residents of the building can be gotten into the difficulties of evacuating from the fire places or may be to death due to a lot of hot toxic gases. In this study, CFD simulations were carried out to study the effects of the openings of stairwell on the fire characteristics of fire room and stairwell. Also, analysis of fire hazard based on the tenability limits of fire and FED(fractional effective dose) was performed to evaluate the life safety of the residents of the building. In the fire room, maximum temperature was about $290^{\circ}C$, maximum CO concentration was about 4,740 ppm, and the time to incapacitation of residents in fire room was about t=144 s. In the stairwell, temperature and CO concentration in the condition of openings to be open were even lower than those in it to be closed. Time to the tenability limit with respect to smoke visibility in the stairwell with openings, which was open, was shorter than that of it without openings to be open. It has been shown from this study that opening the stairwell openings is able to decrease the fire hazards to the life safety in the multi-story residential building fire.

• Journal of Food Hygiene and Safety
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• v.27 no.1
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• pp.37-41
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• 2012

The current standard for testing tetrodotoxin (TTX) in foodstuffs is the mouse bioassay (MBA) in Korea as in many other countries. However, this test suffers from potential ethical concerns over the use of live animals. In addition, the mouse bioassay does not test for a specific toxin thus a sample resulting in mouse incapacitation would need further confirmatory testing to determine the exact source toxin (e.g., TTX, STX, brevotoxin, etc.). Furthermore, though the time of death is proportional to toxicity in this assay, the dynamic range for this proportional relationship is small thus many samples must be diluted and new mice be injected to yield a result that falls within the quantitative dynamic range. Therefore, in recent years, there have been many efforts in this field to develop alternative assays. High performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) has been emerged as one of the most promising options. A LC-MS-MS method involves solid-phase extraction (SPE) and followed by analysis using an electrospray in the positive ionization mode and multiple reactions monitoring (MRM). To adopt LC-MS-MS method as alternative standard for testing TTX, we performed a validation study for the quantification of TTX in puffer fish. This LC-MS-MS method showed good sensitivity as limits of detection (LOD) of $0.03{\sim}0.08{\mu}g/g$ and limits of quantification (LOQ) of $0.10{\sim}0.25{\mu}g/g$. The linearity ($r^2$) of tetrodotoxin were 0.9986~0.9997, the recovery were 80.9~103.0% and the relative standard deviations (RSD) were 4.3~13.0%. The correlation coefficient between the mouse bioassay and LC/MS/MS method was higher than 0.95.

• Journal of Digital Convergence
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• v.20 no.1
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• pp.203-211
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• 2022

This study is to examine the causes of research misconduct such as plagiarism, forgery, redundant publication, unfair author expression, and incapacitation of the research ethics system of university researchers and to suggest improvement plan. It basically relied on literature research. In order to supplement the deficiencies in literature research, I sought advice from an expert professor who had experience working in a research-related field in university or who is currently in a position related to research ethics through the delphi-method. As a result of the study, from the perspective of individual researchers, the complacent attitude, dishonesty, and greed for research funds were identified as the main reasons. In terms of organization, it was analyzed for reasons such as lack of detail and application of regulations, lack of verification system, and performance-oriented research environment. In order to overcome research misconduct caused by the researcher's personal reasons, regularization, increase in the number of research ethics education, and strengthening personal penalties were suggested. As a way to overcome irregularities arising from institutional reasons, the reinforcement of the verification system, the reinforcement of the whistle-blower's personal protection system, the omission of promotion, and the quality and quantitative balance of research evaluation was suggested.