• Archives of Pharmacal Research
• /
• v.26 no.1
• /
• pp.9-14
• /
• 2003

For probing the importance of planarity of imidazolidinone motif of 4-phenyl-1-(benzenesulfonyl)imidazolidinones 1 for their cytotoxicity, 4-phenyl-2-(benzoyl)[1,2,5]thiadiazolidine-1,1-dioxide (2a), 4-phenyl-2-(p-toluoyl)[1,2,5]thiadiazolidine-1,1-dioxide (2b), 4-phenyl-2-(phenylcarbamoyl)[1,2,5]thiadiazolidine-1,1-dioxide (3a), and 4-phenyl-2-(p-tolylcarbamoyl)[1,2,5]thiadiazolidine-1,1-dioxide (3b) were prepared along with their regioisomers (5a, 5b, 9a, 9b) and their cytotoxicity were measured against human lung carcinoma (A549), human colon carcinoma (COLO205), human ovarian cancer (SK-OV-3), human leukemic cancer (K562), and murine colon adenocarcinoma (Colon26) cell lines in vitro. All compounds prepared do not show any activity against all five cancer cell lines unlike 1. Compounds 1 possess planarity of imidazolidinone, especially in sulfonylurea moiety ($-SO_2$NHCONH-). However compounds 2 and 3 have nonplanar 5-membered ring, [1,2,5]thiadiazolidine-1,1-dioxides. Such structural differentiation might result in the loss of activity. Therefore the inactivity of 2 and 3 could also be an indication for the necessity of planarity of imidazolidinone ring of 1 for their cytotoxic activity.

• Proceedings of the IEEK Conference
• /
• 2002.07c
• /
• pp.1606-1609
• /
• 2002

MAC state models appeared with an effort to overcome technical demerits of CDMA in provisioning packet data service. In the scenario of sojourn and transition on MAC states, the design of state sojourn time is a critical issue for an efficient utilization of limited recource; a longer sojourn time leads to more resource being preserved for inactive stations, while more connection components should be recovered with a shorter sojourn time. Thus, the sojourn time at each MAC state must be optimized in consideration of these two conflicting arguments. In this paper, we first present a generic MAC state model. Secondly, based on the generic model, we reveal a relation of inactive period and the delay time of the last packet served in pre- ceding active period and specify a loss function reflect-ing two antinomic features that result from a change of state sojourn time. Using the proposed loss function, we construct a decision problem to find an optima3 rule for state sojourn times. Finally, we present a way of computing Bayes rule by use of the posterior distribution of inactivity duration for given observation on the delay time of last packet. Furthermore, Bayes rules are explicitly expressed for special arrival processes and investigated with respect to traffic load and loss parameters.

• Korean Journal of Health Education and Promotion
• /
• v.32 no.5
• /
• pp.17-31
• /
• 2015

Objectives: This paper aims to identify the health related behaviors patterns and its associated factors among marriage immigrant women in Korea, and discusses their application to health promotion strategies. Methods: The study participants were 7,591 immigrant wives in Gyeonggi province who participated in health examinations conducted by the Korea Association of Health Promotion in 2011-2013. The participants completed self-administered questionnaires on sociodemographics, psychological characteristics, health status and health care factors, and health related behaviors. Results: A 3-latent-class model of health behaviors was identified related to 'lack of physical activity', 'abnormal diet', and 'not experienced medical check-up': 'high risk class', 'middle risk class', and 'low risk class'. Most of the participants belong to 'middle risk class'. Country of origin, age, length of stay, number of children, work status, health insurance status, and unmet health care needs were associated with problematic health behaviors in middle risk health behavior class. Conclusions: Health promotion and intervention programs for marriage immigrant women and their family members need to consider the health behavior patterns of physical inactivity, abnormal diet and no medical check-up and develop multiple behavior intervention with pre-existing program modification.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.1
• /
• pp.193-196
• /
• 2009

Mesoporous $TiO_2$ material was synthesized from diblock copolymers with ethylene oxide chains via a sol-gel process in aqueous solution. The properties of these materials were characterized with several analytical techniques including field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), wide angle X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, and Barrett-Joyner-Halenda (BJH) analysis. The mesoporous $TiO_2$ materials calcined at 400${^{\circ}C}$ were found to have specific surface areas 212 $m^2g^-1$, average pore sizes 6.2 nm, and their average crystal sizes were found to be 8.2 nm. The photocatalytic activity of mesoporous $TiO_2$ was characterized with UV-Vis spectroscopy, and it was found to be 5.8 times higher than that of Degussa P25 $TiO_2$ (P25). For deactivation of Escherichia coli, mesoporous $TiO_2$ also has high photocatalytic inactivity than that of P25. Such a high photocatalytic activity is explained with large surface area and small crystal size with wormhole-like mesoporous structure.

• Smart Structures and Systems
• /
• v.7 no.1
• /
• pp.41-57
• /
• 2011

A deeper understanding of the effectiveness of adopting devices mounting shape memory alloy (SMA) elements in applications targeted to the mitigation of vibrations is pursued via an experimental approach. During a seismic event, less than 1000 loading-unloading cycles of the alloy are required to mitigate the earthquake effects. However, the aging effects during the time of inactivity prior to the oscillations (several decades characterized by the yearly summer-winter temperature wave) should be considered in order to avoid and/or minimize them. In this paper, the results obtained by carrying out, in different laboratories, fatigue tests on SMA specimens are compared and discussed. Furthermore, the effects of seismic events on a steel structure, with and without SMA dampers, are numerically simulated using ANSYS. Under an earthquake excitation, the SMA devices halve the oscillation amplitudes and show re-centering properties. To confirm this result, an experimental campaign is conducted by actually installing the proposed devices on a physical model of the structure and by evaluating their performance under different excitations induced by an actuator.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.22 no.1
• /
• pp.133-140
• /
• 2009

Objective : To evaluate autonomic nerve balance and sympathetic nerve activity in patients with inner ear dysfunction as examined by heart rate variability(HRV) Research Methods and Procedures : One hundred and twenty three patients(between 15 to 59 years old) who visited Dept. of Oriental medical Opthalmology & Otolaryngology, Kyunghee university and had an examination of HRV test, were selected as subjects of our study. We checked items of HRV test(such as SDNN, RMSSD, LF, HF, TP, norm-LF, norm-HF, LF/HF ratio), and analyzed time and frequency domain differences between three groups classified as tinnitus, hearing loss and vertigo. And we compared HRV items(such as SDNN,RMSSD, TP and LF/HF ratio) with standard levels. Results and Conclusion : Our results showed no significant differences between three groups in HRV items except for mean heart rate. Patients with inner ear dysfunction showed significant lower TP than 2000$(ms^{2})$(p <0.001) and significant higher LF/HF ratio than 1.5(p=0.003). So we suggest that patients with inner ear dysfunctions such as tinnitus, vertigo and hearing loss, have sympathetic hypertonus and inactivity of autonomic nerve regulation.

• Research in Community and Public Health Nursing
• /
• v.20 no.3
• /
• pp.296-306
• /
• 2009

Purpose: This study was to identify variables influencing health risk behaviors in adolescents on the basis of the PRECEDE model. Methods: Data were collected from 434 middle school students in Chungbuk Province for two weeks in July 2008. The instrument for this study was a self-reported questionnaire. The SPSS/WIN 12.0 program was used for data analysis, which included t-test, one way ANOVA, Scheffe's test, Pearson's correlation coefficients, and stepwise multiple regression analysis. Results: Adolescents' level of health risk behaviors ($47.32{\pm}7.98$) was below medium. Physical inactivity ($6.73{\pm}2.23$) and Internet addictive behavior ($6.36{\pm}2.11$) were major health risk behaviors. The perceived level of school health education ($30.74{\pm}9.84$) was low. Family function and general self efficacy explained 14.3% of variance in health risk behaviors. Family function was a major predictor of health risk behaviors ($R^2$=.108, p=.000). However, the perceived level of school health education was not a significant predictor of health risk behaviors. Conclusion: For the prevention of health risk behaviors in adolescents, it is necessary that the family and the school collaborate with each other in educational strategies in order to strengthen influential factors such as family function and general self-efficacy.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.27 no.3
• /
• pp.549-562
• /
• 2017

In recent years, as the proportion of mobile banking has become bigger with daily usage of mobile banking, security threats are also increasing according to the feeling. Accordingly, the domestic banking system introduces security solution programs in the banking application and sets security check points to ensure the stability of the application in order to check whether it is always executed. This study presents a vulnerability of inactivity bypassing mobile vaccine program operation checkpoints using the intermediate language statically and dynamically analysis when decompiling the android banking applications of major banks in Korea. Also, through the results, it identifies possible attacks that can be exploited and suggest countermeasures.

• Journal of Korean society of Dental Hygiene
• /
• v.20 no.3
• /
• pp.347-357
• /
• 2020

Objectives: The purpose of the study was to investigate the relationship between frailty and oral health among some elderly community residents. Methods: A self-reported questionnaire was completed by 240 elderly in the Gwangju-Jeonnam area from October 1, 2019, to November 30, 2019, based on convenience sampling. The questionnaire consisted of general characteristics of the subjects, frailty level (Kihon checklist), and Geriatric Oral Health Assessment Index. Results: There were 66 (27.5%) frail elderly, and the GOHAI group with a score less than 45 constituted 187 (77.9%), which was higher than the group with a score of 45 or higher. The distribution of the frail elderly was indicated to be higher in the people with older age (p<0.05), lower educational level (p<0.01), current economic inactivity (p<0.05), living alone (p<0.01), more chronic diseases (p<0.01), and GOHAI score below 45 (p<0.01). Compared to those with a good oral health-related quality of life, those with a poor quality of life showed a 3.03 times higher risk of frailty (95% CI=1.291-7.107)(p<0.05). Conclusions: By recognizing the need for oral health care of the elderly through these results and by identifying the relationship between frailty and oral health, it is possible to consider oral health as a predictor of frailty.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2017.10a
• /
• pp.182-184
• /
• 2017

Recently, adolescent's lack of exercise due to increasing physical inactivity is emerging as a social problem. Accordingly, we planned a smartphone game to increase the physical activity of adolescents. The application is able to induce the interest of the youth through the interesting factor of 'game'. Also it provides the user with information about the physical activity by measuring the amount of physical activity of the user through GPS. We propose a way to continuously motivate adolescent's physical activity through this motion interaction game application.