• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.299-307
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• 2021

Accumulation of amyloid beta (Aβ) and oxidative stress are the most common reason of Alzheimer's disease (AD). In the present study, we investigated the cognitive improvement effects of butanol (BuOH) fraction from Momordica charantia in Aβ_25-35-induced AD mouse model. To develop an AD mouse model, mice were received injection of Aβ_25-35, and then orally administered BuOH fraction from M. charantia at doses of 100 and 200 mg/kg/day during 14 days. In the T-maze and novel object recognition test, administration of BuOH fraction from M. charantia L. at doses of 100 and 200 mg/kg/day improved spatial ability and novel object recognition by increased explorations of novel route and new object. In addition, BuOH fraction of M. charantia-administered groups improved learning and memory abilities by decreased time to reach hidden platform in Morris water maze test. Oral administration of BuOH fraction from M. charantia significantly inhibited lipid peroxidation and nitric oxide levels in the brain, liver, and kidney compared with Aβ_25-35-induced control group. These results indicated that BuOH fraction of M. charantia improved Aβ_25-35-induced cognitive impairment by attenuating oxidative stress. Therefore, M. charantia could be useful for protection from Aβ_25-35-induced cognitive impairment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.8C
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• pp.1113-1124
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• 2004

In this paper, we proposed a hardware(H/W) structure which can compress and recontruct the input image in real time operation and implemented it into a FPGA platform using VHDL(VHSIC Hardware Description Language). All the image processing element to process both compression and reconstruction in a FPGA were considered each of them was mapped into H/W with the efficient structure for FPGA. We used the DWT(discrete wavelet transform) which transforms the data from spatial domain to the frequency domain, because use considered the motion JPEG2000 as the application. The implemented H/W is separated to both the data path part and the control part. The data path part consisted of the image processing blocks and the data processing blocks. The image processing blocks consisted of the DWT Kernel fur the filtering by DWT, Quantizer/Huffman Encoder, Inverse Adder/Buffer for adding the low frequency coefficient to the high frequency one in the inverse DWT operation, and Huffman Decoder. Also there existed the interface blocks for communicating with the external application environments and the timing blocks for buffering between the internal blocks The global operations of the designed H/W are the image compression and the reconstruction, and it is operated by the unit of a field synchronized with the A/D converter. The implemented H/W used the 69%(16980) LAB(Logic Array Block) and 9%(28352) ESB(Embedded System Block) in the APEX20KC EP20K600CB652-7 FPGA chip of ALTERA, and stably operated in the 70MHz clock frequency. So we verified the real time operation of 60 fields/sec(30 frames/sec).

• Journal of Sasang Constitutional Medicine
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• v.27 no.2
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• pp.270-287
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• 2015

Objectives To evaluate the neuroprotective effects of modified Yuldahanso-tang (MYH) in a Parkinson's disease mouse model. Methods 1) Four groups (each of 8 rats per group) were used in this study. 2) The neuroprotective effect of MYH was examined in a Parkinson's disease mouse model. C57BL/6 mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day), intraperitoneal (i.p.) for 5 days. 3) The brains of 2 mice per group were removed and frozen at $-20^{\circ}C$, and the striatum-substantia nigra part was seperated. The protein volume was measured by Bradford method following Bio-Rad protein analyzing kit. Using mouse/Rat Dopamine ELISA Assay Kit. 4) The brains of 2 mice per group were separated and removed. TH-immunohistochemical was examined in the MPTP-induced Parkinson's disease mice to evaluate the neuroprotective effects of MYH on ST and SNpc. 5) Two mice out of each group were anesthetized and skulls were opened from occipital to frontal direction to take out the brains. The brains added TTC solution for 20 minutes for staining. 6) The water tank used for morris water maze test was filled with $28^{\circ}C$ water, and a round platform of 10cm in diameter was installed for mice to step on. The study was carried out once a day within 30 seconds, keep exercising to step on the platform in the pool. 7) The brains of two mice out of each group were fixed in 10% formaldehyde solution and paraphillin substance was infiltrated. They were fragmented by microtome, and observed under an optical microscope after Hematoxylin & Eosin staining. 8) A round acrylic cylinder with its upper side open was filled with clean water and depressive mouse models were forced to swim for 15 minutes. After 24 hours the animals were put in the same equipment for 5 minutes and were forced to swim. 9) The convenient, simple, and accurate high-performance liquid chromatography (HPLC) method was established for simultaneous determination of Neurotransmitters in MPTP-MYH group. Results 1) MYH possess Dopamine cell protective effect on MPTP-induced injury in striatum and substantia nigra pars compacta. 2) MYH inhibits the loss of tyrosine hydroxylase-immunoreacitive (TH-IR) cells in the striatum and substantia nigra pars compacta on MPTP-induced injury in C57BL/6 mice. 3) MYH possesses improvement effect on MPTP-induced memory deterioration in C57BL/6 mice through the reduction of prolongated Sort of lost time by MPTP injection using the Morris water maze test. 4) MYH possesses hippocampal neuron protective effect on MPTP-induced injury in C57BL/6 mice. 5) MYH possesses improvement effect on MPTP-induced motor behaviour deficits and depression in C57BL/6 mice through the reduction of prolongated losing motion by MPTP injection using the Forced swimming test. 6) MYH increases serotonin product amount on MPTP-induced injury in C57BL/6 mice. Conclusions This experiment suggests that the neuroprotective effect of MYH is mediated by the increase in Dopamin, TH-ir cell, Hippocampus and Serotonin. Furthermore, MYH essential oil may serve as a potential preventive or therapeutic agent regarding Parkinson's disease.

• The KIPS Transactions:PartD
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• v.10D no.1
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• pp.1-12
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• 2003

Recently, there have been many indexing schemes for multimedia data such as image, video data. But recent database applications, for example data mining and multimedia database, are required to support multi-user environment. In order for indexing schemes to be useful in multi-user environment, a concurrency control algorithm is required to handle it. So we propose a concurrency control algorithm that can be applied to CBF (cell-based filtering method), which uses the signature of the cell for alleviating the dimensional curse problem. In addition, we extend the SHORE storage system of Wisconsin university in order to handle high-dimensional data. This extended SHORE storage system provides conventional storage manager functions, guarantees the integrity of high-dimensional data and is flexible to the large scale of feature vectors for preventing the usage of large main memory. Finally, we implement the web-based image retrieval system by using the extended SHORE storage system. The key feature of this system is platform-independent access to the high-dimensional data as well as functionality of efficient content-based queries. Lastly. We evaluate an average response time of point query, range query and k-nearest query in terms of the number of threads.

• Clinical and Experimental Pediatrics
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• v.52 no.7
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• pp.824-831
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• 2009

Purpose : We aimed to investigate the efficacy of and functional recovery after intracerebral transplantation of different doses of mouse mesenchymal stem cells (mMSCs) in immature rat brain with hypoxic-ischemic encephalopathy (HIE). Methods : Postnatal 7-days-old Sprague-Dawley rats, which had undergone unilateral HI operation, were given stereotaxic intracerebral injections of either vehicle or mMSCs and then tested for locomotory activity in the 2nd, 4th, 6th, and 8th week of the stem cell injection. In the 8th week, Morris water maze test was performed to evaluate the learning and memory dysfunction for a week. Results : In the open field test, no differences were observed in the total distance/the total duration (F=0.412, P=0.745) among the 4 study groups. In the invisible-platform Morris water maze test, significant differences were observed in escape latency (F=380.319, P<0.01) among the 4 groups. The escape latency in the control group significantly differed from that in the high-dose mMSC and/or sham group on training days 2-5 (Scheffe's test, P<0.05) and became prominent with time progression (F=6.034, P<0.01). In spatial probe trial and visible-platform Morris water maze test, no significant improvement was observed in the rats that had undergone transplantation. Conclusion : Although the rats that received a high dose of mMSCs showed significant recovery in the learning-related behavioral test only, our data support that mMSCs may be used as a valuable source to improve outcome in HIE. Further study is necessary to identify the optimal dose that shows maximal efficacy for HIE treatment.

• Journal of Internet Computing and Services
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• v.16 no.2
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• pp.77-83
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• 2015

Frequent pattern mining, which is one of the major areas actively studied in data mining, is a method for extracting useful pattern information hidden from large data sets or databases. Moreover, frequent pattern mining approaches have been actively employed in a variety of application fields because the results obtained from them can allow us to analyze various, important characteristics within databases more easily and automatically. However, traditional frequent pattern mining methods, which simply extract all of the possible frequent patterns such that each of their support values is not smaller than a user-given minimum support threshold, have the following problems. First, traditional approaches have to generate a numerous number of patterns according to the features of a given database and the degree of threshold settings, and the number can also increase in geometrical progression. In addition, such works also cause waste of runtime and memory resources. Furthermore, the pattern results excessively generated from the methods also lead to troubles of pattern analysis for the mining results. In order to solve such issues of previous traditional frequent pattern mining approaches, the concept of representative pattern mining and its various related works have been proposed. In contrast to the traditional ones that find all the possible frequent patterns from databases, representative pattern mining approaches selectively extract a smaller number of patterns that represent general frequent patterns. In this paper, we describe details and characteristics of pattern condensing techniques that consider the maximality or closure property of generated frequent patterns, and conduct comparison and analysis for the techniques. Given a frequent pattern, satisfying the maximality for the pattern signifies that all of the possible super sets of the pattern must have smaller support values than a user-specific minimum support threshold; meanwhile, satisfying the closure property for the pattern means that there is no superset of which the support is equal to that of the pattern with respect to all the possible super sets. By mining maximal frequent patterns or closed frequent ones, we can achieve effective pattern compression and also perform mining operations with much smaller time and space resources. In addition, compressed patterns can be converted into the original frequent pattern forms again if necessary; especially, the closed frequent pattern notation has the ability to convert representative patterns into the original ones again without any information loss. That is, we can obtain a complete set of original frequent patterns from closed frequent ones. Although the maximal frequent pattern notation does not guarantee a complete recovery rate in the process of pattern conversion, it has an advantage that can extract a smaller number of representative patterns more quickly compared to the closed frequent pattern notation. In this paper, we show the performance results and characteristics of the aforementioned techniques in terms of pattern generation, runtime, and memory usage by conducting performance evaluation with respect to various real data sets collected from the real world. For more exact comparison, we also employ the algorithms implementing these techniques on the same platform and Implementation level.

• Journal of the Korean Institute of Landscape Architecture
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• v.44 no.4
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• pp.22-34
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• 2016

The purpose of this study was to analyze commemoration characteristics of fifty-nine Vietnam war memorials in Korea(VWMK) including monuments and national cemeteries from landscape architectural point of view such as location, spacial characteristic, landscape detail, sculpture, and interpretive text. Based on the commemoration characteristics of the analysis, the commemoration culture among Vietnam, the U.S.A., and Korea were studied and differences compared. The results are as follows. First, monuments were mainly located in public open space such as national cemeteries, parks, and plaza, and some of them were elected along with Korea war memorials to honor Vietnam war veterans at the national level. Second, because the monuments were relatively small and memorial towers were conventionally built on a square platform, the memorial style had been simply standardized to stereotype the commemoration characteristics. Third, outmoded memorial towers, stone plates, emblems, and memorial walls were used as main landscape details and standardized facilities were considered from an artistic and social point of view. Fourth, realistic soldier statues to show heroic and humanitarian image were in majority, while symbolic and abstract sculpture were small in number, they were mostly conventional and unexpressive. Fifth, the causes of participation in the Vietnam War were predominantly expressed as 'defending freedom', 'keeping world peace', and 'national economic development' based on anti-communism and patriotism, and also the collectivity of Vietnam War veterans by troop and local level was emphasized through engraving each veterans's name on towers, plates, and walls. VWMK are mostly conventional and stereotyped in style and show strongly national official memory and the collectivity of veterans from a sociopolitical perspective, and aim for anti-communistic patriotism ideologically. Further study and projects will be required to make creative and innovative memorials and to study how to rethink sublime fundamental themes like war, death, and the individual veteran's experience in VWMK.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.4
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• pp.863-872
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• 2015

Kernel rootkit is recognized as one of the most severe and widespread threats to corrupt the integrity of an operating system. Without an external monitor as a root of trust, it is not easy to detect kernel rootkits which can intercept and modify communications at the interfaces between operating system components. To provide such a monitor isolated from an operating system that can be compromised, most existing solutions are based on external hardware. Unlike those solutions, we develop a kernel introspection system based on the ARM TrustZone technology without incurring extra hardware cost, which can provide a secure memory space in isolation from the rest of the system. We particularly use a secure timer to implement an autonomous switch between secure and non-secure modes. To ensure integrity of reference, this system measured reference from vmlinux which is a kernel original image. In addition, the flexibility of monitoring block size can be configured for efficient kernel introspection system. The experimental results show that a secure kernel introspection system is provided without incurring any significant performance penalty (maximum 6% decrease in execution time compared with the normal operating system).

• Convergence Security Journal
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• v.6 no.3
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• pp.1-12
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• 2006

Malicious codes have been widely documented and detected in information security breach occurrences of Microsoft Windows platform. Legacy information security systems are particularly vulnerable to breaches, due to Window kernel-based malicious codes, that penetrate existing protection and remain undetected. To date there has not been enough quality study into and information sharing about Windows kernel and inner code mechanisms, and this is the core reason for the success of these codes into entering systems and remaining undetected. This paper focus on classification and formalization of type target and mechanism of various Windows kernel-based attacks, and will present suggestions for effective response methodologies in the categories of, "Kernel memory protection", "Process & driver protection" and "File system & registry protection". An effective Windows kernel protection system will be presented through the collection and analysis of Windows kernel and inside mechanisms, and through suggestions for the implementation methodologies of unreleased and new Windows kernel protection skill. Results presented in this paper will explain that the suggested system be highly effective and has more accurate for intrusion detection ratios, then the current legacy security systems (i.e., virus vaccines and Windows IPS, etc) intrusion detection ratios. So, It is expected that the suggested system provides a good solution to prevent IT infrastructure from complicated and intelligent Windows kernel attacks.

• Journal of Navigation and Port Research
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• v.29 no.1 s.97
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• pp.91-96
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• 2005

The National Marine Electronics Association(NMEA) is nonprofit-making cooperation composed with manufacturers, distributors, wholesalers and educational institutions. We use the basic port of equipment in order to process the signal from NMEA signal using equipment. When we don't have enough one, we use the multi-port for processing. However, we need to have module development simulation which could multiplex and provide NMEA related signal that we could solve the problems in multi-port application and exclusive equipment generation for a number of signal. For now, we don't have any case or product using NMEA multiplexer so that we import expensive foreign equipment or embody NMEA signal transmission program like software, using multi-port. These have problems since we have to pay lots ci money and build separate processing part for every application programs. Besides, every equipment generating NMEA signal are from different manufactures and have different platform so that it could cause double waste and loss of recourse. For making up for it, I suggest the NMEA multiplexer embodiment, which could independently move by reliable process and high performance single hardware module, improve the memory efficiency of module by designing the optimized Queue, and keep having reliability for realtime communication among the equipment such as main input sensor equipment Gyrocompass, Echo-sound, and GPS.