• Journal of Trauma and Injury
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• v.33 no.3
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• pp.153-161
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• 2020

Purpose: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an emergency procedure and extremely time-dependent, and the proficiency of the physician is important. Due to a lack of REBOA education programs in Republic of Korea, few physicians have been trained in the procedure. In this study, we examined how REBOA education affects clinical outcomes in a single center. Methods: A retrospective study conducted from February 2017 to June 2020 at a regional trauma center. We collected data of patients who underwent REBOA and analyzed the factors that influenced the outcome. The patients were divided into the educated and non-educated groups (based on REBOA training received by their physicians), and the success and failure groups. Results: A total of 24 patients underwent REBOA during the study. There were eight patients in the success group and 16 patients in the failure group. There are no significant differences between the educated and non-educated groups in sex, age, ISS, shock, injury-to-REBOA time, injury mechanism, injury sites, arrest, access site, type of catheter, type of REBOA, target Zone, mortality, and the result of REBOA. The non-educated group had a higher risk for failure compared to the educated group in multivariate analysis (odds ratio [OR] 154.64, 95% confidence interval [CI] 1.11-22.60). Conclusions: Failure in REBOA is harmful to patients. The risk of failure is increased in the non-educated group. Physicians working in the trauma center or emergency department need to complete the REBOA education program.

• Geotechnical Engineering
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• v.14 no.5
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• pp.143-162
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• 1998

In the present study, a procedure to predict the depth from the ground surface to the center of bulging failure zone in each of the square granular group piles under a rigid mat foundation is proposed. This analytical procedure is established on the basis of the conical modeling of bulging failure shape and the replacement ratio of soft foundation soils. considering the effect of a share of procedure to estimate the ultimate cylindrical pressure in the area reinforced with granular piles and the ultimate bearing capacity of each of granular piles in group. This analytical procedure is also established on the basis of the pre-determined depth to the zone of bulging failure and an iterative solution technique. Finally the analytical procedures proposed in this study are verified by analyzing the results of 3D finite element analyses, and the predictions of ultimate bearing capacity of granular piles are compared with the results obtained from the tests, empirical equation and 3D finite element analyses.

• Korean Journal of Acupuncture
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• v.20 no.2
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• pp.55-66
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• 2003

Objectives : The aim of this experiment is to investigate the effects of moxibustion on SP6, Sp9 and BL28 in uranyl acetate-induced acute renal failure in rats. Methods : To induce experimental acute renal failure, uranyl acetate was intraperitoneally injected to rats by 5mg/kg. 3 days later moxibustion treatment was done at SP6, Sp9 and BL28 bilaterally of the rats. And then 4 days later, we measured rats' body weight, kidney weight, serum BUN, creatinine and serum electrolytic levels(Na, K and Cl). Results : In the SP6 group, serum BUN were significantly decreased (p<0.01). In the BL28 group, serum Na level were significantly decreased (p<0.05). In the $SP6{\cdot}SP9$ group, serum creatinine level were significantly increased but serum Na level, serum Cl level were significantly decreased(p<0.05). In the $SP6{\cdot}BL28$ group, hypertrophy index of kidney and serum creatinine level were significantly decreased(p<0.01) and serum BUN were marginally significantly decreased (0.1

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5699-5703
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• 2013

Objective: To investigate the clinical effects of whole brain radiotherapy concomitant with targeted therapy for brain metastasis in non-small cell lung cancer (NSCLC) patients with chemotherapy failure. Materials and Methods: Of the 157 NSCLC patients with chemotherapy failure followed by brain metastasis admitted in our hospital from January 2009 to August 2012, the combination group (65 cases) were treated with EGFR-TKI combined with whole brain radiotherapy while the radiotherapy group (92 cases) were given whole brain radiotherapy only. Short-term effects were evaluated based on the increased MRI in brain 1 month after whole brain radiotherapy. Intracranial hypertension responses, hematological toxicity reactions and clinical effects of both groups were observed. Results: There were more adverse reactions in the combination group than in radiotherapy group, but no significant differences were observed between the two groups in response rate (RR) and disease control rate (DCR) (P>0.05). Medium progression free survival (PFS), medium overall survival (OS) and 1-year survival rate in combination group were 6.0 months, 10.6 months and 42.3%, while in the radiotherapy group they were 3.4 months, 7.7 months and 28.0%, respectively, which indicated that there were significant differences in PFS and OS between the two groups (P<0.05). Additionally, RPA grading of each factor in the combination group was a risk factor closely related with survival, with medium PFS in EGFR and KRAS mutation patients being 8.2 months and 11.2 months, and OS being 3.6 months and 6.3 months, respectively. Conclusions: Whole brain radiotherapy concomitant with target therapy is favorable for adverse reaction tolerance and clinical effects, being superior in treating brain metastasis in NSCLC patients with chemotherapy failure and thus deserves to be widely applied in the clinic.

• Asian Journal of Innovation and Policy
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• v.3 no.1
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• pp.25-49
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• 2014

We wanted to show the different group dynamics of factors for success and failure cases for technology commercialization in small technology-based firms. Existing studies are based on product level, project level, division level or firm level. We deal with technology level, and at small-technology-based firms. This is a longitudinal case study based on 8 cases from Korea. Our study on technology level is a first trial in success and failure studies unlike all existing studies. As a first step, we introduced new categories and factors such as technology attributes and CEO reflecting data, and especially a new concept of launch readiness level. Finally, we adopted correspondence analysis to show the group dynamics. The results are as follows; Technology factors are the most important factors. Second, resource-based factors are more critical in failure cases than success cases and technology factors are more critical to success.

• International Journal of Heart Failure
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• v.6 no.2
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• pp.84-90
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• 2024

Background and Objectives: Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavorable outcomes. The present study investigated the prevalence of vitamin D deficiency (VDD) and its relationship with cardiometabolic parameters in patients hospitalized for HF living in the city of Recife (latitude 8° South). Methods: Analytical cross-sectional study, with men and women aged 40-64 years. The HF group was recruited during hospitalization due to decompensation. A matched control group was recruited from the general endocrine clinics. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when 25OHD <20 ng/mL (<50 nmol/L). Results: A total of 243 patients were evaluated (HF group: 161, control group: 82). Lower serum 25OHD levels were observed in the HF group (25.2±9.4 vs. 30.0±7.7ng/mL; p<0.001), as well as a higher prevalence of VDD (27.3% vs. 9.8%; prevalence ratio, 2.80; 95% confidence interval, 1.38-5.67; p=0.002). In patients with HF, VDD was associated with diabetes mellitus (65.9% vs. 41.0%; p=0.005) and female sex (65.9% vs. 44.4%; p=0.015). In the subgroup with VDD, higher values of hemoglobin A1c (7.9% [6.0-8.9] vs. 6.2% [5.7-7.9]; p=0.006) and dyslipidemia were also observed. Conclusions: We found higher rates of VDD in patients hospitalized for HF and this was associated with deleterious laboratory metabolic parameters.

• Journal of Cardiovascular Imaging
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• v.30 no.4
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• pp.307-319
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• 2022

BACKGROUND: Current guidelines indicate electrical dyssynchrony as the major criteria for selecting patients for cardiac resynchronization therapy, and 25-35% of patients exhibit unfavorable responses to cardiac resynchronization therapy (CRT). We aimed to evaluate different cardiac mechanical dyssynchrony parameters in heart failure patients using current echo-Doppler modalities and we analyzed their association with electrical dyssynchrony. METHODS: The study included 120 heart failure with reduced ejection fraction (HFrEF) who underwent assessments for left ventricular mechanical dyssynchrony (LVMD) and interventricular mechanical dyssynchrony (IVMD). RESULTS: Patients were classified according to QRS duration: group I with QRS < 120 ms, group II with QRS 120-149 ms, and group III with QRS ≥ 150 ms. Group III had significantly higher IVMD, LVMD indices, TS-SD speckle-tracking echocardiography (STE) 12 segments (standard deviation of time to peak longitudinal strain speckle tracking echocardiography in 12 LV-segments), and LVMD score compared with group I and group II. Group II and group III were classified according to QRS morphology into left bundle branch block (LBBB) and non-LBBB subgroups. LVMD score, TS-SD 12 TDI, and TS-SD 12 STE had good correlations with QRS duration. CONCLUSIONS: HFrEF patients with wide QRS duration (> 150 ms) had more evident LVMD compared with patients with narrow or intermediate QRS. Those patients with intermediate QRS duration (120-150 ms) had substantial LVMD assessed by both TDI and 2D STE, regardless of QRS morphology. Subsequently, we suggest that LVMD indices might be employed as additive criteria to predict CRT response in that patient subgroup. Electrical and mechanical dyssynchrony were strongly correlated in HFrEF patients.

• Journal of the Korea Safety Management & Science
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• v.6 no.1
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• pp.61-70
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• 2004

In this paper, a group replacement policy based on a failure count is analysed. For a group of identical repairable units, a maintenance policy is performed with two phase considerations: a repair interval phase and a waiting interval phase. Each unit undergoes minimal repair at failure during the repair interval. Beyond the interval, no repair is made until a number of failures. The expected cost rate expressions under the policy is derived. A method to obtain the optimal values of decision variables are explored. Numerical examples are given to demonstrate the results.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.660-670
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• 2009

Neighboring construction becomes mainstream of Ground excavation in downtown area. This causes the displacement, deformation, stress condition, etc of the ground surroundings. Therefore Neighboring construction have an effect on Neighboring structure. All these years a lot of Neighboring construction carried out, and the accumulation of technology also get accomplished. But earth retaining structure collapse happens yet. Types of earth retaining structure collapse are 12. 1. Failure of anchor or strut system, 2. Insufficiency of penetration, 3. H-pile Failure on excessive bending moment, 4. Slope sliding failure, 5. Excessive settlement of the back, 6. Deflection of H-pile, 7. Joint failure of coupled H-pile, 8. Rock failure when H-pile penetration is rock mass, 9. Plane arrangement of support systems are mechanically weak, 10. Boiling, 11. Heaving, 12. Over excavation. But field collapses are difficult for classification according to the type, because collapse process are complex with various types. When we consider the 12 collapse field, insufficient recognition of ground condition is 4 case. Thorough construction management prevents from fault construction. For limitations of soil survey, It is difficult to estimate ground condition exactly. Therefore, it should estimate the safety of earth retaining system, plan for necessary reinforcement, according to measurement and observation continuously.

• Korean Journal of Acupuncture
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• v.22 no.4
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• pp.117-127
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• 2005

Objective : This study was undertaken to determine if Plantaginis Semen herbal acupuncture(PSA) has a protective effect on glycerol-induced acute renal failure in rats. Methods : Rats were dehydrated for 24hr and then injected with 4 ml/kg of 50% glycerol in each hindlimb muscle. In experiments for PSA effect, rats were received 0.1 ml of PSA extraction in both sides of corresponding $Sh\grave{e}nsh\bar{u}(BL_{23})$ of human body for 3 days after injection of glycerol. The experimental group were divided into the normal group, the control group, the sample 1,2,3 group. Results : Glycerol injection decreased glomerular filtration rate and increased urine volume, serum creatinine, BUN level and fractional excretion of $Na^+,\;K^+\;and\;Cl^-$. These results show that glycerol injection bring about acute renal failure. PSA significantly increased glomerular filtration rate and significantly decreased serum creatinine, BUN level and fractional excretion of $Na^+,\;and\;Cl^-$ as compared with control group. Conclusion : These results suggest that PSA can be used in prevention and treatment for acute renal failure. However, the precise mechanisms of PSA protection remain to be determined.