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Vitamin D Levels in Patients with Breast Cancer: Importance of Dressing Style

  • Alco, Gul;Igdem, Sefik;Dincer, Maktav;Ozmen, Vahit;Saglam, Sezer;Selamoglu, Derya;Erdogan, Zeynep;Ordu, Cetin;Pilanci, Kezban Nur;Bozdogan, Atilla;Yenice, Sedef;Tecimer, Coskun;Demir, Gokhan;Koksal, Gulistan;Okkan, Sait
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.3
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    • pp.1357-1362
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    • 2014
  • Background: Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer (BC) prevention. It may also be related to prognosis after diagnosis and treatment. The aim of our study was to determine the prevalence of vitamin D deficiency as measured by serum 25-hydroxy vitamin D (25-OHD) levels in patients with BC and to evaluate its correlations with life-style and treatments. Materials and Methods: This study included 186 patients with stage 0-III BC treated in our breast center between 2010-2013. The correlation between serum baseline 25-OHD levels and supplement usage, age, menopausal status, diabetes mellitus, usage of bisphosphonates, body-mass index (BMI), season, dressing style, administration of systemic treatments and radiotherapy were investigated. The distribution of serum 25-OHD levels was categorized as deficient (<10ng/ml), insufficient (10-24 ng/ml), and sufficient (25-80 ng/ml). Results: The median age of the patients was 51 years (range: 27-79 years) and 70% of them had deficient/insufficient 25-OHD levels. On univariate analysis, vitamin D deficiency/insufficiency was more common in patients with none or low dose vitamin D supplementation at the baseline, high BMI (${\geq}25$), no bisphosphonate usage, and a conservative dressing style. On multivariate analysis, none or low dose vitamin D supplementation, and decreased sun-exposure due to a conservative dressing style were found as independent factors increasing risk of vitamin D deficiency/insufficiency 28.7 (p=0.002) and 13.4 (p=0.003) fold, respectively. Conclusions: The prevalence of serum 25-OHD deficiency/insufficiency is high in our BC survivors. Vitamin D status should be routinely evaluated for all women, especially those with a conservative dressing style, as part of regular preventive care, and they should take supplemental vitamin D.

Evaluation of Treatment Outcomes of Early-Stage Endometrial Cancer Radiotherapy: A Single Center Experience

  • Demiral, S.;Beyzadeoglu, M.;Sager, O.;Dincoglan, F.;Uysal, B.;Gamsiz, H.;Akin, M.;Turker, T.;Dirican, B.
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.22
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    • pp.9599-9602
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    • 2014
  • Background: Postoperative adjuvant radiotherapy (RT) in the management of early stage endometrial cancer (EC) is still controversial. Here we report our institutional experience with patients who received postoperative RT for stage I-II EC over a period of 35 years and assess potential predictors of local recurrence (LR), distant metastasis (DM), and overall survival (OS). Materials and Methods: A total of 188 patients undergoing postoperative RT for stage IA-II EC between 1977 and 2012 were evaluated. Some 96 received median 46 Gy whole pelvic radiotherapy (WPRT) (range: 40-60 Gy), 37 were given WPRT with vaginal cuff therapy (VCT), and 55 received only VCT either with brachytherapy (BT) or stereotactic body radiotherapy (SBRT). Chemotherapy was given to 5 patients with uterine papillary serous carcinoma (UPSC). Logistic regression analysis was used to assess the effect of clinicopathological factors on LR, DM, and OS. Results: Median follow-up time was 11 years (range: 1-35 years). At the time of analysis, 34 patients were not alive. Of the 15 patients with LR, 7 (46.7%) recurred in the vaginal stump, 5 (33.3%) in the pelvic region, and 3 (20%) in the paraaortic nodal region, while 12 had distant metastasis. UPSC histology (p=0.027), sole VCT (p=0.041), high histologic grade (p=0.034), and age ${\geq}71$ (p=0.04) were poor prognostic factors on univariate analysis. Conclusions: In our patients receiving radiotherapy for early-stage EC, grade III disease and age ${\geq}71$ were associated with shorter OS whereas UPSC histology was an independent predictor for both LR and DM.

Correlation between TOC and Water Pollution Index in Major Streams of Gwangju (광주지역 주요하천에서 TOC 특성과 수질오염지표와의 상관성에 관한 연구)

  • Yang, Yoon-Cheol;Lee, Dae-Haeng;Lee, Kyung-Seog;An, Sang-Su;Song, Hyeong-Myeong;Lee, Se-Haeng;Yoon, Sang-Hoon;Kim, Sun-Jung;Jeon, Hong-Dae;Cho, Young-Gwan;Seo, Gwang-Yeob
    • Journal of Korean Society on Water Environment
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    • v.33 no.2
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    • pp.203-210
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    • 2017
  • This study was performed to verify the replacement of COD to TOC, which is more accurate and reliable in analysis, as the water quality pollution index and to investigate the characteristics of water quality and the correlations for organic matter, suspended solids and nutrient materials during 2012 to 2015. The oxidation rates were compared by calculating the values of BOD-C/TOC & COD-C/TOC. The average value of TOC was 3.4(1.1 ~ 8.0) mg/L at 14 sites during the period. The ratios of BOD-C/TOC and COD-C/TOC, that mean the resolvability amounts among all carbon materials, were 28.8% and 62.7%, respectively. The correlation coefficient of TOC to COD at all sites was 0.718 (p<0.01), the highest value in comparing all items. The correlation coefficient of TOC to COD at Gwangju stream was 0.753 (p<0.01), the highest compare to the values at other rivers. The correlation coefficient of TOC to COD was 0.757 (p<0.01) at all sites in the range of TP-III ($0.1{\leq}TP$) and the value was 0.762 (p<0.01) in the range of TN-II ($2.0{\leq}TN$<3.0). As a result, TOC could be used as a water pollution index of organic matter instead of COD.

Variation Pattern of mtDNA among Six Subspecies of Apodemus agrarius(Mammalia, Rodentia) in Korea, China, and Russia (한국, 중국, 러시아에 서식하는 등줄쥐, Apodemus agrarius(포유강, 설치목), 6아종의 미토콘도리아 DNA 절단단편의 변이)

  • 고흥선;안용철;유정원;이우재
    • Animal Systematics, Evolution and Diversity
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    • v.15 no.2
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    • pp.153-164
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    • 1999
  • One hundred and eleven samples of six subspecies of striped field mouse, Apodemus agrarius Pallas from Korea, China and Russia, were used for the analysis of mitochondrial DNA(mtDNA) fragment patterns resulted from the digestion with eight restriction enzymes by blot hybridization technique. All 32 fragments, nine mtDNA haplotypes, and four major subgroups with the mean divergence value of 0.896 to 1.150% were revealed. In summary, three forms are recognized: [I, subspecies chejuensis (Chejudo island, Korea)], [II, subspecies pallescens (southwestern Korea), coreae (central Korea), and septentrionalis (Russia)], and [III, subspecies manchuricus (northeastern China) and pallidior (northern China)], although some samples of subspecies coreae are somewhat different from almost all samples of six subspecies, and some samples of subspecies pallidior are similar with all samples of subspecies septentrionalis to form same haplotype. It is confirmed that A. agrarius chejuensis is a distinct subspecies, that subspecies coreae (including pallescens) is also a distinct subspecies, that subspecies manchuricus and pallidior are synonyms of subspecies ningpoensis, and that subspecies septentrionalis is a synonym of subspecies ningpoensis, and that subspecies septentrionalis is a synonym of subspecies agrarius. Moreover, it seems that A. agrarius shows constant karyotype, minimal variation in mtDNA genotype, and considerable divergence in morphometric characters, although further analyses with additional samples of A. agrarius in Eurasia will be necessary to determine the degree of variation of these taxonomic characters and to clarify subspecies classification as well.

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Intrapecific Relationship of Rehmannia glutinosa Lines Collected from Korea, Japan and China by RAPD Analysis (RAPD 방법을 이용한 국내외 수집 지황(地黃)의 유연 관계 분석)

  • Kim, Jong-Yeob;Choi, Sun-Young;Choo, Beng-Gil;Ryu, Jeom-Ho;Kwon, Tae-Ho;Oh, Dong-Hun
    • Korean Journal of Medicinal Crop Science
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    • v.8 no.3
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    • pp.266-273
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    • 2000
  • The optimal conditions of PCR components for the random amplification of genomic DNA were $20\;ng/20{\mu}l$ in template DNAs, 250 mM in dNTP, 10 pM in primer $1.0unit/20{\mu}l$ in Taq DNA polymerase respectively with the annealing temperature at $36^{\circ}C$, respectively. Twelve local lines were divided into 3 groups by the coefficients of 107 polymophic bands by Jaccard and Nei. The coefficients value of group I including Chongup # 1, Seochon # 1, Andong # 1, Chinan # 1, and Danyang # 1 ranged from 0.27 to 0.05 and those of group II including Suwon # 2, Chunchon # 1, Japan # 3, Danyang#2 and $F_1$ (Variety Jihwang $1{\times}$ Seohchon) ranged from 0.29 to 0.11. While, Jihwang 1 originated from China and Japan # 1 in group III showed a distant genetic relationship to Korean local lines.

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Evaluation of friction of esthetic brackets according to different bracket-wire angulations (심미 브라켓의 종류와 브라켓-호선 각도에 따른 마찰 저항에 대한 연구)

  • Je, Young-Ji;Chang, Minn-Hii;Lim, Yong-Kyu;Lee, Dong-Yul
    • The korean journal of orthodontics
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    • v.37 no.5
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    • pp.341-350
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    • 2007
  • The purpose of this study was to evaluate how the friction that occurs during the sliding movement of the archwire through esthetic brackets is differently affected by bracket materials, slot designs, and tip angulations of the archwire. Methods: Eight types of brackets with 0.018 inch slots (composite: Brillant (BR); composite with metal slot: Spirit MB (SP); ceramic: Inspire (IN), Signature (SI), Cristaline V (CR); ceramic with metal slot: Clarity (CL), Luxi II (LU); and metal bracket: Integra (IT)), and placed into groups of 20 brackets in each group, were tested in artificial saliva with 0.018 inch stainless steel wire. The wire tip angulations were given as 0, 4 and 8 degrees. Results: CR group significantly showed the lowest frictional force with all wire tip angulations of 0,4, and 8 degrees. IN significantly showed the highest frictional force (p < 0.001). BR (polyoxymethylene) had significantly less frictional force than SP (polycarbonate) (p < 0.001) and showed no significant difference between metal brackets. Friction was increased as the wire tip angulations were increased, but no notches were observed on any parts of the archwire. Conclusions: According to the results of this study, esthetic brackets are superior or similar to 55 brackets from a frictional point of view.

A Study on the Urban Growth Change using Satellite Imagery Data (위성영상자료를 활용한 도시성장변화에 관한 연구)

  • Kim, Yoon-Soo;Kim, Jung-Hwan;Jung, Eung-Ho;Ryu, Ji-Won
    • Journal of the Korean Association of Geographic Information Studies
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    • v.5 no.2
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    • pp.81-90
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    • 2002
  • Remote Sensing has been very useful tool in monitoring of cities and updating of GIS database compare to traditional methods due to its benefit; wide range covering on low cost and advanced data collection. However it had come to a limited method in limited researches because of its relatively poor spatial resolution in scanning. Recently launched satellites are able to produce improved imageries, and new commercial services have been commenced for the use of general public with higher spatial resolution up to $1m{\times}1m$. This study tackled a potential use of these improved satellite imageries in urban planning based on the Multi-temporal satellite imagery with particular reference to monitoring on urban areas, for example urbanization and its expanding. i) Portion of individual features and elements in each pixel of satellite imagery was computed based on 'Endmember' of targeted elements. ii) Urbanized areas were categorized based on the 'Fraction imagery' derived from the 'SMA algorithm'. iii) Alterations and expanding of urban areas were identified based on the Multi-temporal satellite imageries. Tested method showed a strong potential to produce more advanced monitoring skills of urban areas.

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A Study on Technology Transfer in IT Industry (IT 산업계의 기술이전에 관한 연구)

  • Sung, Tae-Kyung
    • Management & Information Systems Review
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    • v.28 no.3
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    • pp.45-68
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    • 2009
  • The Korean government is actively pursuing an ambitious IT strategy to establish Korea as one of the leaders in the world IT market. To implement the strategy, successful technology transfer from research institutions to market should be achieved. Comprehensive literature identifies sixteen variables affecting the process and results of technology transfer. The research results in four key factors in technology transfer: Communication, Distance, Equivocality, and Motivation. Communication refers to the degree to which a medium is able to efficiently and accurately conveys task-relevant information and media while distance involves both physical and cultural proximity. Equivocality refers to the degree of concreteness of technology to be transferred while motivation involves incentives for and the recognition of the importance of technology transfer activities. Further analysis shows that there are four distinctive clusters and they show very contrasting characteristics in terms of four key factors. The careful mapping of the four clusters on the four key factors show very informative technology transfer patterns, the Technology Transfer Grid.

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Predictive Factors of Ectopic Eruption of the Maxillary First Permanent Molar (상악 제1대구치 이소 맹출의 예측 인자)

  • Sun, Jimin;Nam, Okhyung;Kim, Misun;Lee, Hyoseol;Choi, Sungchul
    • Journal of the korean academy of Pediatric Dentistry
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    • v.43 no.3
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    • pp.284-291
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    • 2016
  • In order to provide a diagnostic basis for predicting the possibility of the self-correction of ectopic first permanent molars, differences among normal eruption, reversible and irreversible ectopic eruption of maxillary first permanent molars were retrospectively analyzed. The angles of the long axes and the occlusal lines between the maxillary first permanent molar and the adjacent tooth were measured by panoramic radiographs. The occlusal relationship of second primary molars was also investigated. There is a statistically significant difference between the ectopic eruption group and normal group (p < 0.05), but not between the reversible and irreversible ectopic eruption groups (p > 0.05). The angles between the second primary molar and the first permanent molar, the second primary molar and the second permanent molar in ectopic groups showed a smaller degree than those of the control group. Mesial step was found more frequently in the ectopic eruption group than the normal group. In conclusion, the angulation of the first permanent molar and tooth germ of the maxillary second permanent molar showed close relation with ectopic eruption of the maxillary first permanent molar and ectopic first permanent molar is likely to occur in class III patients with maxillary deficiency.

The Effect of STS Instruction through Science to Enhance Hypothetical Deductive Thinking Skills for Creativity - Water Section of Chemistry I (창의성의 기저가 되는 가설 연역적 사고력 신장을 고려한 과학 교수인 STS 수업 전략의 효과 - 과학 I의 물 단원)

  • Kang, Soon-Hee;Kim, Eun-Sook
    • Journal of The Korean Association For Science Education
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    • v.25 no.3
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    • pp.327-335
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    • 2005
  • This study investigates student achievement and science-related attitudes on STS hypothetical deductive instruction strategy in the water section of high school chemistry. Two 11th grade co-ed high school classes participated in the study; one control group and one treatment group. After being taught for 10 class periods during the second semester. ANCOVA analysis revealled no significant difference (p>.05) between two groups' achievement tests. However, analysis by ANCOVA did show that the scores for science-related attitudes in the treatment group were significantly higher than those of the control group (p<.05). In particular, the scores of science learning contents and science value about science-related attitude were significantly higher in the treatment group.