Background: There is an urgent need to find reliable and rapid bovine tuberculosis (bTB) diagnostics in response to the rising prevalence of bTB worldwide. Toll-like receptor 2 (TLR2) recognizes components of bTB and initiates antigen-presenting cells to mediate humoral immunity. Evaluating the affinity of antigens with TLR2 can form the basis of a new method for the diagnosis of bTB based on humoral immunity. Objectives: To develop a reliable and rapid strategy to improve diagnostic tools for bTB. Methods: In this study, we expressed and purified the sixteen bTB-specific recombinant proteins in Escherichia coli. The two antigenic proteins, MPT70 and MPT83, which were most valuable for serological diagnosis of bTB were screened. Molecular docking technology was used to analyze the affinity of MPT70, MPT83, dominant epitope peptide of MPT70 (M1), and dominant epitope peptide MPT83 (M2) with TLR2, combined with the detection results of enzyme-linked immunosorbent assay to evaluate the molecular docking effect. Results: The results showed that interaction surface Cα-atom root mean square deviation of proteins (M1, M2, MPT70, MPT83)-TLR2 protein are less than 2.5 A, showing a high affinity. It is verified by clinical serum samples that MPT70, MPT83, MPT70-MPT83 showed good diagnostic potential for the detection of anti-bTB IgG and M1, M2 can replace the whole protein as the detection antigen. Conclusions: Molecular docking to evaluate the affinity of bTB protein and TLR2 combined with ELISA provides new insights for the diagnosis of bTB.
Journal of the Korean Society of Industry Convergence
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v.25
no.6_3
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pp.1183-1190
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2022
Recently, the Ministry of Strategy and Finance announced a plan to reduce the proportion of economic evaluation in non-metropolitan areas and strengthen balanced development evaluation through the reorganization of the preliminary feasibility study system. In addition, the social value of the quality of life, such as job, environment, and safety, which may be affected by the implementation of transportation facility investment projects, was reflected as the main item of policy evaluation. In this study, the ripple effect of the project in terms of social value was reviewed for the Gangil-Chuncheon. The effect of highway opening was investigated by reviewing the feasibility report, post-evaluation report, and statistical indicators. Recently, the Gangil-Chuncheon highway is getting used by around 110,000 people per day. The number of tourists in Chuncheon rapidly has increased from 5 million a year to more than 11 million now. In addition, it was confirmed to produce effects such as population migration, net inflow and land price increase, improvement of living convenience, and expansion of emergency medical care. Although this ripple effect was influenced by various socio-economic factors as well as the opening of the highway, it is clear that it is difficult to occur without the opening of the highway. It is judged that the evaluation of indirect benefits and social values due to the opening of the highway can be quantified through continuous research and data construction. Post-evaluation of construction works, including project efficiency evaluation and ripple effect evaluation, is performed for construction works with a construction cost of more than 50 billion won. In the future, we will continuously improve the evaluation system in order to evaluate the indirect benefits and social values of public investment projects.
Journal of Information Technology Applications and Management
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v.29
no.3
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pp.1-23
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2022
This study is about the change in the importance of shopping value for beauty products of social commerce due to the social crisis or risk caused by COVID-19. It was analyzed focusing on whether the importance of shopping value changed before and after COVID-19. We checked the importance of shopping value after COVID-19 through the AHP results of previous papers before COVID-19, and analyzed the importance by adding variables of risk reduction behavior and delivery convenience according to the situation of COVID-19. The AHP method was used to check the change in the importance of shopping value before and after COVID-19, and the study was conducted using 48 data. The results were as follows. As for the importance of shopping value of social commerce beauty products, it was ranked in the order of time convenience, convenience of delivery, third-ranked trust business operators, fourth-ranked economic aspects, fifth-ranked decision support, sixth-ranked risk reduction behavior, and seventh-ranked business reputation. Compared to previous studies, decision-making support, which was in the second place, fell to the fifth place. This result was confirmed to be a drop in ranking due to the improvement of delivery convenience due to the influence of COVID-19. In addition, in the case of beauty products, it was confirmed that risk reduction behavior related to COVID-19 infection is not a key factor in shopping value. These results confirmed changes in the importance of shopping value compared to pre-COVID-19 studies, and in the case of product groups other than beauty products, further studies are expected as there is a possibility of other results.
Background: The application of Kinesio tape (KT) has become an alternative treatment for the reduction of edema owing to its distinct characteristics that mimic skin behavior. Although many studies have found that KT application has a positive effect on edema related to breast cancer and rehabilitation following mandibular third molar surgery, there is little evidence to support the use of KT for musculoskeletal injuries. Objects: The purpose of this study was to review the literature related to KT application for reducing edema caused by musculoskeletal disorders. Methods: A literature search (July 2022) was performed on PubMed for articles published between January 2012 and June 2022. The following keywords were used: "Kinesio taping," "Kinesio tape," "swelling," and "edema," with different combinations and derivations. Only articles available in English were included in this study. Results: Among 68 identified studies, seven met our search strategy and criteria and were included in the literature review. Five of these studies investigated musculoskeletal disorders of the knee joint; two of them reported that KT application had a positive effect on edema measured using perimetry following total knee replacement and anterior cruciate ligament reconstruction. However, the KT application did not improve swelling in patients with acute lateral ankle sprains. Pediatric patients with acute proximal phalangeal joint sprain experienced a more significant improvement in the reduction of swelling than the group using a splint. Conclusion: This literature review found discrepant evidence to support using KT for edema control in musculoskeletal disorders. Further research is needed to determine the effectiveness of KT for controlling edema following musculoskeletal injuries.
Journal of Information Technology Applications and Management
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v.28
no.6
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pp.97-116
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2021
Due to the decrease in the school-age population and government regulations, universities have made great efforts to secure their own competitiveness. In particular, the selection of universities with financial support based on the recent evaluation of the Ministry of Education has become a major concern enough to affect the existence of the university itself. This paper extracts three-year data from 124 major private universities nationwide, and quantitatively analyzes the variables of major universities selected as self-improvement universities, competency reinforcement universities, and universities with limited financial support. As a result of estimating the selection of self-powered universities using the ordered logit model by hierarchically inputting 12 variables, student competitiveness in the metropolitan area (1.318**), Educational Restitution Rate (4.078***), University operation expenditure index rate (1.088***) values were found. Significant positive coefficient values were found in the admission enrollment rate (45.98***) and the enrollment rate (13.25***). As a result of analyzing the marginal effects, the increase in the rate of reduction of education costs has always been positive in the selection of self-powered universities, but it was observed that the rate of increase decreases in areas of increase of 150% or more. On the contrary, the probability of becoming a Em-powered university was negative in all sectors, but on the contrary, it was analyzed that marginal effects increased at the same time point. On the other hand, the employment rate of graduates was not able to find direct significance with the result of the selection of Self powered universities. Through this paper, it is expected that each university will analyze the possibility and shortcomings of the selection of Self powered universities in policy making, and in particular, the risk of dropout of selection for the vulnerable field can be predicted using marginal effects. It can be used as major research data for both university evaluators, university officials and students.
This study was performed to understand the meaning and essence of class experience of nursing students in the post-COVID 19 age. The participants in this study were 10 enrolled students from freshman to senior students who experienced the face-to-face and contactless classes during four semesters after the COVID-19 pandemic. The data collection period was from December 9 to December 30, 2021. The collected data was analyzed by applying the Colaizzi method. According to the study result, 25 themes, 13 collections of the themes, and six categories were drawn. The six categories were as follows: vagueness of the future, Lack of confidence in nursing practice, Class system stabilization, Acceptance and adaptation of situations, Have a sense of vocational calling as a pre-registration nurses, Finding the direction to improvement of contactless classes. The nursing students' understanding of class experience at present two years after the outbreak of COVID-19 can be used as basic data to seek future educational direction strategy and enhance future education quality.
Seo Yeon Hong;Hwi Jong Yi;Young Nam Yoon;Yun Woo Jang;Ki Do Park;Rameswor Maharjan
KOREAN JOURNAL OF CROP SCIENCE
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v.67
no.4
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pp.285-295
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2022
The trapping efficacy of five commercially available sex pheromones manufactured in Korea, the Netherlands, North America, China, and Costa Rica was evaluated to determine the population dynamics of Spodoptera frugiperda and Mythimna loreyi and their relationships with the weather parameters of maize fields in Miryang, Gyeongnam Province, Korea in 2019. The results show that the sex pheromone manufactured in Costa Rica were more efficient at capturing S. frugiperda and M. loreyi than those manufactured in other countries. The lowest number of S. frugiperda moths were captured using sex pheromones manufactured in the Netherlands. We noted that more than four population peaks of both the moth species and weather parameters influenced the moth population dynamics in Miryang. A positive relationship was observed between the population of S. frugiperda and weather parameters, such as mean temperature, rainfall, and relative humidity, for sex pheromones manufactured in Korea. Furthermore, a positive relationship was recorded between the population of M. loreyi and wind speed for the sex pheromone manufactured in Korea. The results of this study suggest that the sex pheromones manufactured in Costa Rica are the best solution for the efficient capture of S. frugiperda and M. loreyi under typical weather conditions in the southern parts of Korea. In addition, the outcomes of this study are discussed in terms of population dynamics and integrated pest management for S. frugiperda and M. loreyi as alternatives to chemical management by maize producers. Further studies related to the continuous improvement in the capture efficiency of both moth species using sex pheromones are now needed.
Purpose: This study aimed to examine the mediating effects of clinical nurses' job crafting on organizational effectiveness based on the job demands-resources model proposed by Bakker and Demerouti (2017). Methods: The participants consisted of 393 nurses working in nursing units of a tertiary general hospital located in Cheongju region. The data, collected using questionnaire from August 9 to August 20, 2021, were analyzed using SPSS 23.0 and AMOS 27.0. Results: The goodness-of-fit (GoF) test results on the modified model (χ2 = 2.7, GFI = .94, SRMR = .03, RMSEA = .06, NFI = .92, CFI = .94, TLI = .92, AGFI = .90), indicated that the GoF index satisfied the recommended level. Regarding the effects of each variable on organizational effectiveness, job crafting showed statistically significant direct (β = .48, p < .001), indirect (β = .23, p < .001), and total effects (β = .71, p < .001). Burnout showed statistically significant direct effect (β = - .17, p < .001). Work engagement showed statistically significant direct (β = .41, p < .001) and total effects (β = .41, p < .001). The factors explaining organizational effectiveness were job crafting, burnout, and work engagement, which had an explanatory power of 76.7%. Conclusion: Nurses' job crafting is an important mediating factor for enhancing the organizational effectiveness of nursing organizations. Hospitals should develop job-crafting success cases and related education and training programs as a strategy for enhancing the job crafting of nurses and, consequently organizational effectiveness.
This paper aims to confirm the necessity of the consignment system in Korea's trucking market for the purpose of analyzing the difference in perception between the transportation company and the consignment owner to provide a basis for continuous development of the cargo transportation business. A survey was conducted on the current status of the domestic transportation market with transportation companies and consignment owners, and the perceptions between the two were compared and analyzed. Overall, satisfaction with the consignment system was in the order of transportation companies handling supplies, transportation companies that did not pay supplies, consignment owners belonging to supply companies, and consignment orders belonging to non-volume companies. Similar results were obtained in individual questions. In order for transport companies and consignment owners to coexist and develop in the freight car transport market, it will be necessary to prepare a strategy to increase the satisfaction of consignment owners belonging to transport companies that do not handle relatively low-satisfaction.
Journal of Korea Society of Industrial Information Systems
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v.14
no.5
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pp.257-270
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2009
In the ways of coping with the rapidly changing environment, the information technology is recognized a critical factor in order to rethink the effectiveness of business management, and enterprise resource planning(ERP) system has emerged as an essential method for strengthening the competitiveness on the strategic level. This empirical study has revealed the following. First, well-organized system management and the strong will and leadership of top management have significantly positive influence on the reduction of cost and time. Second, system management, users' participation, and the strong will and leadership of top management have significantly positive influence on the improvement of management and informational environment. It also proposes the guidelines of how to establish an ERP system successfully in the public enterprises.
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