• International Journal of Quality Innovation
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• v.7 no.2
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• pp.50-68
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• 2006

Innovation fuels organizations evolving them to withstand rapid changes in markets and challenges from competition. While diversified concepts of innovation are examined, a generic framework for managing organizational innovation is established to portray the notion in a methodical approach. Substantiation of the determinants for organizational innovation is carried out in order to examine the framework against the practical situation. Subsequently, expectations and actual accomplishments of the determinants for organizational innovation from the industry are determined so as to understand the industrial view towards the framework. This paper summarizes the empirical findings of a survey of organizational innovation with a sample of 208 electronic and electrical manufacturing companies in the Greater Pearl River Delta (GPRD), China. On one hand, the survey findings confirm the readiness of the generic framework from the practical perspective of the industry. On the other hand, rankings are obtained for the expected importance and company accomplishment of the determinants for organizational innovation, namely in the areas of management leadership and commitment, employee capability and attitude and strategy development for innovation. The improvement area is also verified by the shortcomings of the expectation in comparison to the company accomplishment in each determinant. Meanwhile, it is believed that a directional attitude towards the determinants can facilitate the accomplishment of the determinants of organizational innovation. Further results will be generated from a more in-depth analysis of variables. The confirmed framework will be further developed into an assessment system for organizational innovation with the support of best practices in each determinant.

• Toxicological Research
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• v.33 no.4
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• pp.343-350
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• 2017

Lamivudine belongs to the set of antiviral agents effective against hepatitis B virus infection. Given case reports on liver injuries after certain antiviral agent treatments, this study examined the effects of lamivudine on alanine aminotransferase (ALT) and total bilirubin (TB) using a medical system database. A total of 1,321 patients taking lamivudine alone or with others were evaluated using laboratory hits in an electronic medical system at Seoul National University Hospital from 2005 through 2011. The patients were grouped according to prior ALT results: G#1, ALT < 40 IU/L; G#2, 40 IU/L ${\leq}$ ALT < 120 IU/L; G#3, 120 IU/L ${\leq}$ ALT < 240 IU/L; and G#4, ALT ${\geq}$ 240 IU/L. In G#1 and G#2 patients, lamivudine or adefovir treatment decreased ALT and TB compared to prior values. In G#3 and G#4 patients with three times the upper limit of normal (ULN) ${\leq}$ ALT < 15 times the ULN, both ALT and TB were decreased after treatment with lamivudine alone, or adefovir following lamivudine therapy, indicating that lamivudine therapy ameliorated liver functions. However, in G#4 patients who experienced severely advanced hepatitis (ALT ${\geq}$ 15 times the ULN, or ${\geq}$ 600 IU/L), lamivudine augmented TBmax ($6.3{\rightarrow}13.3mg/dL$) despite a slight improvement in ALT ($839{\rightarrow}783IU/L$), indicative of exacerbation of bilirubinemia. Patients who used adefovir after lamivudine also showed a high incidence of hyperbilirubinemia when they experienced severely advanced hepatitis. Treatment with adefovir alone did not show the effect. In conclusion, lamivudine may increase the risk of hyperbilirubinemia in patients with severely advanced hepatitis, implying that caution should be exercised when using lamivudine therapy in certain patient populations.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.140-148
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• 2017

Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical, and an immunological view has been suggested as a novel strategy, because hyperlipidemia is closely associated with inflammation and immune dysfunction. In this study, the effects of an aqueous extract of Rubus occidentalis (RO) in obese mice were investigated using immunological indexes. The mice were fed a high-fat diet (HFD) to induce hyperlipidemia, which was confirmed by biochemical analysis and examination of the mouse physiology. Two different doses of RO and rosuvastatin, a cholesterol synthesis inhibitor used as a control, were orally administered. Disturbances in immune cellularity as well as lymphocyte proliferation and cytokine production were significantly normalized by oral administration of RO, which also decreased the elevated serum tumor necrosis factor $(TNF)-{\alpha}$ level and total cholesterol. The specific immune-related actions of RO comprised considerable improvement in cytotoxic T cell killing functions and regulation of antibody production to within the normal range. The immunological evidence confirms the significant cholesterol-lowering effect of RO, suggesting its potential as a novel therapeutic agent for hyperlipidemia and associated immune decline.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.748-753
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• 2005

Among processes to manufacture parts from footwear materials like upper leathers, one of the most essential processes is the cutting one optimally arranging lots of parts on raw footwear materials and cutting. A new nesting strategy was proposed for the 2-dimensional part layout by using a two-stage approach, where which can be effectively used for water jet cutting. In the initial layout stage, a SOAL(Self-Organization Assisted Layout) based on the combination of FCM(Fuzzy C-Means) and SOM was adopted. In the layout improvement stage, SA(Simulated Annealing) based approach was adopted for a finer layout. The proposed approach saves much CPU time through a two-stage approach scheme, while other annealing-based algorithm so far reported fur a nesting problem are computationally expensive. The proposed nesting approach uses the stochastic process, and has a much higher possibility to obtain a global solution than the deterministic searching technique. We developed the automatic nesting software of NST(ver.1.1) software for footwear industry by implementing of these proposed algorithms. The NST software was applied by the optimized automatic arrangement algorithm to cut without the loss of leathers. if possible, after detecting damage areas. Also, NST software can consider about several features in not only natural loathers but artificial ones. Lastly, the NST software can reduce a required time to implement generation of NC code. cutting time, and waste of raw materials because the NST software automatically performs parts arrangement, cutting paths generation and finally NC code generation, which are needed much effect and time to generate them manually.

• The Korean Journal of Health Service Management
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• v.13 no.4
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• pp.215-228
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• 2019

Objectives: The purpose of this study is to figure out that Facilitation education can affect significant improvement in sales staff's understanding of precise pharmacokinetics, benefits, safety, and side effects, etc. and eventually lead to increase in call after taking courses. Methods: Data utilized in this study was collected from 413 sales staffs who completed Facilitation course for 5 months. This study used statistical methodologies, paired t-test, exploratory factor analysis, and logistic regression model in order to identify change in Call and after Facilitation courses. Results: The result shows that there are statistically significant increases in CALL quality after Facilitation courses based on the result of pared t-test. Moreover, Facilitation education is more effective in average time of one-time detail than average number of visits per day and average number of doctors per day from the result of logistic regression. Conclusions: In order for MR in pharmaceutical company to improve CALL quality, the education for precise pharmacokinetics, benefits, safety, and side effects is necessary. In addition, various professional training required for detail, including disease education, Selling Skills education, and literacy education are essential. Therefore, Facilitation education would be desirable choice in terms of pharmaceutical marketing strategy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.711-717
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• 2017

Startability and harmful emissions are the main issues in diesel engine development under cold conditions. The characteristics of combustion with multiple injection were investigated under cold start conditions. For quantitative analysis, the in-chamber pressure profile was measured and combustion visualization using direct imaging was accomplished. With multiple injection, the peak in-chamber pressure and heat release rate were increased compared to single injection. In addition, the period of flame luminosity detection was shortened using multiple injection. Combustion by main injection was improved with an increase in heat released by pilot combustion when the pilot injection quantity was increased. Finally, an increase in injection pressure also showed the possibility of combustion improvement. On the other hand, an increase of in the pilot injection quantity and injection pressure can cause an increase in harmful emissions, such as HC and CO due to wall wetting. Therefore, more sensitive calibration will be needed when applying a multiple injection strategy under cold start conditions.

• Journal of Drive and Control
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• v.10 no.4
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• pp.1-6
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• 2013

With aggravation of environmental contamination and energy resource exhaustion, Hybrid Electric Vehicles (HEV) that can be economically operated with low fuel consumption are receiving greater attention. For performance improvement of such HEV, the development of efficient transmission can be seen as one of core technologies such as performance of components and driving strategy. Dual clutch transmission (DCT) is actively studied as a transmission type for HEV due to its advantages of having excellent power transmission efficiency based on manual transmission characteristic, resolving the problem of power interruption, and realizing driving convenience of automatic transmission (AT). In this paper, one diesel HEV equipped with 6-Speed DCT, modelled using MATLAB/Simulink, and a performance simulator developed for this vehicle are introduced. Driving simulation with driving cycles such as FTP75 and NYCC was performed using the developed performance simulator, and the simulated results regarding state of charge and fuel economy, when AT and DCT are applied to this diesel hybrid vehicle respectively, are compared. This performance simulator can be utilized to develop a control algorithm for improving the fuel economy of HEV with DCT.

• Journal of agriculture & life science
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• v.45 no.6
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• pp.33-40
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• 2011

The purpose of this research is to seek political implications for management and activation of National Forest Complex Management(NFCM). Survey method was utilized for workers as respondents to measure importance and performance of NFCM. As a result, it turned out that the respondents' performance was very high. In addition, out of 14 items, two items -1) activation of e-commerce and direct business transaction, 2) production and sales marketing information, which intensive management strategy, were derived from results. Also, 6 items were derived for on-going maintenance, 3 items were derived for low priority order, and other 4 items were derived for discouragement against excessive efforts. This research may contribute to providing fundamental sources that can be utilized for promoting direction establishment and system improvement of NFCM.

• Journal of the Korean Society of Radiology
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• v.79 no.6
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• pp.332-336
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• 2018

Renal artery injury is a rare complication in blunt trauma, but can cause devascularization of the kidney, leading to renal failure. It requires early diagnosis and management. The treatment of renal artery injury still remains controversial, but recent studies have reported the successful treatment outcome with endovascular stent placement. Nevertheless, there is no standard treatment strategy in cases of pediatric patients. We report a case of a 16-year-old girl with right renal artery occlusion associated with a grade IV liver laceration. She was treated with only balloon angioplasty, and the kidney showed marked improvement of parenchymal perfusion with normalized renal function. Treatment with only balloon angioplasty can be a treatment option in pediatric patients with renal artery injury.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.3
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• pp.394-403
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• 2019

Objectives: This study was conducted to examine the effect of the utilization of the educational planning model (ADDIE) and self-leadership of occupational health managers (OHM) on work performance. Methods: The sample of this study was 180 OHM with over six months of experience, who attended continuing education by the Korean Academic Society of Occupational Health Nursing. Data were collected from April to June 2019 and analyzed using frequency analysis, t-test, F-test, Pearson's correlation analysis, and multiple regression analysis through SPSS Program Ver. 23. Results: According to the results of multiple regression analysis of the factors influencing the work performance of OHM, the model was significant and the explanatory power was 40%. Self-leadership (${\beta}=.45$, p=.001), utilization of the educational planning model (${\beta}=.20$, p<.005), and position (${\beta}=.16$, p=.024) were significant influence factors on work performance. Conclusions: To improve the work performance of OHM, a customized program needs to be developed that promotes the utilization ability of the educational planning model and a strategy of benchmarking high performers in the light of their positions. The improvement of the work performance of OHM will eventually make a contribution to the reduction of industrial disaster and occupational diseases.