• Molecules and Cells
• /
• 제41권3호
• /
• pp.244-255
• /
• 2018

Low-grade pro-inflammatory state and leptin resistance are important underlying mechanisms that contribute to obesity-associated hypertension. We tested the hypothesis that Astragaloside IV (As IV), known to counteract obesity and hypertension, could prevent obesity-associated hypertension by inhibiting pro-inflammatory reaction and leptin resistance. High-fat diet (HFD) induced obese rats were randomly assigned to three groups: the HFD control group (HF con group), As IV group, and the As IV + ${\alpha}$-bungaratoxin (${\alpha}-BGT$) group (As IV+${\alpha}-BGT$ group). As IV ($20mg{\cdot}Kg^{-1}{\cdot}d^{-1}$) was administrated to rats for 6 weeks via daily oral gavage. Body weight and blood pressure were continuously measured, and NE levels in the plasma and renal cortex was evaluated to reflect the sympathetic activity. The expressions of leptin receptor (LepRb) mRNA, phosphorylated signal transducer and activator of transcription-3 (p-STAT3), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), suppressor of cytokine signaling 3 (SOCS3) mRNA, and protein-tyrosine phosphatase 1B (PTP1B) mRNA, pro-opiomelanocortin (POMC) mRNA and neuropeptide Y (NPY) mRNA were measured by Western blot or qRT-PCR to evaluate the hypothalamic leptin sensitivity. Additionally, we measured the protein or mRNA levels of ${\alpha}7nAChR$, inhibitor of nuclear factor ${\kappa}B$ kinase subunit ${\beta}/nuclear$ factor ${\kappa}B$ ($IKK{\beta}/NF-KB$) and pro-inflammatory cytokines ($IL-1{\beta}$ and $TNF-{\alpha}$) in hypothalamus and adipose tissue to reflect the anti-inflammatory effects of As IV through upregulating expression of ${\alpha}7nAChR$. We found that As IV prevented body weight gain and adipose accumulation, and also improved metabolic disorders in HFD rats. Furthermore, As IV decreased BP and HR, as well as NE levels in blood and renal tissue. In the hypothalamus, As IV alleviated leptin resistance as evidenced by the increased p-STAT3, LepRb mRNA and POMC mRNA, and decreased p-PI3K, SOCS3 mRNA, and PTP1B mRNA. The effects of As IV on leptin sensitivity were related in part to the up-regulated ${\alpha}7nAchR$ and suppressed $IKK{\beta}/NF-KB$ signaling and pro-inflammatory cytokines in the hypothalamus and adipose tissue, since co-administration of ${\alpha}7nAChR$ selective antagonist ${\alpha}-BGT$ could weaken the improved effect of As IV on central leptin resistance. Our study suggested that As IV could efficiently prevent obesityassociated hypertension through inhibiting inflammatory reaction and improving leptin resistance; furthermore, these effects of As IV was partly related to the increased ${\alpha}7nAchR$ expression.

• 대한약리학회지
• /
• 제22권2호
• /
• pp.79-87
• /
• 1986

중추 dopamine(DA)계가 신장기능 조절에 관여하고 있으며 뇌실내로 DA를 투여하면 norepinephrine(NE)처럼 항이뇨와 항Na 배설을 초래함이 보고된 바 있고, 중추 DA작용에 있어서 adrenergic system이 관여한다는 많은 시사가 있다. 따라서 본 연구에서는alpha-2 adrenocopter 차단제인 yohimbine이 측뇌실내 DA의 신장작용에 어떠한 영향을 미치는가를 관찰하였다. Yohimbine $100\;{\mu}g/kg$을 가토측뇌실내로 투여시(icv) 신혈류 및 사구체 여과율의 감소와 함께 현저한 항이뇨 및 Na 배설감소를 초래하였으며, DA $15\;{\mu}g/kg$ icv 역시 항이뇨를 초래하였으나 yohimbine 전 처치후에는 뇨량 및 Na배설의 증가를 초래하였다. 양을 더올려 $150\;{\mu}g/kg$의 DA를 yohimbine 전처치 가토에 투여하면 3배 이상의 Na배설 증가와 함께 현저한 이뇨작용이 나타났으며 이 작용은 약 20분간 지속되었다. 이때 신혈류 역학은 일부 개선되었다. 다른 DA agonist인 apomorphine은 $100\;{\mu}g/kg$ icv로 현저한 이뇨와 Na 배설증가를 나타내며 신혈류역학도 개선하였으나, yohimbine은 이같은 apomoiphine작용을 차단하지 못하였다. NE $10\;{\mu}g/kg$ icv도 항이뇨 작용을 나타냈으나 yohimbine 전처치에 의하여 차단되지 아니하였다. 이 연구결과로, 중추 DA의 신장작용은 NE처럼 단순하지 않고, 이뇨작용은 신혈류역학의 감퇴에 기인한 항이노작용에 의해 은폐되어 있으며, yohimbine은 DA의 항이뇨작용은 차단하나 이뇨작용에는 영향을 미치지 못하며, DA의 항이뇨작용이 지양될때에만 이뇨작용이 발현됨을 알 수 있었다. 또한 중추를 통한 DA의 신장작용에는 adrenergic system이 관여하지 않은 것으로 보인다.

• ETRI Journal
• /
• 제29권3호
• /
• pp.281-291
• /
• 2007

Wearable computers consisting of various small devices such as smart phones, digital cameras, MP3 players and specialized I/O devices in personal area networks will play an important role in future ubiquitous computing. In this environment, accessing user data is quite complex due to the dynamic and heterogeneous characteristics of the underlying networks. Moreover, since the amount of user data increases rapidly, automatic data backup management is also critical. To overcome these challenges, several studies have been conducted including our previously proposed file service system, PosCFS, which could be adapted to the requirements with a virtualization technique allowing per-user global namespace for managing and accessing data stored on physical storage spaces detected in PAN. In this paper, we present a smart file service framework, PosCFS+ which is an improved and extended version of our previous work. Performance improvement is made possible by redesigning the metadata management scheme based on database and keywords rather than ontology. In addition, the automatic data replication management is newly designed based on the OSD protocol.

• 대한음성학회지:말소리
• /
• 제68권
• /
• pp.115-126
• /
• 2008

In this paper, we propose a vocabulary coverage improvement method for embedded continuous speech recognition (CSR) using knowledgebase. A vocabulary in CSR is normally derived from a word frequency list. Therefore, the vocabulary coverage is dependent on a corpus. In the previous research, we presented an improved way of vocabulary generation using part-of-speech (POS) tagged corpus. We analyzed all words paired with 101 among 152 POS tags and decided on a set of words which have to be included in vocabularies of any size. However, for the other 51 POS tags (e.g. nouns, verbs), the vocabulary inclusion of words paired with such POS tags are still based on word frequency counted on a corpus. In this paper, we propose a corpus independent word inclusion method for noun-, verb-, and named entity(NE)-related POS tags using knowledgebase. For noun-related POS tags, we generate synonym groups and analyze their relative importance using Google search. Then, we categorize verbs by lemma and analyze relative importance of each lemma from a pre-analyzed statistic for verbs. We determine the inclusion order of NEs through Google search. The proposed method shows better coverage for the test short message service (SMS) text corpus.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1992년도 하계학술대회 논문집 B
• /
• pp.911-914
• /
• 1992

We have investigated the micro-discharge in plasma display panel using 2 dimensional 2 fluid MHD equations. Plasma display utilizes the physical phenomena of the normal glow or abnormal glow and is considered to be able to provide the largest display area among various flat panel. 2 fluid, 2 dimensional Magneto-Hydro-Dynamic equations are applied to Computational field of 100${\times}$800${\mu}m^2$. Time varing glows and after-glows were investigated for 11 $\mu$sec. We obtained the distribution of the microscopic variables such as the density, temperature, velocity of Ne+Ar0.1% gas plasma. During the first 6$\mu$ sec, glow discharge dued to DC pulse was investigated. Time varing phenomena of after-glow was also investigated during the last 5 $\mu$set. From results, it was found that the driving efficiency of a DC Plasma Display Panel could be improved when the diffusion of ions and electrons are controlled by the pulses applied to the auxiliary anode.

• Ocean and Polar Research
• /
• 제26권2호
• /
• pp.361-365
• /
• 2004

Deep-sea Resources Research Center (DRRC) has been using a free-fall grab (FFG) for the resource evaluation of polymetallic nodules in the KODOS (Korea Deep Ocean Study) area, NE Pacific, since 1992. A FFG model (Model 4200, Benthos) adapting one glass buoy system (diameter 17 inch, net buoyance 25.4 kg) has been used until 1993. Since then, DRRC has carried out a study to increase the recovery rate of FFG and it was found that a revised system adapting an additional buoy (diameter 10 inch, net buoyance 4.5 kg) gives improved results. The nodule sampling tests were performed using two different models for the same study area and the resulting recovery rates were compared. The result shows no distinct difference in recovery time between two models, but average recovery rate of the revised model was increased to 99.44% from 96.06% of the original model.

• 한국전기전자재료학회논문지
• /
• 제18권2호
• /
• pp.180-186
• /
• 2005

As a driving method of AC-PDP, Address-Display Separated(ADS) driving has been widely adopted for its simple architecture and low discharge failure rate. However, a high definition like a HDTV has defect of long addressing time by reason of a number of pixels. Priming effect isn't fully sustained because of long addressing time during the address period. Therefore, it has different wall charge and luminance of each addressing time in the sustain period. In this study, we suggest a new driving waveform on the address period to improve these defects. We applied a ramp waveform, instead of a square waveform, to an address period in ADS, for operating on the AC-PDP, which used the conventional gas [He-Ne-Xe]. When the ramp waveform is applied to the address period, we experimented for uniform wall charge and the improved luminance by sustained Priming effect at each addressing time in the sustain period.

• 한국항공우주학회지
• /
• 제31권10호
• /
• pp.66-72
• /
• 2003

우주발사체의 2단용 엔진으로 10톤급 케로신 액체로켓엔진에 대한 냉각 기구로서, 재생냉각과 막냉각을 고려한 냉각특성에 대한 해석전 연구를 수행하였다. 연소기 내에서 연소 가스의 유동이 축방향으로 층류화되어 있다는 개념하에, 엔진 단면을 서로 독립적인 중심부와 외곽부로 나누며, 외곽부에는 여분의 연료를 분무시킴으로써 연소가스 온도를 낮추어 냉각채널로 전달되는 열유속량과 벽면 온도를 감소시킬 수 있었으며, 엔진의 열적 안정성을 향상시킬 수 있었다.

• Journal of the Optical Society of Korea
• /
• 제12권3호
• /
• pp.126-130
• /
• 2008

We propose and experimentally demonstrate an effective method to reduce near-field speckle noise at the output of a 50 ${\mu}m$ graded index multimode fiber using a short cylindrical piezoelectric transducer(PZT) vibrating in the radial direction. The fiber was coiled as tightly as possible around the mandrel of the PZT and a periodic stretching effect was caused by the radial oscillations of the actuator. The output of the optical fiber using the He-Ne laser source was intensively observed by a CCD camera. By counting all the pixels corresponding to relative intensity graded into 256 levels in the selected area and by calculating standard deviation and mean value of the intensity, we could measure the speckle contrast and vibration effect quantitatively with reduction ratio of pixels and line profile of the illuminated region. It was clearly observed that the characteristics of the speckle pattern in the vibration-on state were significantly improved over that of the vibration-off state due to time-averaged smoothing.

• The Korean Journal of Pain
• /
• 제4권1호
• /
• pp.51-55
• /
• 1991

There is a variety of therapeutic modality for herniated nucleus pulposus. Recently the low level laser has come into use for treatment for it. We treated two patients suffered from herniated nucleus pulposus of the central type of $L_{3,4}$ level, with He-Ne, $CO_2$ and Ga Al As laser simultaneously daily under hospitalization. In order to determine the efficacy of treatment, we used the "visual analogue scale" and its improvement rate. The results were as follows; Case I complained of gait disturbance, and hypoesthesia on the lateral side of the left lower leg, as and as low back pain. At the 15th day after treatment, VAS improvement rate was 40%, and the gait disturbance and hypoesthesia were markedly improved. 35th days after tratement, VAS improvement rate was 80%. Case II complained only of low back pain. At the 15th day after treatment, the VAS improvement rate was 68%, and at 20 days after treatment it was 84%. We sugsest that, using the low level laser for treatment of herniated nucleus pulposus increased the cartilage entrophism, and inhibitory effects of the inflammatory materials such as acid glycosaminoglycan by its anti-inflammatory and analgesic effects.