• Journal of Korean Academy of Nursing Administration
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• v.8 no.2
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• pp.295-308
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• 2002

Purpose: The purpose of this quasi-experimental research is to develop the CP for primary THR patients and verify its effectiveness. Method: The CP is designed for both patients and medical employees to meet the 14-day-long hospitalization with an expert and clinical validity test, and the standardized orders are also created. 21 eligible subjects for the control group(with common care plan) and 27 subjects for the experimental group(with CP service) were assigned. Data were collected from questionnaires to evaluate patients' satisfaction level of nursing care and CP, investigation of physical complications, inspection of LOS(length of hospital stay) and hospital charges from April 2000 to February 2001 at K-hospital in Daegu. The collected data were analyzed by using the SAS program. Results: After implementation of CP, there was a statistically significant reduction in mean length of stay. The hospital charges have no considerable difference between two groups. Frequency of physical complications is reduced considerably. The experimental group scored much higher than the control group on the satisfaction level toward nursing care. And in the analysis of CP satisfaction questionnaires, many subjects have high satisfaction in items of 'I see the treatment process and hospital life', 'I feel that I am participating in my treatment process with health care staff'. The analysis of variances which cause a prolonged LOS supports that it's necessary to strengthen an evaluation of pre-operative outpatients' condition and link the home nursing care system in discharge for more shortening of LOS. Conclusion: The above results show that CP can have a positive impact on satisfaction level of inpatients with primary THR and the hospital.

• Journal of the Korean Society of School Health
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• v.32 no.1
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• pp.50-58
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• 2019

Purpose: The purpose of this study was to examine the mediating effect of self-perception on the relationship between body image and depressive symptoms in middle school adolescents. Methods: This study performed a pathway analysis with a sample of 284 adolescents recruited from three middle schools. Self-reported questionnaires consisted of items regarding body image, self-perception, and depressive symptoms. Results: Body image, self-perception, and depressive symptoms showed a significant correlation. Self-perception was directly affected by body image and depressive symptoms were not affected by body image. The mediating effect of self-perception on body image's impact on depressive symptoms was confirmed. Self-perception had a significant indirect effect on depressive symptoms, which means that self-perception has a full mediating effect on body image's impact on depressive symptoms. Conclusion: The effect of body image on depressive symptoms was fully mediated by self-perception in early adolescents. It suggests that self-perception needs to be considered when providing nursing interventions for adolescents.

• Journal of Microbiology and Biotechnology
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• v.23 no.7
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• pp.923-931
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• 2013

Rapamycin, known as an inhibitor of Target of Rapamycin (TOR), is an immunosuppressant drug used to prevent rejection in organ transplantation. Despite the close association of the TOR signaling cascade with various scopes of metabolism, it has not yet been thoroughly investigated at the metabolome level. In our current study, we applied mass spectrometric analysis for profiling primary metabolism in order to capture the responsive dynamics of the Chlamydomonas metabolome to the inhibition of TOR by rapamycin. Accordingly, we identified the impact of the rapamycin treatment at the level of metabolomic phenotypes that were clearly distinguished by multivariate statistical analysis. Pathway analysis pinpointed that inactivation of the TCA cycle was accompanied by the inhibition of cellular growth. Relative to the constant suppression of the TCA cycle, most amino acids were significantly increased in a time-dependent manner by longer exposure to rapamycin treatment, after an initial down-regulation at the early stage of exposure. Finally, we explored the isolation of the responsive metabolic factors into the rapamycin treatment and the culture duration, respectively.

• Journal of The Korean Society of Agricultural Engineers
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• v.55 no.3
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• pp.13-24
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• 2013

Agriculture is affected directly by climate conditions and changes, and it is necessary to understand the impact of climate change on agricultural reservoirs which are the main water resources for paddy fields in Korea. This study aimed to evaluate the impact of climate change on the anti-drought capacity including water supply capability (WSC) and drought response ability (DRA) of agricultural reservoirs based on RCP (Representative Concentration Pathway) 4.5 and 8.5 scenarios of CanESM2 (The Second Generation Earth System Model) provided by CCCma (Canadian Center for Climate Modeling and Analysis). The WSC and DRA were estimated using frequency analysis and runs theory. The six reservoirs (Yooshin, Nogok, Kumsung, Songgok, Gapyung, Seoma) were selected considering geographical characteristics and design criteria of reservoir capacity. In case of Seoma reservoir, more than 10 year drought return period (DRP), the variation of the WSC was estimated larger than the others. In case of Yooshin reservior (2~5 DRP) DRC was decreased in 2025s under RCP8.5. These results could be utilized for agricultural reservoirs management and future design criteria considering climate change impacts on paddy irrigation.

• Journal of Wetlands Research
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• v.13 no.3
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• pp.465-470
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• 2011

Liquid fertilizer and composted cattle manure were applied to an agricultural land. This study was conducted to find the pathway of the nutrients transport. Nitrogen concentration was decreased by the repeatable precipitation in surface runoff, but the nitrate concentration in ground water was gradually increased by biological metabolism, especially with pig liquid fertilizer. Phosphorus was mostly adsorbed into the soil, and its reduction was affected by the soil drain by surface runoff in the summer. Averaged adsorption capacity of the phosphorus via Jar-test was determined as 21.5 mg P/kg of soil.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.271-280
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• 2019

Purpose: The purpose of this study was to examine the effect of depression and job satisfaction on life satisfaction of the elderly and prove the mediating effect of job satisfaction. Methods: This study is a pathway analysis study using 3060 working elderly. This study was performed as secondary analysis using the data from the 2017 Korean Elderly Examination Survey. Data were analyzed using descriptive statistics, correlation analysis and pathway analysis. Results: Depression, job satisfaction and life satisfaction showed significant correlation. Life satisfaction was directly affected by depression(.38, p=.019) and job satisfaction(.22, p=.009). Job satisfaction was also directly affected by depression(.20, p=.009). Depression was mediated by job satisfaction in affecting to life satisfaction. Conclusion: Depression and job satisfaction affect to life satisfaction of the working elderly and life satisfaction is affected by depression via job satisfaction. It suggests that it needs to provide nursing intervention for job satisfaction for life satisfaction of the working elderly.

• International Journal of Oral Biology
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• v.34 no.2
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• pp.53-59
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• 2009

Periodontal ligament (PDL) tissue is a connective tissue that is interposed between the roots of the teeth and the inner wall of the alveolar bone socket. PDL is always exposed to physiologic mechanical force such as masticatory force and PDL cells play important roles during orthodontic tooth movement by synthesizing and secreting different mediators involved in bone remodeling. The Wnt/${\beta}$-catenin signaling pathway was recently shown to play a significant role in the control of bone formation. In the present study, we applied cyclic tensile stress of 20% elongation to cultured human PDL cells and assessed its impact after six days upon components of the Wnt/${\beta}$-catenin signaling pathway. RTPCR analysis showed that Wnt1a, Wnt3a, Wnt10b and the Wnt receptor LRP5 were down-regulated, whereas the Wnt inhibitor DKK1 was up-regulated in response to these stress conditions. In contrast, little change was detected in the mRNA expression of Wnt5a, Wnt7b, Fz1, and LRP6. By western blotting we found decreased expression of the ${\beta}$-catenin and p-GSK-3${\beta}$ proteins. Our results thus show that mechanical stress suppresses the canonical Wnt/${\beta}$-catenin signaling pathway in PDL cells.

• Journal of Preventive Medicine and Public Health
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• v.24 no.4 s.36
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• pp.485-495
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• 1991

This study examined the effects of referral requirements for insurance patients which have been enforced since July 1, 1989 when medical insurance coverage was extended to the whole population except beneficiaries of medical assistance program. The requirements are mainly aimed at discouraging the use of tertiary care hospitals by imposing restrictions on the patient's choice of a medical service facility. The expectation is that such change in the pattern of medical care utilization would produce several desirable effects including increased efficiency in patient care and balanced development of various types of medical service facilities. In this study, these effects were assessed by the change in the number of out-patient visits and bed-days per illness episode and the share of each type of facility in the volume of services and the amount of expenditures after the implementation of the new referral system. The data for analysis were obtained from the claims to the insurance for government and school employees. The sample was drawn from the claims for the patients treated during the first six months of 1989, prior to the enforcement of referral requirements, and those of the patients treated during the first six months of 1990, after the enforcement. The 1989 sample included 299,824 claims (3.6% of total) and the 1990 sample included 332,131 (3.7% of total). The data were processed to make the unit of analysis an illness episode instead of an insurance claim. The facilities and types of care utilized for a given illness episode are defined to make up the pathway of medical care utilization. This pathway was conceived of as a Markov Chain process for further analysis. The conclusion emerged from the analysis is that the enforcement of referral requirements resulted in less use of tertiary care hospitals, and thereby decreased the volume of services and the amount of insurance expenses per illness episode. However, there are a few points that have to be taken into account in relation to the conclusion. The new referral system is likely to increase the use of medical services not covered by insurance, so that its impact on national health expenditures would be different from that on insurance expenditures. The extension of insurance coverage must have inereased patient load for all types of medical service organizations, and this increase may be partly responsible for producing the effects attributed to the new referral system. For example, excessive patient load for tertiary care hospitals may lead to the transfer of their patients to other types of facilities. Another point is that the data for this study correspond to very early phase of the new system. But both patients and medical care providers would adapt themselves to the new system to avoid or overcome its disadvantages for them, so as that its effects could change over time. Therefore, it is still necessary to closely monitor the impact of the referral requirements.

• Journal of Veterinary Science
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• v.24 no.1
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• pp.13.1-13.11
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• 2023

Background: Highly pathogenic avian influenza viruses (HPAIVs) is an extremely contagious and high mortality rates in chickens resulting in substantial economic impact on the poultry sector. Therefore, it is necessary to elucidate the pathogenic mechanism of HPAIV for infection control. Objective: Gene set enrichment analysis (GSEA) can effectively avoid the limitations of subjective screening for differential gene expression. Therefore, we performed GSEA to compare HPAI-infected resistant and susceptible Ri chicken lines. Methods: The Ri chickens Mx(A)/BF2(B21) were chosen as resistant, and the chickens Mx(G)/BF2(B13) were selected as susceptible by genotyping the Mx and BF2 genes. The tracheal tissues of HPAIV H5N1 infected chickens were collected for RNA sequencing followed by GSEA analysis to define gene subsets to elucidate the sequencing results. Results: We identified four differentially expressed pathways, which were immune-related pathways with a total of 78 genes. The expression levels of cytokines (IL-1β, IL-6, IL-12), chemokines (CCL4 and CCL5), type interferons and their receptors (IFN-β, IFNAR1, IFNAR2, and IFNGR1), Jak-STAT signaling pathway genes (STAT1, STAT2, and JAK1), MHC class I and II and their co-stimulatory molecules (CD80, CD86, CD40, DMB2, BLB2, and B2M), and interferon stimulated genes (EIF2AK2 and EIF2AK1) in resistant chickens were higher than those in susceptible chickens. Conclusions: Resistant Ri chickens exhibit a stronger antiviral response to HPAIV H5N1 compared with susceptible chickens. Our findings provide insights into the immune responses of genetically disparate chickens against HPAIV.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3388-3400
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• 2023

Detailed analysis of the neutron pathway through matter inside the nuclear reactor core is exceedingly needed for safety and economic considerations. Due to the constant development of high-performance computing technologies, neutronics analysis using computer codes became more effective and efficient to perform sophisticated neutronics calculations. In this work, a commercial pressurized water reactor (PWR) presented by Virtual Environment for Reactor Applications (VERA) Core Physics Benchmark are modeled and simulated using a high-fidelity simulation of OpenMC code in terms of criticality and fuel pin power distribution. Various problems have been selected from VERA benchmark ranging from a simple two-dimension (2D) pin cell problem to a complex three dimension (3D) full core problem. The development of the code capabilities for reactor physics methods has been implemented to investigate the accuracy and performance of the OpenMC code against VERA SCALE codes. The results of OpenMC code exhibit excellent agreement with VERA results with maximum Root Mean Square Error (RMSE) values of less than 0.04% and 1.3% for the criticality eigenvalues and pin power distributions, respectively. This demonstrates the successful utilization of the OpenMC code as a simulation tool for a whole core analysis. Further works are undergoing on the accuracy of OpenMC simulations for the impact of different fuel types and burnup levels and the analysis of the transient behavior and coupled thermal hydraulic feedback.