• Korean Journal of Clinical Pharmacy
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• v.28 no.1
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• pp.65-75
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• 2018

Objective: Over the last several years, immunotherapy has become one of the most promising therapeutic options for cancer. This study aims to summarize the updates on cancer immunotherapy focusing on immune checkpoint inhibitors, such as programmed cell death-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitors, which have received attention as new anticancer therapeutic agents. Methods: A literature survey was carried out on PubMed to identify high-impact papers on cancer immunotherapy from 2010. The most recent data on clinical efficacy and safety have been included highlighting the response characteristics to recently approved immunotherapeutic agents. Results: In various cancers, immune checkpoints are a means for cancer cells to evade the immune system. Furthermore, CTLA-4 and PD-L1 can be overexpressed, allowing malignant cells to evade T-cells. Numerous clinical trials have been performed to seek appropriate indication of these products in various cancer types. Among them, the most conspicuous types are melanoma, non-small-cell lung cancer, and head and neck cancer. The approval of ipilimumab by Food and Drug Administration (FDA) commenced a new era of cancer immunotherapy. This was followed by the approval of nivolumab and pembrolizumab. Currently, combination therapies are being investigated for various cancer types. Conclusion: In this study, we reviewed recently reported scientific and clinical evidence for currently approved immune checkpoint inhibitors. Although these novel checkpoint inhibitors are ever evolving for cancer therapies, there exist limitations that need to be overcome, indicating the necessity for further studies aiming to improve their efficacy, toxicity, and cost.

• Journal of Ocean Engineering and Technology
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• v.32 no.3
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• pp.184-191
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• 2018

Recently, as sea ice in the Arctic has been decreasing due to global warming, it has become easier to develop oil and gas resources buried in the Arctic region. As a result, Russia, the United States, and other Arctic coastal states are increasingly interested in the development of oil and gas resources, and the demand for offshore structures to support Arctic sea resources development is expected to significantly increase. Since offshore structures operating in Arctic regions need to secure safety against various drifting ice conditions, the concept of an ice-strengthened design is introduced here, with a priority on calculation of ice load. Although research on the estimation of ice load has been carried out all over the world, most ice-load studies have been limited to estimating the ice load of the icebreaker in a non-oblique state. Meanwhile, in the case of Arctic offshore structures, although it is also necessary to estimate the ice load according to oblique angles, the overall research on this topic is insufficient. In this paper, we suggest algorithms for calculating the ice load of managed ice (pack ice, 100% concentration) in an oblique state, and discuss validity. The effect of oblique angle according to estimated ice load with various oblique angles was also analyzed, along with the impact of ship speed and ice thickness on ice load.

• Korean Journal of Health Education and Promotion
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• v.28 no.3
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• pp.31-42
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• 2011

Objectives: Busan had the highest mortality and the shortest life expectancy at birth among 16 provinces in Korea in 2008 and there were considerable health inequalities within the region. This study was performed to build up a priority setting framework in Healthy City Busan project. Methods: Analytic hierarchy process was used to determine the relative priority weight for different strategic and program dimensions along with the consistency of response. An on-site workshop-based meeting (calculating importance) and online survey (calculating risk) were conducted to obtain data from 8 experts. Results: The results showed that in strategic criteria "active health promotion & diseases prevention" and "building infrastructure for the Health City project" were two most important factors. In program criteria, considering both importance and risk scores, "making a healthy community" and "building community health centers" in disadvantaged areas were a top priority group. In addition, "enacting an ordinance for the Healthy City", "building the infrastructure for health impact assessment" and "making health care safety net for vulnerable population" were also higher priorities group. Conclusions: Our findings suggest that the Healthy City project in Busan should be focused on strengthening health equity and building infrastructure for sustainability of the project.

• Earthquakes and Structures
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• v.11 no.6
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• pp.925-942
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• 2016

With ongoing development of earthquake engineering research and the lessons learnt from a series of strong earthquakes, the seismic design concept of "resilience" has received much attention. Resilience describes the capability of a structure or a city to recover rapidly after earthquakes or other disasters. As one of the main features of urban constructions, tall buildings have greater impact on the sustainability and resilience of major cities. Therefore, it is important and timely to quantify their seismic resilience. In this work, a quantitative comparison of the seismic resilience of two tall buildings designed according to the Chinese and US seismic design codes was conducted. The prototype building, originally designed according to the US code as part of the Tall Building Initiative (TBI) Project, was redesigned in this work according to the Chinese codes under the same design conditions. Two refined nonlinear finite element (FE) models were established for both cases and their seismic responses were evaluated at different earthquake intensities, including the service level earthquake (SLE), the design-based earthquake (DBE) and the maximum considered earthquake (MCE). In addition, the collapse fragility functions of these two building models were established through incremental dynamic analysis (IDA). Based on the numerical results, the seismic resilience of both models was quantified and compared using the new-generation seismic performance assessment method proposed by FEMA P-58. The outcomes of this study indicate that the seismic resilience of the building according to the Chinese design is slightly better than that according to the US design. The conclusions drawn from this research are expected to guide further in-depth studies on improving the seismic resilience of tall buildings.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.205-211
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• 2016

Excessive exposure to chemicals in the workplace can cause poisoning and various diseases. Thus, for the protection of labor, it is necessary to examine the exposure of people to chemicals and risks from these materials. The purpose of this study is to evaluate semi-quantitative health risks of exposure to harmful chemical agents in the context of carcinogenesis in a latex glove manufacturing industry. In this cross-sectional study, semi-quantitative risk assessment methods provided by the Department of Occupational Health of Singapore were used and index of LD50, carcinogenesis (ACGIH and IARC) and corrosion capacity were applied to calculate the hazard rate and the biggest index was placed as the basis of risk. To calculate the exposure rate, two exposure index methods and the actual level of exposure were employed. After identifying risks, group H (high) and E (very high) classified as high-risk were considered. Of the total of 271 only 39 (15%) were at a high risk level and 3% were very high (E). These risks only was relevant to 7 materials with only sulfuric acid placed in group E and 6 other materials in group H, including nitric acid (48.3%), chromic acid (6.9%), hydrochloric acid (10.3%), ammonia (3.4%), potassium hydroxide (20.7%) and chlorine (10.3%). Overall, the average hazard rate level was estimated to be 4 and average exposure rate to be 3.5. Health risks identified in this study showed that the manufacturing industry for latex gloves has a high level of risk because of carcinogens, acids and strong alkalisand dangerous drugs. Also according to the average level of risk impact, it is better that the safety design strategy for latex gloves production industry be placed on the agenda.

• Journal of Korean Tunnelling and Underground Space Association
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• v.5 no.1
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• pp.13-21
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• 2003

To investigate the safety and stability of a concrete lining, numerous studies have been conducted over the years and several methods have been developed. Most signal processing techniques of NDT have been based on Fourier analysis. However, the application of Fourier analysis to analyze recorded vibrational signal shows results in the frequency domain only, and it is not enough to analyze transient waves precisely. In this study, Wavelet theory was employed for the analysis of non-stationary wave induced by mechanical impact on tunnel concrete lining. The Wavelet transform of transient signals provides a method for mapping the frequency spectrum as a function of time. To verify the availability of Wavelet transform as a time-frequency analysis tool, model experiments have been conducted and the thickness of the concrete lining was estimated based on the proposed theory. From this study, it was found that the contour map by Wavelet transform provides more distinct results than the power spectrum by Fourier transform and it was also found that Wavelet transform was also an effective tool for the analysis of dispersive waves in tunnel concrete linings.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5319-5321
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• 2012

Objective: To observe efficacy and side effects, as well as the impact on quality of life, of Kanglaite$^{(R)}$ (Coix Seed Oil) injections combined with chemotherapy in the treatment of advanced gastric cancer patients. Method: A consecutive cohort of 60 patients were divided into two groups: the experimental group receiving Kanglaite$^{(R)}$ Injection combined with chemotherapy and the control group with chemotherapy alone. After more than two courses of treatment, efficacy, quality of life and side effects were evaluated. Results: The response rate and KPS score of experimental group were significantly improved as compared with those of the control group (P<0.05). In addition, gastrointestinal reactions and bone marrow suppression were significantly lower than in the control group (P<0.05). Conclusions: Kanglaite$^{(R)}$ Injection enhanced efficacy and reduced the side effects of chemotherapy, improving quality of life of gastric cancer patients; use of Kanglaite$^{(R)}$ injections deserves to be further investigated in randomized control clinical trails.

• The Journal of the Korea Contents Association
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• v.16 no.1
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• pp.42-51
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• 2016

For changes in the distribution structure these days, consumer demand is moving rapidly from offline to online. The consumers' mentality to purchase products conveniently is reflected in this phenomenon. Also for agricultural products, safety to protect contents, brand and design which can provide credibility to consumers are recognized as most important than ever. Especially, strawberry is thin-skinned so that the quality of product may deteriorate even with weak impact and shaking, so it is significantly influenced by the structural packaging or material. Also, strawberry is frequently distributed through direct trading, it is the reality that the package design of strawberry is less competitive than that of other products due to inadequate environments of commercial farms. That is, the demand of strawberry increases everyday but the strawberry package cannot fulfill the needs of producers and consumers. In order to reinforce competitiveness in strawberry sales, it is urgent to carry out fundamental studies regarding the development of package. Therefore, the purpose of this study is to supplement and improve issues arising from the usage of current strawberry package. Through the analysis of strawberry package elements (shape, material, design) and understand the points of improvement sought by producers and consumers through IPA MAP (importance, satisfaction level) analysis.

• The Journal of the Korea Contents Association
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• v.20 no.2
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• pp.360-370
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• 2020

In order to understand the factors related to the unmet dental needs, analysis was performed using the data of community health survey data. Targeting population of 214,861 aged 25 and over demographic factors, socioeconomic factors, social support, social environmental factors, social and physical environmental factors, and factors related to necessary unmet dental needs visit it was confirmed. The lower the age, the higher the income level, the lower the education level, the less contact with relatives and friends, the less likely they are to participate in relatives and leisure activities, dissatisfied with sociophysical environment(safety level, natural environment, living environment, public transportation, medical services) the higher unmet dental needs. It was confirmed that not only demographic and socioeconomic factors but also social support, social environmental factors, social and physical environmental factors had a statistically significant impact on the need of unmet dental needs. Future research that includes policy factors as social determinants of health will be needed as a way to increase the unmet dental needs.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.5
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• pp.589-601
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• 2014

Natural gas hydrate (NGH) is emerging as a new eco-friendly source of energy to replace fossil fuels in the 21st century. It is well known that the Natural Gas Hydrate contains large amount of natural gas about 170 times as much as its volume and it is easy to be stored and transported safely at about $-20^{\circ}C$ under atmospheric pressure due to so called "self-preservation effect". The option of gas transport by gas hydrate pellets carrier has been investigated and developed in various industry and academy. The natural gas hydrate pellet carrier is on major link in a potential gas hydrate process chain, starting with the extraction of natural gas from the reservoir, followed by the production of hydrate pellets and the transportation to an onshore terminal for further processing or marketing. In recent years, Korean project team supported by Korean Government has been working on the development of NGH total systems including novel NGH carrier since 2011. In order to increase the knowledge on the NGH pellet carrier developed and to understand the major hazards that could have significant impact on the safety of the vessel, this paper presents and evaluates the pros and cons of cargo holds, loading and unloading systems through the analysis of current patent technology. Based on the proven and well-known technologies as well as potential measures to mitigate sintering and minimize mechanical stress on the hydrate pellet in the self-preservation state, this study presents the conceptual and basic design for NGH carrier.