• Proceedings of the PSK Conference
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• 2001.04a
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• pp.144.2-145
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• 2001

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.128-128
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• 2004

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.80-80
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• 2003

The use of skin whitening agents have been recently increased in various kinds of cosmetic products, although there were reports that whitening agents might cause allergic contact dermatitis. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pigs for contact sensitization potential. This study was carried out to investigate the skin sensitization potential of three whitening agents, kojic acid, arbutin, azelaic acid, by LLNA using a non-radioistopic endpoint.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.124-124
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• 2003

A murine local lymph node assay(LLNA) has been developed as an alternative method to guinea pig maximization test for contact sensitization potential. This study was carried out to investigate the potential use of cytokine producing cells to discriminate between allergens and irritant in the LLNA.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.11b
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• pp.185-185
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• 2002

A murine local lymph node assay (LLNA) has been developed as an alternative test to guinea pig maximization test. The disadvantage of LLNA is the need for the use of radioactive material. In this study, we aimed to investigate the development of non-radio isotopic endpoint for local lymph node assay in Balb/c mice using Enzyme-linked immunosorbent assay (ELISA) based on Bromodeoxyuridine (BrdU) incorporation.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2001.10a
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• pp.193-193
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• 2001

A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for contact sensitization potential. However, a disadvantage of the LLNA is the need for the use of radioactive material. In this study, we aimed to investigate the development of non-radio isotopic endpoint for LLNA using immunohistochemistry.(omitted)

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2001.10b
• /
• pp.193-193
• /
• 2001

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2002.05a
• /
• pp.98-98
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• 2002

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2003.05a
• /
• pp.78-79
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• 2003

Organophosphorus (OP) pesticides have largely replaced the use of organochlorine pesticides and have been widely used in agriculture and houses in recent years because of their rapid breakdown in water and their low environmental persistence. As a result, consumers are directly or indirectly exposed to organophosphorus pesticides through several food groups including meat, dairy products, fruits, vegetables, dried foods, and most processed food in which a significant amount of pesticide residues have been found.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.194-194
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• 2001

Preclinical test methods for allergenic potential chemicals has been widely used to assess human risks and has been developed. Recently, the murine local lymph node assay (LLNA) has been proposed as a prospective method to identify contact allergens and to replace conventional the guinea pig maximization test (GPMT). The objective of this study was to establish LLNA and to evaluate allergenicity of chemicals by LLNA. (omitted)