• Journal of the Korean Institute of Telematics and Electronics A
• /
• v.29A no.4
• /
• pp.38-48
• /
• 1992

OEIC(Optoelectronic Integrated Circuit)'s can be integrated horizontally or vertically. Horizontal integration approach is, however, more immune to parasitic and more universally applicable. In this paper, a structural modeling, fabrication and characterization of PIN photodiodes which can be used in the horizontal integration are performed. For device modeling, we build a transmission line model from 2-D device simulation, from which lumped model parameters are extracted. The speed limits of the PIN photodiodes can also be calculated under various structural conditions from the model. Thus optimum design of horizontally integrated PIN photodiodes for high speed operation are possible. Such InGaAs/InP PIN photodiodes for long-wavelength communications are fabricated using pit etch, epi growth, planarization, diffusion and metallization processes. Planarization process using both RIE and wet etching and diffusion process using evaporated Zn$_{3}P_{2}$ film are developed. Characterization of the fabricated devices is performed through C-V and I-V measurements. At a reserve bias of 10V, the dark current is less than 5nA and capacitance is about 0.4pF. The calculated bandwidth using the measured series resistance and capacitance is about 4.23GHz.

• Proceedings of the KIEE Conference
• /
• 2015.07a
• /
• pp.579-580
• /
• 2015

Power frequency is one of important operational parameters evaluating reliability, stability, and measuring efficiency of power. Therefore, an accurate and fast estimate of the power frequency is required. The magnitude gains of cosine and sine filters become different when the power frequency is deviated from the nominal value. The proposed algorithm estimates the power frequency based on this. To demonstrate the performance of the proposed algorithm, RTDS and DSP are used. The simulation results show that the algorithm has not only a high level of robustness but also high measurement accuracy over a wide range of frequency changes. In addition, the algorithm was immune to harmonics and noise.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.5
• /
• pp.2309-2312
• /
• 2014

Esophageal squamous cell carcinoma (ESCC) is the most common histologic subtype of esophageal cancer and is characterized by a poor prognosis. Determining gene changes in ESCCs should improve understanding of putative risk factors and provide potential targets for therapy. We sequenced about 55 million pair-end reads from a pair of adjacent normal and ESCC samples to identify the gene expression level and gene fusion. Sanger sequencing was used to verify the result. About 17 thousand genes were expressed in the tissues, of which approximately 2400 demonstrated significant differences between tumor and adjacent non tumor tissue. GO and KEGG pathway analysis revealed that many of these genes were associated with cellular adherence and movement, simulation responses and immune responses. Notably we identified and validated one fusion gene, HLA-E and HLA-B, located 1 MB apart. We also identified thousands of remarkably expressed transcripts. In conclusion, a novel fusion gene HLA-E and HLA-B was identified in ESCC via whole transcriptome sequencing, which would be a biomarker for ESCC diagnosis and target for therapy, shedding new light for better understanding of ESCC tumorigenesis.

• Communications for Statistical Applications and Methods
• /
• v.25 no.5
• /
• pp.471-488
• /
• 2018

In this paper, we propose extending proportional hazards frailty models to allow a discrete distribution for the frailty variable. Having zero frailty can be interpreted as being immune or cured. Thus, we develop a new survival model induced by discrete frailty with zero-inflated power series distribution, which can account for overdispersion. This proposal also allows for a realistic description of non-risk individuals, since individuals cured due to intrinsic factors (immunes) are modeled by a deterministic fraction of zero-risk while those cured due to an intervention are modeled by a random fraction. We put the proposed model in a Bayesian framework and use a Markov chain Monte Carlo algorithm for the computation of posterior distribution. A simulation study is conducted to assess the proposed model and the computation algorithm. We also discuss model selection based on pseudo-Bayes factors as well as developing case influence diagnostics for the joint posterior distribution through ${\psi}-divergence$ measures. The motivating cutaneous melanoma data is analyzed for illustration purposes.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.16 no.3
• /
• pp.300-311
• /
• 2016

The analog-to-digital-converter-based (ADC-based) backplane receivers that consist of a front-end ADC followed by a digital equalizer are gaining more popularity in recent years, as they support more sophisticated equalization required for high data rates, scale better with fabrication technology, and are more immune to PVT variations. Unfortunately, designing an ADC-based receiver that meets tight power and performance budgets of high-speed backplane link systems is non-trivial as both front-end ADC and digital equalizer can be power consuming and complex when running at high speed. This paper reviews the state of art designs for the front-end ADC and digital equalizers to suggest implementation choices that can achieve high speed while maintaining low power consumption and complexity. Design-space exploration using system-level models of the ADC-based receiver allows through analysis on the impact of design parameters, providing useful information in optimizing the power and performance of the receiver at the early stage of design. The system-level simulation results with newer device parameters reveal that, although the power consumption of the ADC-based receiver may not comparable to the receivers with analog equalizers yet, they will become more attractive as the fabrication technology continues to scale as power consumption of digital equalizer scales well with process.

• Journal of Communications and Networks
• /
• v.13 no.5
• /
• pp.442-448
• /
• 2011

It's a challenging task to design a high performance modulation for satellite and space communications due to the limited power and bandwidth resource. Constant envelope modulation is an attractive scheme to be used in such cases for their needlessness of input power back-off about 2~3 dB for avoidance of nonlinear distortion induced by high power amplifier. The envelope of Feher quadrature phase shift keying (FQPSK) has a least fluctuation of 0.18 dB (quasi constant envelope) and can be further improved. This paper improves FQPSK by defining a set of new waveform functions, which changes FQPSK to be a strictly constant envelope modulation. The performance of the FQPSK adopting new waveform is justified by analysis and simulation. The study results show that the novel FQPSK is immune to the impact of HPA and outperforms conventional FQPSK on bit error rate (BER) performance. The BER performance of this novel modulation is better than that of FQPSK by more than 0.5 dB at least and 2 dB at most.

• Journal of Power Electronics
• /
• v.15 no.4
• /
• pp.974-986
• /
• 2015

A novel inverter fault-tolerant control scheme is proposed to drive brushless DC motor. A fault-tolerant inverter and its three fault-tolerant schemes (i.e., phase A fault-tolerant, phase B fault-tolerant, and phase C fault-tolerant) are analyzed. Eight voltage vectors are summarized and a voltage vector selection table is used in the control scheme to improve the midpoint current of the split capacitors. A stator flux observer is proposed. The observer can improve flux estimation, which does not require any speed adaptation mechanism and is immune to speed estimation error. Global stability of the flux observer is guaranteed by the Lyapunov stability analysis. A novel stator resistance estimator is incorporated into the sensorless drive to compensate for the effects of stator resistance variation. DC offset effects are mitigated by introducing an integral component in the observer gains. Finally, a control system based on the control scheme is established. Simulation and experiment results show that the method is correct and feasible.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.8
• /
• pp.2494-2504
• /
• 2014

P38 mitogen activated protein (MAP) kinase is an important anti-inflammatory drug target, which can be activated by responding to various stimuli such as stress and immune response. Based on the conformation of the conserved DFG loop (in or out), binding inhibitors are termed as type-I and II. Type-I inhibitors are ATP competitive, whereas type-II inhibitors bind in DFG-out conformation of allosteric pocket. It remains unclear that how these allosteric inhibitors stabilize the DFG-out conformation and interact. Organosilicon compounds provide unusual opportunity to enhance potency and diversity of drug molecules due to their low toxicity. However, very few examples have been reported to utilize this property. In this regard, we performed docking of an inhibitor (BIRB) and its silicon analog (Si-BIRB) in an allosteric binding pocket of p38. Further, molecular dynamics (MD) simulations were performed to study the dynamic behavior of the simulated complexes. The difference in the biological activity and mechanism of action of the simulated inhibitors could be explained based on the molecular mechanics/generalized Born surface area (MM/GBSA) binding free energy per residue decomposition. MM/GBSA showed that biological activities were related with calculated binding free energy of inhibitors. Analyses of the per-residue decomposed energy indicated that van der Waals and non-polar interactions were predominant in the ligand-protein interactions. Further, crucial residues identified for hydrogen bond, salt bridge and hydrophobic interactions were Tyr35, Lys53, Glu71, Leu74, Leu75, Ile84, Met109, Leu167, Asp168 and Phe169. Our results indicate that stronger hydrophobic interaction of Si-BIRB with the binding site residues could be responsible for its greater binding affinity compared with BIRB.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2004.05b
• /
• pp.391-394
• /
• 2004

Change of paradigm of network attack technique was begun by fast extension of the latest Internet and new attack form is appearing. But, Most intrusion detection systems detect informed attack type because is doing based on misuse detection, and active correspondence is difficult in new attack. Therefore, to heighten detection rate for new attack pattern, visibilitys to apply human immunity mechanism are appearing. In this paper, we create self-file from normal behavior profile about network packet and embody self recognition algorithm to use self-nonself discrimination in the human immune system to detect anomaly behavior. Sense change because monitors self-file creating anomaly detector based on Negative Selection Algorithm that is self recognition algorithm's one and detects anomaly behavior. And we achieve simulation to use DARPA Network Dataset and verify effectiveness of algorithm through the anomaly detection rate.

• Journal of Power Electronics
• /
• v.17 no.4
• /
• pp.972-982
• /
• 2017

The Park's vector of stator current is a popular technique for the detection of induction motor faults. While the detection of the faulty condition using the Park's vector technique is easy, the classification of different types of faults is intricate. This problem is overcome by the Multiple Park's Vector (MPV) approach proposed in this paper. In this technique, the characteristic fault frequency component (CFFC) of stator winding faults, rotor winding faults, unbalanced voltage and bearing faults are extracted from three phase stator currents. Due to constructional asymmetry, under the healthy condition these characteristic fault frequency components are unbalanced. In order to balanced them, a correction factor is added to the characteristic fault frequency components of three phase stator currents. Therefore, the Park's vector pattern under the healthy condition is circular in shape. This pattern is considered as a reference pattern under the healthy condition. According to the fault condition, the amplitude and phase of characteristic faults frequency components changes. Thus, the pattern of the Park's vector changes. By monitoring the variation in multiple Park's vector patterns, the type of fault and its severity level is identified. In the proposed technique, the diagnosis of faults is immune to the effects of unbalanced voltage and multiple faults. This technique is verified on a 7.5 hp three phase wound rotor induction motor (WRIM). The experimental analysis is verified by simulation results.