• 대한방사선기술학회지:방사선기술과학
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• 제20권1호
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• pp.29-34
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• 1997

For radiological test in soft tissue or neighboring part with same signal intensity, proper test method and equipment shall be selected as needed. In case of female pelvic cavity, ultrasonography or computed tomography alternatively used, but MRI can be more usefully applied to design treatment method or operation plan by improving the diagnostic accuracy and careful observation of lesion characteristics. Magnetic Resonance Imaging using recently developed Enteral MRI contrast media can acquire more diagnostic information than using only intravenous contrast media. Thus this study attempted to examine the utility of anatomic structure and diagnostic acquisition by imaging the female pelvic cavity using Enteral MRI contrast media. As a result of analyzing magnetic resonance Imaging after administering Enteral MRI contrast media to pelvic cavity suspect patients, more diagnostic information media could be acquired than only using Intravenous contrast. Expecially, in the diagnosis of lesion position, shape, distinction from neighboring tissues it is thought that external Enteral MRI contrast media should be used.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2006년도 학술발표회 논문집
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• pp.25-32
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• 2006

We present a imaging method of seismic sources by time reversal propagation of seismic waves. Time-reversal wave propagation is actively used in medical imaging, non destructive testing and waveform tomography. Time-reversal wave propagation is based on the time-reversal invariance and the spatial reciprocity of the wave equation. A signal is recorded by an array of receivers, time-reversed and then back-propagated into the medium. The time-reversed signal propagates back into the same medium and the energy refocuses back at the source location. The increasing power of computers and numerical methods makes it possible to simulate more accurately the propagation of seismic waves in heterogenous media. In this work, a staggered-grid finite-difference solution of the elastic wave equation is employed for the wave propagation simulation. With numerical experiments, we show that the time-reversal imaging will enable us to explore the spatio-temporal history of complex earthquake.

• The Journal of the Acoustical Society of Korea
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• 제18권2E호
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• pp.10-17
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• 1999

The aim of the work described in this paper is to develop a complex underground acoustic system which detects and localizes the origin of an underground hammering sound using an array of hydrophones located about 100m underground. Three different methods for the sound localization will be presented, a time-delay method, a power-attenuation method and a hybrid method. In the time-delay method, the cross correlation of the signals received from the array of sensors is used to calculate the time delays between those signals. In the power-attenuation method, the powers of the received signals provide a measure of the distances of the source from the sensors. In the hybrid method, both informations of time-delays and power-ratios are coupled together to produce better performance of position estimation. A new acoustic imaging technique has been developed for improving the hybrid method. This new acoustic imaging method shows the multi-dimensional distribution of the normalized cost function, so as to indicate the trend of the minimizing direction toward the source location. For each method the sound localization is carried out in three dimensions underground. The distance between the true and estimated origins of the source is 28m for a search area of radius 250m.

• Nuclear Medicine and Molecular Imaging
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• 제42권1호
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• pp.1-7
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• 2008

PET allows non-invasive, quantitative and repetitive imaging of biological function in living animals. Small animal PET imaging with $[^{18}F]$FDG has been successfully applied to investigation of metabolism, receptor-ligand interactions, gene expression, adoptive cell therapy and somatic gene therapy. Experimental condition of animal handling impacts on the biodistribution of $[^{18}F]$FDG in small animal study. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point. Tumor imaging in small animal with small animal $[^{18}F]$FDG PET should be considered fasting, warming, and isoflurane anesthesia level. Registered imaging with small animal PET and CT image could be useful for the detection of tumor. Small animal experimental condition of animal handling and registration method will be of most importance for small lesion detection of metastases tumor model.

• Investigative Magnetic Resonance Imaging
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• 제20권1호
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• pp.36-43
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• 2016

Visualization of the tissue loss tangent property can provide distinct contrast and offer new information related to tissue electrical properties. A method for non-invasive imaging of the electrical loss tangent of tissue using magnetic resonance imaging (MRI) was demonstrated, and the effect of loss tangent was observed through simulations assuming a hyperthermia procedure. For measurement of tissue loss tangent, radiofrequency field maps ($B_1{^+}$ complex map) were acquired using a double-angle actual flip angle imaging MRI sequence. The conductivity and permittivity were estimated from the complex valued $B_1{^+}$ map using Helmholtz equations. Phantom and ex-vivo experiments were then performed. Electromagnetic simulations of hyperthermia were carried out for observation of temperature elevation with respect to loss tangent. Non-invasive imaging of tissue loss tangent via complex valued $B_1{^+}$ mapping using MRI was successfully conducted. Simulation results indicated that loss tangent is a dominant factor in temperature elevation in the high frequency range during hyperthermia. Knowledge of the tissue loss tangent value can be a useful marker for thermotherapy applications.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.294-298
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• 1997

In the magnetic resonance imaging, the fast spin echo imaging technique is a widely used clinical imaging method, since its scanning time is much shorter than the conventional spin echo imaging and it gives the almost same image quality. However, the fast spin echo technique has two times longer imaging time or the dual echo acquisition which can obtain a spin density image and a $T_2$-weighted image simultaneously. To overcome such a drawback, this paper proposes a new fast dual echo imaging technique which can give the same quality images at the single echo imaging time. The proposed technique reduces the imaging time by overlapping most of echo train data for each image reconstruction. In order to verify its validity and usability the human head experimental results which were obtained at the 0.3T permanent MRI system are presented.

• 한국광학회:학술대회논문집
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• 한국광학회 2006년도 동계학술발표회 논문집
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• pp.359-360
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• 2006

Functional photoacoustic tomography is a new non-invasive imaging modality, and it is emerging as a very practical method for imaging biological tissue structures by means of laser-induced ultrasound. Structures with high optical absorption, such as blood vessels, can be imaged with the spatial resolution of ultrasound, which is not limited by the strong light scattering in biological tissues. By varying wavelengths of the laser light and acquiring photoacoustic images, optical absorption spectrum of each image pixel is found. Since the biochemical constituents of tissues determine the spectrum, useful functional information like oxygen saturation ($SO_2$) and total haemoglobin concentration (HbT) can be extracted. In this study, as a proof-of-principle experiment, hypoxic brain tumor vasculature and traumatic brain injury (TBI) of small animal brain are imaged with functional photoacoustic tomography. High resolution brain vasculature images of oxygen saturation and total hemoglobin concentration are provided to visualize hypoxic tumor vasculature, and hemorrhage on the cortex surface by the TBI.

• 대한의용생체공학회:의공학회지
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• 제30권3호
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• pp.233-240
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• 2009

Using a spatial compound imaging technique in a medical ultrasound imaging system, the average speed of sound in a medium of interest is measured, and imaging of its distribution is implemented. When the brightness reaches the highest level in an ultrasonic image obtained as the speed of sound used in focusing is varied, it turns out that the focusing has been accomplished satisfactorily and that the speed of sound which has been adopted becomes the sought-after average speed of sound. Because spatial compound imaging provides many different views of the same object, the adverse effect of erroneous speed-of-sound estimation tends to be more severe in compound imaging than in plain B-mode imaging. Thus, in compound imaging, the average speed of sound even in the case of speckled images can be accurately estimated by observing the brightness change due to different speeds of sound employed. Using this new method that offers spatial diversity, we can construct an image of the speed of sound distribution in a phantom embedded with a 10-mm diameter plastic cylinder whose speed of sound is different from that of the background. The speed of sound in the cylinder is found to be different from that of the surrounding medium.

• Clinical Endoscopy
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• 제51권6호
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• pp.527-533
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• 2018

There have been many advances in endoscopic imaging technologies. Magnifying endoscopy with narrow-band imaging is an innovative optical technology that enables the precise discrimination of structural changes on the mucosal surface. Several studies have demonstrated its usefulness and superiority for tumor detection and differential diagnosis in the stomach as compared with conventional endoscopy. Furthermore, magnifying endoscopy with narrow-band imaging has the potential to predict the invasion depth and tumor margins during gastric endoscopic submucosal dissection. Classifications of the findings of magnifying endoscopy with narrow-band imaging based on microvascular and pit patterns have been proposed and have shown excellent correlations with invasion depth confirmed by microscopy. In terms of tumor margin prediction, magnifying endoscopy with narrow-band imaging offers superior delineation of gastric tumor margins compared with traditional chromoendoscopy with indigo carmine. The limitations of narrow-band imaging, such as the need for considerable training, long procedure time, and lack of studies about its usefulness in undifferentiated cancer, should be resolved to confirm its value as a complementary method to endoscopic submucosal dissection. However, the role of magnifying endoscopy with narrow-band imaging is expected to increase steadily with the increasing use of endoscopic submucosal dissection for the treatment of gastric tumors.

• 한국전자파학회논문지
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• 제22권11호
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• pp.1054-1062
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• 2011

무인 차량의 야지 자율 주행을 위한 근거리 초광대역 bistatic 레이다에 적합한 시간 영역 영상화 기법의 구현에 대해 기술한다. 기존의 SAR(Synthetic Aperture Radar) 영상화 기법에서 주파수 영역에 기반을 둔 방법은 원전계 조건을 만족하는 응용 분야에는 잘 적용되지만, 근거리에 적용할 경우 근사화에 따른 위상 오차가 크게 되어 영상의 품질을 떨어뜨린다. 따라서 근거리 영상 레이다에서는 시간 영역에 기반을 둔 back-projection 방법이 적합하다. 그러나 back-projection의 경우 수행 시간이 매우 긴 단점이 있다. 따라서 시간 영역에 기반을 두고 영상의 품질은 back-projection과 유사하며, 수행 시간을 줄일 수 있는 방법으로 개발된 것이 FFBP(Fast Factorized Back-Projection) 방법이다. 야지에서 획득한 레이다 원시데이터를 사용하여 back-projection 방법과 FFBP 방법을 구현하고 영상의 품질 및 수행 시간을 비교하여 bistatic 전방 관측 레이다의 시간 영역 영상화 기법의 적용 가능성을 입증한다.