• 한국산학기술학회논문지
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• 제13권6호
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• pp.2600-2606
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• 2012

본 연구의 목적은 시뮬레이션 기반 정맥주사 교육의 효과를 시뮬레이션 매체별로 비교 분석하고 대상자 만족도를 평가함으로써 시뮬레이션 기반 교육이 간호학생의 임상실무수행능력과 수행 자신감을 향상시킴과 동시에 대상자 만족도를 높이는데 도움이 되는 교육 방법임을 검증하는 것이다. 본 연구에서는 간호학과 2학년생 90명을 무작위로 동영상군에 31명, 모형군에 28명, 컴퓨터시스템군에 31명을 배정하였다. 동영상군은 기본간호학회에서 개발한 교육용비디오를, 모형군은 정맥주사모형을, 컴퓨터시스템군은 컴퓨터로 작동되는 정맥주사용 교육프로그램을 이용하여 1회 교육과 5회 실습을 실시한 후 대상자들끼리 짝을 이루어 손등 부위에 정맥주사를 시행하였다. 간호학생의 임상수행능력을 정맥주사 성공률로 분석한 결과, 동영상군 16.1%, 모형군 64.3%, 컴퓨터시스템군 38.7%가 성공한 것으로 나타났으며 세 군간에 유의한 차이가 있었다. 수행 자신감은 정맥 주사 전, 후 모두 세 군간에 유의한 차이가 없었으나 정맥주사 성공여부에 따른 차이를 비교한 결과, 정맥 주사 전, 후에 모두 유의한 차이가 있었다. 대상자 만족도는 세 군간에는 유의한 차이가 없었으나 정맥주사 성공여부에 따라서는 유의한 차이가 있었다. 이상의 연구결과에서 정맥주사 기술은 동영상과 컴퓨터시스템보다 모형을 이용한 시뮬레이션 기반 교육이 간호학생의 임상실무 능력을 향상시키는데 기여한 것으로 나타났으며 정맥주사에 성공한 학생이 성공하지 못한 학생보다 수행 자신감이 더 높은 것으로 나타났다. 그러나 이는 한 가지 간호 기술과 관련된 결과로 추후 다양한 간호기술에 적합한 시뮬레이션 교육매체를 평가하는 연구가 필요하다.

• Perspectives in Nursing Science
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• 제11권2호
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• pp.144-152
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• 2014

Purpose: The purpose of the study is to offer necessary data to develop nursing interventions to reduce intravenous injection pain and uneasiness among hospitalized children. Methods: A total of 200 patients aged 1-72 months were selected. Pain during intravenous cannulation was assessed using the Procedural Behavior Checklist (PBCL) and the Faces Pain Rating Scale (FPRS). Data were analyzed by t-test and ANOVA using the SPSS/WIN 12.0. Results: Younger patients showed higher pain response than older patients (F=33.87, p<.001). Children with respiratory diseases showed higher responses in FPRS and PBCL than children without respiratory disease (F=4.17, p=.017; F=25.31, p<.001, respectively). Children of preschool age showed higher pain response during IV cannulation than the comparison group (t=2.04, p=.045). Children who had previous experiences with hospitalization and injections showed higher response to pain than those without these experiences (t=2.05, p=.045). In regards to FPRS, patients who were recannulated showed more painful restarts compared with patients injected just once (t=-3.60, p<.001). In regards to PBCL, infants and toddlers (t=-4.88, p<.001) and preschoolers (t=-3.86, p<.001) showed high pain scores during recannulation. Conclusion: A sick child's response to pain may be worse as they feel more pain over time. These characteristics should be considered for development of nursing interventions.

• Journal of Korean Neurosurgical Society
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• 제30권5호
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• pp.638-641
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• 2001

Carboplatin intra-arterial chemotherapy(IAC) has an advantage of increased uptake during the first passage of the drugs through tumor capillaries. Although not common, this type of therapy is known to cause neurological complications, myelosuppression, and ototoxicity. However, the incidence of ocular toxicity is reported to be rare. Eleven of our patients with glioma(Grade II Astrocytoma : 3, Grade III Astrocytoma : 1, Grade IV Astrocytoma : 5, Gliofibroma : 1, Oligodendroglioma : 1) underwent IAC regimen with carboplatin($300mg/m^2$) which were administrated after blood-brain barrier disruption. Of there, 3 patients had ocular complications after supra-ophthalmic IAC injection of carboplatin but fully recovered following steroid therapy. Although our results from IAC seem to be favorable for these patients, we suggest that its complications, such as ocular toxicity, need to be carefully considered prior to treatment.

• Bulletin of the Korean Chemical Society
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• 제29권1호
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• pp.61-68
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• 2008

High initial (2 minutes after iv injection) brain-uptake of PET agents is required to deliver the agent to binding sites in brain tissue but, for quantification of the specific binding, relatively rapid washout of free and non-specifically bound PET agents from the brain (30 minutes after injection) also is required. In order to compare the physicochemical properties of the PET agents which are responsible for early brain-uptake and rapid washout, respectively, chemometric analysis on brain-uptake of PET agents was performed via a classical VolSurf approach. According to the PCA and PLS results, high 2-30 min brain-uptake ratio seems to be related to the large hydrophobic regions in the PET agents which are not confined to a particular surface.

• 대한한방내과학회지
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• 제19권2호
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• pp.317-332
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• 1998

The purpose of this study is to find out the effects of Poria extract on rat's nephrotoxicity induced by CsA. The experimental animals were divided into 3 groups and treated as follows; Nothing was given to Sample A, Sample B was given normal saline after IV injection of CsA and Sample C was given Poria extract after CsA injection. After precription of medicine, serum BUN, creatinine, total protein, sodium, potassium, chloride ions were measured. 1. Changes in serum level. ALT, BUN, chloride ion were significantly reduced in experimental group as compaired to control group, and total protein showed significant elevation in experimental group. AST was reduced, but not significant and creatine level was below the normal range. K level showed mild elevation initially and later showed mild decrease, but no significance is noted. There were no significant differance in the sodium level. 2. Changes in Urine level. Urinary specific gravity showed significant increase in experimental group compaired to control group. Urinary creatinine level initially increased, and later decreased but showed no significance. To conclude, it can be inferred that Poria may improve nephrotoxicity and hepatotoxicity in rat induced by Cyclosporin A.

• Asian-Australasian Journal of Animal Sciences
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• 제13권8호
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• pp.1059-1062
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• 2000

The objective of the investigation was to study the effect of intramuscular $PGF_2\;{\alpha}$ and GnRH on estrus behavior and ovarian response in Murrah buffalo heifers. Twelve Murrah buffalo heifers at 32 months of age that had not exhibited behavioral estrus symptom were included in the experiment. Out of 12,4 heifers were in follicular phase (plasma estradiol $57.05{\pm}12.52pg/ml$), another 4 heifers were in luteal phase (Plasma progesterone $2.24{\pm}0.25ng/ml$) while the ovaries of remaining four heifers were inactive (estradiol $23.70{\pm}1.66pg/ml$and progesterone $0.32{\pm}0.06ng/ml$). $PGF_2\;{\alpha}$ (25 mg, Lutalyse, im) and GnRH (200 ug, Fertagyl, iv) was administered to each heifer at interval of 10 days. The plasma progesterone concentration decreased within 48 hrs after $PGF_2\;{\alpha}$ injection and followed thereafter with follicular growth, estrus and ovulation. GnRH administration induced follicular growth, elevation of plasma estradiol concentration with subsequent exhibition of behavioral estrus in 2 out of 4 heifers having inactive ovary. The observation reveals that Murrah buffalo heifers at 32 months of age have developed receptors for $PGF_2\;{\alpha}$ and GnRH on ovarian and pituitary tissue respectively and response the single injection of $PGF_2\;{\alpha}$ and GnRH similar to the mature cycling animals.

• 약학회지
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• 제46권2호
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• pp.124-128
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• 2002

The nitrone-based free radical trapping reagent, $\alpha$-phenyl-n-tert-butyl nitrone (PBN) has been proposed as therapeutic agent for stroke. We used this for model drug of development of new drug for neuroprotection. The purpose of this study was to evaluate the blood-brain barrier (BBB) permeability of PBN in Sprague-Dawly (SD) rats. The BBB transport of PBN was investigated in SD rats using internal carotid artery perfusion (ICAP) method at a rate of 4 mι/min for 15 second. We also obtained pharmacokinetic parameters of PBN using single intravenous injection technique. When we estimated BBB permeability of PBN with ICAP method, the brain volume of distribution of PBN was 60.0 $\pm$ 12.0 $\mu\textrm{g}$/ι. The brain uptake of PBN after IV injection at 120 min was 0.15 $\pm$ 0.01%ID/g. The PBN was transported to the brain through the BBB well in rats, because PBN is small molecule (MW 177) and lipid-soluble (log P 1.23) compound.

• Restorative Dentistry and Endodontics
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• 제17권2호
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• pp.343-354
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• 1992

본 연구의 목적은 여러가지 근관충전법으로 충전된 근관의 폐쇄효과를 정선적 및 정량적으로 측정하여 각 충전법간의 폐쇄효과를 비교하므로써 정선적 측정법 및 정량적 측정법간의 상호 관계를 규명하는데 있다. 108개의 발거된 상악중절치 및 측절치와 상하악 견치에서 치관을 절제하고 통법대로 근관형성한 다음 4개군으로 나누어 제 I 군은 sealer를 사용하고 측방 가압근관충전법으로, 제 II 군은 sealer를 사용하고 저온연화 gutta-percha주입근관충전법으로, 제 III 군은 sealer를 사용하고 Thermafil근관충전법으로 그리고 제 IV 군은 sealer를 사용하지 않고 고온용융 gutta-percha주입근관충전법으로 충전하고 전 시편을 2 % methylene blue 용액 속에 근단부를 1mm담근 채 $37^{\circ}C$ 항온기에서 10일간 경과시켜 근단공을 통한 색소침투를 정선적 및 정량적으로 측정하여 다음의 결과를 얻었다. 정선적 측정에서는 II 군은 III군, I군 및 IV군보다, III군은 IV군보다 유의상 있게 색소침투가 적게 나타났으나 (P<0.05), 그 이외의 군들 상호간에는 유의한 차이가 없었다. 정량적 측정에서는 II 군이 가장 적게 나타나 I 군 및 IV군과는 유의한 차이가 있었으나 (P<0.05), III군과는 유의한 차이가 없었다(P>0.05). 정선적 측정과 정량적 측정과의 사이에는 미약하지만 유의한 상관관계가 있었다(r=0.3391, P<0.001).

• Radiation Oncology Journal
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• 제13권3호
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• pp.233-241
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• 1995

Purpose : To analyse clinical outcome and prognostic factors according to treatment modality, this paper report our experience of retrospective study of patients with esophageal cancer Materials and Methods : One hundred and ten patients with primary esophageal cancer who were treated in Presbyterian Medical Center from May 1985 to December 1992. We analysed these patients retrospectively with median follow up time of 28 months, one hundred and four patients($95{\%}$) were followed up from 15 to 69 months. In methods, twenty-eight patients were treated with median radiation dose irradiated 54.3Gy only. Fifty-six patients were treated with combined chemoradiotherapy. Sixteen cases of these patients were treated with concurrent chemoradiation and the other patients(forty cases) were treated sequential chemoradiotherapy. In concurrent chemoradiotherapy group, patients received 5-FU continuous IV infusion for 4 days. Cisplatin IV bolus. and concurrent esophageal irradiation to 30 Gy. After that patients received 5-FU continuous IV, Cisplatin bolus injection and Mitomycin-C bolus IV, Bleomycin continuous IV, and irradiation to 20 Gy. In sequential chemoradiotherapy group, the chemotherapy consisted of 5-FU 1,000mg/$m^2$ administered as a continuous 24 hour intravenous infusion during five days and Cisplatin 80-100mg/$m^2$ bolus injected, or Bleomycin, Vinblastine, Cisplatin, Methotrexate were used of 1 or 2 cycles. After preoperative concurrentm chemoradiation twenty-six patients underwent radical esophagectomy. Results : Ninety-three patients could be examined for response assessment, By treatment modality, response rates were $85.1{\%}$ for radiation alone group and $86.3{\%}$ for combined chemoradiation group. But in operation group, after one cycle of concurrent chemoradiation treatment, response rate was $61.9{\%}$. The pathologic complete response were $15.4{\%}$ in operation group. Overall median survival was II months and actuarial 5-year survival rate was $8{\%}$. The median survival interval was 6 months for radiation alone group, 11 months for combined chemoradiation group and 19 months for operation group. And also median survival was 19 months for complete responder group that 8 months for noncomplete responder group. In univariative analysis, statistically significant prognostic factors were tumor size, clinical stage, tumor response, and operation. In multivariative analysis, significantly better survival was associated with clinical stage, tumor response, radiation dose, and operation. Conclusion : Compared with radiotherapy alone, combined multimodality may improve the median survival in patients with localized carcinoma of the esophagus and toxicity is acceptable.

• 한국산학기술학회논문지
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• 제21권12호
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• pp.131-141
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• 2020

본 연구는 정맥주사용 가상학습 시뮬레이터와 마네킨 팔 모형을 병합한 정맥주사 실습교육이 간호대학생의 지식, 수행자신감, 간호수행능력에 미치는 효과를 확인하기 위한 연구이다. 본 연구설계는 비동등성 대조군 사전 사후 유사실험설계를 사용하였다. 연구의 참여자는 일 대학 기본간호학을 수강하는 2학년 간호대학생으로 총 93명이 모집되었으며 참여자는 병합교육군 46명, 마네킨군 47명으로 두 그룹으로 나누어 진행하였다. 자료수집기간은 2019년 3월 18일부터 3월 29일까지였다. 동일한 기간동안 실험군은 정맥주사용 가상학습 시뮬레이터와 마네킨 팔 모형을 이용한 병합교육을 각 기자재 별로 15분씩, 총 30분간 실시하였으며 대조군은 마네킨 팔 모형만을 이용한 교육을 총 30분간 실시하였다. 실험 중재 후, 실험군과 대조군의 지식점수는 통계적으로 유의한 차이가 나타나지 않았고(F=2.52, p=.116), 수행자신감(t=2.14, p=.035)과 간호수행능력(t=5.34, p<.001)은 병합교육을 받은 실험군이 마네킨 팔 모형만을 이용하여 교육을 받은 대조군보다 통계적으로 유의하게 높았다. 이상의 연구결과를 통해 본 연구에서는 정맥주사용 가상학습 시뮬레이터와 마네킨 팔 모형을 병합한 실습교육이 간호학생의 수행자신감과 간호수행능력을 향상시킨다는 실증적인 근거를 제시하였다는 것을 알 수 있었다.