• 제목/요약/키워드: IT Routine

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Comparative Analysis between Multilevel Sectioning with Conventional Haematoxylin and Eosin Staining and Immunohistochemistry for Detecting Nodal Micrometastases with Stage I and II Colorectal Cancers

  • Wong, Yin-Ping;Shah, Shamsul Azhar;Shaari, Noorsajida;Mohamad Esa, Mohd Shafbari;Sagap, Ismail;Isa, Nurismah Md
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권4호
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    • pp.1725-1730
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    • 2014
  • Management of patients with stage II colorectal carcinomas remains challenging as 20 - 30% of them will develop recurrence. It is postulated that these patients may harbour nodal micrometastases which are imperceptible by routine histopathological evaluation. The aims of our study were to evaluate (1) the feasibility of multilevel sectioning method utilizing haematoxylin and eosin stain and immunohistochemistry technique with cytokeratin AE1/AE3, in detecting micrometastases in histologically-negative lymph nodes, and (2) correlation between nodal micrometastases with clinicopathological parameters. Sixty two stage I and II cases with a total of 635 lymph nodes were reviewed. Five-level haematoxylin and eosin staining and one-level cytokeratin AE1/AE3 immunostaining were performed on all lymph nodes retrieved. The findings were correlated with clinicopathological parameters. Two (3.2%) lymph nodes in two patients (one in each) were found to harbour micrometastases detected by both methods. With cytokeratin AE1/AE3, we successfully identified four (6.5%) patients with isolated tumour cells, but none through the multilevel sectioning method. Nodal micrometastases detected by both multilevel sectioning and immunohistochemistry methods were not associated with larger tumour size, higher depth of invasion, poorer tumour grade, disease recurrence or distant metastasis. We conclude that there is no difference between the two methods in detecting nodal micrometastases. Therefore it is opined that multilevel sectioning is a feasible and yet inexpensive method that may be incorporated into routine practice to detect nodal micrometastases in centres with limited resources.

무선 Ad Hoc 네트워크를 위한 개선된 위치정보 기반의 에너지를 고려한 라우팅 프로토콜 (An Improved Energy Aware Greedy Perimeter Stateless Routing Protocol for Wireless Ad Hoc Network)

  • 김학제;윤원식
    • 대한전자공학회논문지TC
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    • 제46권11호
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    • pp.25-31
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    • 2009
  • 기존 GPSR(Greedy Perimeter Stateless Routing) 프로토콜의 Greedy Forwarding에서는 항상 목적지에 가까운 노드만을 Next-Hop으로 설정하는 방식으로, 어느 특정 노드의 에너지 소모가 커지는 경향이 있는데, 이를 해결하기 위하여 기존의 Greedy Forwarding 방식에 목적지에 가까운 노드를 선택하면서 각 노드의 에너지 잔량을 고려하여 전체 네트워크의 수명(Network lifetime)을 연장시킬 수 있는 방법을 제안한다. 무선 ad hoc 네트워크를 구성하는 노드들의 한정된 에너지를 효율적으로 사용하기 위하여 네트워크의 수명에 초점을 맞추어 각 노드들의 에너지 잔량을 고려하면서 최단 거리 역시 고려할 수 있는 라우팅 기법인 개선된 EAGPSR(Energy Aware Greedy Perimeter Stateless Routing)을 제안한다. 제한된 프로토콜의 성능 평가를 위하여 ns-2를 사용하였으며, 성능 평가를 통하여 GPSR과 기존의 EAGPSR와 비교하여 네트워크 수명이 향상된 것을 확인할 수 있다.

Validation of One-Step Real-Time RT-PCR Assay in Combination with Automated RNA Extraction for Rapid Detection and Quantitation of Hepatitis C Virus RNA for Routine Testing in Clinical Specimens

  • KIM BYOUNG-GUK;JEONG HYE-SUNG;BAEK SUN-YOUNG;SHIN JIN-HO;KIM JAE-OK;MIN KYUNG-IL;RYU SEUNG-REL;MIN BOK-SOON;KIM DO-KEUN;JEONG YONG-SEOK;PARK SUE-NIE
    • Journal of Microbiology and Biotechnology
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    • 제15권3호
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    • pp.595-602
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    • 2005
  • A one-step real-time quantitative RT-PCR assay in combination with automated RNA extraction was evaluated for routine testing of HCV RNA in the laboratory. Specific primers and probes were developed to detect 302 bp on 5'-UTR of HCV RNA. The assay was able to quantitate a dynamic linear range of $10^7-10^1$ HCV RNA copies/reaction ($R^2=0.997$). The synthetic HCV RNA standard of $1.84{\pm}0.1\;(mean{\pm}SD)$ copies developed in this study corresponded to 1 international unit (IU) of WHO International Standard for HCV RNA (96/790 I). The detection limit of the assay was 3 RNA copies/reaction (81 IU/ml) in plasma samples. The assay was comparable to the Amplicor HCV Monitor (Monitor) assay with correlation coefficient r=0.985, but was more sensitive than the Monitor assay. The assay could be completed within 3 h from RNA extraction to detection and data analysis for up to 32 samples. It allowed rapid RNA extraction, detection, and quantitation of HCV RNA in plasma samples. The method provided sufficient sensitivity and reproducibility and proved to be fast and labor-saving, so that it was suitable for high throughput HCV RNA test.

A comparison of the aerobic cost and muscle use in aerobic dance to the energy costs and muscle use on treadmill, elliptical trainer and bicycle ergometry

  • Petrofsky, Jerrold;Laymon, M.;Mcgrew, R.;Papa, D.;Hahn, R.;Kaethler, R.;Johnson, M.;Wernow, B.;Poblete, D.
    • Physical Therapy Rehabilitation Science
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    • 제2권1호
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    • pp.12-20
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    • 2013
  • Objective: To determine the energy consumed and muscle use during dance compared to different standard exercise devices. Design: Longitudinal study. Methods: Fifteen female subjects were evaluated to assess the energy cost and muscle activity during a 20 minute dance video compared to treadmill, elliptical track and bicycle ergometry. The later 3 forms of exercise were accomplished in four, 5 minute bouts at different intensities of exercise. Subjects were in the age range of 22-24 years old, were free of cardiovascular disease and did not have any neurological injuries. They were not sedentary and exercised at least twice a week. During the exercise, muscle activity was measured by the electromyogram recorded by surface electrodes on 6 muscle groups. A Cosmed metabolic cart was used to measure oxygen consumption during the exercise. Results: The aerobic dance video that was tested here was equivalent to a hard workout on any of the 3 exercise modalities. The dance routine was equivalent in terms of energy consumed to running at 225 watts of work or running for 20 minutes at a speed of 2 meters per second (4.47 miles per hour). Compared to the bicycle, it was equivalent to cycling at 112 watts for 20 minutes (2.25 kpm), and for the elliptical trainer, dance was equivalent to 435 watts. Concerning muscle use, the dance routine was the most balanced for upper, core and lower body muscles. Although the elliptical trainer was close, it required muscle less muscle use. Conclusion: A good dance video can be more effective than standard exercise equipment.

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Spinal Hydatid Cyst Disease : Challenging Surgery - an Institutional Experience

  • Caglar, Yusuf Sukru;Ozgural, Onur;Zaimoglu, Murat;Kilinc, Cemil;Eroglu, Umit;Dogan, Ihsan;Kahilogullari, Gokmen
    • Journal of Korean Neurosurgical Society
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    • 제62권2호
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    • pp.209-216
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    • 2019
  • Objective : Hydatid cyst disease is caused by the parasite Echinococcus granulosus. It is rarely seen in the vertebral system, occurring at a rate of 0.2-1%. The aim of this study is to present 12 spinal hydatid cyst cases, and propose a new type of drainage of the cyst. Methods : Twelve cases of spinal hydatid cysts, surgical operations, multiple operations, chronic recurrences, and spinal hydatic cyst excision methods are discussed in the context of the literature. Patients are operated between 2005 and 2016. All the patients are kept under routine follow up. Patient demographic data and clinicopathologic characteristics are examined. Results : Six male and six female patients with a median age of 38.6 at the time of surgery were included in the study. Spinal cyst hydatid infection sites were one odontoid, one cervical, five thoracic, two lumbar, and three sacral. In all cases, surgery was performed, with the aim of total excision of the cyst, decompression of the spinal cord, and if necessary, stabilization of the spinal column. Mean follow up was 61.3 months (10-156). All the patients were prescribed Albendazole. Three patients had secondary hydatid cyst infection (one lung and two hepatic). Conclusion : The two-way drainage catheter placed inside a cyst provides post-operative chlorhexidine washing inside the cavity. Although a spinal hydatid cyst is a benign pathology and seen rarely, it is extremely difficult to achieve a real cure for patients with this disease. Treatment modalities should be aggressive and include total excision of cyst without rupture, decompression of spinal cord, flushing of the area with scolicidal drugs, and ensuring spinal stabilization. After the operation the patients should be kept under routine follow up. Radiological and clinical examinations are useful in spotting a recurrence.

대한민국 상급 종합병원 임상현장에서 환자자기평가결과(Patient-Reported Outcome)의 일상적인 사용 현황 (Current status of routine use of Patient-Reported Outcome in the tertiary hospital clinical setting in Republic of Korea)

  • 방가람;강단비;조주희
    • 한국임상약학회지
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    • 제32권2호
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    • pp.74-83
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    • 2022
  • Objective: There is a growing movement to introduce Patient-Reported Outcome (PRO) to clinical settings. This study aimed to investigate the routine use of PRO in tertiary hospital clinical settings. Methods: From January 2016 to December 2018, the usage status of Patient-Reported Outcome Measures (PROMs) submitted to the electronic medical record of a tertiary hospital clinical setting was investigated. Descriptive analysis was conducted to investigate the usage status of PROMs by 42 departments. Also, the most frequently used PROMs by departments, the purpose of measurement, the use rate of verified PROMs were investigated. Results: The PROMs accounted for 66% (98) of the 148 Instruments. Of the 98 PROMs, 64% (63) were using a validation Korean version of PROMs. Only about 1% of total outpatient visits applied PROMs, and among them, it was frequently used in urology (13%), orthopedics (8%), and otolaryngology (5%). The use rate of the validated PROMs was found to be 64%. Conclusions: The use of PROMs in domestic clinical settings was found to be very limited and frequently used only in specific departments. It is essential to use a PROMs that has been validated according to guidelines, as the use of validated PROMs will provide beneficial information to health professionals and also for the patient health improvement by objectively measuring the patient's health status.

IoT Security and Machine Learning

  • Almalki, Sarah;Alsuwat, Hatim;Alsuwat, Emad
    • International Journal of Computer Science & Network Security
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    • 제22권5호
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    • pp.103-114
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    • 2022
  • The Internet of Things (IoT) is one of the fastest technologies that are used in various applications and fields. The concept of IoT will not only be limited to the fields of scientific and technical life but will also gradually spread to become an essential part of our daily life and routine. Before, IoT was a complex term unknown to many, but soon it will become something common. IoT is a natural and indispensable routine in which smart devices and sensors are connected wirelessly or wired over the Internet to exchange and process data. With all the benefits and advantages offered by the IoT, it does not face many security and privacy challenges because the current traditional security protocols are not suitable for IoT technologies. In this paper, we presented a comprehensive survey of the latest studies from 2018 to 2021 related to the security of the IoT and the use of machine learning (ML) and deep learning and their applications in addressing security and privacy in the IoT. A description was initially presented, followed by a comprehensive overview of the IoT and its applications and the basic important safety requirements of confidentiality, integrity, and availability and its application in the IoT. Then we reviewed the attacks and challenges facing the IoT. We also focused on ML and its applications in addressing the security problem on the IoT.

역할 창조를 위한 '몸틀(body schema)' 형성 연구 (A Study on Forming 'Body Schema' for Role Creating)

  • 송효숙
    • 한국연극학
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    • 제52호
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    • pp.319-357
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    • 2014
  • Formation of 'body schema' is the start for actor to create role and becomes the root and the foundation of existing as a role on the stage. For this, an actor needs to form 'scheme of role' with escaping from own 'body schema.' 'Schema of role' is formed by acquiring through synthesizing daily basic actions, namely, walking, standing, sitting, hand stretching, bending, and touching. The body schema, which was made with simple and usual actions, has fundamental significance in a sense of becoming the body in which the past traces in a role are habituated while energy as a role flows. As for the process of forming body schema, an actor first needs to obtain the visualized materials like photo, magazine, picture and image available for seeing a role specifically and clearly based on what analyzed a character. An actor needs to have three-dimensional image available for always recalling it in the head during acting. To do this, image data available for fundamentally capturing routine actions along with body structure are still more useful. Next, the body schema is formed by interaction with environment. Thus, there is a need of passing through the two-time process of forming body schema. Firstly, the body schema is made on routine actions in a role as physical condition of a role in actor's own everyday life. Secondly, the body schema is made on routine actions available for moving efficiently and economically in line with the environment of performance. A theatrical stage is the temporal space of rhythm and rule different from routine space. What forms body schema immediately in the second phase without body schema in the first phase ultimately becomes what exists as actor's own body, not the body of a role. The body schema, which was formed as the second process, is what truly has identity as a role in the ontological aspect, comes to experience the oppositional force in muscle, a qualitative change in energy, and emotional agitation in the physical aspect, and experiences perception, thinking, volition, and even consciousness with the entire body in the cognitive dimension. Thus, the formation of body schema can be known to be just a method of changing even spiritual and emotional layer. Body schema cannot be made if there is no process of embodiment and habit. Embodiment and habit are not simply the repeated, empty and mechanical action in the body. But, habit itself has very important meanings for forming body schema for role creating. First, habit allows the body itself to learn and understand a meaning. Second, habit relies upon environment, thereby allowing an actor of making the habituated body schema to recognize environment. Third, habit makes the mind. The habituated body schema is just the mind and the ego of a person who possesses the body schema. Fourth, habit comes to experience the expansion in energy and the expansion in existence. It may be experienced through interrelation among actor's body, tool, and environment. Fifth, habit makes identity of the body. Hence, this just becomes what secures identity of a role. These implications of habit are the formation of body schema, which is maintained with the body of being remembered firmly through being closely connected with the process of neural adaptation. Finally, it sought for possibility of practice as one method of forming body schema for role creating through Deleuze's '-becoming' theory. As 'actual animal-becoming' is real '-becoming' of forming structural transformation in the physical dimension, it meets with what the formation of body schema pursues actuality and reality. This was explained with a concept as saying of 'all '-becoming' molecular' by Deleuze/Guattari. 'Animal of having imitated animal's characteristic- becoming' is formed by which the body schema relies upon environment. In this way, relationship among the body, tool and environment has influence even upon a change in consciousness, thinking, and emotion, thereby being able to be useful for forming body schema in a sense of possibly experiencing ultimately expansion in role, namely, expansion in existence.

IT 기반의 파일 설계 시스템 개발 (Development of IT-based pile design system)

  • 유충식;김선빈;이주탁;송기용;김기욱
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2008년도 춘계 학술발표회 초청강연 및 논문집
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    • pp.335-342
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    • 2008
  • This paper concerns the development of a IT-based pile design system within the framework of geographic information system(GIS). The system is aimed at expediting a routine pile design works such as determination of pile length and stability analysis of the selected pile. The detailed system development process and functions of sub modules are provided in this paper.

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IT 기반의 지하 대공간 설계/안정성 평가 시스템 개발 (Development of IT-based Cavern Design/Stability analysis System)

  • 유충식;김선빈;조완기;유광호;박인준
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2008년도 춘계 학술발표회 초청강연 및 논문집
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    • pp.34-41
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    • 2008
  • This paper concerns the development of a IT-based tunnel design system within the framework of artificial neural networks(ANNs). The system is aimed at expediting a routine cavern design works such as determination of support patterns and stability analysis of the selected support patterns. The detailed system development process and functions of sub modules are provided in this paper.

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