• Title/Summary/Keyword: IS1112

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Novel 99mTc(CO)3 Complexes with WAY-100635 Moiety for the Development of 5-HT1A Receptor lmaging Agent

  • Choi, Kang-Hyuk;Pyun, Mi-Sun;Hong, Young-Don;Choi, Sun-ju
    • Bulletin of the Korean Chemical Society
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    • v.30 no.5
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    • pp.1107-1112
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    • 2009
  • The aim of this study is to develop and synthesize $5-HT_{1A}$ receptor imaging agents with WAY-100635 moiety and $^{99m}Tc(CO)_3$ core. WAY-100635 is commonly known as $5-HT_{1A}$ antagonist and its labeled compound ([$^{11}C$] WAY-100635) has been used as effective radioligand for imaging brain $5-HT_{1A}$ receptors with PET(Positron Emission Tomography). However, there are several restrictions in using a radioisotope of C-11 and requires for more effective radioisotopes and ligands. In order to produce a structure most similar to WAY-100635, WAY-100635 derivatives containing a cysteine chelator were designed and confirmed by using in silico (Hyperchem). The novel compounds (7a, 7b, 7c) were prepared in five or 7 steps with yields of 16%, 36% and 42%, respectively and radiolabeled with $[^{99m}Tc(CO)_3(H_2O)_3]^{+}$. The labeling yield was 99% for all the newly synthesized compounds. [$^{99m}Tc(CO)_3$]- WAY-100635 derivatives show a neutral charge which were confirmed by paper electrophoresis.

Alarm and Memo Application for Group (그룹 사용자를 위한 알람 및 메모 애플리케이션)

  • Lim, Yong-Min;Kwon, Doo-Wy;Park, Suhyun
    • Proceedings of the Korea Information Processing Society Conference
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    • 2013.05a
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    • pp.1111-1112
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    • 2013
  • The number of users topped 30 million smartphones in Korea, has become a necessity of modern people. There are many applications to provide alarm and memo, but most of them are for personal usage not groups. In this study, we present an application providing alarms and memos to all users in a group. The group alarm function provides an alarm to all members in a group when a group member set an alarm. When a memo is written by one member, the memo is shared to all members in the group. Our application will be useful to groups that should notice important information and meeting time among group members.

Design and Implement of XrML Document editing system for digital contents copyright administration (디지털 컨텐츠 저작권 관리를 위한 XrML 문서 편집 시스템의 설계 및 구현)

  • 임산송;홍진우;정회경
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.6 no.7
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    • pp.1106-1112
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    • 2002
  • Lively circulation of digital contents through internet digital contents copyright information for contents at the same time protectingness express and had many interests managing. XrML(eXtensible rights Markup Language) that is application of XML(eXtensible Markup Language) to permit efficient present and storage of copyright information for digital contents, share hereupon established by each venders laying stress on W3C. Need system that could express copyright information for digital contents in structural language by creation of this XrML document and user who use structural information of XrML to make out XrML document effectively can edit efficiently. So that user can edit XrML document that can describe about copyright or working conditions for digital contents in treatise that see hereupon efficiently, XrML text editing system for digital contents copyright administration design and embody.

Isolation of Conditional Lethal Temperature-sensitive Mutants of Bacillus sphaericus (Bacillus sphaericus의 치사감온성 돌연변이체의 분리)

  • Kim, Young Han;Lee, Hyung Hoan
    • Microbiology and Biotechnology Letters
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    • v.13 no.1
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    • pp.41-49
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    • 1985
  • Bacillus sphaericus was mutagenized with UV light irradiation and dimethyl sulfate. Thirty-five conditional lethal temperature-sensitive(ts) mutants were isolated at the nonpermissive temperature of $42^{\circ}C$ and classified into three groups by their growth characteristics on the nutrient broth, peptone glucose yeast extract agar and mineral salts agar. First was the lethal ts group, 24 mutants, which did not grow at the nonpermissive temperature, the second, 9 mutants, was the less growth is group whose growth was restricted to one-half, and the third, 2 mutants, was the cold lethal ts group whose growth was restricted at the permissive temperature($25^{\circ}C$and $30^{\circ}C$)

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Microbial Dynamics of Commercial Makgeolli Depending on the Storage Temperature

  • Kim, Hye-Ryun;Lee, Ae Ran;Kim, Jae-Ho;Ahn, Byung-Hak
    • Journal of Microbiology and Biotechnology
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    • v.22 no.8
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    • pp.1101-1106
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    • 2012
  • Market fresh makgeolli was stored at different temperatures of $4^{\circ}C$ and $25^{\circ}C$ to assess the change of the microbial diversity according to the storage temperature and period. Yeast counts increased until day 3 of storage and decreased thereafter. General and lactic acid bacterial counts continuously increased during storage. The data indicated that the control of growth of microorganisms, particularly general bacteria and lactic acid bacteria (LAB), is essential. Total acid levels started to decrease in the makgeolli stored at $4^{\circ}C$, and increased from day 6 of storage in the makgeolli stored at $25^{\circ}C$. The increase of total acid in the non-refrigerated condition greatly affected the quality of makgeolli. In both the fresh makgeolli samples stored at $4^{\circ}C$ and $25^{\circ}C$, yeast (Saccharomyces cerevisiae) and molds (Aspergillus tubingensis, Candida glaebosa, and Aspergillus niger) were noted. Denaturing gradient gel electrophoresis (DGGE) band patterns were almost constant regardless of the storage period. As for bacteria, Lactobacillus crustorum, L. brevis, and Microlaena stipoides were found in the makgeolli stored at $4^{\circ}C$, and L. crustorum, Lactobacillus sp., L. plantarum, L. brevis, L. rhamnosus, and L. similis were found in the makgeolli stored at $25^{\circ}C$. In particular, in the makgeolli stored at $25^{\circ}C$, L. crustorum and L. plantarum presented dark bands and were identified as the primary microorganisms that affected spoilage of fresh makgeolli.

Identification of Lactic Acid Bacteria in Galchi- and Myeolchi-Jeotgal by 16S rRNA Gene Sequencing, MALDI-TOF Mass Spectrometry, and PCR-DGGE

  • Lee, Yoonju;Cho, Youngjae;Kim, Eiseul;Kim, Hyun-Joong;Kim, Hae-Yeong
    • Journal of Microbiology and Biotechnology
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    • v.28 no.7
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    • pp.1112-1121
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    • 2018
  • Jeotgal is a Korean traditional fermented seafood with a high concentration of salt. In this study, we isolated lactic acid bacteria (LAB) from galchi (Trichiurus lepturus, hairtail) and myeolchi (Engraulis japonicas, anchovy) jeotgal on MRS agar and MRS agar containing 5% NaCl (MRS agar+5% NaCl), and identified them by using 16S rRNA gene sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as culture-dependent methods. We also performed polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) as a culture-independent method to identify bacterial communities. Five samples of galchi-jeotgal and seven samples of myeolchi-jeotgal were collected from different regions in Korea. A total of 327 and 395 colonies were isolated from the galchi- and myeolchi-jeotgal samples, respectively. 16S rRNA gene sequencing and MALDI-TOF MS revealed that the genus Pediococcus was predominant on MRS agar, and Tetragenococcus halophilus on MRS agar+5% NaCl. PCR-DGGE revealed that T. halophilus, Tetragenococcus muriaticus, and Lactobacillus sakei were predominant in both types of jeotgal. T. halophilus was detected in all samples. Even though the same species were identified by both culture-dependent and -independent methods, many species identified by the culture-dependent methods were not in the bacterial list identified by the culture-independent methods. The distribution of bacteria in galchi-jeotgal was more diverse than in myeolchi-jeotgal. The diverse LAB in galchi- and myeolchi-jeotgals can be further studied as candidates for starter cultures to produce fermented foods.

Identification of Polymorphisms of Fas Gene and Association Analysis in Hanwoo

  • Kim, Seung-Chang;Lee, Seung-Hwan;Kim, Bum-Soo;Kim, Tae-Hun;Seong, Hwan-Hoo;Oh, Sung-Jong;Yoon, Du-Hak;Choi, Bong-Hwan
    • Journal of Animal Science and Technology
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    • v.53 no.6
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    • pp.511-516
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    • 2011
  • Fas gene known to associate with intramuscular fat content in Korean cattle was selected for DNA marker development. Fas (APO-1, CD95), a member of the tumor necrosis factor (TNF) receptor superfamily, is a cell membrane protein that mediates apoptosis (programmed cell death). We discovered single nucleotide polymorphisms (SNPs) within Fas gene in order to develop novel DNA markers at genomic level. Of this gene to search for SNP, sequences of whole exon and 1kb range of both front and back of the gene using 24 cattle were determined by direct-sequencing methods. As a result, 16 SNPs in exon, 37 SNPs in intron and 2 SNPs in promoter region, a total of 55 SNPs were discovered. In these SNPs, thirty-one common polymorphic sites were selected considering their allele frequencies, haplotype-tagging status and Linkage Disequilibrium (LD) for genotyping in larger-scale subjects. Selected SNPs were confirmed genotype through SNaPshot method (n=274) and were examined for possible genetic association of Fas polymorphisms with carcass weight (CWT), eye muscle area (EMA), and backfat thickness (BF). So, the SNP have been identified significant g.-12T>G, g.1112T>G and g.32548T>C. These results suggest that polymorphism of Fas gene was associated with meat quality traits in Hanwoo.

Mitral Valve Reconstruction (승모판 재건술)

  • 이현우
    • Journal of Chest Surgery
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    • v.28 no.12
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    • pp.1107-1112
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    • 1995
  • Between December 1993 and December 1994, fifty-eight percent of the mitral valve patients[33/57 had undergone mitral valve repair. Their mean age was 49[SD-16 years[range 11 - 75 and they were consisted with 15 males and 18 females. The causes of mitral disease in 33 patients were classified as follows: 19 cases[58% were degenerative, 9[27% were rheumatic, 3[9% were congenital and 2[6% were infectious. Carpentier`s functional classification was consisted with Class I 4 cases[12% , II 25 [76% and III 4 [12% . Surgical techniques included prosthetic annuloplasty in 32 cases[97% , leaflet resection in 16[48% , chorda shortening in 13[39% , chorda transfer in 9[27% , new chorda formation in 7[21% , commissurotomy in 7[21% , leaflet mobilization in 4[12% , chorda resection in 3[9% , papillary muscle splitting in 2[6% , cleft repair in 2[6% , leaflet patching in 1[3% and vegetation removal in 1[3% . Average number of mitral anatomical lesions per patient was 3.3 and We used average 3.0 procedures upon mitral valve apparatus per patient. Intraoperative transesophageal echocardiography was carried out in 27 patients[82% for providing an immediate and accurate assessment of the adequacy of the reconstruction before closure of the chest. Operative mortality was absent. The mean functional class[NYHA was 2.87 preoperative and improved to 1.03 postoperatively. Postoperative Doppler echocardiography showed much improvement from grade II MR[5 , grade III[5 , grade IV[21 to no MR[26 , only trace MR[3 , grade III MR[2 . Postoperative mean mitral valve area was 2.4$\pm$0.6cm2[range 1.5 - 4.0 . We conclude that cautiously evaluated mitral valve reconstruction is stable and predictable operation with minimal postoperative left ventricular dysfunction.

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The Design Development of Man's Royal Costume in TV Historical Drama (TV 사극 <이산>의 현대적 감각의 남자 궁중의상디자인 개발)

  • Lee, Keum-Hee;Lee, Hye-Lan
    • The Research Journal of the Costume Culture
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    • v.17 no.6
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    • pp.1112-1128
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    • 2009
  • The purpose of this study was to develop royal costume design with contemporary taste depending on the character of hero, Lee San, and time flow of TV historical drama and research design discrimination and creative expression. As study methods, the literature study using books and theses concerning costume, fine art, culture and history were used for theoretical background and the empirical study method manufacturing actual costume on the basis of literature and relic were used for dress manufacture. The design concept of costume was modern & chic & clean. The costume was designed through straight silhouette, clean & bright colors excluding prime colors, style transformed to permanent straight pleats on the basis of chulik, 100% silk material focusing on high quality and pattern & decoration of the age of Three Kingdoms. As results, the designs of princess' official rob, day dress and chulik, and emperor's official robe, chulik, military dress and chun-dam-bok were developed. The design discrimination depending on social status change. In the period of princess, black, white, silver and blue were used but in the period of emperor, red, gold and black were used. It was expressed through dragon pattern and extended length used in cloth. The design discrimination depending on character change was visualized through color. Although it is not consistent with historical investigation, contemporary fashion design elements were added to royal costume through color contrast of black & white, permanent straight pleats, velcore, wristlet, extended length and layered-look.

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Synthesis and Characterization of Dense Ceramic Membranes for Methane Conversion - Part II

  • Santos, A.;Fontes, V.A.;Fontes, F.A.Oliveira;De Sousa, J.F.;De Souza, C.P.
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09b
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    • pp.1112-1113
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    • 2006
  • The perovskite- type oxide $(ABO_3)$ containing transition metals on the B-site show mixed (electronic/ionic) conductivity. These mixed-conductivity oxides are promising materials for oxygen permeating membranes. The main objective of this research work is to synthesize and characterization ceramic powders of the Sr-Co-Fe-O system for methane conversion using membrane reactor. SCFO powders were synthesized from the route was based on the complex method of combination of acid EDTA and citrate and shown be available by control efficient of synthesis to performed $SrCo_{0.8}Fe_{0.2}O_{3-\delta$, moreover, it presented easy implementation, reproducibility and operation. Powder ceramic was characterized by XRD, microscopic optic, SEM and TG-DTA.

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