• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6053-6057
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• 2014

Aim: To determine utility of the frozen section (FS) in the operative management of endometrial pre-malignant lesions. Materials and Methods: We retrospectively analyzed patients who underwent abdominal hysterectomy with preoperative diagnosis of complex atypical endometrial hyperplasia (CAEH) and simple endometrial hyperplasia (SEH) between May 2007 and December 2013. Frozen and paraffin section (PS) results were compared. Sensitivity, specificity, the positive predictive value (PPV), the negative predictive value (NPV) and the accuracy in predicting EC on FS were evaluated with 95% confidence intervals (CIs) for each parameter. The correlation between FS and PS was calculated as an ${\kappa}$ coefficient. Results: Among 143 preoperatively diagnosed CAEH cases, 60 (42%) were malignant and 83 (58%) were benign in PS; and among 60 malignant cases diagnosed in PS, 43 (71%) were "malignant" in FS. Sensitivity, specificity, PPV and NPV for FS were 76%, 100%, 100% and 87.5%, respectively. Conclusions: We found that FS is reliable and applicable in the management of endometrial hyperplasias. It is important that the pathologist should be experienced because FS for endometrial pre-malignant lesions has significant inter-observer variability. The other conclusion is that patients with the diagnosis of EH, especially those who are postmenopausal, should undergo surgery where FS investigation is available.

• 보건교육건강증진학회지
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• 제21권3호
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• pp.87-100
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• 2004

Objective: This research has been conducted in order to conduct sex education using information and communication technologies (ICT) which is currently taught to elementary school students, understand how this method of education affects the knowledge of and attitude towards sexual health in them, so that it could be actually applied in classrooms. Subject: 115 students were divided into three different groups: a comparison group of 38 students (who were given no sex education at all), control 2 group of 39 students (who were given sex education via video programmes), and control 1 group of 38 students (who were given sex education using ICT). Research Tool: A questionnaire used by the literature studies. After verifying content validity, it was modified and supplemented in this way: sex knowledge was reduced to 26, and sex attitude was also reduced to 11. The reliability of the research tool was Cronbach's a=0.86 for sex knowledge tool, and Cronbach's a=0.81 for sex attitude tool. The collected data have been analysed using SPSS 11.0 program. The content validity was analysed by factor analysis and multiple regression analysis, and hypothesis verification was analysed using repeated measure ANOVA test. Result: 1) In sex knowledge marks, there was a significant difference according to the group (p=.009) and point of time (p=.000), and there was a significant interaction between the groups and point of time(P=.000). As a result, it turned out that both video programmes and ICT were significantly effective in improve the knowledge. 2) In sex attitude marks, there were no significant differences according to the group (p=.213), but there was a significant difference according to point of time (p=.002), and there was a significant interaction between the groups and point of time(P=.018). As a result, it turned out that only the education method using ICT was effective in improving the attitude. Conclusion: From the results of this research, it can be said that the sex education using ICT was the most effective method in improving the sex knowledge and attitude of students at elementary school. Therefore, it is advisable that the sex education methods using ICT should be developed and applied continuously.

• Mass Spectrometry Letters
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• 제11권4호
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• pp.113-117
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• 2020

Cytochrome P450 2J2 (CYP2J2) is a member of the cytochrome P450 superfamily, and is known to be arachidonic acid epoxygenase that mediates the formation of four bioactive regioisomers of epoxyeicosatrienoic acids (EETs). CYP2J2 is also involved in the metabolism of drugs such as albendazole, astemizole, danazol, ebastine, and terfenadine. CYP2J2 is highly expressed in the heart and cancer tissues. In this study, the inhibitory potential of ten natural products against CYP2J2 activity was evaluated using human liver microsomes and tandem mass spectrometry. Among them, bilobetin, which is a kind of biflavonoid, exhibits a strong inhibitory effect against the CYP2J2-mediated astemizole O-demethylation (IC50 = 0.73 μM) and terfenadine hydroxylation (IC50 = 0.89 μM). This result suggests that bilobetin can be used as strong CYP2J2 inhibitor in drug metabolism study.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4127-4131
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• 2015

Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.

• International Journal of Knowledge Content Development & Technology
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• 제11권3호
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• pp.45-62
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• 2021

Half a century has passed since the academic field of library and information science, which was born at the end of the 19th Century in the Western world, was introduced to Korea. Despite years of quantitative growth and qualitative maturation, the field has been facing the inconvenient truths of discrepancies in education levels arising from varying education providers, and weakened public confidence in librarian certification. Based on analysis of librarian training and education programs and the certification system, this research seeks to point out the limitations of the national librarian certification system, which is losing public confidence, and present a model for improvement. Library and information science education has expanded from universities to the academy of librarian education and lifelong education centers, and the librarian certification system has emerged as a target of reform. This research presents measures to improve the librarian certification system to government bodies and the Committee on Library and Information Policy with the purpose of providing grounds for policy enforcement.

• 한국전문물리치료학회지
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• 제12권1호
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• pp.100-110
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• 2005

Patient education is one of the most important roles of a physical therapist. Physical therapists have to teach and provide information about illness, instruct for home exercise, and give advice relating to correct posture and daily activities et al. For an efficient education some strategies are required. The purpose of this article is to review general learning methods, to introduce elements that influence the procedure of patient education and learning, and to plan an education strategy.

• 4차산업연구
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• 제2권2호
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• pp.1-9
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• 2022

Purpose - The purpose is to present an efficient library-use education model in the form of flip learning, reflecting traditional teaching methods and gamification elements even in such non-face-to-face and face-to-face situations after COVID-19. Research design, data, and methodology - Research on library use education, research on ubiquitous environment and gamification instructional design, flip the learning, and gamification elements are classified, compared, and analyzed to present educational models for library education, COVID-19 Pandemic situation, and subsequent library use education. Result - We propose an e-learning content development strategy for flipped learning-based library education. First, benchmark and use the existing educational contents. Second, a user-friendly interface is configured so that learners can flexibly organize their learning contents. Third, it allows learners to experience it directly or indirectly in a virtual space. Conclusion - If the e-learning environment can be standardized to the level of schools or educational institutions, a good educational model that can be used not only in library user education but also in other fields will be possible.

• 유통과학연구
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• 제21권1호
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• pp.23-31
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• 2023

Purpose: this study is aimed at assessing the contribution of education and innovation to the economic growth of Kazakhstan, the correlation between them is checked based on two levels on a national scale and a regional scale. Based on the literature review, it was revealed that in the vastness of the scientific community, there are many views concerning the influence of educational and innovative factors on economic growth. Research design, data and methodology: the research methodology is divided into two levels, at the first level, a correlation analysis is carried out between key factors and the economic growth of the country (GDP), at the second level, the same factors are analyzed, but the impact on the economic growth of the region (GRP) is estimated. Statistical data on educational and innovation potential is taken from the Bureau of National Statistics for the period 2003-2021. Results: in this study, it was revealed that the economic development of regions could be influenced by such indicators that cannot affect the entire state in aggregate and vice versa. In addition, the correlation analysis results showed that investments in innovations affect economic growth at the country and the regional level. Conclusions: based on the results of the assessment of educational and innovative potential, policy recommendations and further research in this area were proposed.

• 통상정보연구
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• 제15권3호
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• pp.411-430
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• 2013

전자무역의 단계별 성과를 볼 때 계약체결 이전 단계의 해외마케팅은 해외시장진출의 가장 큰 장애요인이면서 가장 많은 역량이 투여되는 부문으로 이에 대한 교육 및 연구체계를 재정립할 필요가 있다. 전자무역은 인터넷과 정보통신기술의 발전에 따른 파생적 수요성격이 강한 학문적 영역으로 무역실무와 더불어 무역학의 핵심주제로 부각되고 있다. 그러나 2000년대 중반이후 전자무역 관련분야 연구와 교육교재개발 등이 점차 감소되고 있는 실정이다. 따라서 본 연구에서는 우리나라 전자무역 중 해외마케팅의 측면에서 교육 및 학문적 연구체계와 성과를 검토하고 향후 해외마케팅 부문 교육과 연구체계 수립에 대한 방향을 제시하였다. 그 결과 전자무역관련 교육 및 연구 중 산업계에서 활성화되고 있는 검색엔진마케팅, 검색엔진최적화, 소셜네트워크분석 등에 대한 교육 및 연구체계를 확립해 나가는 것이 시급하다고 할 수 있다. 또한 이론과 실무가 접목되어 병행되는 캡스톤디자인 교과목의 도입이 필요하다고 할 수 있다.

• 대한화학회지
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• 제43권5호
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• pp.564-577
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• 1999

본 연구는 학생들이 갖고 있는 입자개념과 분자운동에 관한 개념을 바탕으로 기체의 상태변화, 분자운동, 압력과 부피, 기체법칙 등 기체의 성질과 관련된 중${\cdot}$고등학생들의 오개념을 조사하고, 그 오개념의 분포상황을 고찰함으로서 개념 학습의 효율화를 추구하고, 교사에게는 관련 단원의 학습 전개에 도움을 주고자 하였다. 이를 위해 중학교 3학년 1O0명, 고등학교 2학년 150명을 대상으로 기체의 성질과 관련된 개념조사 문항지를 개발하여 오개념의 유형을 조사하엿다. 그 결과 학생들은 기체의 성질에 대한 다양한 오개념을 가지고 있었으며, 주 오개념은 다음과 같다.(1) '기체 분자들끼리 부딪혀 에너지를 방츨한다' 또는 '기체 분자들 사이에 공기가 채워져 압력이 나타난다'를 비롯하여 '압력이 작용하는 방향은 중력 방향과 관련 있다', (2) 온도에 따른 부피변화에서 '분자가 열을 받으면 분자의 크기가 커져 부피가 증가한다'와 '분자수가 증가해 분자들의 운동이 활발하다', (3) 고도에 따른 압력과 부피 개념에서는 지상에서 높이 을라감에 따라 압력이 낮아지는 것은 온도가 낮아지기 때문이다'와 '기체 분자의 압력은 기체분자의 충돌 수에 반비례한다', (4) '분자의 크기가 다르므로 같은 부피에 존재하는 분자수가 다르다' 등이었다.