• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(1)
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• pp.435-438
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• 2002

A design of Ku-band(11.7~12.20Hz) monolithic microwave integrated circuit(MMIC) low noise block(LNB) downconverter using self oscillating mixer (SOM) for direct broadcast satellite(DBS) application is presented The proposed LNB downconverter is composed of low noise amplifier(LNA), image reject filter(IRF), SOM , low pass filter(LPF). The conversion gain is 30dB , VSn is less than 1.7: 1 and overall noise figure is less than 1.2dB.

• 대한토목학회논문집
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• 제33권1호
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• pp.207-218
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• 2013

대형 사력댐의 내진성능 평가에서 필히 요구되는 입력상수는 사력재료, 코아매질의 전단파 속도이다. 이를 표면파 시험으로 평가하기 위해서는 사력골재의 불연속, 매질의 비균질, 사면 경계면 등 표면파 시험결과의 신뢰도를 떨어뜨리는 조건을 극복해야 한다. 본 연구에서는 이러한 표면파시험의 한계를 극복하기 위하여 기존 빔형성기법의 원리를 응용한 SBF (Short-Array Beamforming) 기법을 제안하였다. SBF 기법은 3~9 m의 짧은 측선과 원거리 발진원을 이용함으로써, 빔형성기법 고유의 장점인 측정자료의 자동화분석뿐만 아니라 근접장 문제의 해결, 국부적 이상대의 발견 등의 기능을 가지도록 개발되었다. 본 연구에서는 이러한 SBF 기법과 IRF(Impulse-Response Filtration) 기법을 활용하여 대형 사력댐의 전단파속도를 신뢰성 있게 평가하는 방법을 정립하였다. 정립된 기법은 사력댐의 사력재료와 유사한 암버럭으로 매립 성토된 철도 노반에서 다운홀 시험, CapSASW (Common-Array-Profiling SASW) 시험과의 비교를 통하여 그 신뢰성과 실용성을 검증하였다.

• Journal of Chest Surgery
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• 제53권5호
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• pp.250-257
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• 2020

Background: Lung adenocarcinoma (LUAD) with ground-glass opacity (GGO) can become aggravated, but the reasons for this aggravation are not fully understood. The goal of this study was to analyze the genetic features and causes of progression of GGO LUAD. Methods: LUAD tumor samples and normal tissues were analyzed using an Illumina HiSeq 4000 system. After the tumor mutational burden (TMB) was calculated, the identified mutations were classified as those found only in GGO LUAD, those present only in nonGGO LUAD, and those common to both tissue types. Ten high-frequency genes were selected from each domain, after which protein interaction network analysis was conducted. Results: Overall, 227 mutations in GGO LUAD, 212 in non-GGO LUAD, and 48 that were common to both tumor types were found. The TMB was 8.8 in GGO and 7.8 in non-GGO samples. In GGO LUAD, mutations of FCGBP and SFTPA1 were identified. FOXQ1, IRF5, and MAGEC1 mutations were common to both types, and CDC27 and NOTCH4 mutations were identified in the non-GGO LUAD. Protein interaction network analysis indicated that IRF5 (common to both tissue types) and CDC27 (found in the non-GGO LUAD) had significant biological functions related to the cell cycle and proliferation. Conclusion: In conclusion, GGO LUAD exhibited a higher TMB than non-GGO LUAD. No clinically meaningful mutations were found to be specific to GGO LUAD, but mutations involved in the epithelial-mesenchymal transition or cell cycle were found in both tumor types and in non-GGO tissue alone. These findings could explain the non-invasiveness of GGO-type LUAD.

• 한국식품과학회지
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• 제39권5호
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• pp.481-487
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• 2007

Toll-like receptors (TLRs) induce innate immune responses that are essential for host defenses against invading microbial pathogens, thus leading to the activation of adaptive immune responses. In general, TLRs have two major downstream signaling pathways: the MyD88- and TRIF-dependent pathways, which lead to the activation of $NF-{\kappa}B$ and IRF3. Numerous studies have demonstrated that certain phytochemicals possessing anti-inflammatory effects inhibit $NF-{\kappa}B$ activation induced by pro-inflammatory stimuli, including lipopolysaccharides and $TNF{\alpha}$. However, the direct molecular targets for such anti-inflammatory phytochemicals have not been fully identified. Identifying the direct targets of phytochemicals within the TLR pathways is important because the activation of TLRs by pro-inflammatory stimuli can induce inflammatory responses that are the key etiological conditions in the development of many chronic inflammatory diseases. In this paper we discuss the molecular targets of resveratrol, (-)-epigallocatechin-3-gallate (EGCG), and curcumin in the TLR signaling pathways. Resveratrol specifically inhibited the TRIF pathway in TLR3 and TLR4 signaling, by targetting TBK1 and RIP1 in the TRIF complex. Furthermore, EGCG suppressed the activation of IRF3 by targetting TBK1 in the TRIF-dependent signaling pathways. In contrast, the molecular target of curcumin within the TLR signaling pathways is the receptor itself, in addition to $IKK{\beta}$. Together, certain dietary phytochemicals can modulate TLR-derived signaling and inflammatory target gene expression, and in turn, alter susceptibility to microbial infection and chronic inflammatory diseases.

• 대한한방부인과학회지
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• 제21권1호
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• pp.39-54
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• 2008

Purpose: The purpose of this study was to investigate the anti-inflammatory effects of the water extract of Omisodokeum (OMSDE) on peritoneal macrophages, Methods: To verify the anti-inflammatory mechanism of OMSDE, the activation of nuclear $factor-{\kappa}B$ $(NF-{\kappa}B)$ and the phosphorylation of MAPK were examined. Results: The extract of OMSDE suppressed the production of LPS-induced nitric oxide (NO), tumor necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\beta}$, IL-6 and IL-12 in the macrophages. OMSDE inhibited the degradation of inhibitory ${\kappa}B-{\alpha}$ $(I{\kappa}B-{\alpha})$ and it suppressed the activation of extracellular signal-regulated kinase (ERK 1/2) but didn't inhibit c-Jun N-terminal kinase (JNK) and p38, indicating that OMSDE may inhibit the pro-inflammatory cytokine production process by inhibiting the activation of $NF-{\kappa}B$ and ERK 1/2. Furthermore, OMSDE inhibited the production of interferon $(IFN)-{\beta}$ but didn't inhibit of $IFN-{\alpha}$ in the LPS-stimulated macrophages through the down-regulation of interferon regulatory factor (IRF)-1 and IRF-7. The Oral administration of OMSDE inhibited LPS-induced endotoxin shock and the production of $TNF-{\alpha}$ in serum but didn't inhibit of $IL-1{\beta}$ and IL-6. Conclusion: These results suggest that OMSDE may be effective in the prevention and treatment of inflammatory diseases.

• Journal of Microbiology and Biotechnology
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• 제29권12호
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• pp.2014-2021
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• 2019

Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the genus Betacoronavirus and causes severe morbidity and mortality in humans especially when infected patients have underlying diseases such as chronic obstructive pulmonary disease (COPD). Previously, we demonstrated that MERS-CoV-encoded ORF8b strongly inhibits MDA5- and RIG-I-mediated induction of the interferon beta (IFN-β) promoter activities. Here, we report that ORF8b seemed to regulate MDA5 or RIG-I differentially as protein levels of MDA5 were significantly down-regulated while those of RIG-I were largely unperturbed. In addition, ORF8b seemed to efficiently suppress phosphorylation of IRF3 at the residues of 386 and 396 in cells transfected with RIG-I while total endogenous levels of IRF3 remained largely unchanged. Furthermore, ORF8b was able to inhibit all forms of RIG-I; full-length, RIG-I-1-734, and RIG-I-1-228, the last of which contains only the CARD domains. Taken together, it is tempting to postulate that ORF8b may interfere with the CARD-CARD interactions between RIG-I and MAVS. Further detailed analysis is required to delineate the mechanisms of how ORF8b inhibits the MDA5/RIG-I receptor signaling pathway.

• 한국인터넷방송통신학회논문지
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• 제20권3호
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• pp.9-14
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• 2020

본 논문에서는 SAR 탑재체에 적용할 수 있는 X-band 주파수합성기 인증모델(QM)을 설계 및 제작하고, 우주환경모의 시험을 통해 그 성능을 검증하였다. 제작된 주파수합성기는 상하향변환에 필요한 13.XXGHz 의 저잡음 국부신호를 생성하는 역할을 수행하며, 10Hz에서 1MHz 까지 측정된 적분 위상잡음은 -37.91 dBc 이다. 측정된 위상잡음을 통해 SAR 성능지표인 IRF성능 영향분석을 수행하였으며, 0.2 ps 의 지터로 PSLR과 ISLR에 영향 없이 SAR 시스템에 적용 가능함을 확인하였다. 또한, 열분석, 구조분석을 수행하여 안정성을 확인하였으며, 열진공, 열주기, 진동, 충격 시험을 통해 우주환경 내성을 확인하였다. 제작된 QM 급 주파수합성기는 L-band, C-band, Ku-band 주파수를 출력하며, 6U모듈 2개로 설계를 하였다. 본 연구를 통해 국내 위성용 RF 모듈의 국산화 기술 확보와 SAR 위성용 주파수합성기 기술 개발에 활용이 가능하다.

• IMMUNE NETWORK
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• 제12권3호
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• pp.113-117
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• 2012

FasL, perforin, $TNF{\alpha}$, IL-1 and NO have been considered as effector molecule(s) leading to ${\beta}$-cell death in autoimmune diabetes. However, the real culprit(s) of ${\beta}$-cell destruction have long been elusive despite intense investigation. Previously we have suggested $IFN{\gamma}/TNF{\alpha}$ synergism as the final effector molecules in autoimmune diabetes of NOD mice. A combination of $IFN{\gamma}$ and $TNF{\alpha}$ but neither cytokine alone, induced classical caspase-dependent apoptosis in murine insulinoma and pancreatic islet cells. $IFN{\gamma}$ treatment conferred susceptibility to $TNF{\alpha}$-induced apoptosis on otherwise resistant murine insulinoma cells by STAT1 activation followed by IRF-1 induction. Here we report that $IFN{\gamma}/TNF{\alpha}$ synergism induces apoptosis of human pancreatic islet cells. We also observed STAT1 activation followed by IRF-1 induction by $IFN{\gamma}$ treatment in human islet cells. Taken together, we suggest that $IFN{\gamma}/TNF{\alpha}$ synergism could be involved in human islet cell death in type 1 diabetes, similar to murine type 1 diabetes.

• 한국항행학회논문지
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• 제21권3호
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• pp.220-229
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• 2017

본 연구는 다양한 DC 전원을 활용할 수 있는 승압형 DC-DC 컨버터로 설계사양을 통한 인덕터 L과 커패시터 C의 값을 산출하여 PSPICE를 통한 최적의 값을 추정하였다. 승압형 DC-DC 컨버터는 스위치 소자로 IRF840을 사용하였으며 역회복 시간(reverse recovery time)이 뛰어난 쇼트키 다이오드(schottky rectifiers)인 D10SC6M을 사용하여 정전류 제어 (constant current controller)가 가능하도록 구성하였으며 열저항을 고려한 파워 LED 모듈 (power LED module)을 제작하여 구동하였다. 컨버터의 스위칭 주파수는 50 kHz로 최초 듀티비는 10 %에서 출력전압의 검출 값에 따라 점차적으로 증가시키도록 하였다. 그 결과로 승압형 파워 LED 구동기를 시뮬레이션 한 특성은 설계사양과 비교하여 5 %이하의 오차로 근사적으로 나타났고, 입력전압 15 V를 인가하여 안정된 24 V의 안정된 출력전압을 얻었으며 디밍제어 (dimming control)를 통한 밝기 조절 및 소비전류의 조정이 가능하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제1회 추계심포지움 and 제2회 생리분자과학연구센터워크숍
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• pp.17-20
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• 1993

As a step toward a more complete understanding of the molecular actions of TNF, we prepared a cDNA library from TNF-treated human FS-4 fibroblasts and used differential hybridization to identify cDNA clones corresponding to mRNAs enriched in TNF-treated eells. In Quiescent FS-4 cells n induces an increase in the level of some mRNAs within 20 to 30 min. Some of these immediate-early response mRNAs are elevated only transiently for about 30 to 120 min, e. g., c-fos and c-myc (Lin and Vilcek,1987) or the transcription factor IRF-1 (Fujita et al.1989). Such immediate-early gene products may be important for the activation of other genes, but their transient induction suggests that they are not the actual effector molecules responsible for the phenotypic changes induced by TNF. We chose a 3-h incubation with W because we were seeking cDNAs corresponding to messages that are more stably elevated after TNF treatment. Indeed, the results shown in Figure 8 and 9 indicate that all of the mRNAs corresponding to the eight TSG cDNAs isolated remained significantly elevated after 16h of continuous treatment with TNF, and their kinetics of induction were clearly different from those of the immediate-early response mRNAs such as c-fos, c-myc or IRF-1. Nevertheless, only the induction of TSG-21 (collagenase) and TSG-27 (stromelysin) nNAs was completely inhibited by cycloheximide and the induction of TSG-37 (metallothionein-II) was reduced in the presence of this inhibitor of protein synthesis. Induction of the other five TSG mRNAs by TNF was completelyresistant to cycloheximide, suggest ins that no protein intermediate is needed for the upregulation of these mRNAs.