• Korean Journal of Poultry Science
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• v.28 no.2
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• pp.99-106
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• 2001

Pathologic changes and distribution of viral antigen as determined by immunohistochemistry were compared among 4-wk-old specific-pathogen free (SPF) chickens inoculated intratracheally with velogenic vis-cerotropic Newcastle disease virus isolated in Korea. Although the pattern of organ involvement and severity of lesion was different among chickens infected with different velogenic viscerotropic Newcastle disease (VVND) viruses, the pathological types of lesion was similar among the chickens. Severe lymphocytic necrosis and depletion were main histologic lesions in the immune related organs such as thymus, Fabricius bursa and spleen. The frequency of IP positive staining was variable depends on the types of tissues but not types of the kinds of VVND viruses infected. Brain, Fabricius bursa, thymus, cecal tonsil and trachea were IP positive with fairly high frequency and spleen, lung, proventriculus, intestine, pancreas, liver, kidney, heart and Harderian gland were with relatively low frequency. These results suggest that histologic evaluation and viral antigen specific immunohistochemical staining methods to determine virus distribution will be useful for pathogenic study of velogenic viscerotropic Newcastle disease virus infection in chicken.

• Journal of Gifted/Talented Education
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• v.20 no.3
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• pp.767-788
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• 2010

The purpose of this study was to examine emotional characteristics and to provide information about the special needs of counselling of science gifted in Korea. The subjects were 143 science gifted high school students in Busan that had been tested MBTI and MMPI-A. The distribution map of MBTI type was examined and Pearson's correlation, one-way ANOVA, multiple regression analysis were used to analyse the relation between MBTI and MMPI-A through SPSS 17.0 program. The results showed as follows: first, ENTP, INTP, ISTJ personality types and NT temperament type were the most frequently from the distribution map of MBTI type. Second, F1, F2, F, Hs, D, Pt, Sc and Si scales of MMPI-A were positively related to I preference of MBTI and K and Ma scales of MMPI-A were significantly related to E preference of MBTI from Pearson's correlation. Third, The score of IN group was significantly more high in F1, Hs, D, SC and Si scales of MMPI-A than other group in the relation between two combination preferences of MBTI and scale of MMPI-A. The following results were same; IS group in D, Si scales, EN group in Ma scale, IT group in Hs, D, Pt and S scales, IF group in VRIN, D and Si scales, ET in Ma scale, IJ group in D and Si, IP group in F1, F, Hs, D, Hy, Pt, Sc and Si scales, EJ and EP groups in Ma scale. Finally, I preference of MBTI by F1, F2, F, Hs, D, Pt, Sc and Si scales of MMPI-A, E preference of MBTI by Ma scale of MMPI-A, F preference of MBTI by K scale of MMPI-A and P preference of MBTI by Hy scale of MMPI-A were significantly predicted from multiple regression analysis. Limitations of the current study and the suggestions for further research were offered.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.6
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• pp.341-346
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• 2005

The mechanism underlying oxidant-induced intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) increase was studied in cultured bovine aortic endothelial cells (BAECs) using fura-2 AM. In the presence of 2 mM extracellular $Ca^{2+}$, the application of DTBNP ($20{\mu}M$), a membrane-permeable oxidant, caused an increase in $[Ca^{2+}]_i$, and DTT (2 mM) as a reductant completely reversed the effect of DTBNP. The $[Ca^{2+}]_i$ increase induced by DTBNP was also observed in an extracellular $Ca^{2+}$-free/2 mM EGTA solution, indicating the release of $Ca^{2+}$ from intracellular store(s). After endoplasmic reticulum was depleted by an $IP_3$-generating agonist, ATP ($30{\mu}M$) or an ER $Ca^{2+}$ pump inhibitor, thapsigargin ($1{\mu}M$), DTBNP-stressed BAECs showed an increase of $[Ca^{2+}]_i$ in $Ca^{2+}$-free/2 mM EGTA solution. Ratio-differences before and after the application of DTBNP after pretreatment with ATP or thapsigargin were $0.42{\pm}0.15$ and $0.49{\pm}0.07$, respectively (n=7), which are significantly reduced, compared to the control value of $0.72{\pm}0.07$ in a $Ca^{2+}$-free/2 mM EGTA solution. After the protonophore CCCP ($10{\mu}M$) challenge to release mitochondrial $Ca^{2+}$, the similar result was obtained. Ratio-difference before and after the application of DTBNP after pretreatment with CCCP was $0.46{\pm}0.09$ (n=7). Simultaneous application of thapsigargin and CCCP completely abolished the DTBNP-induced $[Ca^{2+}]_i$ increase. The above results together indicate that the increase of $[Ca^{2+}]_i$ by DTBNP resulted from the release of $Ca^{2+}$ from both endoplasmic reticulum and mitochondria.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.8B
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• pp.492-501
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• 2007

UMTS-WLAN interworking approach can make the best use of the advantages of both networks by eliminating the stand-alone defects of the two services. For the interworking mechanisms of WLANs and UMTS networks, two major solutions have been proposed, namely loose coupling and tight coupling. The loose coupling approach provides separate data paths for WLAN and UMTS. On the other hand, the tight coupling provides a full integration of the WLAN network and the UMTS core network. The loose coupling has been preferred due to the simplicity and less reconfiguration requirement. However, loose coupling is worse in seamless mobility, QoS provision, and network security. In order to lessen the problems involved in the UMTS-WLAN interworking approaches, we propose a new interworking network architecture and a fast vertical handover scheme by employing Mobility Anchor(MA) for interworking between the two different networks. MA can enable authentication and session initialization before L2 handover of the mobile terminal, so that the seamless and fast vertical handover become possible. Thru analysis and numerical experiments, we proved that the proposed scheme has been validated.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.48 no.11
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• pp.27-33
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• 2011

Recently many display devices support the digital display interface as display market growth. DisplayPort is a next generation display interface at the PC, projector and high definition content applications in more widely used connection solution development. This paper implements multiple streams based on the behavior of the main link that is suitable for the display port v1.1a standard. The limit point of Displayport, interface between the Sink Device and Sink Device is also implemented. And two or more differential image data are enable to output the result through four Lanes stated in display port v1.1a, of two or more display devices without the addition of a separate Lane. The Multiple Video Streaming Controller is implemented with 6,222 ALUTs and 6,686 register, 999,424 of block memory bits synthesized using Quartus II at Altera Audio/Video Development board (Stratix II GX FPGA Chip).

• Journal of the Korean Society of Systems Engineering
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• v.15 no.2
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• pp.66-71
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• 2019

In digital pathology, an electronic system in the biomedical domain storage of the files is a big constrain and because all the analysis and annotation takes place at every user-end manually, it becomes even harder to manage the data that is being shared inside an enterprise. Therefore, we need such a storage system which is not only big enough to store all the data but also manage it and making communication of that data much easier without losing its true from. A virtual server setup is one of those techniques which can solve this issue. We set a main server which is the main storage for all the virtual machines(that are being used at user-end) and that main server is controlled through a hypervisor so that if we want to make changes in storage overall or the main server in itself, it could be reached remotely from anywhere by just using the server's IP address. The server in our case includes XML-RPC based API which are transmitted between computers using HTTP protocol. JAVA API connects to HTTP/HTTPS protocol through JAVA Runtime Environment and exists on top of other SDK web services for the productivity boost of the running application. To manage the server easily, we use Tkinter library to develop the GUI and pmw magawidgets library which is also utilized through Tkinter. For managing, monitoring and performing operations on virtual machines, we use Python binding to XML-RPC based API. After all these settings, we approach to make the system user friendly by making GUI of the main server. Using that GUI, user can perform administrative functions like restart, suspend or resume a virtual machine. They can also logon to the slave host of the pool in case of emergency and if needed, they can also filter virtual machine by the host. Network monitoring can be performed on multiple virtual machines at same time in order to detect any loss of network connectivity.

• BMB Reports
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• v.53 no.5
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• pp.266-271
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• 2020

Breast cancer encompasses a major portion of human cancers and must be carefully monitored for appropriate diagnoses and treatments. Among the many types of breast cancers, triple negative breast cancer (TNBC) has the worst prognosis and the least cases reported. To gain a better understanding and a more decisive precursor for TNBC, two major histone modifications, an activating modification H3K4me3 and a repressive modification H3K27me3, were analyzed using data from normal breast cell lines against TNBC cell lines. The combination of these two histone markers on the gene promoter regions showed a great correlation with gene expression. A list of signature genes was defined as active (highly enriched H3K4me3), including NOVA1, NAT8L, and MMP16, and repressive genes (highly enriched H3K27me3), IRX2 and ADRB2, according to the distribution of these histone modifications on the promoter regions. To further enhance the investigation, potential candidates were also compared with other types of breast cancer to identify signs specific to TNBC. RNA-seq data was implemented to confirm and verify gene regulation governed by the histone modifications. Combinations of the biomarkers based on H3K4me3 and H3K27me3 showed the diagnostic value AUC 93.28% with P-value of 1.16e-226. The results of this study suggest that histone modification analysis of opposing histone modifications may be valuable toward developing biomarkers and targets for TNBC.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4349-4356
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• 2015

This study examine operating system for eco-friendly container terminal and shows the usefulness of the Importance-performance analysis grid in evaluating container terminal operating technology. Importance-performance analysis enables management to evaluate and identify the major strengths and weaknesses of eco-friendly container terminal operating technology's key success factors. This study identified a list of 20 items from the eco-friendly container terminal literature reviews, and each item was rated using a 5-point Likert scale. Responses were obtained from 250 questionnaires. The importance-performance grid shows that 13 items fall into the "Keep up the good work" quadrant, 2 items fall into the "Concentrate here" quadrant, 2 items fall into the "Low priority" quadrant, and 3 items fall into the "Possible overkill" quadrant. The findings suggest that an eco-friendly container terminal operating technology is necessary to enhance eco-friendly operating system. The results are useful in identifying areas for strategic focus to help container terminal managers develop eco-friendly container terminal operating technology strategies.

• ETRI Journal
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• v.36 no.3
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• pp.352-360
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• 2014

This paper presents a 900 MHz zero-IF RF transceiver for IEEE 802.15.4g Smart Utility Networks OFDM systems. The proposed RF transceiver comprises an RF front end, a Tx baseband analog circuit, an Rx baseband analog circuit, and a ${\Delta}{\Sigma}$ fractional-N frequency synthesizer. In the RF front end, re-use of a matching network reduces the chip size of the RF transceiver. Since a T/Rx switch is implemented only at the input of the low noise amplifier, the driver amplifier can deliver its output power to an antenna without any signal loss; thus, leading to a low dc power consumption. The proposed current-driven passive mixer in Rx and voltage-mode passive mixer in Tx can mitigate the IQ crosstalk problem, while maintaining 50% duty-cycle in local oscillator clocks. The overall Rx-baseband circuits can provide a voltage gain of 70 dB with a 1 dB gain control step. The proposed RF transceiver is implemented in a $0.18{\mu}$ CMOS technology and consumes 37 mA in Tx mode and 38 mA in Rx mode from a 1.8 V supply voltage. The fabricated chip shows a Tx average power of -2 dBm, a sensitivity level of -103 dBm at 100 Kbps with PER < 1%, an Rx input $P_{1dB}$ of -11 dBm, and an Rx input IP3 of -2.3 dBm.

• International Journal of Vascular Biomedical Engineering
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• v.3 no.2
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• pp.1-9
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• 2005

Flow-induced dilation of blood vessel is the result of a series of bioreaction in vascular endothelial cells(VEC). Shear stress change by blood flow in human artery or vein is sensed by the mechanoreceptor and responsible for such a chain reaction. The inositol(1,4,5)-triphophate($IP_3$) is produced in the first stage to elevate permeability of the intercellular membrane to calcium ions by which the cytosolic calcium concentration is consequently increased. This intracellular calcium transient triggers synthesis of EDRF and prostacyclin. The mathematical model of this VEC calcium dynamics is reproduced from the literature. We then use the Computational Fluid Dynamics(CFD) technique to investigate the blood stream dictating the VEC calcium dynamics. The pulsatile blood flow in a stenosed blood vessel is considered here as a part of study on thrombogenesis. We calculate the pulsating shear stress (thus its temporal change) distributed over the stenosed artery that is implemented to the VEC calcium dynamics model. It has been found that the pulsatile shear stress induces larger intracellular $Ca^{2+}$ transient plus much higher amount of EDRF and prostacyclin release in comparison with the steady shear stress case. It is concluded that pulsatility of the physiological shear stress is important to keep the vasodilation function in the stenosed part of the blood vessel.