• Title/Summary/Keyword: INFECTION INDEX

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Postoperative infection after cranioplasty in traumatic brain injury: a single center experience

  • Mahnjeong, Ha;Jung Hwan, Lee;Hyuk Jin, Choi;Byung Chul, Kim;Seunghan, Yu
    • Journal of Trauma and Injury
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    • v.35 no.4
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    • pp.255-260
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    • 2022
  • Purpose: To determine the incidence and risk factors of postoperative infection after cranioplasty in patients with traumatic brain injury (TBI). Methods: Data of 289 adult patients who underwent cranioplasty after TBI at a single regional trauma center between year 2018 and 2021 were reviewed retrospectively. Patient characteristics and various procedural variables, such as interval between craniectomy and cranioplasty, estimated blood loss, laterality and materials of the bone flap, and duration and classification of perioperative antibiotics usage were analyzed. Results: Postoperative infection occurred in 17 patients (5.9%). Onset time of infectious symptom ranged from 9 days to 174 days (median, 24 days) after cranioplasty. The most common cultured organism was Staphylococcus aureus (47.1%), followed by Klebsiella pneumoniae (17.6%) and Enterococcus faecalis (17.6%). Patients with postoperative infection were more likely to have diabetes (odds ratio [OR], 6.96; 95% confidence interval [CI], 1.92-25.21; P=0.003), lower body mass index (OR, 0.81; 95% CI, 0.66-0.98; P=0.029), and shorter duration of perioperative antibiotics (OR, 0.83; 95% CI, 0.71-0.98; P=0.026). Conclusions: For TBI patients with diabetes, poor nutritional status should be managed cautiously for increased risk of infection after cranioplasty. Further studies and discussions are needed to determine an appropriate antibiotics protocol in cranioplasty.

Correlation between clinical changes and viral genome copy number in rock bream infected with red sea bream iridovirus (참돔이리도바이러스 감염 돌돔에서 임상적 변화와 viral genome copy number 간의 상관관계)

  • Dong Jun Shin;Yi Seol Jeong;Min Jae Kim;Guk Hyun Kim;Kwang Il Kim
    • Journal of fish pathology
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    • v.36 no.2
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    • pp.229-238
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    • 2023
  • In this study, the correlation between clinical changes and RSIV genome copy number was investigated to determine the quantitative criteria for the characteristics of RSIV infection. The rock bream (Oplegnathus fasciatus) was intraperitoneally injected with three different doses (1.0×101, 1.0×103 and 1.0×105 viral genome copies/fish) as low, medium, and high doses, respectively. The clinical signs (spleen enlargement, death) observation and real-time PCR were conducted at 5, 10 and 14 days post-injection. During the experiment, spleen index as a quantitative indicator for spleen enlargement was continuously increased in the medium- (up to 2.26) and high-dose (up to 4.99) challenge groups, respectively. Notably, when the spleen index was over 1.5, 2.0, 2.5 and 3.0, a positive correlation was revealed with average viral genome copy numbers of 2.51, 3.37, 4.97 and 5.43×107 viral genome copies/mg, respectively. Moreover, the threshold of spleen index over 1.5 was 1.0×106 viral genome copies/mg, while the thresholds of spleen index over 2.0 and dead was 2.51×107 viral genome copies/mg and the thresholds of spleen index over 2.5 and 3 was 3.98×107 viral genome copies/mg. These findings suggest the possibility of quantitatively analyzing the characteristics and development process of RSIV infection.

A contact investigation after exposure to a child with disseminated tuberculosis mimicking inflammatory bowel disease

  • Kim, Dongsub;Lee, Sodam;Kang, Sang-Hee;Park, Mi-Sun;Yoo, So-Young;Jeon, Tae Yeon;Choi, JoonSik;Kim, Bora;Choi, Jong Rim;Cho, Sun Young;Chung, Doo Ryeon;Choe, Yon Ho;Kim, Yae-Jean
    • Clinical and Experimental Pediatrics
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    • v.61 no.11
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    • pp.366-370
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    • 2018
  • Purpose: Tuberculosis (TB) is one of the most important diseases that cause significant mortality and morbidity in young children. Data on TB transmission from an infected child are limited. Herein, we report a case of disseminated TB in a child and conducted a contact investigation among exposed individuals. Methods: A 4-year-old child without Bacille Calmette-$Gu{\acute{e}}rin$ vaccination was diagnosed as having culture-proven disseminated TB. The child initially presented with symptoms of inflammatory bowel disease, and nosocomial and kindergarten exposures were reported. The exposed individuals to the index case were divided into 3 groups, namely household, nosocomial, or kindergarten contacts. Evaluation was performed following the Korean guidelines for TB. Kindergarten contacts were further divided into close or casual contacts. Chest radiography and tuberculin skin test or interferon-gamma-releasing assay were performed for the contacts. Results: We examined 327 individuals (3 household, 10 nosocomial, and 314 kindergarten contacts), of whom 18 (5.5%), the brother of the index patient, and 17 kindergarten children were diagnosed as having latent TB infection (LTBI). LTBI diagnosis was more frequent in the children who had close kindergarten contact with the index case (17.1% vs. 4.4%, P=0.007). None of the cases had active TB. Conclusion: This is the first reported case of TB transmission among young children from a pediatric patient with disseminated TB in Korea. TB should be emphasized as a possible cause of chronic diarrhea and failure to thrive in children. A national TB control policy has been actively applied to identify Korean children with LTBI.

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

  • Pandey, Renu;Misra, Vatsala;Misra, Sri Prakash;Dwivedi, Manisha;Misra, Alok
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9171-9176
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    • 2014
  • Aim: P53, the most commonly mutated tumor suppressor gene in all types of human cancer, is involved in cell cycle arrest and control of apoptosis. Although p53 contains several polymorphic sites, the codon 72 polymorphism is by far more common. There are divergent reports but many studies suggest p53 pro/pro SNP may be associated with susceptibility to developing various cancers in different regions of the world. The present study aimed to find any correlation between H. pylori infection and progression of carcinogenesis, by studying apoptosis and the p53 gene in gastric biopsies from north Indian population. Materials and Methods: A total of 921 biopsies were collected and tested for prevalence of H. pylori by rapid urease test (RUT), imprint cytology and histology. Apoptosis was studied by the TUNEL method. Analysis of p53 gene polymorphism at codon 72 was accomplished by PCR using restriction enzyme BstU1. Observation: Out of 921 samples tested 56.7% (543) were H. pylori positive by the three techniques. The mean apoptotic index (AI) in the normal group was 2.12, while gastritis had the maximum 4.24 followed by gastric ulcer 2.28, gastropathy 2.22 and duodenal ulcer 2.08. Mean AI in cases with gastric cancer (1.72) was less than the normal group. The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% & 33.66%) as compared to p53 pro/pro variant (25.74%) inthe healthy population. Conclusions: The North Indian population harbors Arg or Pro/Arg SNP that is capable of withstanding stress conditions; this may be the reason of low incidence of gastric disease in spite of high infection with H. pylori. There was no significant association with H. pylori infection and AI. However, there is increased apoptosis in gastritis which may occur independent of H. pylori or p53 polymorphism.

Mapping of the Damaged Forest by Oak Wilt Disease in Bukhansan National Park (북한산국립공원 참나무시들음병 피해지 맵핑 연구)

  • Yeum, Jung-Hun;Han, Bong-Ho;Choi, Jin-Woo;Jeong, Hee-Un
    • Korean Journal of Environment and Ecology
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    • v.27 no.6
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    • pp.704-717
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    • 2013
  • This study aims to provide basic data for management and prevention of infection damage by Oak wilt disease through mapping method of status with infected level in damaged area of Bukhansan National Park. Survey was carried out in the distributed area of oak trees with mapping unit of polygon of actual vegetation and mapped of infection ratio and infection index applying weight according to infected level. Infection ratio of oak trees in Bukhansan National Park was 58.5%, and lightly damaged ratio was 29.6%, half of the damaged ratio was 16.1%, seriously damaged ratio was 8.8% and withered ratio was 4.1%. It was serious to be infected from Beomgol ridge in Wondobong district to Hyeongjaebong in Jeongrung district. Although the infected ratio of the western part of Songchu district, Sanseong district and Gugi district centering main ridge of Bukhansan National Park was low, it of ridge and main valley was high. Infection index of hardly damaged area was 39.1% of whole area, and slightly damaged area was 41.0%, half of the damaged area was 16.1%, seriously damaged area was 3.3% and alarmed withering area was 0.4%. Infection index was high around Musugol valley in Dobong district and Jaunbong, and it of Bohyunbong of Jeongrung district and the part of Hyojari valley of Sanseong district was serious. Predicted numbers of the trees affected Oak wilt disease compared to the distributed area of oak trees was 1,585,937 trees among 2,709,147 trees of Quercus spp. 352,931 trees among the 306,161 trees of oak were infected in Woi district, the most seriously infected area and 53,141 trees among the 145,747 trees of oak was infected in Gugi district, the most slightly infected area.

Heterophil Phagocytic Activity Stimulated by Lactobacillus salivarius L61 and L55 Supplementation in Broilers with Salmonella Infection

  • Sornplang, Pairat;Leelavatcharamas, Vichai;Soikum, Chaiyaporn
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.11
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    • pp.1657-1661
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    • 2015
  • Newborn chicks are susceptible to Salmonella enterica serovar Enteritidis (SE). The objective of this study was to evaluate the effect of Lactobacillus probiotic isolated from chicken feces on heterophil phagocytosis in broiler chicks. A total of 150 newborn broiler chicks were divided into 5 groups (30 chicks per group) as follows: group 1 (normal control), given feed and water only, group 2 (positive control) given feed, water and SE infection, group 3 (L61 treated) given feed, water, SE infection followed by Lactobacillus salivarius L61 treatment, group 4 (L55 treated) given feed, water, SE infection followed by L. salivarius L55 treatment, and group 5 given feed, water, SE infection followed by L. salivarius L61 + L55 combination treatment. After SE infection, L. salivarius treatment lasted for 7 days. The results showed that L. salivarius L61 and L. salivarius L55 treatment, either alone or combination of both, increased the survival rate after SE infection, and upregulated heterophil phagocytosis and phagocytic index (PI). Conversely, chick groups treated with Lactobacillus showed lower SE recovery rate from cecal tonsils than that of the positive control group. The PI values of the chicken group with SE infection, followed by the combination of L. salivarius L61 and L. salivarius L55 were the highest as compared to either positive control or normal control group. Two Lactobacillus strains supplementation group showed significantly (p<0.05) higher PI value at 48 h than 24 h after treatment.

High Seroprevalence of Helicobacter pylori Infection in Korean Adolescent Athletes (한국의 청소년 운동선수들에서 Helicobacter pylori IgG의 높은 혈청 양성률)

  • Kim, Heung-Ryel;Ahn, Yeon-Hwa;Choe, Yon-Ho;Lee, Ji-Eun;Hong, Yun-Chul
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.4 no.2
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    • pp.161-166
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    • 2001
  • Purpose: Poor living conditions such as overcrowding and sharing a bed are reported to be significant risk factors for H. pylori infection throughout childhood. We investigated the prevalence of Helicobacter pylori infection in Korean athletes who are obliged to live together in training camps over six months a year. Methods: Blood sampling and surveying through questionnaire were performed on 440 regular high school students (228 boys and 212 girls) and 220 athletes (148 boys and 72 girls) of a physical education high school. We measured serum IgG Ab to H. pylori in order to compare the prevalence of H. pylori infection between normal adolescents and athletes. In addition, we conducted a nutritional analysis and questionnaire survey for socioeconomic status in order to compare other risk factors that might influence H. pylori infection between groups. Results: The prevalence (43.2%) of H. pylori infection in athletes was higher than that (22.7%) in the controls. No significant differences in the nutritional factors or socioeconomic status, such as Hollingshead index, type of house, and crowding index, were found between the groups. Multivariate analysis showed that crowding and the difference in school type were the significant predictors of H. pylori seropositivity after controlling for dietary and socioeconomic factors. Conclusion: Living together in training camps might be a significant risk factor for H. pylori infection in athletes.

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Review of Clinical Research about Herbal Medicine Treatment on Recurrent Respiratory Tract Infection in Children (소아 반복성 호흡기 감염의 한약 치료에 대한 임상 연구 동향: 중의학 논문을 중심으로)

  • Lee, Ji Hong;Lee, Eun Ju;Lee, Bo Ram;Chang, Gyu Tae
    • The Journal of Pediatrics of Korean Medicine
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    • v.30 no.2
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    • pp.82-95
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    • 2016
  • Objectives The purpose of this study is to investigate recent clinical studies on effect of herbal medicine treatment for recurrent respiratory tract infection in children. Methods We searched some clinical studies about recurrent respiratory tract infection in children from the China Academic Journal (CAJ) of China National Knowledge Infrastructure (CNKI) (January 2011 to December 2015). Results 50 papers were selected from 168 studies. The herbal decoction was main herbal medicine treatment for recurrent respiratory tract infection in children. Commonly used herbs were Atractylodis Rhizoma Alba, Glycyrrhizae Radix, Astragali Radix, Saposhnikovia Radix and Pseudostellariae Radix. Yupingfeng keli was the most frequently used herbal compound. Total effective rate was 66.4-100%, experimental group was significantly higher than control group in 45 papers (P<0.05). Immune index (in 22 papers) and curative effect of TCM syndrome (in 7 papers) were significantly higher than those of control group after treatment (p<0.05). Conclusions Herbal medicine has been shown as an effective treatment on recurrent respiratory tract infection in children. These research results can be utilized in other clinical studies and in treatment of recurrent respiratory tract infection for children.

Recommendation for conducting process of an epidemiological survey in respiratory syncytial virus infection (호흡기세포융합바이러스감염증 역학조사 수행절차 제안)

  • Kim, Dae Soon;Bae, Jong-Myon
    • Journal of Medicine and Life Science
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    • v.17 no.1
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    • pp.29-32
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    • 2020
  • As respiratory syncytial virus(RSV) is transmitted either via directly contact with an infected case or via indirectly contaminated fomites or skin, the major preventive measures are strict hand hygiene, early detection of transmitted sources, and rapid isolation of RSV patients. Especially early detection of hidden cases is the most critical control measure when an index case was notified in a postpartum center. The Guideline of Korea Centers for Diseases Control and Prevention defines potential contacts in an epidemiologic survey as admitted newborns, parents of index cases, center's workers, and visitors for 10 days before the first diagnosis day of index case. However, it needs to classify potential contacts in more detail in order to conduct a successful survey. Authors conducted to search related literatures and appraise the evidences. Firstly, potential contacts would be classified into RSV-related symptomatic contacts(SxC) and asymptomatic contacts. And then, mother, caring workers, and visitors of the index cases among asymptomatic contacts would be defined as the asymptomatic close contacts(ASCC). Finally, the rest would be defined as the asymptomatic regular contacts(ASRC). The defined test using reverse transcription-PCR is applied to SxC and ASCC, and decision of isolation or regular activities are made according to the results. The rapid antigen detection test kits are applied to ASRC. These suggestions might be helpful to detect hidden cases earlier and prevent a further infection.

The Efficacy of Chlorhexidine in Hemodialysis Vascular Access Device Disinfection (혈액투석 혈관통로 소독에 있어 클로르헥시딘의 효과)

  • Yang, Ji-Hyun;Yu, Young-Mi;Yu, Min-Gyeong;Moon, Sung-Mi;Park, Sue-Jean
    • Quality Improvement in Health Care
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    • v.23 no.1
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    • pp.55-67
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    • 2017
  • Purpose:The purpose of this study was to apply the disinfection method using chlorhexidine in practice on disinfection of vascular access for hemodialysis. Methods: This study was designed as a randomized controlled trial for examining effectiveness on infection of the vascular access device for hemodialysis when using chlorhexidine and betadine/alcohol. One-hundred-thirty study participants were separated into two groups randomly. Infection signs of the vascular access device for hemodialysis were observed and recorded before disinfection on vascular access device. Result: Before the study, there was no difference between the experimental group (chlorhexidine group) and the control group (betadine/alcohol group) in general characteristics and hematological index. Incidence of infection rate of chlorhexidine group was 0 percent and the betadine/alcohol group was 1.5 percent. There was no significant difference between the two groups. Conclusion: This study examined the effectiveness of prevention of infection with the disinfection method using chlorhexidine and betadine/alcohol. The disinfection method using chlorhexidine is considered an effective and alternative method of betadine/alcohol.