• 제목/요약/키워드: IL2RA

검색결과 375건 처리시간 0.029초

고려홍삼의 콜라겐 유도 관절염의 예방과 억제효과 (Preventive and Inhibitory Effect of Korean Red Ginseng on Collagen-Induced Arthritis in Mice)

  • 조미란;왕옥철;장진선;김채균
    • Journal of Ginseng Research
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    • 제33권2호
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    • pp.149-154
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    • 2009
  • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by inhibiting the secretion of inflammatory cytokines like $TNF-{\alpha}$, IL-1, -6, and -8, and $IPN-{\gamma}$. In this study, whether KRG extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To induce arthritis, type II collagen emulsified in Complete Freund's Adjuvant was intradermally injected into the base of the tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund's Adjuvant was administered. The oral administration of KRG extract for 8${\sim}$10 weeks at the dose of 300 mg/kg (three days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-${\alpha}$, but the plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that KRG has preventive and inhibitory effects on collagen-induced arthritis.

김발형 초음파 이동음원 추적센서 개발을 위한 의사최적 도래각 추정기법 (Quasi-Optimal DOA Estimation Scheme for Gimbaled Ultrasonic Moving Source Tracker)

  • 한슬기;이혜경;나원상;박진배;임재일
    • 전기학회논문지
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    • 제61권2호
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    • pp.276-283
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    • 2012
  • In this paper, a practical quasi-optimal DOA(direction of arrival) estimator is proposed in order to develop a one-axis gimbaled ultrasonic source tracker for mobile robot applications. With help of the gimbal structure, the ultrasonic moving source tracking problem can be simply reduced to the DOA estimation. The DOA estimation is known as one of the representative long-pending nonlinear filtering problems, but the conventional nonlinear filters might be restrictive in many actual situations because it cannot guarantee the reliable performance due to the use of nonlinear signal model. This motivates us to reformulate the DOA estimation problem in the linear robust state estimation setting. Based on the assumption that the received ultrasonic signals are noisy sinusoids satisfying linear prediction property, a linear uncertain measurement model is newly derived. To avoid the DOA estimation performance degradation caused by the stochastic parameter uncertainty contained in the linear measurement model, the recently developed NCRKF (non-conservative robust Kalman filter) scheme [1] is utilized. The proposed linear DOA estimator provides excellent DOA estimation performance and it is suitable for real-time implementation for its linear recursive filter structure. The effectiveness of the suggested DOA estimation scheme is demonstrated through simulations and experiments.

e-Lollapalooza: A Process-Driven e-Business Service Integration System fore-Logistics Services

  • Kim, Kwang-Hoon;Ra, Il-Kyeun
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제1권1호
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    • pp.33-51
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    • 2007
  • There are two newly emerging research issues in the enterprise information systems literature. One is the scalability issue for rapidly increasing choreographic volumes between interrelated organizations. The other is the business intelligence issue for traceable and monitorable business processes and services interchanging e-Business data and applications across organizations. Based upon these emerging issues, through a functional extension of the ebXML technology we have developed a process-driven e- Business service integration (BSI) system, which is named ‘e-Lollapalooza’. It consists of three major components ? the Choreography Modeler coping with the processdriven collaboration issue, the Runtime & Monitoring Client for coping with the business intelligence issue and the EJB-based BSI Engine coping with the scalability issue. This paper particularly focuses on the e-Lollapalooza’s development aspects for supporting the ebXML-based choreography and orchestration among the engaged organizations in a process-driven multiparty collaboration for e-Logistics and e- Commerce services. Here, it is fully deployed in an EJB-based middleware computing environment for e-Logistics process automation and B2B choreography.

ACRT에 의한 초크랄스키 대류진동 제어 (Control of oscillatory Czochralski convection by ACRT)

  • 최정일;성형진
    • 대한기계학회논문집B
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    • 제20권7호
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    • pp.2397-2408
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    • 1996
  • A numerical study was made of the control of transient oscillatory flow modes in Czochralski convection. The reduction of temperature oscillation was achieved by changing the rotation rate of crystal rod, .OMEGA.$_{S}$=.OMEG $A_{S0}$(1+ $A_{S}$sin(2.pi. $f_{S}$/ $t_{p}$t)). The temporal behavior of oscillation flow was scrutinized over broad ranges of two parameters, i.e., the rotation amplitude( $A_{S}$.leq.0.5) and the nondimensional frequency (0.9.leq. $f_{S}$.leq.1.5). The mixed convection parameter was ranged 0.225.leq.Ra/PrR $e^{2}$.leq.0.929, which encompassed the buoyancy-and forced-dominant convection regimes. Computational results revealed that the temperature oscillations could be reduced effectively by a proper adjustment of the control parameters. The uniformity of temperature distribution near the crystal rod was examined. The control of oscillatory flow modes was also made for a realistic, low value of Pr.

습식 석탄 가스화 장치에서 버너노즐에 따른 미립화 특성 (Atomization characteristics of burner nozzle for entrained flow gasifier)

  • 라호원;이재구;최영찬;윤상준;손영일;홍재창
    • 한국신재생에너지학회:학술대회논문집
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    • 한국신재생에너지학회 2008년도 춘계학술대회 논문집
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    • pp.353-355
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    • 2008
  • 최근 석탄 가스화 기술은 화석연료인 석탄을 기존의 공해물질 발생을 90%이상 줄이면서 고효율로 활용할 수 있는 방법으로 각광받고 있다. 본 연구는 습식 석탄 가스화기에서 가스화의 핵심적인 요소인 버너의 분무 관계 분야에 대한 분무 특성 및 무화성능을 높일 수 있는 분무기의 구조 및 운전 조건 등을 제시 할 목적으로 분무 시 내부를 관찰 할 수 있는 아크릴을 이용하여 내부 혼합식 버너를 제작하였다. 미립화 특성을 파악하기 위하여 $O_2$/Fuel Ratio 및 버너의 내부 혼합 방식, 분사각도, 각 분사 높이에 따른 미립화 특성을 관찰하였으며, 입도 분석은 심파텍사의 입도 분석기를 이용하여 측정하였다. 내부 혼합식 버너의 입도는 분사 각도와 $O_2$/Fuel Ratio에 따라서 변화하는 경향을 나타냈으며, 공급되어지는 Fuel은 석탄 슬러리와 물을 이용하여 각각의 입도를 측정하였다. slurry의 공급량이 고정된 상태에서 산소 공급량이 증가함에 따라 미립화도는 증가하는 경향을 나타내었으며, 슬러리 공급량과 산소 공급량이 동일한 경우 버너의 분사 각도에 따라 미립화도가 다르게 나타나는 특성을 관찰하였다.

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Nutritional Quality of Dried Pig Placenta

  • Jang, Ae-Ra;Kim, Il-Joon;Lee, Moo-Ha;Jo, Cheo-Run
    • Preventive Nutrition and Food Science
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    • 제12권2호
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    • pp.89-94
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    • 2007
  • Nutrients and hormone levels of dried pig placenta were studied. Placentas were freeze-dried (FD), oven-dried at 60 (OD-60), and 90$^{\circ}C$ (OD-90) and then crushed by a blender into small pieces. FD and OD-60 pig placenta had a higher moisture content than did OD-90, with no difference between FD and OD-60. There were no large differences in compositions of crude protein, crude fat, and crude ash of dried placenta among the treatments and the contents of K, Fe, and ${\alpha}$-tocopherol were highest in FD (p<0.05). Glutamine and glycine were the most abundant amino acids in all dried placenta and tyrosine was highly retained in FD placenta, compared with OD (p<0.05). Estradiol was the major sex hormone, followed by progesterone and testosterone in all dried placentas. Antibiotics including amoxicillin, sulfamethazine, tylosin, and chlorotetracyclin were not detected from the pig placentas tested. These results demonstrate that placenta is a good biomaterial with high nutritional quality, and that freeze drying is superior to oven drying for processing pig placenta.

저소득층 가정 부모의 아동안전사고 예방행위 실천에 영향을 미치는 요인 (Factors Affecting Parental Practices of In-home Injury Prevention for Young Children in Low-Income Families)

  • 황라일;임여진
    • 한국보건간호학회지
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    • 제27권2호
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    • pp.254-266
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    • 2013
  • Purpose: This study examined the characteristics of in-home injuries of children in low-income families and sought to identify the factors affecting parental in-home injury prevention practices. Methods: A cross-sectional descriptive survey design was applied, using questionnaires on in-home injury characteristics in children, parental in-home injury prevention practices, parental perceptions and knowledge on childhood injuries, and the Parental Stress Index. We queried 169 parents of children less than 5years of age who were enrolled in Nutrition Plus Projects at community health centers. Results: Overall, 92.7% of children had experienced in-home injuries, with sliding crashes and bumping injuries as the most frequent type of injury. The recovery rate with a scar after injury was 26.3%. Parental practices for in-home injury prevention were higher according parental age, educational status, and previous learning experiences regarding in-home safety and injury prevention. The two most significant factors affecting parental in-home injury prevention practices were age and parental perception of childhood injuries as being controllable and preventable. Conclusions: Considering the high risk of in-home childhood injuries in low-income families, safety education and the promotion of injury prevention practices for parents are recommended. The strategy to enhance the parental perception on preventing childhood injuries needs to be addressed.

치주조직유도재생술 시행시 Gore-tex 차폐막에 부착되는 치주세균에 대한 미노클린첨부제의 향균력에 대한 미생물학적 연구 (Microbiological study of the antibacterial effects of locally delivered $Minocycline^R$ on the plaque accumulation on $Gore-tex^R$ membrane during the guided tissue regeneration therapy)

  • 최점일;주애라
    • Journal of Periodontal and Implant Science
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    • 제26권2호
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    • pp.356-364
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    • 1996
  • The present study was done to evaluate the antibacterial effects of $Minoclin^R$ which was localally delivered on the $Gore-tex^R$ barrier membrane in the guided tissue regeneration(GTR) therapy for treatment of human furcal defects. Beneath the membranes. the antibiotics were applied for 1 week and then changed with new one. The $Minoclin^R$ was removed out one week later. 6 weeks after the GTR therapy. No systemic antibiotics were administered except for oral mouthrinses with chlorhexidines. 2 weeks and 6 weeks following the membrane therapy, the bacterial samples were examined for periodontopathic microorganisms. The results indicated that the locally delivered $Minoclin^R$ successfully inhibited the growth of periodontopathic organisms. This results might be further applied in the subgingival plaque control regimen in the GTR procedure, especialy in patients who is contraindicated for oral administration of systemic antibiotics

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간호사의 직장 내 약자 괴롭힘, 리더-구성원 교환관계가 이직의도에 미치는 영향 (Influence of Workplace Bullying and Leader-Member Exchange on Turnover Intention among Nurses)

  • 한미라;구정아;유일영
    • 간호행정학회지
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    • 제20권4호
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    • pp.383-393
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    • 2014
  • Purpose: The purpose of this descriptive study was to identify the impact of workplace bullying and LMX (Leader-Member Exchange) on turnover intention among nurses. Methods: The participants were 364 nurses from the Seoul metropolitan area who were attending a continuing education program. A structured questionnaire was used for data collection and data were analyzed using the SPSS/Window program. Hierarchical multiple regression analysis was performed to verify the effect of variables on turnover intention. Results: Higher workplace bullying was associated with higher turnover intention. Workplace bullying was negatively correlated with leader-member exchange. The most influential factors for turnover intention were LMX (${\beta}=-7.22$, p<.001), work load (${\beta}=2.96$, p=.003), and workplace bullying (${\beta}=2.64$, p=.009). These factors accounted for 28% of the variance in turnover intention. Conclusion: The study results indicate that there is need to develop strategies to prevent workplace bullying and cultivate a good relationship between nursing managers and nurses to lower nurses' turnover intention.

초고에너지 우주선 관측을 위한 JEM-EUSO 프로젝트의 진행 현황

  • 임희진;김석환;김순욱;박일흥;양종만;이직;정애라
    • 천문학회보
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    • 제37권2호
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    • pp.222.1-222.1
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    • 2012
  • JEM-EUSO (Extreme Universe Space Observatory on-board the Japanese Experiment Module)는 국제우주정거장(International Space Station)의 일본 실험 모듈인 'KIBO'에 우주 망원경을 설치하여, 100 EeV이상의 초고에너지 우주선 관측을 수행함으로써, 초고에너지의 스펙트럼, 구성성분과 기원을 연구하는 국제공동연구 프로젝트이다. 구경 2.5 m로 60도의 광시야각을 가지는 대형 굴절 망원경을 통해서, 지구 대기에 우주선 shower로부터 발생한 형광 신호를 관측하려고 한다. 이 프로젝트는 2016~2017년에 발사되어, 5년 이상의 임무 수행을 목표로 하고 있으며, 그 전단계로 Prototype 시스템을 가지고 지상실험인 EUSO-TA와 고도 40 km에서 수행할 EUSO-Balloon실험을 준비하고 있다. 먼저, 망원경의 prototype을 2012년 12월쯤 미국 유타에 있는 Telescope Array(TA) 실험에 설치하여 우주선 또는 임의로 인가한 광원에 의해서 생성된 shower를 TA의 Fluorescence Detector와 함께 측정하여, 시스템 calibration과 더불어 지상에 검출된 우주선을 연구할 계획이다. 그 이듬해인 2013년 여름에는 Balloon에 망원경의 Engineering model을 실어서, 대기고도 40 km아래에서 우주선에 의해 생성되는 shower를 개발한 트리거 시스템을 통해서 검출하고, 대기권에 존재하는 UV background 광원들을 측정하여 우주선을 연구할 예정이다. 한국 그룹은 JEM-EUSO을 위해서 개발한 디지털 신호처리 및 트리거 장치의 제작 중에 있으며, 위의 실험들을 위해 망원경과 함께 조립하여 테스트를 수행할 계획이다.

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